Article
Psychiatry
Kirupamani Viswasam, David Berle, Denise Milicevic, Vladan Starcevic
Summary: This study investigated the prevalence of anxiety and related disorders during pregnancy, with OCD showing a steady increase in prevalence from the first to the third trimester. A significant proportion of women developed these disorders during pregnancy, indicating a potential risk factor. The findings have important implications for the recognition, prevention, and treatment of anxiety disorders during pregnancy.
PSYCHIATRY RESEARCH
(2021)
Article
Clinical Neurology
T. Pattyn, L. Schmaal, F. Van den Eede, L. Cassiers, B. W. Penninx, B. C. G. Sabbe, D. J. Veltman
Summary: This study found that panic disorder patients had lower brain activity in response to angry faces, driven mainly by the autonomic subtype. While no significant differences were found in other brain regions, the use of a subtype approach can help advance our neurobiological understanding of panic disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Seoyoung Yoon, Yong-Ku Kim
Summary: Anxiety and mood disorders are common and challenging to treat, and oxytocin is believed to have therapeutic effects. However, the results of studies on the relationship between oxytocin and these disorders are inconsistent, possibly due to factors such as participant characteristics and research methodology.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Health Care Sciences & Services
Alice Caldiroli, Lia Colzani, Enrico Capuzzi, Cecilia Quitadamo, Davide La Tegola, Teresa Surace, Stefania Russo, Mauro Capetti, Silvia Leo, Agnese Tringali, Matteo Marcatili, Francesco Zanelli Quarantini, Fabrizia Colmegna, Antonios Dakanalis, Massimiliano Buoli, Massimo Clerici
Summary: Generalized Anxiety Disorder (GAD) and Panic Disorder (PD) share similar neurobiological mechanisms and clinical features, leading to potential misdiagnosis and delayed treatment. This study aimed to assess the relationship between clinical and socio-demographic markers and GAD/PD diagnosis. Out of 290 outpatients identified with PD or GAD in mental health services in Italy, post-onset psychiatric and medical comorbidities were associated with GAD, while treatment with selective serotonin reuptake inhibitors (SSRIs) was associated with PD. GAD patients had a worse prognosis due to higher comorbidity rates, relapses, and poorer treatment compliance. The association between GAD and psychodynamic psychotherapy was a unique finding of this study.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Neurosciences
Xuyan Guan, Peng Cao
Summary: This article provides an overview of panic disorder in humans, including its definition, subtypes, models used to trigger panic attacks, related hypotheses, neurotransmitter systems involved, and current clinical treatments. It also discusses animal models of panic-like behavior and brain regions that may be involved, offering insights for further understanding of the neural circuit mechanisms behind panic attacks.
NEUROSCIENCE BULLETIN
(2023)
Article
Clinical Neurology
Eun Jung Cha, Sumin Hong, Doo-Heum Park, Seung-Ho Ryu, Jee Hyun Ha, Hong Jun Jeon
Summary: This study aimed to improve our understanding of panic disorder by estimating a network structure of its symptoms using network analysis. The results showed that fear of cognitive dyscontrol, impairment in social functioning, phobic avoidance of situations, and panic-focused anticipatory anxiety were central symptoms in panic disorder. These findings have implications for the etiology of panic disorder and support the efficacy of Cognitive Behavioral Therapy.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Endocrinology & Metabolism
Dirk Alexander Wittekind, Jurgen Kratzsch, Roland Mergl, Steffi Riedel-Heller, A. Veronica Witte, Arno Villringer, Michael Kluge
Summary: The hormone ghrelin is believed to play a role in regulating anxiety. This study found a positive association between ghrelin and mild anxiety, suggesting that ghrelin may be involved in the regulation of physiological anxiety in humans. This association is similar to findings in animals regarding the effects of ghrelin in acute and chronic stress.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Health Care Sciences & Services
So Young Kim, Dae Myoung Yoo, Mi-Jung Kwon, Ji-Hee Kim, Joo-Hee Kim, Woo-Jin Bang, Hyo Geun Choi
Summary: This study found that during the COVID-19 pandemic, there was an increase in medical visits for depressive disorder, bipolar disorder, primary insomnia, panic disorder, hypochondriasis, PTSD, anxiety disorder, anorexia nervosa, and gambling addiction among Korean adults. However, medical visits for schizophrenia, alcoholism, and nicotine dependency decreased during this period.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Psychiatry
Krzysztof Malyszczak, Anna Janocha
Summary: This study compares the nocturnal drop in blood pressure among patients with panic disorder (PD), generalized anxiety disorder (GAD), and healthy individuals. The results show that patients with GAD have a higher nocturnal drop in blood pressure compared to those with PD, while patients with PD have almost flat circadian blood pressure.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2022)
Article
Clinical Neurology
Kyoung-Sae Na, Seo-Eun Cho, Seong-Jin Cho
Summary: This study utilized machine learning approach with heart rate variability as input to differentiate panic disorder from other anxiety disorders. The L1-regularized logistic regression showed the best accuracy, suggesting HRV can be used as a diagnostic tool in machine learning. Future studies with larger sample sizes and longitudinal design are needed to confirm the diagnostic utility of HRV.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Borwin Bandelow, Dirk Wedekind
Summary: This study reviewed and conducted a meta-analysis on internet-delivered psychotherapeutic interventions during the COVID-19 pandemic. The results showed that these interventions were as effective as face-to-face therapy and superior to waitlist controls for treating anxiety disorders. However, the effect sizes of these interventions may be overestimated and there were limitations in the study, such as the lack of blinding and limitations in participant backgrounds.
