期刊
MOLECULAR PHYLOGENETICS AND EVOLUTION
卷 56, 期 1, 页码 486-491出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ympev.2010.02.015
关键词
Tetraspanins; Disulfide bonds; Protein evolution
资金
- FIS [02/3003, PI070789]
- ISCIII-ICS in Catalonia
- Sackler Institute for Comparative Genomics
- Korein Family Foundation
By analyzing the evolution of cysteine patterns in the large extracellular loop (LEL) of tetraspanins across all eukaryotes, we report the following: (1) the origin of the cysteine-cysteine-glycine (CCG) motif in the common ancestor of unikonts (Animalia, fungi and amoebozoa); (2) tracing cysteine motifs on an eukaryotic phylogeny which includes protists, animals and plants match organismal evolution; (3) using this evolutionary approach we have determined some of the cysteines in these proteins that are involved in specific bonds in the LEL. Our study provides a framework to better understand tetraspanin formation, diversification and the evolutionary history of these important proteins. (C) 2010 Elsevier Inc. All rights reserved.
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