Review
Health Care Sciences & Services
Md Abdus Subhan, Satya Siva Kishan Yalamarty, Nina Filipczak, Farzana Parveen, Vladimir P. Torchilin
Summary: The article discusses the importance of nanodrugs in cancer therapy, targeting tumors through the EPR effect and addressing the lack of selectivity in traditional anticancer drugs.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Huang Wen, Pekka Poutiainen, Enkhzaya Batnasan, Leena Latonen, Vesa-Pekka Lehto, Wujun Xu
Summary: Mesoporous silicon nanoparticles (PSi NPs) are a promising nanomedicine platform with the ability of radiolabeling, drug loading, and cancer targeting. The functionalized NPs showed good radiochemical and colloidal stability, and exhibited enhanced cellular uptake and improved chemotherapy in vitro.
Article
Biotechnology & Applied Microbiology
Jayasree S. Kanathasan, Uma Devi Palanisamy, Ammu K. Radhakrishnan, Srikumar Chakravarthi, Tan Boon Thong, Varghese Swamy
Summary: This study investigates the targeting potential of pSi NPs functionalized with two types of peptides and finds that the linear peptide-pSi NP conjugate has better stability and higher binding efficiency under tumor conditions. In vivo studies show a higher accumulation of linear peptide-conjugated pSi NPs in the tumor site. These results suggest that the linear peptide-pSi NP formulation is a potential drug-delivery platform and fluorescence bioimaging agent.
Article
Chemistry, Applied
Pritam Sharma, John Dell, Giacinta Parish, Adrian Keating
Summary: Porous silicon films with high temperature coefficient of resistance and microfabrication compatibility are suitable candidates for thermal sensors. Surface passivation at 600 degrees Celsius can significantly reduce the 1/f noise in the films, leading to higher sensitivity in thermal sensors.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Materials Science, Ceramics
Jahir Ahmed, M. Faisal, S. A. Alsareii, Mohammed Jalalah, Mabkhoot Alsaiari, Farid A. Harraz
Summary: In this study, a novel Acetaminophen (AcP) sensor utilizing a Mn2O3-embedded mesoporous silicon nanocomposite fabricated glassy carbon electrode was developed. The sensor showed excellent sensitivity, a wide linear dynamic range, and a very low detection limit. It was also successful in detecting AcP concentration in commercial tablets and checking potential chemical interference. Therefore, this Mn2O3@PSi/GCE sensor assembly is expected to be an effective route in developing an efficient AcP sensor.
CERAMICS INTERNATIONAL
(2023)
Article
Chemistry, Analytical
Abdullah Alrashidi, Anas M. El-Sherif, Jahir Ahmed, M. Faisal, Mabkhoot Alsaiari, Jari S. Algethami, Mohamed I. Moustafa, Abdulaziz A. M. Abahussain, Farid A. Harraz
Summary: An efficient electrochemical sensor based on a Pd@PSi-PPy-C nanocomposite was developed to detect and quantify hydroquinone (HQ), which can have negative impacts on health and the environment.
Review
Biochemistry & Molecular Biology
Aya A. Sebak, Basma M. El-Shenawy, Sara El-Safy, Mohamed El-Shazly
Summary: Nanomedicine is revolutionizing cancer treatment with unprecedented outcomes, but the heterogeneous nature of the EPR effect poses challenges. Active targeting strategies have shown limited success in enhancing therapeutic outcomes, prompting exploration of TME reengineering and the use of companion diagnostics to improve NP interactions with biological macromolecules.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2021)
Article
Chemistry, Applied
M. Alejandra Mazo, Maria T. Colomer, Aitana Tamayo, Juan Rubio
Summary: Novel hierarchical micro-meso-macroporous fluorine-doped silicon oxycarbide derived materials were obtained through HF etching and pyrolysis, showing good electrochemical performance and potential applications as electrodes for supercapacitors in the field of energy storage.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Article
Engineering, Chemical
Jahir Ahmed, M. Faisal, Farid A. Harraz, Mohammed Jalalah, S. A. Alsareii
Summary: An electrochemical sensor for ascorbic acid (AA) based on PSi-MC NCs-modified GCE was developed, showing high sensitivity and selectivity for a wide range of AA levels in serum. The sensor also demonstrated excellent performance in detecting potential interference and accurately measuring AA in human blood serum and vitamin C tablets, showcasing good reproducibility and long-term stability.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2021)
Article
Materials Science, Ceramics
Navya Kota, Siddhartha Roy
Summary: Open-porous silicon nitride ceramics were successfully fabricated via low-temperature processing using phosphoric acid as a binder and pore-forming agent. The detailed analysis showed that samples with a phosphoric acid content of 40% exhibited the best mechanical properties.
