期刊
MOLECULAR PSYCHIATRY
卷 17, 期 6, 页码 634-641出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/mp.2011.41
关键词
association; case-control; DISC1; GWAS; meta-analysis; schizophrenia
资金
- Wellcome Trust
Several polymorphisms in the Disrupted-in-Schizophrenia-1 (DISC1) gene are reported to be associated with schizophrenia. However, to date, there has been little effort to evaluate the evidence for association systematically. We carried out an imputation-driven meta-analysis, the most comprehensive to date, using data collected from 10 candidate gene studies and three genome-wide association studies containing a total of 11 626 cases and 15 237 controls. We tested 1241 single-nucleotide polymorphisms in total, and estimated that our power to detect an effect from a variant with minor allele frequency > 5% was 99% for an odds ratio of 1.5 and 51% for an odds ratio of 1.1. We find no evidence that common variants at the DISC1 locus are associated with schizophrenia. Molecular Psychiatry (2012) 17, 634-641; doi:10.1038/mp.2011.41; published online 12 April 2011
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