Article
Health Care Sciences & Services
Boris Karpov, Jari Olavi Lipsanen, Ville Ritola, Tom Rosenstroem, Suoma Saarni, Satu Pihlaja, Jan -Henry Stenberg, Paula Laizane, Grigori Joffe
Summary: This study aimed to investigate the relationship between the Overall Anxiety Severity and Impairment Scale (OASIS) and disorder-specific instruments in internet-delivered cognitive behavioral therapy (iCBT) for anxiety disorders. The results showed a clear and relatively stable association between OASIS and disorder-specific symptom measures, suggesting that OASIS could be used as an outcome measurement instrument in both disorder-specific and transdiagnostic iCBT programs for anxiety disorders.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Psychiatry
Oday M. Abushalbaq, Hussain Y. Khdour, Eid G. Abo Hamza, Ahmed A. Moustafa, Mohammad M. Herzallah
Summary: Anxiety spectrum disorders are associated with deficits in working memory, but patients with different anxiety disorders exhibit variations in working memory function. Patients with generalized anxiety disorder and social anxiety disorder show poor performance in the maintenance component of working memory, while this is not evident in patients with panic disorder.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Armin Zlomuzica, Fine Kullmann, Julia Hesse, Laurin Plank, Ekrem Dere
Summary: Anxiety disorders lead to cognitive dysfunctions, and the threat of shock paradigm can be used to measure the impact of anxiety on cognitive processes. Experimental anxiety was found to impair recognition memory for complex information, and the threat announcement had a negative effect on participants' memory.
SCIENTIFIC REPORTS
(2022)
Article
Psychiatry
Jasper A. J. Smits, Marie-H Monfils, Michael W. Otto, Michael J. Telch, Jason Shumake, Justin S. Feinstein, Sahib S. Khalsa, Adam R. Cobb, E. Marie Parsons, Laura J. Long, Bryan McSpadden, David Johnson, Alma Greenberg
Summary: This study aims to validate CO2 reactivity as a biomarker for exposure-based therapy non-response. By assessing CO2 reactivity in 600 adults and incorporating it into a multivariate model, the study seeks to predict treatment non-response and validate the mechanistic specificity and predictive utility of the CO2 reactivity biomarker.
