期刊
MOLECULAR PSYCHIATRY
卷 14, 期 7, 页码 653-667出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/mp.2009.16
关键词
smoking; addiction; knockout mice; translational model; comorbidity; genetic susceptibility
资金
- National Institute on Drug Abuse (NIH) [R01 DA013232, R01 DA024330]
The core nature of nicotine dependence is evident in wide variations in how individuals become and remain smokers. Individuals with pre-existing behavioral traits are more likely to develop nicotine dependence and experience difficulty when attempting to quit. Many molecular factors likely contribute to individual variations in the development of nicotine dependence and behavioral traits in complex manners. However, the identification of such molecules has been hampered by the phenotypic complexity of nicotine dependence and the complex ways molecules affect elements of nicotine dependence. We hypothesize that nicotine dependence is, in part, a result of interactions between nicotine and pre-existing behavioral traits. This perspective suggests that the identification of the molecular bases of such pre-existing behavioral traits will contribute to the development of effective methods for reducing smoking dependence and for helping smokers to quit. Molecular Psychiatry (2009) 14, 653-667; doi:10.1038/mp.2009.16; published online 24 February 2009
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据