CERAMICS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
T. G. Diaz-Rodriguez, Christian A. Celaya, Jesus Muniz
Summary: Porous silicon (PSi) has been investigated as a biosensor material due to its large surface area and biocompatibility. In this study, the authors conducted a theoretical investigation on PSi models functionalized with -H and -OH, using density functional theory. The results showed that the adsorption of a DMPC lipid on PSi was highly selective, depending on the degree of functionalization at the pore. The absorption spectra could be used to identify the degree of functionalization, which may have practical applications in capturing and identifying adverse agents in the environment.
BIOPHYSICAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Thu Hang Lai, Barbara Wenzel, Rares-Petru Moldovan, Peter Brust, Klaus Kopka, Rodrigo Teodoro
Summary: In this study, a reliable and reproducible automated production method for [F-18]FLUDA was successfully developed. The method utilized a GE TRACERlab FX2 N radiosynthesizer and achieved high radiochemical yields and purity for the final product.
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2022)
Article
Gastroenterology & Hepatology
Zhi Liu, Ning-Yuan Chen, Zhao Zhang, Sai Zhou, San-Yuan Hu
Summary: Whole genome sequencing analysis revealed upregulation of FBXO2 gene in liver tissues of patients with NAFLD. Overexpression of FBXO2 exacerbated lipid accumulation in a NAFLD mouse model and facilitated proteasomal degradation of HADHA, leading to oxidative stress. FBXO2 may serve as a potential therapeutic target for NAFLD.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Proceedings Paper
Optics
F. Cassio, L. Poffo, N. Lorrain, P. Pirasteh, J. Lemaitre, M. Guendouz
Summary: In this letter, the authors investigate the impact of structuration on the polarization of porous silicon in the near infra-red range. They perform optical characterizations of porous silicon ridge waveguides with different input polarization at around 1550 nm, both as standalone structures and in micro-resonator configurations. The authors highlight the filtering effect of porous silicon, which attenuates the transverse electric mode.
INTEGRATED PHOTONICS PLATFORMS II
(2022)
Article
Chemistry, Medicinal
I Al Jammaz, B. Al-Otaibi, Y. Al-Malki, A. Abousekhrah, S. M. Okarvi
Summary: The synthesis of new radiofluorinated peptides and their hybrids was successful, showing promising results in both in vitro and in vivo evaluations. This study suggests that MUC1-FA-[F-18] SFB may be a useful PET imaging probe for breast cancer.
EJNMMI RADIOPHARMACY AND CHEMISTRY
(2021)
Article
Chemistry, Analytical
Maddalena Negrin, Elena Macerata, Francesca Concia, Mario Mariani, Eros Mossini, Sudeep Das, Anu J. Airaksinen, Marko Strok, Vivien Pottgiesser, Clemens Walther, Petr Distler, Jan John, Mojmir Nemec, Teodora Retegan
Summary: This article discusses the issue of expertise loss in the field of nuclear and radio-chemistry, and presents a strategy for developing an online course targeted at young students to improve their awareness of this discipline.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Jialiang Li, Jiqiang Fan, Yan Gao, Shuodan Huang, Di Huang, Jiachen Li, Xiaoyu Wang, Helder A. Santos, Pingping Shen, Bing Xia
Summary: The development of mitochondria-targeted bovine serum albumins (BSAs) conjugated with fluorescent, lipophilic, and cationic rhodamine 110 molecules enhances the proinflammatory phenotype of macrophages and inhibits their anti-inflammatory phenotype. Porous silicon nanocarriers further boost the immunomodulation of mitochondria-targeted BSAs, accompanied by the secretion of proinflammatory mediators. The mechanism involves the delivery of mitochondria-targeted BSA into macrophages to generate mitochondrial ROS and trigger proinflammatory signaling transduction pathways.
