Review
Medicine, General & Internal
Linda Frintrop, Stefanie Trinh, Jochen Seitz, Markus Kipp
Summary: Eating behavior is regulated by hypothalamic circuits, with glia cells potentially playing a role in this process. Recent studies have shown a reduction in the number of astrocytes in an experimental anorexia nervosa model. Anorexia nervosa is associated with brain volume loss and neuropsychological deficits, and the underlying pathophysiology is still unknown. Understanding the role of glia cells in eating disorders, including anorexia nervosa, may lead to the identification of new drug targets.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Behavioral Sciences
Elisa Giunti, Roberto Collu, Simona Dedoni, M. Paola Castelli, Walter Fratta, Maria Scherma, Paola Fadda
Summary: Data supports altered dopamine and serotonin signaling in anorexia nervosa. Dopamine levels are increased in the cerebral cortex, prefrontal cortex, and nucleus accumbens, while serotonin levels are enhanced in the nucleus accumbens and hippocampus. Additionally, dopamine and serotonin turnover are impaired, and D2 receptor density is increased in the nucleus accumbens shell.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Multidisciplinary Sciences
Trent Davidson, David B. Braudt, Robert Keers, Elham Assary, Kathleen Mullan Harris, Jason D. Boardman
Summary: This study re-evaluated one of the most cited and disputed papers in gene-environment interaction literature, using a genome-wide polygenic indicator to examine the genetic determinants of stress sensitivity. The results supported the stress-diathesis perspective and validated the scientific contributions of the original paper.
SCIENTIFIC REPORTS
(2021)
Article
Psychology, Clinical
Julius Steding, Franziska Ritschel, Ilka Boehm, Daniel Geisler, Joseph A. King, Veit Roessner, Michael N. Smolka, Florian Daniel Zepf, Stefan Ehrlich
Summary: This study investigated the neural responses related to reward processing in individuals with a history of anorexia nervosa (recAN) during acute tryptophan depletion (ATD). The results suggested a normalization of reward-related neural responses in recAN during ATD.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Farnaz Fouladi, Emily C. Bulik-Sullivan, Elaine M. Glenny, Laura M. Thornton, Kylie K. Reed, Stephanie Thomas, Susan Kleiman, Ashlie Watters, Judy Oakes, Eun-Young Huh, Quyen Tang, Jintong Liu, Zorka Djukic, Lauren Harper, Yesel Trillo-Ordonez, Shan Sun, Ivory Blakely, Philip S. Mehler, Anthony A. Fodor, Lisa M. Tarantino, Cynthia M. Bulik, Ian M. Carroll
Summary: This study investigates the composition of gut microbiota in patients with anorexia nervosa (AN) and its influence on the host. The researchers collected fecal samples from AN patients before and after treatment at two different eating disorder units. The results show that the gut microbiota of AN patients remained distinct from non-eating disorder controls even after treatment. The study highlights the important role of gut microbiota in AN patients and its impact on recovery.
