Article
Nanoscience & Nanotechnology
Jiaying Zhou, Meiyu Wang, Tingting Wei, Lingchuang Bai, Jing Zhao, Kai Wang, Yakai Feng
Summary: The intelligent gene delivery small-caliber vascular graft combines EC adhesive peptide and responsive gene delivery system to achieve rapid endothelialization with high transfection efficiency. The gene release system on the graft surface undergoes enzymatic release, while also specifically adhering to ECs and maintaining temporary stability in blood flow due to the GPQGIWGQ-C peptide linker.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Jizhuang Ma, Yongfeng Chen, Keda Zhang, Tianzhi Yang, Huichao Xie, Xinggang Yang, Pingtian Ding
Summary: In this study, researchers developed a novel sclerosing agent called POL-TA. By inducing endothelial cell damage and releasing tranexamic acid, POL-TA can stabilize the fibrin network of thrombus and promote vascular fibrosis, which can be used for the treatment of venous malformations.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Pharmacology & Pharmacy
Ildiko Szabo, Mo'ath Yousef, Dora Soltesz, Csaba Bato, Gabor Mezo, Zoltan Banoczi
Summary: Cell-penetrating peptides (CPPs) are a diverse group of molecules with promising potential for transporting compounds into cells, but face challenges such as non-specific internalization and rapid elimination from the body. Despite growing understanding of the mechanisms involved, predicting and designing the cell-penetrating properties of CPPs remains a complex task. Efforts are being made to modify well-known CPPs in order to overcome their limitations and enhance their internalization capabilities and penetration mechanisms.
Review
Biochemistry & Molecular Biology
Sayed Sartaj Sohrab, Riya Raj, Amka Nagar, Susan Hawthorne, Ana Claudia Paiva-Santos, Mohammad Amjad Kamal, Mai M. M. El-Daly, Esam I. I. Azhar, Ankur Sharma
Summary: The body's immune response to an invading pathogen that causes infection results in inflammation, which can lead to chronic inflammatory diseases and cancer. Inflammation can be short-term and non-specific, or long-term and specific, causing angiogenesis, fibrosis, tissue destruction, and cancer progression.
Article
Multidisciplinary Sciences
Masataka Michigami, Kentaro Takahashi, Haruna Yamashita, Zhengmao Ye, Ikuhiko Nakase, Ikuo Fujii
Summary: The generation of ligand-targeting peptidedrug conjugates (PDCs) provides a new approach for targeted intracellular drug delivery utilizing receptor-mediated endocytosis. The designed helix-loop-helix (HLH) peptide acts as the drug carrier, forming a ternary complex with VEGF and its receptor, leading to internalization into cells via VEGF receptor-mediated endocytosis. These HLH peptides and their PDCs show great potential as a new modality for targeted molecular therapy.
Review
Medicine, Research & Experimental
Li Qiao, Huishu Yang, Xin-xin Shao, Qiuyan Yin, Xian-Jun Fu, Qingcong Wei
Summary: Glioma is the most common and aggressive primary intracranial tumor within the central nervous system. The blood-brain barrier has been a major obstacle for effective glioma treatment. Nanocarrier-mediated drug delivery has emerged as an effective and noninvasive system for treating glioma, showing great potential in glioma therapy.
MOLECULAR PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Jung Su Ryu, Felix Kratz, Drazen Raucher
Summary: Elastin-like polypeptides (ELPs) can be used as a thermosensitive vector for targeting hyperthermic tumors, and can also be modified with an enzyme-cleavable linker for drug release within tumors, leading to better treatment outcomes for cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Longkun Wang, Chunqian Zhao, Lu Lu, Honglei Jiang, Fengshan Wang, Xinke Zhang
Summary: Triple-negative breast cancer (TNBC) is an aggressive subtype with poor prognosis, and the current treatment mainly relies on surgery and chemotherapy. However, the application of paclitaxel (PTX) is limited due to its hydrophobicity and side effects. To overcome these problems, a novel PTX conjugate called PTX-SM-TAR was constructed, which improved the specificity and penetrability of PTX at the tumor site. PTX-SM-TAR exhibited receptor-targeting and endocytosis-mediated cell uptake, as well as great transvascular transport and tumor penetration ability. In vivo experiments showed that PTX-SM-TAR had higher antitumor effects compared to PTX, suggesting its potential as a targeted delivery system for TNBC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Bruna Stefane Alves de Oliveira, Ana Carolina Correa de Assis, Natalia Melo Souza, Luiz Fernando Romanholo Ferreira, Renato Nery Soriano, Muhammad Bilal, Hafiz M. N. Iqbal
Summary: Cancer is projected to become the leading cause of mortality worldwide in the future, with tumorigenesis being a complex process involving cancer stem cells playing a significant role. Research on targeting CSCs in cancer treatment is on the rise, showing promising results in pathways and CSC-surface markers targeting.
