Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion

Serine racemase and the serine shuttle between neurons and astrocytes

(2011) Herman Wolosker   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse

(2011) Keisuke Kuroda et al.   HUMAN MOLECULAR GENETICS

Serine racemase deletion abolishes light-evoked NMDA receptor currents in retinal ganglion cells

(2011) Steve J. Sullivan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Linking neurodevelopmental and synaptic theories of mental illness through DISC1

(2011) Nicholas J. Brandon et al.   NATURE REVIEWS NEUROSCIENCE

Contributions of the d-serine pathway to schizophrenia

(2011) Viviane Labrie et al.   NEUROPHARMACOLOGY

Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner

(2011) A. J. Ramsey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DISC1 at 10: connecting psychiatric genetics and neuroscience

(2011) David J. Porteous et al.   TRENDS IN MOLECULAR MEDICINE

Serine Racemase Knockout Mice

(2010) Hisashi Mori et al.   CHEMISTRY & BIODIVERSITY

Neuronal release of d-serine: a physiological pathway controlling extracellular d-serine concentration

(2010) Dina Rosenberg et al.   FASEB JOURNAL

Serine racemase deletion disrupts memory for order and alters cortical dendritic morphology

(2010) L. M. DeVito et al.   GENES BRAIN AND BEHAVIOR

The DISC1 Ser704Cys substitution affects centrosomal localization of its binding partner PCM1 in glia in human brain

(2010) S. L. Eastwood et al.   HUMAN MOLECULAR GENETICS

Brain-specificPhgdhDeletion Reveals a Pivotal Role for l-Serine Biosynthesis in Controlling the Level of d-Serine, anN-methyl-d-aspartate Receptor Co-agonist, in Adult Brain

(2010) Jung Hoon Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders

(2010) Y Ayhan et al.   MOLECULAR PSYCHIATRY

Long-term potentiation depends on release of d-serine from astrocytes

(2010) Christian Henneberger et al.   NATURE

Disrupted-in-Schizophrenia-1 expression is regulated by  -site amyloid precursor protein cleaving enzyme-1-neuregulin cascade

(2010) S. Seshadri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High dose D-serine in the treatment of schizophrenia

(2010) Joshua T. Kantrowitz et al.   SCHIZOPHRENIA RESEARCH

Feedback inactivation of D-serine synthesis by NMDA receptor-elicited translocation of serine racemase to the membrane

(2009) L. Balan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epidemiology-driven neurodevelopmental animal models of schizophrenia

(2009) Urs Meyer et al.   PROGRESS IN NEUROBIOLOGY

Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1–ErbB4 and DISC1

(2009) Hanna Jaaro-Peled et al.   TRENDS IN NEUROSCIENCES

A Critique of the Dopamine Hypothesis of Schizophrenia and Psychosis

(2009) Joanna Moncrieff   HARVARD REVIEW OF PSYCHIATRY

Schizophrenia Candidate Genes: Are We Really Coming Up Blank?

(2008) Steven P. Hamilton   AMERICAN JOURNAL OF PSYCHIATRY

Modulation of d-Serine Levels in Brains of Mice Lacking PICK1

(2008) Takatoshi Hikida et al.   BIOLOGICAL PSYCHIATRY

Serine racemase is predominantly localized in neurons in mouse brain

(2008) Kazushi Miya et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior

(2008) A C Basu et al.   MOLECULAR PSYCHIATRY

Expression of l-Serine Biosynthetic Enzyme 3-Phosphoglycerate Dehydrogenase (Phgdh) and Neutral Amino Acid Transporter ASCT1 Following an Excitotoxic Lesion in the Mouse Hippocampus

(2008) Gye Sun Jeon et al.   NEUROCHEMICAL RESEARCH

Neuron-Astrocyte Signaling in the Development and Plasticity of Neural Circuits

(2008) Beth Stevens   NEUROSIGNALS

Glycine and d-serine, but not d-cycloserine, attenuate prepulse inhibition deficits induced by NMDA receptor antagonist MK-801

(2008) Nobuhisa Kanahara et al.   PSYCHOPHARMACOLOGY