Article
Psychology, Clinical
Emma C. Johnson, Manav Kapoor, Alexander S. Hatoum, Hang Zhou, Renato Polimanti, Frank R. Wendt, Raymond K. Walters, Dongbing Lai, Rachel L. Kember, Sarah Hartz, Jacquelyn L. Meyers, Roseann E. Peterson, Stephan Ripke, Tim B. Bigdeli, Ayman H. Fanous, Carlos N. Pato, Michele T. Pato, Alison M. Goate, Henry R. Kranzler, Michael C. O'Donovan, James T. R. Walters, Joel Gelernter, Howard J. Edenberg, Arpana Agrawal
Summary: This study used large-scale genome-wide association study data to identify genetic correlations between alcohol use disorder and schizophrenia, as well as shared and disorder-specific genetic variants. The study also found evidence of gene expression mediation in the prefrontal cortex for genes associated with both disorders.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Alexander Refisch, Shoko Komatsuzaki, Martin Ungelenk, Ha-Yeun Chung, Andy Schumann, Susann S. Schilling, Wibke Jantzen, Sabine Schroeder, Thomas W. Muehleisen, Markus M. Noethen, Christian A. Huebner, Karl-Jurgen Baer
Summary: This study found associations between CHRM2 polymorphisms and heart rate variability in patients with schizophrenia, suggesting a potential role for these genetic variations in cardiac autonomic dysfunction in schizophrenia.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Article
Cardiac & Cardiovascular Systems
Jan Gehlen, Anja Stundl, Radoslaw Debiec, Federica Fontana, Markus Krane, Dinara Sharipova, Christopher P. Nelson, Baravan Al-Kassou, Ann Sophie Giel, Jan Malte Sinning, Christopher M. H. Bruenger, Carolin F. Zelck, Laura L. Koebbe, Peter S. Braund, Thomas R. Webb, Simon Hetherington, Stephan Ensminger, Buntaro Fujita, Salah A. Mohamed, Malakh Shrestha, Heike Krueger, Matthias Siepe, Fabian Alexander Kari, Peter Nordbeck, Larissa Buravezky, Malte Kelm, Verena Veulemans, Matti Adam, Stephan Baldus, Karl Ludwig Laugwitz, Yannick Haas, Matthias Karck, Uwe Mehlhorn, Lars Oliver Conzelmann, Ingo Breitenbach, Corinna Lebherz, Paul Urbanski, Won Keun Kim, Joscha Kandels, David Ellinghaus, Ulrike Nowak-Goettl, Per Hoffmann, Felix Wirth, Stefanie Doppler, Harald Lahm, Martina Dressen, Moritz von Scheidt, Katharina Knoll, Thorsten Kessler, Christian Hengstenberg, Heribert Schunkert, Georg Nickenig, Markus M. Noethen, Aidan P. Bolger, Salim Abdelilah-Seyfried, Nilesh J. Samani, Jeanette Erdmann, Teresa Trenkwalder, Johannes Schumacher
Summary: This study provides deeper insights into the genetic risk architecture of bicuspid aortic valve (BAV) disease, including both single-marker and polygenic levels. The study identified a new risk locus and confirmed previously reported risk loci. Additionally, the study revealed that the transcriptome profile in endothelial cells plays a major role in the pathology of BAV.
CARDIOVASCULAR RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Julia Schroeder, Laura Chegwidden, Carlo Maj, Jan Gehlen, Jan Speller, Anne C. Boehmer, Oleg Borisov, Timo Hess, Nicole Kreuser, Marino Venerito, Hakan Alakus, Andrea May, Christian Gerges, Thomas Schmidt, Rene Thieme, Dominik Heider, Axel M. Hillmer, Julian Reingruber, Orestis Lyros, Arne Dietrich, Albrecht Hoffmeister, Matthias Mehdorn, Florian Lordick, Gertraud Stocker, Michael Hohaus, Daniel Reim, Jennis Kandler, Michaela Mueller, Alanna Ebigbo, Claudia Fuchs, Christiane J. Bruns, Arnulf H. Holscher, Hauke Lang, Peter P. Grimminger, Dani Dakkak, Yogesh Vashist, Sandra May, Siegfried Gorg, Andre Franke, David Ellinghaus, Sara Galavotti, Lothar Veits, Josef Weismuller, Jens Dommermuth, Udo Benner, Thomas Roesch, Helmut Messmann, Brigitte Schumacher, Horst Neuhaus, Carsten Schmidt, Thaddaus T. Wissinowski, Markus M. Noethen, Jing Dong, Jue-Sheng Ong, Matthew F. Buas, Aaron P. Thrift, Thomas L. Vaughan, Ian Tomlinson, David C. Whiteman, Rebecca Claire Fitzgerald, Janusz Jankowski, Michael Vieth, Andreas Mayr, Puya Gharahkhani, Stuart MacGregor, Ines Gockel, Claire Palles, Johannes Schumacher
Summary: This study utilized GWAS, genetic correlation analysis, and polygenic risk modeling to investigate the genetic causes of BE/EA. The findings identified new risk loci and candidate genes associated with BE/EA development. The study also revealed differences in the etiology of BE and EA and demonstrated improved risk prediction models when combining PRS with risk factors. These findings provide valuable insights into the mechanisms underlying BE/EA and improve our understanding of the disease.
Article
Nutrition & Dietetics
Christina-Alexandra Schulz, Leonie Weinhold, Matthias Schmid, Markus M. Noethen, Ute Noethlings
Summary: This study aimed to investigate the influence of diet on fluid intelligence and whether this association is modified by individual genetic disposition. The results showed no significant association between diet score and fluid intelligence, even after stratification by polygenic score.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Psychiatry
Alice Braun, Julia Kraft, Stephan Ripke
Summary: This study aims to collect a genetically dense cohort of 1,000 schizophrenia cases and 1,000 controls to investigate genotype-phenotype associations, specific disease subtypes, and gene-environment interactions. The ultimate goal is to gain insights into the etiological mechanisms of schizophrenia and inform risk prediction and treatment strategies.
