Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder

De novo mutations in schizophrenia implicate synaptic networks

(2014) Menachem Fromer et al.   NATURE

PAK1 Protein Expression in the Auditory Cortex of Schizophrenia Subjects

(2013) Anthony J. Deo et al.   PLoS One

Differences in the Circuitry-Based Association of Copy Numbers and Gene Expression Between the Hippocampi of Patients With Schizophrenia and the Hippocampi of Patients With Bipolar Disorder

(2012) Guoqing Sheng et al.   ARCHIVES OF GENERAL PSYCHIATRY

Abnormalities of the Duo/Ras-Related C3 Botulinum Toxin Substrate 1/p21-Activated Kinase 1 Pathway Drive Myosin Light Chain Phosphorylation in Frontal Cortex in Schizophrenia

(2012) María D. Rubio et al.   BIOLOGICAL PSYCHIATRY

RNA-Seq analysis implicates dysregulation of the immune system in schizophrenia

(2012) Junzhe Xu et al.   BMC GENOMICS

Integrative pathway analysis of genome-wide association studies and gene expression data in prostate cancer

(2012) Peilin Jia et al.   BMC Systems Biology

The extracellular matrix proteoglycan perlecan facilitates transmembrane semaphorin-mediated repulsive guidance

(2012) J. Y. Cho et al.   GENES & DEVELOPMENT

Focal adhesion kinase modulates Cdc42 activity downstream of positive and negative axon guidance cues

(2012) Jonathan P. Myers et al.   JOURNAL OF CELL SCIENCE

Quantitative Proteomic and Genetic Analyses of the Schizophrenia Susceptibility Factor Dysbindin Identify Novel Roles of the Biogenesis of Lysosome-Related Organelles Complex 1

(2012) A. Gokhale et al.   JOURNAL OF NEUROSCIENCE

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Experimental validation of candidate schizophrenia gene ZNF804A as target for hsa-miR-137

(2012) Albert H. Kim et al.   SCHIZOPHRENIA RESEARCH

Genetic overlap between schizophrenia and bipolar disorder: A study with AKT1 gene variants and clinical phenotypes

(2012) Félicien Karege et al.   SCHIZOPHRENIA RESEARCH

Rho GTPases as regulators of morphological neuroplasticity

(2011) Maria Auer et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Common Proteomic Changes in the Hippocampus in Schizophrenia and Bipolar Disorder and Particular Evidence for Involvement of Cornu Ammonis Regions 2 and 3

(2011) Melanie Föcking et al.   ARCHIVES OF GENERAL PSYCHIATRY

Regulation of axonal outgrowth and pathfinding by integrin-ecm interactions

(2011) Jonathan P. Myers et al.   Developmental Neurobiology

Constitutive Upregulation of Chaperone-Mediated Autophagy in Huntington's Disease

(2011) H. Koga et al.   JOURNAL OF NEUROSCIENCE

Regulation of the cytoskeleton by Disrupted-in-Schizophrenia 1 (DISC1)

(2011) Qi Wang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse

(2011) Jennifer Larimore et al.   MOLECULAR BIOLOGY OF THE CELL

Validation of schizophrenia-associated genes CSMD1, C10orf26, CACNA1C and TCF4 as miR-137 targets

(2011) E Kwon et al.   MOLECULAR PSYCHIATRY

Hypothesis review: are clathrin-mediated endocytosis and clathrin-dependent membrane and protein trafficking core pathophysiological processes in schizophrenia and bipolar disorder?

