Article
Chemistry, Multidisciplinary
Zachary T. Rosenkrans, Jessica C. Hsu, Eduardo Aluicio-Sarduy, Todd E. Barnhart, Jonathan W. Engle, Weibo Cai
Summary: The therapeutic efficacy of photodynamic therapy is limited by the ability of light to penetrate tissues. Cerenkov luminescence from radionuclides has been proposed as an alternative light source in a strategy called Cerenkov radiation-induced therapy. Semiconducting polymer nanoparticles (SPNs) with ideal optical properties can amplify the relatively weak Cerenkov luminescence produced by radionuclides. An optimized photosensitizer-doped SPN was investigated as a nanosystem for cancer theranostics and showed excellent potential in an in vivo tumor therapy study.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Madhura Murar, Lorenzo Albertazzi, Silvia Pujals
Summary: Nanomedicine utilizes nanotechnology for clinical applications and holds promise for improving cancer treatments. Personalized Medicine aims to match the most effective treatment to individual patients, and nanotheranostics, which combine therapy and diagnostic imaging, can help in treatment selection, monitoring response, and planning therapy.
Review
Pathology
Luca Filippi, Luca Urso, Francesco Bianconi, Barbara Palumbo, Maria Cristina Marzola, Laura Evangelista, Orazio Schillaci
Summary: In the past decade, two new radionuclide-based therapies, (223)Radichloride and radioligand therapy (RLT) targeting prostate-specific membrane antigen (PSMA), have been approved for the management of castrate-resistant prostate cancer (PCa). This article illustrates the basic principles of PCa molecular imaging, with a focus on the combined use of diagnosis and therapy for response prediction and assessment. Radiomics, an emerging discipline based on quantitative features extracted from medical images, is also discussed for its potential in this field.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2023)
Review
Pharmacology & Pharmacy
Marjolein I. Priester, Timo L. M. ten Hagen
Summary: Significant advancements have been made in the development of solid tumor treatment, particularly through the implementation of nanosystems for drug delivery, which have reduced side effects and improved drug delivery to tumor regions. However, challenges still exist in clinical translation, and the development of smart drug delivery systems that can be actively manipulated to control drug release shows promise as a powerful strategy to improve drug activity at the target site.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Engineering, Biomedical
Seung Kwan Kang, Jae Sung Lee
Summary: This study proposes a Bowsher prior based on the l(1)-norm and an iteratively reweighting scheme for Anatomy-Guided regularized PET image reconstruction, which overcomes the limitations of the original Bowsher method and improves small lesion detection and contrast enhancement.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Natalia Lopuszynska, Wladyslaw P. Weglarz
Summary: Poor pharmacokinetics and low aqueous solubility combined with rapid clearance from the circulation of drugs result in their limited effectiveness and generally high therapeutic doses. The use of nanocarriers for drug delivery can prevent the rapid degradation of the drug, improve its solubility and stability, enhance distribution and targeting, ensure sustained release, and reduce drug resistance. Nanotechnology enables the combination of therapeutics with biomedical imaging agents to overcome the challenges of disease diagnosis and therapy. This paper presents scientific reports on polymeric nanocarriers for MRI-guided drug delivery, focusing on their contrasting properties and categorizing them into three main groups based on the type of contrast agents.
Editorial Material
Hematology
Andrew Wirth, N. George Mikhaeel
Summary: This study demonstrates that in patients with DLBCL, those who are EOT PET-negative may be spared from radiotherapy, while selected patients with EOT PET-positive sites can achieve outcomes comparable to PET-negative patients when receiving selective treatment.
