Article
Psychiatry
Darryl Bassett, Philip Boyce, Bill Lyndon, Roger Mulder, Gordon Parker, Richard Porter, Ajeet Singh, Erica Bell, Amber Hamilton, Grace Morris, Gin S. Malhi
Summary: Psychotic episodes occur in a significant proportion of patients with major mood disorders, and their nature and management are less understood compared to non-psychotic periods of illness. This is concerning due to the higher risk of suicide and comorbidity in this subtype of mood disorder. The relationship between psychotic mood and other forms of psychosis, particularly schizophrenia, remains poorly understood. Therefore, our targeted review aims to provide clinical context and a framework for managing these disorders in real-world practice, considering both biological and psychological interventions.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychology, Clinical
Julie Ramain, Lilith Abrahamyan Empson, Luis Alameda, Alessandra Solida, Julien Elowe, Nadir Mebdouhi, Philippe Conus, Philippe Golay
Summary: This study aims to investigate the impact of mood disturbances on the course and outcome of early psychosis. The results revealed that patients with co-occurring manic and depressive dimensions had poorer outcomes, highlighting the importance of accurate assessment and treatment of mood dimensions in early psychosis.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Clinical Neurology
Jan Scott, Havard Kallestad, Oystein Vedaa, Borge Sivertsen, Bruno Etain
Summary: The study suggests a moderate but significant association between sleep disturbances and the first onset of mood and psychotic disorders in adolescents and early adulthood, particularly for sleep disturbances meeting diagnostic criteria.
SLEEP MEDICINE REVIEWS
(2021)
Review
Psychology, Clinical
Francesco Bartoli, Christian Nasti, Dario Palpella, Susanna Piacenti, Maria Elisa Di Lella, Stefano Mauro, Luca Prestifilippo, Cristina Crocamo, Giuseppe Carra
Summary: A systematic review and meta-analysis of 21 studies found that compared to bipolar disorder, unipolar mania is positively or negatively associated with factors such as male gender, age at onset, number of hospitalizations, family history, suicide attempts, comorbid anxiety disorders, and psychotic features. The evidence quality varied, but this study supports the idea that unipolar mania may represent a distinct diagnostic construct with specific clinical correlates. Further research is needed to better differentiate unipolar mania and improve personalized care approaches.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Haitham Jahrami, Ahmed S. BaHammam, Eman Ahmed Haji, Nicola L. Bragazzi, Ihab Rakha, Amani Alsabbagh, Boya Nugraha, Stefan M. Pasiakos
Summary: The study found that Ramadan fasting did not worsen depressive symptoms in adult males diagnosed with major depressive disorder (MDD) during the 4-week period, and also led to improvements in body weight and composition.
Review
Behavioral Sciences
Susana Gomes-da-Costa, Wolfgang Marx, Filippo Corponi, Gerard Anmella, Andrea Murru, Maria Teresa Pons-Cabrera, Anna Gimenez-Palomo, Felipe Gutierrez-Arango, Cristian Daniel Llach, Giovanna Fico, Georgios D. Kotzalidis, Norma Verdolini, Marc Valenti, Michael Berk, Eduard Vieta, Isabella Pacchiarotti
Summary: This study found through a systematic review and meta-analysis that the use of lithium in patients with Bipolar Disorder does not significantly lead to weight gain. Shorter treatment duration is associated with more pronounced weight gain. There were no significant differences in weight gain between lithium and placebo, but weight gain with lithium was lower compared to other active comparators.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Psychiatry
Michael J. Spoelma, Katherine M. Ponte, Gordon Parker
Summary: This study aimed to identify common concerns of caregivers in the management of individuals with bipolar disorder. The results showed that concerns about work capacity and family impacts were almost ubiquitous, along with general feelings of ineffectiveness and irritation. Caregivers were more likely to fear suicide during depressive phases, while they were more likely to experience anger, concerns for their own safety, and take safety precautions during hypo/manic phases.
INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY
(2023)
Article
Biology
Timothy R. Wong, Ian B. Hickie, Joanne S. Carpenter, Elizabeth M. Scott, Adam J. Guastella, Parisa Vidafar, Jan Scott, Daniel F. Hermens, Jacob J. Crouse
Summary: There is limited evidence that chronotype can predict future hypo/manic and depressive symptoms in young people with emerging mental disorders.
CHRONOBIOLOGY INTERNATIONAL
(2023)
Article
Health Care Sciences & Services
Lavinia De Chiara, Gloria Angeletti, Gaia Anibaldi, Chiara Chetoni, Flavia Gualtieri, Francesca Forcina, Paride Bargagna, Georgios Demetrios Kotzalidis, Tommaso Callovini, Marco Bonito, Alexia Emilia Koukopoulos, Alessio Simonetti
Summary: This study aimed to assess the impact of the COVID-19 pandemic on the mental health of pregnant women. The results showed that compared to a non-COVID sample, the COVID sample exhibited higher levels of mild depression and hypomania. However, there were no significant differences in terms of major depression and suicidal ideation.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Gordon Parker, Michael J. Spoelma, Gabriela Tavella, Martin Alda, Tomas Hajek, David L. Dunner, Claire O'Donovan, Janusz K. Rybakowski, Joseph F. Goldberg, Adam Bayes, Verinder Sharma, Philip Boyce, Vijaya Manicavasagar
Summary: The study used machine learning to identify highly discriminating symptoms between bipolar disorder and unipolar depression patients, assisting clinicians in distinguishing between the two conditions. Despite the unbalanced sample, the prediction rule ensembles showed potential in accuracy and may supersede traditional classificatory approaches.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Multidisciplinary
Alexandru I. Tiba, Simona Trip, Carmen H. Bora, Marius Drugas, Feliciana Borz, Daiana C. Miclaus, Laura Voss, Sorin C. Iova, Simona Pop
Summary: Primary irrational beliefs, especially those related to positive events, are found to be significantly associated with the risk of Bipolar Disorder. These findings highlight the importance of addressing positive primary irrational beliefs in the treatment of BPD.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Clinical Neurology
Mai Uchida, Dina Hirshfeld-Becker, Maura DiSalvo, Jerrold Rosenbaum, Aude Henin, Allison Green, Joseph Biederman
Summary: This study confirms that subsyndromal scores on the CBCL-Anx/Dep scale can increase the risk of developing depression in children, especially those at high risk for depression. Children with familial risk but no subsyndromal scores had an intermediate risk, higher than the controls who had the lowest risk.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Medicine, General & Internal
Eve Cosker, Marie Moulard, Samuel Schmitt, Karine Angioi-Duprez, Cedric Baumann, Vincent Laprevote, Raymund Schwan, Thomas Schwitzer
Summary: Major depressive disorder affects over 264 million people worldwide and current treatments show limited effectiveness. This study evaluates the efficacy of light therapy delivered via a portable device in addition to usual care for patients with MDD. The findings of this study will be published in peer-reviewed journals.
Article
Cell Biology
Michael Maes, Muanpetch Rachayon, Ketsupar Jirakran, Pimpayao Sodsai, Siriwan Klinchanhom, Piotr Galecki, Atapol Sughondhabirom, Agnieszka Basta-Kaim
Summary: This study examines the association between the reoccurrence of illness (ROI), the phenome of depression, and major dysmood disorder (MDMD) features and immune response in major depressive disorder and a major depressive episode (MDD/MDE). The results show that MDMD is characterized by heightened immune responses, which are a consequence of ROI-associated sensitization combined with immunostimulatory triggers.
Article
Medicine, General & Internal
Hiwot Tesfa, Dube Jara, Wubetu Woyiraw, Eyob Ketema Bogale, Biksegn Asrat
Summary: This study aimed to assess the prevalence of undernourishment and associated factors among adults with major depressive disorder (MDD) in Northwest Ethiopia. The results showed a high prevalence of undernourishment among adults with MDD, with significant associations found with female gender, rural residence, illiteracy, antidepressant side effects, and HIV/AIDS.