Review
Pharmacology & Pharmacy
Leen Magarbeh, Claudia Hassel, Maximilian Choi, Farhana Islam, Victoria S. Marshe, Clement C. Zai, Rayyan Zuberi, Roseann S. Gammal, Xiaoyu Men, Maike Scherf-Clavel, Dietmar Enko, Benicio N. Frey, Roumen Milev, Claudio N. Soares, Sagar V. Parikh, Franca Placenza, Stephen C. Strother, Stefanie Hassel, Valerie H. Taylor, Francesco Leri, Pierre Blier, Faranak Farzan, Raymond W. Lam, Gustavo Turecki, Jane A. Foster, Susan Rotzinger, Stefan Kloiber, James L. Kennedy, Sidney H. Kennedy, Chad A. Bousman, Daniel J. Muller
Summary: In this study, the association between six ABCB1 single-nucleotide polymorphisms (SNPs) and antidepressant treatment outcomes was investigated through a systematic review and meta-analysis. No significant association was found between ABCB1 SNPs and antidepressant treatment outcomes in the CAN-BIND-1 sample. However, a significant association between rs1128503 and treatment response was observed in the meta-analysis. These findings provide limited evidence for the implementation of ABCB1 genotyping to inform antidepressant treatment.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Psychiatry
Tolou Maslahati, Katja Wingenfeld, Julian Hellmann-Regen, Julia Kraft, Jing Lyu, Marie Keinert, Aline Voss, An Bin Cho, Stephan Ripke, Christian Otte, Katharina Schultebraucks, Stefan Roepke
Summary: This study investigates the effect of oxytocin administration during the consolidation of a trauma analogue on the formation of intrusive memories. The results suggest that genetic, neurobiological, and psychological factors play a role in the consolidation of intrusive memories, while oxytocin does not have a significant effect.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
Katharina Lechner, Sarah Heel, Manfred Uhr, Tatjana Dose, Florian Holsboer, Susanne Lucae, Ludwig Schaaf, Stephany Fulda, Stefan Kloiber, Johannes M. Hennings
Summary: This study found that the use of mirtazapine, a commonly prescribed antidepressant, is associated with weight gain and dyslipidemia. Despite highly controlled conditions, including diet and physical activity, the administration of mirtazapine negatively affects lipid metabolism in healthy men. This is the first study to demonstrate adverse changes in lipid metabolism under mirtazapine in healthy individuals.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Neurosciences
Ling Zhao, Thomas W. Muehleisen, Dominique I. Pelzer, Bettina Burger, Eva C. Beins, Andreas J. Forstner, Stefan Herms, Per Hoffmann, Katrin Amunts, Nicola Palomero-Gallagher, Sven Cichon
Summary: Neurotransmitter receptors play a crucial role in signal transmission and their dysfunction is linked to brain disorders. The connection between receptors and their corresponding genes, especially in humans, is not well understood. In this study, both receptor densities and gene expression levels were quantified in the human hippocampus to investigate the relationship. The results showed that differences in receptor densities were mainly observed in metabotropic receptors, while differences in gene expression levels mainly pertained to ionotropic receptors. Furthermore, the correlation between receptor densities and gene expression levels varied widely and was generally weak-to-moderate, indicating that post-translational factors also influence receptor densities.