Article
Pharmacology & Pharmacy
Elisavet Lambidis, Chun-Chieh Chen, Dave Lumen, Ana Isabel Fraguas Sanchez, Mirkka Sarparanta, R. Holland Cheng, Anu J. Airaksinen
Summary: Integrins are cell surface receptors that play important roles in cellular functions. This study explores the overexpression of α13-integrins in tumor cells, making them potential biomarkers for diagnostic imaging and tumor-targeted drug delivery. The research focuses on the evaluation of HEVNPs as drug delivery agents, and the conjugation of LXY30 peptide to enhance the binding and internalization of HEVNPs to α3131 integrin expressing cells.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Mahsa Sedighi, Zahra Mahmoudi, Alireza Ghasempour, Mehdi Shakibaie, Fahimeh Ghasemi, Mahsa Akbari, Samin Abbaszadeh, Ebrahim Mostafavi, Helder A. Santos, Mohammad-Ali Shahbazi
Summary: Inspired by natural resources, glycopolypeptide biopolymers have emerged as a new form of biopolymers in biomedical applications. They have well-defined secondary structures and pendant glycosides, and the ability to self-assemble into diverse structures. The nanostructures of glycopolypeptides have opened up new perspectives in drug delivery, diagnosis, and regenerative medicine due to their stable three-dimensional structures, high drug loading efficiency, excellent biocompatibility, and biodegradability.
JOURNAL OF CONTROLLED RELEASE
(2023)
Editorial Material
Chemistry, Multidisciplinary
Helder A. Santos, Irina N. N. Savina
Summary: Professor Helder A. Santos and Dr. Irina N. Savina introduce the themed collection on Nanomaterials in drug delivery in RSC Advances.
Article
Nanoscience & Nanotechnology
Giuseppina Molinaro, Flavia Fontana, Ruben Pareja Tello, Shiqi Wang, Sandra Lopez Cerda, Giulia Torrieri, Alexandra Correia, Eero Waris, Jouni T. Hirvonen, Goncalo Barreto, Helder A. Santos
Summary: This study developed acetalated-dextran nanoparticles (AcDEX NPs) loaded with curcumin and coated with tannic acid (TA) for the treatment of tendinitis. The nanoparticles showed good stability and interaction with human tenocytes and macrophages due to the TA coating. The curcumin-loaded particles exhibited anti-inflammatory properties, while the TA-coated particles showed anti-fibrotic effects. Overall, the nanosystem has promising properties for future application in tendinitis.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Pei Zhang, Yingxin Liu, Guobing Feng, Cong Li, Jun Zhou, Chunyang Du, Yuancheng Bai, Shuai Hu, Tianhe Huang, Guan Wang, Peng Quan, Jouni Hirvonen, Jin Fan, Helder A. Santos, Dongfei Liu
Summary: Microparticles with ultrahigh drug loading and zero-order release of protein payloads are successfully engineered through controlled interfacial self-assembly of polymers. Protein molecules are transformed into nanoparticles covered with a polymer layer to improve their miscibility with carrier materials. The resulting microparticles achieve superior encapsulation efficiency and controlled payload release, enabling efficient glycemic control in type 1 diabetes.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Physical
Voitto Kankanen, Micaela Fernandes, Zehua Liu, Jani Seitsonen, Sami-Pekka Hirvonen, Janne Ruokolainen, Joao F. Pinto, Jouni Hirvonen, Vimalkumar Balasubramanian, Helder A. Santos
Summary: This study reports the development of poly(ethylene glycol)-block-(e-caprolactone) (PEG-b-PCL) nanoparticles using a microfluidic technique for intravenous drug delivery. The optimized formulation achieved spherical morphology, small particle size (dH < 80 nm), uniform size distribution (PDI < 0.2), high drug loading degree (16%), and encapsulation efficiency of 54%. Furthermore, the nanoparticles exhibited stability and sustained release of sorafenib in vitro over several days. Overall, this research demonstrates the use of microfluidic approach in optimizing drug delivery systems.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Han Gao, Shiqi Wang, Qiang Long, Ruoyu Cheng, Wenhua Lian, Artturi Koivuniemi, Ming Ma, Baoding Zhang, Jouni Hirvonen, Xianming Deng, Zehua Liu, Xiaofeng Ye, Helder A. Santos