Review
Nanoscience & Nanotechnology
Yongqing Yang, Nianlan Cheng, Qiao Luo, Ni Shao, Xiaocong Ma, Jifeng Chen, Liangping Luo, Zeyu Xiao
Summary: Glioblastoma is a deadly brain cancer with poor prognosis. Recent advancements in nanotechnology have provided potential solutions for treating brain tumors by designing nanoplatforms. Biomimetic nanoplatforms have gained attention in biomedical applications due to their advantages in extended circulation times and improved immune evasion.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Bing Yang, Tian-tian Wang, Yu-shun Yang, Hai-liang Zhu, Jian-hua Li
Summary: Peptides, as compounds formed by linking amino acids, have excellent biological activity and have become one of the most promising research hotspots in drug delivery systems. They can be used as carriers, drug modifiers, targeting peptides, and intracellular delivery carriers, improving drug efficiency and reducing toxicity.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Review
Chemistry, Inorganic & Nuclear
Van-Nghia Nguyen, Thuy Nguyen Thi Dao, Moonyeon Cho, Hyunsun Jeong, Minh-Tri Nguyen-Le, Yong Shin, Juyoung Yoon
Summary: Due to the limitations of conventional antitumor agents, efforts are being made to develop advanced drug delivery systems using extracellular vesicles, particularly exosomes. These membrane-bound vesicles, secreted by various human cells, have unique features that make them promising nanocarriers for cancer therapy. This review provides knowledge on extracellular vesicles and highlights exosomes as potential nanocarriers for drug delivery. It also discusses recent developments of exosome-based nanotherapeutic agents for cancer treatment and presents challenges and prospects for the future development of exosomal drug delivery systems.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Biophysics
Monika K. Nisiewicz, Agata Kowalczyk, Aleksandra Gajda, Artur Kasprzak, Magdalena Bamburowicz-Klimkowska, Ireneusz P. Grudzinski, Anna M. Nowicka
Summary: Studies have shown that MMPs play a key role in cancer growth and metastasis, and a new voltammetric biosensor has been developed for sensitive detection of MMP-9 in plasma samples. The biosensor has a wide analytical range and low detection limit, making it a valuable tool for cancer diagnosis and treatment research.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biochemistry & Molecular Biology
Shurong Liu, Ye Tian, Sujun Jiang, Zihua Wang
Summary: Tumor-targeting peptide-drug conjugates (PDCs) have gained attention for their potential in cancer therapy. This study presents a novel PDC molecule based on a HER-2-targeting peptide and an acid-sensitive hydrazone bond, aiming to enhance the anti-tumor effect of the drug DOX while minimizing its toxic side effects. The PDC demonstrated high cellular uptake and cytotoxicity in vitro, and effectively inhibited the growth of HER2-positive breast cancer xenografts in mice in vivo. This research offers a promising approach to overcome limitations of DOX in breast cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Qin Wang, Qirui Liang, Jiaxiang Dou, Han Zhou, Cici Zeng, Huimin Pan, Yanqiong Shen, Quan Li, Yi Liu, David Tai Leong, Wei Jiang, Yucai Wang
Summary: This study identifies the tumour vascular basement membrane as a barrier to nanoparticle delivery and proposes an immune-driven strategy to overcome this barrier, increasing nanoparticle movement into tumours.
NATURE NANOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Aaron G. Bart, Goreti Morais, Venu R. Vangala, Paul M. Loadman, Klaus Pors, Emily E. Scott
Summary: Re-engineering Duocarmycin structure to enable bioactivation by tissue-specific cytochrome P450 enzymes has shown promising results in xenograft studies. Analyzing interactions of duocarmycin prodrugs with CYP1A1 and CYP2W1 reveals potential pathways to design compounds with selective P450 enzyme activity.