Article
Psychiatry
Stephanie Schrempft, Nick Pullen, Helene Baysson, Ania Wisniak, Maria-Eugenia Zaballa, Francesco Pennacchio, Peter Vollenweider, Pedro Marques-Vidal, Martin Preisig, Idris Guessous, Silvia Stringhini
Summary: This study examines the prevalence and predictors of psychological distress during and after the COVID-19 pandemic wave in Switzerland in 2021. The results show that the prevalence of psychological distress after the pandemic wave is comparable to pre-pandemic levels, and anxiety and depression were highest at the start of the wave and declined with the relaxation of measures. Predictors of psychological distress include younger age, female gender, single parenting, unemployment, changes in employment status, perceived severity and contagiousness of COVID-19, and self-reported post COVID-19 symptoms. These findings emphasize the need for additional mental health support during times of stricter government policies related to COVID-19, while also suggesting that individuals can adapt relatively quickly to the changing context.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Clinical Neurology
Nicola Andrea Marchi, Mathieu Berger, Geoffroy Solelhac, Virginie Bayon, Jose Haba-Rubio, Julie Legault, Cynthia Thompson, Nadia Gosselin, Peter Vollenweider, Pedro Marques-Vidal, Armin von Gunten, Marie-Pierre Francoise Strippoli, Martin Preisig, Bogdan Draganski, Raphael Heinzer
Summary: Research has found conflicting results regarding the relationship between obstructive sleep apnea and cognitive functioning in older adults, and the moderating factors of this association have not been well studied. This study investigated the association between obstructive sleep apnea and cognitive functioning in older adults, as well as the moderating effects of age, sex, apolipoprotein E4, and obesity on this association. The findings suggest that apolipoprotein E4 carriers and obese individuals may be more vulnerable to the negative effects of severe obstructive sleep apnea on processing speed.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Psychiatry
Gilles Ambresin, Marie-Pierre F. Strippoli, Caroline L. Vandeleur, Yves de Roten, Jean-Nicolas Despland, Martin Preisig
Summary: This study compared individuals with chronic major depressive disorder (MDD), non-chronic MDD, and no mood disorder. It focused on specific atypical and melancholic depression symptoms, subtypes of MDD, family history of mood disorders, cardiovascular risk factors, personality traits, coping style, and adverse life events. The findings showed that chronic MDD was associated with increased appetite/weight, suicidal ideation/attempts, exposure to life events in adulthood, higher levels of neuroticism, lower levels of extraversion, lower levels of informal help-seeking behavior, but less frequent family history of MDD compared to non-chronic MDD.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Geriatrics & Gerontology
Thomas Bastelica, Louis-Ferdinand Lespine, Isabelle Rouch, Myriam Tadri, Jean-Michel Dorey, Marie-Pierre F. Strippoli, Thierry d'Amato, Armin von Gunten, Martin Preisig, Romain Rey
Summary: This study examines the inter-relationships among cognitive functioning, personality traits, and inflammatory markers in elderly individuals. The results show that openness is associated with verbal fluency, and agreeableness is associated with immediate free recall. However, no association was found between inflammatory markers and personality traits or cognitive performance.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Laurence Bamps, Jean-Philippe Armenti, Mirela Bojan, Bruno Grandbastien, Christophe von Garnier, Renaud Du Pasquier, Florian Desgranges, Matthaios Papadimitriou-Olivgeris, Lorenzo Alberio, Martin Preisig, Jurg Schwitter, Benoit Guery
Summary: This study collected health complaints from 474 patients one year after COVID-19 diagnosis and found that age, comorbidity index, and smoking habits were associated with hospital admission. Patients with a history of thromboembolism before SARS-CoV-2 infection had a higher risk of recurrence of thromboembolism at 1 year. Fatigue was the most common neurologic symptom, followed by feeling slowed down, headache, and smell disturbance. COVID-19 patients scored higher in anxiety, depression, fatigue, and sleep measures compared to the healthy population.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Olga Trofimova, Adeliya Latypova, Giulia DiDomenicantonio, Antoine Lutti, Ann-Marie G. de Lange, Matthias Kliegel, Silvia Stringhini, Pedro Marques-Vidal, Julien Vaucher, Peter Vollenweider, Marie-Pierre F. Strippoli, Martin Preisig, Ferath Kherif, Bogdan Draganski
Summary: MRI data from over 1000 participants between the ages of 46 and 87 reveals that cardiovascular risk factors are associated with myelin loss and neuroinflammation in the brain. Associations between CVRFs and white matter microstructure were observed predominantly in limbic and prefrontal tracts. Moderate-to-vigorous physical activity was linked to higher myelin content independently of CVRFs.