Article
Clinical Neurology
Tomas Weinert, Fabio Bernardoni, Joseph King, Julius Steding, Ilka Boehm, Merle Mannigel, Franziska Ritschel, Florian Zepf, Veit Roessner, Stefan Ehrlich
Summary: Previous studies suggest that individuals recovered from anorexia nervosa (AN) as well as those at risk for AN may exhibit increased serotonergic activity and elevated anxiety levels. This study found that experimentally induced short-term depletion of tryptophan (TRP), the precursor of serotonin (5-HT), did not effectively reduce anxiety or improve mood in weight-recovered AN patients. More research is needed to understand the role of 5-HT dysfunction in the pathophysiology of AN.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Review
Medicine, General & Internal
Kaixin Huang, Claire J. Foldi
Summary: Deficits in cognitive flexibility are commonly observed in patients with anorexia nervosa (AN). These deficits are believed to contribute to the persistence of the disorder, as they result in deeply ingrained patterns of thought and behavior that are resistant to change. Neurobiological factors that drive cognitive inflexibility share similarities with the abnormal brain function observed in AN patients, such as disrupted prefrontal cortical function and dysregulated dopamine and serotonin neurotransmitter systems. The activity-based anorexia (ABA) model replicates key features of AN in human patients, making it a valuable tool for investigating the cognitive and neurobiological causes of pathological weight loss. This review aims to explore the relationship between AN, neural function, and cognitive flexibility in human patients, and highlight how behavioral neuroscience techniques can enhance the use of animal models to advance the development of novel therapies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Clinical Neurology
Robertas Strumila, Aiste Lengvenyte, Emilie Olie, Philippe Courtet, Sebastien Guillaume
Summary: The lack of a safe and effective pharmacological treatment for anorexia nervosa is a major challenge in research. Based on the understanding of the neurobiology of anorexia nervosa, the use of escitalopram, a widely available drug, is proposed as a potential option. Escitalopram can boost serotonin levels and decrease dopaminergic transmission, which are two key features in the treatment of anorexia nervosa.
JOURNAL OF PSYCHOPHARMACOLOGY
(2022)
Article
Anatomy & Morphology
Muzi Du, Adrienne Santiago, Cenk Akiz, Chiye Aoki
Summary: This study used the animal model ABA to investigate the neurobiology underlying vulnerability to anorexia nervosa in adolescent females. The activation of mPFC -> DR neurons was found to be positively correlated with food intake following ABA induction. Additionally, GABA-IN in the mPFC was recruited to dampen food intake through feedback inhibition of mPFC -> DR neurons. This study provides insights into the neurobiological mechanisms of anorexia nervosa vulnerability.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Biochemistry & Molecular Biology
Gordana Nedic Erjavec, Mirko Grubor, Maja Zivkovic, Nada Bozina, Marina Sagud, Matea Nikolac Perkovic, Alma Mihaljevic-Peles, Nela Pivac, Dubravka Svob Strac
Summary: Antipsychotic-induced parkinsonism is the most common extrapyramidal side effect caused by the blockage of dopamine receptors. This study found significant associations between HTR6 gene polymorphism and tremor and rigidity induced by haloperidol. Additionally, a combined effect of HTR6 T and SLC6A3 9R alleles on AIP was observed.
Review
Psychiatry
Natalie Gukasyan, Colleen C. Schreyer, Roland R. Griffiths, Angela S. Guarda
Summary: Recent studies suggest that psychedelics may have therapeutic effects on eating disorders through various mechanisms. More research is needed to establish the safety and efficacy of PAT in eating disorder treatment, but it has the potential to enhance current interventions.
CURRENT PSYCHIATRY REPORTS
(2022)
Article
Neurosciences
Pan Yan, Bing Gao, Shuqi Wang, Shengdong Wang, Jing Li, Mingfen Song
Summary: This meta-analysis examined the association of -1438A/G polymorphism with the risk of anorexia nervosa and bulimia nervosa. The results showed a significant association between this polymorphism and anorexia nervosa risk in Caucasians, but not in Asians, and no significant association with bulimia nervosa risk was observed in overall or in Caucasian population.
NEUROSCIENCE LETTERS
(2021)
Article
Cell Biology
Hsin-Yu Liu, Li-Ning Peng, Wei-Ju Lee, Ming-Yueh Chou, Chih-Kuang Liang, Fei-Yuan Hsiao, Ming-Hsien Lin, Liang-Kung Chen
Summary: The study revealed a significant association between Social Vulnerability Index (SVI) and all-cause mortality, with the impact of SVI being more pronounced in non-ApoE gene e4 carriers.
Article
Psychology, Clinical
Shannon S. C. Herrick, Laura Hallward, Lindsay R. Duncan
Summary: The study analyzed 150 TikTok posts under the hashtag #EDrecovery to explore the content related to eating disorder recovery. Five themes were identified, including ED awareness, inpatient stories, eating in recovery, transformations, and gallows humor. The content on TikTok reflected a blend of recovery narratives and pro-ED content, highlighting the blurred boundary between them.