Summary: Researchers developed a virus-mimicking polysaccharide nanocomplex for specific gene delivery to a subset of leukocytes. The nanocomplex exhibited pH-dependent endosomal membrane destabilization capabilities and efficient gene silencing potency against Dectin-1+ monocytes/macrophages. In murine inflammation models, the nanocomplex showed enhanced accumulation at cardiac lesion sites, indicating its exclusive targeting capability for ischemic heart diseases. This design has translational potential as a versatile platform in inflammation-related diseases.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Sandra Lopez Cerda, Flavia Fontana, Shiqi Wang, Alexandra Correia, Giuseppina Molinaro, Ruben Pareja Tello, Jouni Hirvonen, Christian Celia, Goncalo Barreto, Helder A. Santos
Summary: Macrophages play a critical role in various diseases, and single-drug loaded nanoparticles have been developed to target them. However, macrophage dysfunction can lead to multiple conditions, such as inflammation and fibrosis. This study developed hybrid lipid-polymer nanoparticles (LPNs) loaded with both budesonide and enhanced green fluorescence protein siRNA (eGFP-siRNA) to modulate macrophage dysfunction. The LPNs showed efficient loading, controlled release, non-toxicity, and high transfection efficiency, making them a suitable nanoplatform for the dual drug delivery to macrophages.
ADVANCED THERAPEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Qingqing Huo, Yue Gao, Wenbo Wu, Shuai Hu, Enpeng Dong, Yiyang Zhang, Yuling Tian, Yang Huang, Peng Quan, Dongfei Liu
Summary: Encapsulation is a promising technology to improve the pharmacokinetic properties of proteins and peptides. This study explores the use of amphiphilic polymers to achieve efficient encapsulation. The findings show that these polymers enhance solvation and form a barrier to prevent protein and peptide escape during encapsulation, resulting in high encapsulation efficiency and therapeutic efficacy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Medicine, Research & Experimental
Antti Aarela, Tatsiana Auchynnikava, Olli Moisio, Heidi Liljenba''ck, Putri Andriana, Imran Iqbal, Jyrki Lehtimaki, Johan Rajander, Harri Salo, Anne Roivainen, Anu J. Airaksinen, Pasi Virta
Summary: F-18-labeled [60]fullerene-based molecular spherical nucleic acids (MSNAs), specifically synthesized and administered intravenously to HER2 expressing HCC1954 tumor-bearing mice, were monitored in vivo using PET/CT imaging. MSNA-PS, with improved enzymatic stability compared to MSNA-PO, exhibited an intriguing biodistribution profile in the body.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Sofia Otaru, Tatu Martinmaki, Iida Kuurne, Andreas Paulus, Kerttuli Helariutta, Mirkka Sarparanta, Anu J. Airaksinen
Summary: For the English summary, this paragraph discusses the tetrazine ligation based on the inverse-electron demand Diels-Alder (IEDDA), which is a chemoselective cycloaddition reaction used for chemical modifications and synthesis of biomolecule-based radiopharmaceuticals for PET imaging. However, this reaction has the drawback of forming a mixture of reduced DHPs and oxidized cycloadducts. A mild, rapid, and catalyst-free method for the conversion of DHPs to stable pyridazines is reported in this study.
Article
Materials Science, Biomaterials
Ruben Pareja Tello, Shiqi Wang, Flavia Fontana, Alexandra Correia, Giuseppina Molinaro, Sandra Lopez Cerda, Sami Hietala, Jouni Hirvonen, Goncalo Barreto, Helder A. Santos
Summary: Microfluidic on-chip production of iEDDA-crosslinked polymeric hydrogel microspheres is developed via water-in-oil emulsification (W/O) glass microfluidics. The microspheres are composed of two polyethylene glycol precursors modified with either tetrazine or norbornene. Using a single co-flow glass microfluidic platform, homogenous MPs of sizes 200-600 μm are developed and crosslinked within 2 minutes. The iEDDA-crosslinked hydrogels exhibit maintained rheological properties, low swelling degree, and slow degradation under physiological conditions, making them potential drug vehicles and cell encapsulation systems in the biomedical field.
BIOMATERIALS SCIENCE
(2023)