(2011) K O Schubert et al.   MOLECULAR PSYCHIATRY

De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia

(2011) G Kirov et al.   MOLECULAR PSYCHIATRY

Modelling schizophrenia using human induced pluripotent stem cells

(2011) Kristen J. Brennand et al.   NATURE

Genome-wide association study identifies five new schizophrenia loci

(2011)   NATURE GENETICS

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

(2011)   NATURE GENETICS

Common DISC1 Polymorphisms Disrupt Wnt/GSK3β Signaling and Brain Development

(2011) Karun K. Singh et al.   NEURON

New insights in endosomal dynamics and AMPA receptor trafficking

(2011) Peter van der Sluijs et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A Versatile Gene-Based Test for Genome-wide Association Studies

(2010) Jimmy Z. Liu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Altered Cortical CDC42 Signaling Pathways in Schizophrenia: Implications for Dendritic Spine Deficits

(2010) Masayuki Ide et al.   BIOLOGICAL PSYCHIATRY

Detection of characteristic sub pathway network for angiogenesis based on the comprehensive pathway network

(2010) Yezhou Huang et al.   BMC BIOINFORMATICS

Expression of the tyrosine kinase discoidin domain receptor 1 (DDR1) in human central nervous system myelin

(2010) Bàrbara Roig et al.   BRAIN RESEARCH

Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries

(2010) H. J. Williams et al.   HUMAN MOLECULAR GENETICS

Amyloid-Independent Mechanisms in Alzheimer's Disease Pathogenesis

(2010) S. W. Pimplikar et al.   JOURNAL OF NEUROSCIENCE

DISC1 regulates cell–cell adhesion, cell–matrix adhesion and neurite outgrowth

(2010) T Hattori et al.   MOLECULAR PSYCHIATRY

The endocytic matrix

(2010) Giorgio Scita et al.   NATURE

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

(2010) Marta Martinez-Vicente et al.   NATURE NEUROSCIENCE

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intron 12 in NTRK3 is associated with bipolar disorder

(2010) Lavinia Athanasiu et al.   PSYCHIATRY RESEARCH

Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude

(2010) X. Yi et al.   SCIENCE

Roles of the Akt/GSK-3 and Wnt Signaling Pathways in Schizophrenia and Antipsychotic Drug Action

(2009) Zachary Freyberg et al.   AMERICAN JOURNAL OF PSYCHIATRY

SOAP2: an improved ultrafast tool for short read alignment

(2009) R. Li et al.   BIOINFORMATICS

Retinotopic Mapping Requires Focal Adhesion Kinase-Mediated Regulation of Growth Cone Adhesion

(2009) S. Woo et al.   JOURNAL OF NEUROSCIENCE

Roles of BLOC-1 and Adaptor Protein-3 Complexes in Cargo Sorting to Synaptic Vesicles

(2009) Karen Newell-Litwa et al.   MOLECULAR BIOLOGY OF THE CELL

Evidence for a possible association of neurotrophin receptor (NTRK-3) gene polymorphisms with hippocampal function and schizophrenia

(2009) Mona K. Otnæss et al.   NEUROBIOLOGY OF DISEASE

Apoptotic Engulfment Pathway and Schizophrenia

(2009) Xiangning Chen et al.   PLoS One

Schizophrenia: The "BLOC" May Be in the Endosomes

(2009) P. V. Ryder et al.   Science Signaling

SOAP: short oligonucleotide alignment program

(2008) R. Li et al.   BIOINFORMATICS

PAK signalling in neuronal physiology

(2008) Patricia Kreis et al.   CELLULAR SIGNALLING

FAK–MAPK-dependent adhesion disassembly downstream of L1 contributes to semaphorin3A-induced collapse

(2008) Ahmad Bechara et al.   EMBO JOURNAL

Correlation analysis between genome-wide expression profiles and cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders

(2008) S Kim et al.   MOLECULAR PSYCHIATRY

The dystrobrevin-binding protein 1 gene: features and networks

(2008) A Y Guo et al.   MOLECULAR PSYCHIATRY

Integrated network analysis platform for protein-protein interactions

(2008) Jianmin Wu et al.   NATURE METHODS

Mapping and quantifying mammalian transcriptomes by RNA-Seq

(2008) Ali Mortazavi et al.   NATURE METHODS