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2021)
Article
Neurosciences
Daniel Halls, Monica Leslie, Jenni Leppanen, Felicity Sedgewick, Simon Surguladze, Leon Fonville, Katie Lang, Mima Simic, Dasha Nicholls, Steven Williams, Kate Tchanturia
Summary: This study investigated the neural basis of social-emotional processing in individuals with Anorexia Nervosa (AN) using functional magnetic resonance imaging and functional connectivity methods. The results revealed group level functional connectivity differences in AN patients when viewing happy faces, which were positively correlated with eating disorder symptoms.
HUMAN BRAIN MAPPING
(2021)
Article
Nutrition & Dietetics
Neus Sole-Morata, Isabel Baenas, Mikel Etxandi, Roser Granero, Manel Gene, Carme Barrot, Monica Gomez-Pena, Laura Moragas, Nicolas Ramoz, Philip Gorwood, Fernando Fernandez-Aranda, Susana Jimenez-Murcia
Summary: Gambling Disorder (GD) is influenced by both genetic and environmental factors. This study investigated the underlying mechanisms of GD severity by examining the interactions between genetic, psychological, socio-demographic, and clinical factors. Pathway analysis revealed that specific genetic variants, in interaction with other biopsychological features, predicted greater severity of GD. These findings highlight the complex interplay between biopsychosocial variables in the development and severity of GD, and provide support for the involvement of genetic variants from the neurotrophic factor family.
Article
Psychology, Clinical
Michael Zeiler, Stefanie Truttmann, Julia Philipp, Leonie Kahlenberg, Tanja Wittek, Claudia Franta, Andrea Schneider, Hartmut Imgart, Annika Zanko, Andreas Karwautz, Gudrun Wagner
Summary: The aim of this study was to validate a German version of the Eating Disorder Symptom Impact Scale (EDSIS) and examine its factors and scale characteristics. A total of 335 parents of adolescents and young adults with anorexia nervosa completed the translated EDSIS and other measures. The 6-factor model of the EDSIS showed the best fit and strong invariance between mothers and fathers.
Article
Endocrinology & Metabolism
Isabel Baenas, Romina Miranda-Olivos, Neus Sole-Morata, Susana Jimenez-Murcia, Fernando Fernandez-Aranda
Summary: Neuroendocrine alterations in hunger and satiety signaling may contribute to the development and maintenance of compulsive overeating in individuals with binge eating disorder (BED). Studies have shown dysfunctions in hormones involved in both homeostatic and hedonic pathways, with a hyperactivated mechanism promoting hunger and potentially abnormal satiety threshold. However, it remains unclear whether these alterations are specific to BED pathology or are related to an obesogenic pattern due to the inclusion of patients with both BED and obesity. Identifying endophenotypes in BED may lead to new therapeutic targets for aberrant eating behavior.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Lucia Camacho-Barcia, Ignacio Lucas, Romina Miranda-Olivos, Susana Jimenez-Murcia, Fernando Fernandez-Aranda
Summary: Individual differences in obesity are not only explained by metabolic and medical complications, but also by alterations in eating behaviour and psychological processes. The heterogeneity of psychological evidence associated with obesity has made it challenging to determine whether psycho-behavioural phenotypes can enhance treatment outcomes. This narrative review summarizes studies on psycho-behavioural phenotypes associated with obesity, identifying three psychological constructs: reward dependence, cognitive control, and mood and emotion. These findings highlight the complexity of psycho-behavioural features in obesity and emphasize the need to consider them in order to improve treatment outcomes.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Public, Environmental & Occupational Health
Yassir Abdul Rahim, Fernando Fernandez-Aranda, Susana Jimenez-Murcia, Anders Hakansson
Summary: The potential link between bariatric surgery and gambling disorder (GD) has not been studied before, but observations suggest that patients undergoing bariatric surgery may develop GD. Obese, older adults, and women may be more susceptible to developing GD due to higher rates of somatic comorbidities. Further research is needed to understand the factors influencing the development of GD in patients undergoing bariatric surgery and to explore preventive measures.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Psychology, Clinical
Tamara Escriva-Martinez, Laura Galiana, Rocio Herrero, Marta Rodriguez-Arias, Fernando Fernandez-Aranda, Ashley N. Gearhardt, Rosa M. Banos
Summary: This study aims to validate the Spanish version of mYFAS 2.0, analyze the relationships between food addiction and other eating behaviors, sociodemographic variables, and BMI, and test the eating-related variables that account for the variance in food addiction. The results show that mYFAS 2.0 has good validity and reliability in the Spanish population. Food addiction is significantly and positively related to eating styles, binge eating, and bulimia, indicating that these variables can be used to identify individuals at high risk of food addiction.