DRUG METABOLISM AND DISPOSITION
(2022)
Article
Pharmacology & Pharmacy
Francis M. Barnieh, Goreti Ribeiro Morais, Herbie Garland, Paul M. Loadman, Robert A. Falconer
Summary: ICT2588 is a tumour-selective prodrug that targets MT1-MMP and releases ICT2552 in tumour cells, leading to G2/M cell cycle arrest and apoptosis. The intracellular release of ICT2552 after prodrug activation shows synergistic effects with an ATR inhibitor.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Chemistry, Organic
Katreen A. F. Banisalman, Athina Polykandritou, Francis M. Barnieh, Goreti Ribeiro Morais, Robert A. Falconer
Summary: Glycosylation is commonly used to mimic post-translational modifications and modify the properties of peptides. This study introduces a simple and chemoselective method to prepare disulfide-linked glycopeptides. The procedure is highly reactive with cysteine residues in peptides and can be used with unprotected carbohydrates.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Correction
Geriatrics & Gerontology
Rachael E. E. Redgrave, Emily Dookun, Laura K. K. Booth, Maria Camacho Encina, Omowumi Folaranmi, Simon Tual-Chalot, Jason H. H. Gill, W. Andrew Owens, Ioakim Spyridopoulos, Joao F. Passos, Gavin D. D. Richardson
Article
Geriatrics & Gerontology
Rachael E. Redgrave, Emily Dookun, Laura K. Booth, Maria Camacho Encina, Omowumi Folaranmi, Simon Tual-Chalot, Jason H. Gill, W. Andrew Owens, Ioakim Spyridopoulos, Joao F. Passos, Gavin D. Richardson
Summary: Myocardial infarction is a major cause of heart disease, and senescent cardiac cells play a crucial role in pathological remodeling of the heart. Inhibiting senescent cardiac cells can reduce inflammation, improve myocardial remodeling, and enhance cardiac function. This study demonstrates that senescent cardiomyocytes contribute to pathological myocardial remodeling and provides important insights for understanding the mechanisms of cardiomyocyte senescence and optimizing therapeutic strategies targeting these cells.
Review
Geriatrics & Gerontology
Laura K. Booth, Rachael E. Redgrave, Omowumi Folaranmi, Jason H. Gill, Gavin D. Richardson
Summary: Cancer therapy-induced cardiotoxicity is a rising concern, and cellular senescence is gaining attention as a major contributor to this. Targeting senescence may prove to be a therapeutic strategy to prevent or reverse chemotherapy-induced cardiac dysfunction.
FRONTIERS IN AGING
(2022)
Meeting Abstract
Oncology
Athina Polykandritou, Alexandra Serre, Hannah Spencer, Goreti R. Morais, Amanda Race, Steven Shnyder, Paul Loadman, Robert A. Falconer
Meeting Abstract
Oncology
Elisabet Batlle Rocafort, Ali I. Ibrahim, Maria Sadiq, Sneha Smarakan, Vibhu Jha, Tiziano Tuccinardi, Fiona Frame, Norman Maitland, Rafael Jimenez Aguilar, Raquel Pequerul Pavon, Xavier Pares Casampera, Goreti Ribeiro Morais, Jaume Farres Vicen, Klaus Pors
Meeting Abstract
Oncology
Francis M. Barnieh, Goreti Ribeiro Morais, Paul M. Loadman, Robert A. Falconer
Review
Oncology
Hannah L. M. Spencer, Steven D. Shnyder, Paul M. Loadman, Robert A. Falconer
Summary: This review summarizes the expression and potential role of Membrane - type 1 matrix metalloproteinase (MT1-MMP) in osteosarcoma (OS), and assesses its therapeutic potential as a drug target. The findings suggest that exploiting the expression and proteolytic capacity of MT1-MMP could lead to the discovery of novel, safer and more selective drugs for the treatment of OS.
JOURNAL OF CANCER METASTASIS AND TREATMENT
(2022)
Review
Peripheral Vascular Disease
Laura J. Philip, Simon G. Findlay, Jason H. Gill
Summary: This study summarizes the relationship between baseline blood pressure and anthracycline-associated cardiotoxicity. It found that adult patients with elevated blood pressure have an increased vulnerability to cardiotoxicity. Pre-hypertension or an imbalance between systolic and diastolic pressure may indicate an overlooked population at risk. Recommendations are made to include baseline blood pressure and individual systolic versus diastolic pressures in cardio-oncology risk prediction models to guide clinical decision-making.
INTERNATIONAL JOURNAL OF CARDIOLOGY CARDIOVASCULAR RISK AND PREVENTION
(2022)
Correction
Engineering, Civil
Z. Xie, B. Lin, R. A. Falconer, A. Nichols, S. J. Tait, K. Horoshenkov
JOURNAL OF HYDRAULIC RESEARCH
(2022)