期刊
MOLECULAR PLANT PATHOLOGY
卷 10, 期 3, 页码 337-346出版社
WILEY
DOI: 10.1111/J.1364-3703.2009.00536.X
关键词
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资金
- Crop Functional Genomics Center (CG1141)
- 21st Century Frontier Research Program
- Ministry of Science and Technology
- Biogreen21 project [20080401-034-044-008-01-00]
- Rural Development Administration
- Korea Science and Engineering Foundation (KOSEF)
- Korea government (MEST) [R11-2008-062-03001-0]
- Ministry of Education
- Brain Korea 21 Program
- National Research Foundation of Korea [과C6A2206, R11-2008-062-03001-0, 07-2007-03-001-00] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Rural Development Administration (RDA), Republic of Korea [PJ00700820091136300] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Calcium signalling has profound implications in the fungal infection of plants and animals, during which a series of physiological and morphological transitions are required. In this article, using a model fungal pathogen, Magnaporthe oryzae, we demonstrate that the regulation of the intracellular calcium concentration ([Ca2+](int)) is essential for fungal development and pathogenesis. Imaging of [Ca2+](int) showed that infection-specific morphogenesis is highly correlated with the spatiotemporal regulation of calcium flux. Deletion of the fungal phospholipase C gene (M. oryzae phospholipase C 1, MoPLC1) suppressed calcium flux, resulting in a fungus defective in developmental steps, including appressorium formation and pathogenicity. Surprisingly, the PLC-delta 1 gene of mouse was able to functionally substitute for MoPLC1 by restoring the calcium flux, suggesting the evolutionary conservation of the phospholipase C-mediated regulation of calcium flux. Our results reveal that MoPLC1 is a conserved modulator of calcium flux that is essential for the regulation of key steps in fungal development and pathogenesis.
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