JOURNAL OF EATING DISORDERS
(2023)
Article
Endocrinology & Metabolism
Pablo Maturana-Quijada, Trevor Steward, Nuria Vilarrasa, Romina Miranda-Olivos, Susana Jimenez-Murcia, Holly J. Carey, Jose-Antonio Fernandez-Formoso, Fernando Guerrero-Perez, Isabel Sanchez, Nuria Custal, Nuria Virgili, Rafael Lopez-Urdiales, Carles Soriano-Mas, Fernando Fernandez-Aranda
Summary: This study found that individuals with higher weight showed hypoactivity in prefrontal regulatory systems during emotional regulation, leading to difficulties in inhibiting amygdala activity. These findings suggest that alterations in fronto-amygdalar connectivity contribute to difficulties in regulating negative affect in individuals with higher weight.
Article
Psychology, Clinical
Sangeetha Shyam, Carlos Gomez-Martinez, Indira Paz-Graniel, Jose J. Gaforio, Miguel Angel Martinez-Gonzalez, Dolores Corella, Montserrat Fito, J. Alfredo Martinez, Angel M. Alonso-Gomez, Julia Warnberg, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Jose Manuel Santos-Lozano, J. Luis Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Vicente Martin Sanchez, Xavier Pinto, Maria Ramos, Josep Vidal, Maria Mar Alcarria, Lidia Daimiel, Emilio Ros, Fernando Fernandez-Aranda, Stephanie K. Nishi, Oscar Garcia Regata, Estefania Toledo, Jose V. Sorli, Olga Castaner, Antonio Garcia-Rios, Rafael Valls-Enguix, Napoleon Perez-Farinos, M. Angeles Zulet, Elena Rayo-Gago, Rosa Casas, Mario Rivera-Izquierdo, Lucas Tojal-Sierra, Miguel Damas-Fuentes, Pilar Buil-Cosiales, Rebeca Fernandez-Carrion, Albert Goday, Patricia J. Pena-Orihuela, Laura Compan-Gabucio, Javier Diez-Espino, Susanna Tello, Ana Gonzalez-Pinto, Victor de la O, Miguel Delgado-Rodriguez, Nancy Babio, Jordi Salas-Salvado
Summary: COVID-19 is associated with long-term depression risk in older adults, especially in women. Long-term evaluations of the impact of COVID-19 on mental health and preventive public health initiatives are necessary for older adults.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Diana Klinger, Stefan Riedl, Heidi Elisabeth Zesch, Sofia-Marie Oehlke, Sabine Voelkl-Kernstock, Paul L. L. Plener, Andreas Karwautz, Oswald D. D. Kothgassner
Summary: This study aimed to assess and compare the mental health of transgender youth by sex assigned at birth. The results showed that assigned male at birth (AMAB) adolescents were more likely to have internalizing problems, while assigned female at birth (AFAB) adolescents were more likely to have externalizing problems.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Michael Frey, Lukasz Smigielski, Elvira Tini, Stefanie Fekete, Christian Fleischhaker, Christoph Wewetzer, Andreas Karwautz, Christoph U. Correll, Manfred Gerlach, Regina Taurines, Paul L. Plener, Uwe Malzahn, Selina Kornbichler, Laura Weninger, Matthias Brockhaus, Su-Yin Reuter-Dang, Karl Reitzle, Hans Rock, Hartmut Imgart, Peter Heuschmann, Stefan Unterecker, Wolfgang Briegel, Tobias Banaschewski, Joerg M. Fegert, Tobias Hellenschmidt, Michael Kaess, Michael Koelch, Tobias Renner, Christian Rexroth, Susanne Walitza, Gerd Schulte-Koerne, Marcel Romanos, Karin Maria Egberts, Paolo Magni
Summary: This study investigated the relationship between drug dose and serum concentration of fluoxetine in children and adolescents and established the therapeutic serum reference range. The study found a positive correlation between dose and serum concentration of fluoxetine and its metabolite, with higher body weight and female sex associated with lower serum concentrations and therapeutic response. Most patients showed marked or minimal improvements during treatment, with no reported adverse effects.
