HMGCR is a genetic modifier for risk, age of onset and MCI conversion to Alzheimer’s disease in a three cohorts study

HNRNPA1 regulates HMGCR alternative splicing and modulates cellular cholesterol metabolism

(2013) Chi-Yi Yu et al.   HUMAN MOLECULAR GENETICS

The Aging Brain and Cognition

(2013) Natalie L. Marchant et al.   JAMA Neurology

Statins, Risk of Dementia, and Cognitive Function: Secondary Analysis of the Ginkgo Evaluation of Memory Study

(2011) Kerstin Bettermann et al.   Journal of Stroke & Cerebrovascular Diseases

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Proposed mechanism for lipoprotein remodelling in the brain

(2010) Chunjiang Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cholesterol-related genes in Alzheimer's disease

(2010) M. Axel Wollmer   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A functional polymorphism in the HMGCR promoter affects transcriptional activity but not the risk for Alzheimer disease in Swedish populations

(2010) Lina Keller et al.   BRAIN RESEARCH

Current status on Alzheimer disease molecular genetics: from past, to present, to future

(2010) K. Bettens et al.   HUMAN MOLECULAR GENETICS

Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort

(2010) Li Shen et al.   NEUROIMAGE

Clinical trial efforts in Alzheimer disease: Why test statins?

(2010) Z. Arvanitakis et al.   NEUROLOGY

Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe

(2010) H. H. Feldman et al.   NEUROLOGY

Concordant Association of Insulin Degrading Enzyme Gene (IDE) Variants with IDE mRNA, Aß, and Alzheimer's Disease

(2010) Minerva M. Carrasquillo et al.   PLoS One

Interaction between HMGCR and ABCA1 cholesterol-related genes modulates Alzheimer's disease risk

(2009) Eloy Rodríguez-Rodríguez et al.   BRAIN RESEARCH

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Common SNPs in HMGCR in Micronesians and Whites Associated With LDL-Cholesterol Levels Affect Alternative Splicing of Exon13

(2008) Ralph Burkhardt et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Variation in the 3-Hydroxyl-3-Methylglutaryl Coenzyme A Reductase Gene Is Associated With Racial Differences in Low-Density Lipoprotein Cholesterol Response to Simvastatin Treatment

(2008) Ronald M. Krauss et al.   CIRCULATION

Alternative Splicing of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Is Associated With Plasma Low-Density Lipoprotein Cholesterol Response to Simvastatin

(2008) Marisa Wong Medina et al.   CIRCULATION

Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study

(2008) M D M Haag et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors

(2008) Raj N Kalaria et al.   LANCET NEUROLOGY

Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts

(2008) Yurii S Aulchenko et al.   NATURE GENETICS