Review
Pharmacology & Pharmacy
Shubham Roy, Neelanjana Bag, Souravi Bardhan, Ikram Hasan, Bing Guo
Summary: Fluorescence imaging in the second near-infrared window (NIR-II) has many advantages, making it a popular choice for imaging-guided drug delivery (IGDD) paradigms. This review discusses the recent progress in NIR-II IGDD-mediated cancer therapeutics, including design approaches, different therapies, and updated platforms. The review also highlights the innovation directions for NIR-II IGDD platforms to improve theranostic outcomes and clinical translation. This review will contribute to the development of safe and efficient NIR-II fluorescence-mediated anticancer drug delivery.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Oncology
Steven P. Rowe, Martin G. Pomper
Summary: Molecular imaging, defined as visualizing, characterizing, and measuring biological processes at the molecular and cellular levels, has rapidly developed in recent years, with a particular focus on oncology for early detection and optimal disease management. The expansion of molecular imaging is driven by new animal models, sensitive imaging devices, high-throughput methods, genetic manipulation techniques, and cloud computing. Researchers and clinicians are utilizing molecular imaging for a variety of physiological processes, with a focus on oncology for its potential in detecting diseases at an early stage.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Article
Pharmacology & Pharmacy
Paulina Gonzalez, Sashi Debnath, Yu-An Chen, Elizabeth Hernandez, Preeti Jha, Marianna Dakanali, Jer-Tsong Hsieh, Xiankai Sun
Summary: The study reports a small molecule prodrug conjugate (T-SMPDC) for targeted positron emission tomography (PET) imaging and chemotherapy of neuroendocrine prostate cancer (NEPC). The T-SMPDC is designed with a chelating moiety for PET imaging, a targeting peptide for somatostatin receptor 2 (SSTR2) in the tumor microenvironment, and an antagonist of sphingosine kinase 1. In vivo experiments showed selective binding and internalization of the T-SMPDC in SSTR2-positive prostate cancer xenografts, and release of the cytotoxic molecule FTY720. These findings validate the design concept of the T-SMPDC for targeted diagnosis and therapy of NEPC.
Article
Computer Science, Artificial Intelligence
Yuya Onishi, Fumio Hashimoto, Kibo Ote, Hiroyuki Ohba, Ryosuke Ota, Etsuji Yoshikawa, Yasuomi Ouchi
Summary: An unsupervised 3D PET image denoising method with an anatomical information-guided attention mechanism was proposed in this study. Leveraging encoder-decoder and deep decoder subnetworks, the method effectively utilizes spatial details and semantic features of MR-guidance images, achieving superior performance compared to conventional denoising techniques. Experimentally validated, the proposed method shows promising denoising performance across various noisy PET images, indicating its potential for reducing scan times and tracer doses without compromising patient care.
MEDICAL IMAGE ANALYSIS
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Andor F. van den Hoven, Ruth G. M. Keijsers, Marnix G. E. H. Lam, Andor W. J. M. Glaudemans, Frederik A. Verburg, Wouter V. Vogel, Jules Lavalaye
Summary: This study provides a comprehensive bibliometric overview of scientific publications on fibroblast activation protein inhibitor (FAPI) positron emission tomography imaging and radionuclide therapy. The majority of studies focused on imaging topics, comparing FAPI-PET/CT with other imaging techniques and histopathology. The research activity is expanding to include radionuclide therapy, with preliminary reports showing potential benefits.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Pharmacology & Pharmacy
Xue Ran, Junyi Shi, Yalan Chen, Kui Jiang
Summary: This study proposes a multi-kernel version for multimodal data fusion based on the regularized label relaxation linear regression model, which improves the diagnosis performance of Alzheimer's disease. The promising results show that the multimodality fusion method outperforms single modality and reduces overfitting, enhancing generalization ability.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Libor Kostka, Lenka Kotrchova, Eva Randarova, Carolina A. Ferreira, Iva Malatova, Hye Jin Lee, Aeli P. Olson, Jonathan W. Engle, Marek Kovar, Weibo Cai, Milada Sirova, Tomas Etrych
Summary: nanomedicines are being developed as an improved therapeutic option with reduced side effects, and this study introduces tailored nanosystems for the treatment of solid tumors or hematological malignancies. The relationship between the structure of the nanosystem and its distribution in the body was evaluated through independent assessments of the polymer carrier and drug pharmacokinetics. The results showed enhanced tumor accumulation of the polymer carriers in mice with solid tumors, as well as significant accumulation of doxorubicin bound to the polymer carriers in specific tumor types.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Inorganic & Nuclear
Xi-Yang Cui, Yu Liu, Changlun Wang, Zihao Wen, Yichen Li, Haocheng Tang, Juan Diwu, Yuchuan Yang, Mengchao Cui, Zhibo Liu
Summary: This review provides a comprehensive overview of the progress of radiopharmaceuticals in China in recent years, covering various areas such as brain imaging agents, cardiovascular imaging agents, infection and inflammation imaging agents, tumor radiopharmaceuticals, and boron delivery agents. The review highlights the advancements in radiopharmaceutical chemistry and discusses major events, clinical study status, and national regulatory support. The review concludes with a brief commentary on remaining limitations and emerging opportunities for China's radiopharmaceuticals.