COMMUNICATIONS BIOLOGY
(2023)
Article
Geriatrics & Gerontology
Beatriz Pozuelo Moyano, Marie-Pierre F. Strippoli, Setareh Ranjbar, Caroline L. Vandeleur, Julien Vaucher, Martin Preisig, Armin von Gunten
Summary: The stability of different subtypes of MDD in older adults was assessed, with a specific focus on the atypical subtype. It was found that the atypical subtype showed strong stability, while there was overlap between the subtypes. Mild cognitive impairment did not impact the stability of the subtypes.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Environmental Sciences
Marvin Bundo, Martin Preisig, Kathleen Merikangas, Jennifer Glaus, Julien Vaucher, Gerard Waeber, Pedro Marques-Vidal, Marie-Pierre F. Strippoli, Thomas Muller, Oscar Franco, Ana Maria Vicedo-Cabrera
Summary: Recent research suggests that higher temperatures may adversely affect mental health and increase hospitalization for mental illness. This study investigates the associations between ambient temperatures and daily mood, as well as the variables that modify this association. The findings show that higher temperatures are associated with a lower probability of having a bad mood in the general population, but individuals with certain psychiatric disorders may exhibit altered responses to heat.
ENVIRONMENTAL HEALTH
(2023)
Article
Psychiatry
Jennifer Glaus, Sun Jung Kang, Wei Guo, Femke Lamers, Marie-Pierre F. Strippoli, Andrew Leroux, Debangan Dey, Kerstin J. Plessen, Julien Vaucher, Peter Vollenweider, Vadim Zipunnikov, Kathleen R. Merikangas, Martin Preisig
Summary: The aim of this study was to investigate the associations of major depressive disorder (MDD) and its subtypes with actigraphy-derived measures of sleep, physical activity, and circadian rhythms, as well as the mediating role of sleep, physical activity, and circadian rhythms in the associations between the atypical MDD subtype and BMI and MeS. The results showed that MDD and its subtypes were associated with various actigraphy-derived variables, and sleep midpoint and physical activity partially mediated the associations between atypical MDD and BMI and MeS. These findings highlight the importance of considering atypical MDD, sleep, and sedentary behavior as cardiovascular risk factors.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Clinical Neurology
Nicola Andrea Marchi, Arton Peci, Jose Haba-Rubio, Geoffroy Solelhac, Virginie Bayon, Mathieu Berger, Peter Vollenweider, Pedro Marques-Vidal, Armin von Gunten, Marie-Pierre Francoise Strippoli, Martin Preisig, Bogdan Draganski, Raphael Heinzer
Summary: This cross-sectional study found no significant association between periodic leg movements and cognitive functioning among community-dwelling older adults. However, further studies are needed to clarify the relationship between periodic leg movements and cognitive functioning, as there is a lack of data in this field.
Article
Public, Environmental & Occupational Health
Yara Shoman, Setareh Ranjbar, Marie-Pierre Strippoli, Roland von Kanel, Martin Preisig, Irina Guseva Canu
Summary: This prospective study found no longitudinal association between Effort-Reward Imbalance (ERI) and over-commitment and the scores of burnout dimensions. However, higher scores of exhaustion, cynicism, and professional efficacy were independently associated with higher scores of the same burnout dimensions, regardless of the effects of ERI and over-commitment.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2023)