Review
Neurosciences
Gemma Mestre-Bach, Roser Granero, Fernando Fernandez-Aranda, Susana Jimenez-Murcia, Marc N. Potenza
Summary: This narrative review explored studies that used independent component analysis (ICA) to investigate different brain networks associated with internet gaming disorder (IGD). Most studies identified alterations in the default-mode network, executive-control network, and salience network in individuals with IGD, which may contribute to the development and maintenance of this disorder. However, further research is needed to better understand the specific role of each network in the symptomatology and treatment of IGD.
DIALOGUES IN CLINICAL NEUROSCIENCE
(2023)
Article
Psychiatry
Cristina Vintro-Alcaraz, Gemma Mestre-Bach, Roser Granero, Monica Gomez-Pena, Laura Moragas, Fernando Fernandez-Aranda, Marc N. Potenza, Susana Jimenez-Murcia
Summary: This study found differences between patients with gambling disorder (GD) with and without self-reported ADHD symptoms in terms of psychopathology, personality, and treatment outcomes. Patients with self-reported ADHD symptoms were more severe in their GD and experienced more severe relapses following treatment. Therefore, more vigilant follow-up and interventions are needed for patients with this comorbidity.
COMPREHENSIVE PSYCHIATRY
(2024)
Meeting Abstract
Psychiatry
C. Vintro-Alcaraz, G. Mestre-Bach, R. Granero, M. Gomez-Pena, L. Moragas, F. Fernandez-Aranda, M. N. Potenza, S. Jimenez-Murcia
EUROPEAN PSYCHIATRY
(2023)
Article
Substance Abuse
Gemma Mestre-Bach, Roser Granero, Fernando Fernandez-Aranda, Marc N. Potenza, Susana Jimenez-Murcia
Summary: This study aimed to explore the specific role of emotional regulation processes and alexithymia in gambling disorder (GD) through network analysis. Critical nodes related to emotion dysregulation were identified, as well as independent clusters between alexithymia and other emotion dysregulation dimensions.
JOURNAL OF GAMBLING STUDIES
(2023)
Article
Substance Abuse
Ana Estevez, Laura Macia, Hibai Lopez-Gonzalez, Janire Momene, Paula Jauregui, Nerea Etxaburu, Roser Granero, Fernando Fernandez-Aranda, Gemma Mestre-Bach, Cristina Vintro-Alcaraz, Lucero Munguia, Isabel Baenas, Teresa Mena-Moreno, Bernat Mora-Maltas, Eduardo Valenciano-Mendoza, Susana Jimenez-Murcia
Summary: The presence of unsuitable coping and emotion regulation strategies in young populations with gambling disorder and in those who have experienced cyberbullying victimization has been suggested. This study found that adolescents and young adults who were victims of cyberbullying show difficulties in emotion regulation and maladaptive coping strategies when trying to solve problems. Public prevention policies targeting these risk factors could benefit vulnerable populations at young ages.
JOURNAL OF GAMBLING STUDIES
(2023)