Article
Engineering, Biomedical
Sixiang Shi, Kai Yang, Hao Hong, Feng Chen, Hector F. Valdovinos, Shreya Goel, Todd E. Barnhart, Zhuang Liu, Weibo Cai
Review
Pharmacology & Pharmacy
Hao Hong, Feng Chen, Yin Zhang, Weibo Cai
ADVANCED DRUG DELIVERY REVIEWS
(2014)
Article
Chemistry, Multidisciplinary
Rubel Chakravarty, Hector F. Valdovinos, Feng Chen, Christina M. Lewis, Paul A. Ellison, Haiming Luo, M. Elizabeth Meyerand, Robert J. Nickles, Weibo Cai
ADVANCED MATERIALS
(2014)
Article
Oncology
Lu Wang, Zibo Zhao, Mark B. Meyer, Sandeep Saha, Menggang Yu, Ailan Guo, Kari B. Wisinski, Wei Huang, Weibo Cai, J. Wesley Pike, Ming Yuan, Paul Ahlquist, Wei Xu
Review
Medicine, Research & Experimental
Haiming Luo, Hao Hong, Sarah P. Yang, Weibo Cai
MOLECULAR PHARMACEUTICS
(2014)
Article
Medicine, Research & Experimental
Reinier Hernandez, Hector F. Valdovinos, Yunan Yang, Rubel Chakravarty, Hao Hong, Todd E. Barnhart, Weibo Cai
MOLECULAR PHARMACEUTICS
(2014)
Article
Medicine, Research & Experimental
Feng Chen, Tapas R. Nayak, Shreya Goel, Hector F. Valdovinos, Hao Hong, Charles P. Theuer, Todd E. Barnhart, Weibo Cai
MOLECULAR PHARMACEUTICS
(2014)
Article
Nanoscience & Nanotechnology
Yumiao Zhang, Mansik Jeon, Laurie J. Rich, Hao Hong, Jumin Geng, Yin Zhang, Sixiang Shi, Todd E. Barnhart, Paschalis Alexandridis, Jan D. Huizinga, Mukund Seshadri, Weibo Cai, Chulhong Kim, Jonathan F. Lovell
NATURE NANOTECHNOLOGY
(2014)
Review
Chemistry, Multidisciplinary
Shreya Goel, Feng Chen, Weibo Cai
Article
Chemistry, Multidisciplinary
Shreya Goel, Feng Chen, Emily B. Ehlerding, Weibo Cai
Article
Chemistry, Multidisciplinary
Feng Chen, Weibo Cai
Review
Oncology
Yuchen Jin, Beibei Liu, Muhsin H. Younis, Gang Huang, Jianjun Liu, Weibo Cai, Weijun Wei
Summary: Molecular imaging utilizes radionuclides or artificially modified molecules to image specific disease targets, with newly developed probes enabling target-specific diagnosis and treatment of diseases. Advances in molecular imaging have led to the development of novel tracers based on aptamer, peptide, antibody, nanobody, antibody fragment, and nanoparticle platforms, supporting the management of diseases such as thyroid cancer.
Review
Oncology
Huiling Li, Zhen Liu, Lujie Yuan, Kevin Fan, Yongxue Zhang, Weibo Cai, Xiaoli Lan
Summary: Breast cancer is a common malignant tumor that affects women globally, posing a significant threat to their health. Early detection of breast cancer can greatly improve patient prognosis and survival rates, with radionuclide molecular imaging techniques offering advantages in functional detection. Using radionuclide-labeled compounds for noninvasive visualization of biological processes helps elucidate the metabolic state of breast cancer, while receptor-targeted radionuclide molecular imaging is sensitive and specific for visualizing overexpressed molecular markers in the disease, aiding in early diagnosis and improved patient care. Rapid developments in radionuclide probes are contributing to the diagnosis of breast cancer across various aspects, with promising tools being developed for early detection.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hakan Orbay, Yin Zhang, Hector F. Valdovinos, Guoqing Song, Reinier Hernandez, Charles P. Theuer, Timothy A. Hacker, Robert J. Nickles, Robert J. Nickles, Weibo Cai
AMERICAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2014)