Article
Psychiatry
Marta M. Maslej, Stefan Kloiber, Marzyeh Ghassemi, Joanna Yu, Sean L. Hill
Summary: Advancements in AI have led to the development of clinical support tools in psychiatry, but it is important to understand how psychiatrists will respond to AI-based information, especially if it is incorrect. An experiment was conducted to examine psychiatrists' perceptions of AI-based tools for treating major depressive disorder (MDD). The findings suggest that psychiatrists prefer human-derived clinical support tools.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Azmeraw T. Amare, Anbupalam Thalamuthu, Klaus Oliver Schubert, Janice M. Fullerton, Muktar Ahmed, Simon Hartmann, Sergi Papiol, Urs Heilbronner, Franziska Degenhardt, Fasil Tekola-Ayele, Liping Hou, Yi-Hsiang Hsu, Tatyana Shekhtman, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Barbara Arias, Jean-Michel Aubry, Roland Hasler, Helene Richard-Lepouriel, Nader Perroud, Lena Backlund, Abesh Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M. Biernacka, Armin Birner, Cynthia Marie-Claire, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Maria Del Zompo, J. Raymond DePaulo, Bruno etain, Stephane Jamain, Peter Falkai, Andreas J. Forstner, Louise Frisen, Mark A. Frye, Sebastien Gard, Julie S. Garnham, Fernando S. Goes, Maria Grigoroiu-Serbanescu, Andreas J. Fallgatter, Sophia Stegmaier, Thomas Ethofer, Silvia Biere, Kristiyana Petrova, Ceylan Schuster, Kristina Adorjan, Monika Budde, Maria Heilbronner, Janos L. Kalman, Mojtaba Oraki Kohshour, Daniela Reich-Erkelenz, Sabrina K. Schaupp, Eva C. Schulte, Fanny Senner, Thomas Vogl, Ion-George Anghelescu, Volker Arolt, Udo Dannlowski, Detlef Dietrich, Christian Figge, Markus Jaeger, Fabian U. Lang, Georg Juckel, Carsten Konrad, Jens Reimer, Max Schmauss, Andrea Schmitt, Carsten Spitzer, Martin von Hagen, Jens Wiltfang, Joerg Zimmermann, Till F. M. Andlauer, Andre Fischer, Felix Bermpohl, Philipp Ritter, Silke Matura, Anna Gryaznova, Irina Falkenberg, Cueneyt Yildiz, Tilo Kircher, Julia Schmidt, Marius Koch, Kathrin Gade, Sarah Trost, Ida S. Haussleiter, Martin Lambert, Anja C. Rohenkohl, Vivien Kraft, Paul Grof, Ryota Hashimoto, Joanna Hauser, Stefan Herms, Per Hoffmann, Esther Jimenez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John Kelsoe, Sarah Kittel-Schneider, Ewa Ferensztajn-Rochowiak, Barbara Koenig, Ichiro Kusumi, Gonzalo Laje, Mikael Landen, Catharina Lavebratt, Marion Leboyer, Susan G. Leckband, Alfonso Tortorella, Mirko Manchia, Lina Martinsson, Michael J. McCarthy, Susan McElroy, Francesc Colom, Vincent Millischer, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Noethen, Tomas Novak, Claire O'Donovan, Norio Ozaki, Andrea Pfennig, Claudia Pisanu, James B. Potash, Andreas Reif, Eva Reininghaus, Guy A. Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofield, Barbara W. Schweizer, Giovanni Severino, Paul D. Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M. Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Mario Maj, Gustavo Turecki, Eduard Vieta, Julia Veeh, Stephanie H. Witt, Adam Wright, Peter P. Zandi, Philip B. Mitchell, Michael Bauer, Martin Alda, Marcella Rietschel, Francis J. McMahon, Thomas G. Schulze, Scott R. Clark, Bernhard T. Baune
Summary: A polygenic score (Li-PGS(+)) for lithium treatment response in bipolar disorder patients was developed in this study. Li-PGS(+) was found to be positively associated with lithium treatment response. Gene-based analysis also identified 36 candidate genes related to lithium's molecular mechanism.
MOLECULAR PSYCHIATRY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Carlo Maj, Emadeldin Hassanin, Hannah Klinkhammer, Friederike David, Dheeraj Bobbili, Rana Aldisi, Nuria Duenas, Claudia Perne, Markus M. Noethen, Robert Huneburg, Peter Krawitz, Joan Brunet, Gabriel Capella, Patrick May, Andreas Forstner, Andreas Mayr, Isabel Spier, Stefan Aretz
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Eva Beins, Ronja Hollstein, Kerstin Ludwig, Per Hoffmann, Markus M. Noethen, Andreas Forstner
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Review
Psychiatry
Gunter Schumann, Ole A. Andreassen, Tobias Banaschewski, Vince D. Calhoun, Nicholas Clinton, Sylvane Desrivieres, Ragnhild Eek Brandlistuen, Jianfeng Feng, Soeren Hese, Esther Hitchen, Per Hoffmann, Tianye Jia, Viktor Jirsa, Andre F. Marquand, Frauke Nees, Markus M. Noethen, Gaia Novarino, Elli Polemiti, Markus Ralser, Michael Rapp, Kerstin Schepanski, Tamara Schikowski, Mel Slater, Peter Sommer, Bernd Carsten Stahl, Paul M. Thompson, Sven Twardziok, Dennis van der Meer, Henrik Walter, Lars Westlye
Summary: Climate change, pollution, urbanization, socioeconomic inequality, and the COVID-19 pandemic have affected brain health. Research using innovative data integration tools can identify brain mechanisms underlying environment-related mental illness and inform innovative treatments. This research will lead to the development of objective biomarkers and evidence-based interventions to improve outcomes of environment-related mental illness.
