Article
Biochemistry & Molecular Biology
Kaiyan Wu, Bingxiang Wang, Ruyue Dou, Yiqun Zhang, Zhongxin Xue, Yongfeng Liu, Yuzhong Niu
Summary: A series of eco-friendly bioadsorbents were synthesized by decorating apple residue cellulose with different generation Schiff base functionalized PAMAM dendrimers. These bioadsorbents exhibit competitive adsorption capacity and remarkable selectivity for Hg(II) in the presence of other metal ions. They also show satisfactory adsorption performance in real water samples and can be regenerated for reuse. The adsorption mechanism involves the participation of functional groups OH, -CONH-, C-N, and N=C.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Dinesh Dhumal, Bar Maron, Einav Malach, Zhenbin Lyu, Ling Ding, Domenico Marson, Erik Laurini, Aura Tintaru, Brigino Ralahy, Suzanne Giorgio, Sabrina Pricl, Zvi Hayouka, Ling Peng
Summary: The urgent need for innovative antibacterial agents due to the antibiotic resistance crisis is addressed in this study. The researchers developed antibacterial candidates based on self-assembled supramolecular dendrimer nanosystems, which exhibited strong antibacterial activity and prevented biofilm formation.
Article
Biochemistry & Molecular Biology
Rashmi Kumar, Candace C. C. Liu, Sean C. Bendall, Michael Angelo
Summary: This study introduces a synthesis method of a dendrimer-based polymer and its application in MIBI-TOF tissue imaging. By comparing the staining performance of antibodies conjugated with dendrimers or linear polymers in FFPE tissue, it was found that dendrimers and linear polymers have comparable avidities. Moreover, dendrimers have advantages such as less background staining and no off-target binding in neural tissue. Overall, this research provides a versatile framework for using third-generation dendrimer-conjugated antibodies with improved staining compared to conventional linear polymers.
Article
Pharmacology & Pharmacy
Londiwe Simphiwe Mbatha, Fiona Maiyo, Aliscia Daniels, Moganavelli Singh
Summary: Messenger RNA (mRNA) has been overlooked for gene therapy due to its instability, but recent studies have shown its advantages over DNA in cancer immunotherapy and vaccine development. This study successfully formulated folic-acid-(FA)-modified, poly-amidoamine-generation-5 (PAMAM G5D)-grafted gold nanoparticles (AuNPs) and demonstrated higher transgene expression in FA receptor-overexpressing cells, highlighting the importance of AuNP delivery system.
Review
Chemistry, Organic
Luis Daniel Pedro-Hernandez, Marcos Martinez-Garcia
Summary: Nanotechnology has become crucial in research and development in recent years, with dendrimers offering unique properties that make them attractive for new technology development. The physical and chemical properties of dendrimers depend on their generation number or size.
CURRENT ORGANIC CHEMISTRY
(2021)
Article
Materials Science, Ceramics
Zachary Kegley, Michael Makay, Joshua Rogers, Katrina Phelps, Colleen Malcom, David Hellmig, Anna Kroninger, Xiangdong Bi
Summary: The purpose of this research is to develop a hydrogel delivery system using PAMAM dendrimer to enhance the solubility and sustained release of hydrophobic drugs. The research shows that with the presence of PAMAM dendrimer, the solubility of diflunisal in water is significantly improved and the hydrogel system can achieve sustained release of the drug.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiamin Ban, Sidi Li, Qi Zhan, Xuepin Li, Huike Xing, Ning Chen, Lixia Long, Xin Hou, Jin Zhao, Xubo Yuan
Summary: The study demonstrates the use of PMPC-modified PAMAM nanoparticles as a drug delivery system for glioma treatment, showing that PMPC can reduce toxicity and effectively target brain tumors.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Rishi Sharma, Joshua E. Porterfield, Hyoung-Tae An, Ambar Scarlet Jimenez, Seulki Lee, Sujatha Kannan, Anjali Sharma, Rangaramanujam M. Kannan
Summary: The GAL-24 glycodendrimer is designed for targeted drug delivery to hepatocytes by exploiting the asialoglycoprotein receptor 1 (ASGP-R). It demonstrates significant accumulation in the liver shortly after systemic administration and maintains hepatocyte-targeting capabilities in mouse and rat models, showing promise for improved drug delivery in treating various liver disorders.
Article
Chemistry, Multidisciplinary
Le Thi Thuy, Namyoung Kang, Minyoung Choi, Minhyung Lee, Joon Sig Choi
Summary: This study developed dendrimeric micelles for the encapsulation of paclitaxel and curcumin in the treatment of melanoma. The results showed that PHRC/TPGS dendrimeric micelles exhibited high potential for the nano-formulation of hydrophobic drugs and good bioavailability and bioactivity against skin cancer.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Yvonne Lerchbammer-Kreith, Michaela Hejl, Petra Vician, Michael A. Jakupec, Walter Berger, Mathea S. Galanski, Bernhard K. Keppler
Summary: Based on their drug delivery properties and activity against tumors, PAMAM dendrimers were combined with platinum(IV) complexes to improve anticancer treatment. The conjugates showed faster reduction behavior compared to the platinum(IV) complexes and exhibited significantly increased cytotoxic activity in human cell lines. In vivo experiments demonstrated tumor growth inhibition and prolonged animal survival.
Article
Polymer Science
Juan Encalada-Alayola, Jorge A. Uribe-Calderon, Wilberth A. Herrera-Kao, Santiago Duarte-Aranda, Gerardo M. Alonzo-Medina, Ruben Dominguez-Maldonado, Jose Manuel Cervantes-Uc
Summary: The aim of this study was to investigate the potential of low-generation PAMAM dendrimers as drug nanocarriers for 5-FU and determine the most efficient generation type. PAMAM dendrimers (up to 2.0 generation) were synthesized and characterized, followed by successful incorporation of 5-FU. In vitro release studies showed that full-generation dendrimers exhibited the highest drug load capacity and slowest release rate, and the drug release kinetics were best described by the Korsmeyer-Peppas model. These results confirm the suitability of low-generation dendrimers as polymeric nanocarriers for drug delivery applications.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Yanmiao Fan, Soumitra Mohanty, Yuning Zhang, Mads Luchow, Liguo Qin, Lisa Fortuin, Annelie Brauner, Michael Malkoch
Summary: Novel cationic hydrogels based on amino-functional hyperbranched dendritic-linear-dendritic copolymers exhibit excellent antimicrobial activity against a wide range of clinical bacteria, including drug-resistant strains. The hydrogels can induce the expression of antimicrobial peptides in human keratinocytes, reducing inflammation and promoting bacterial killing.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Physical
Juliette W. Strasser, Richard M. Crooks
Summary: This study reports the presence of small clusters and single atoms in dendrimer-encapsulated nanoparticle solutions. The findings provide insights into the synthesis and stability mechanisms of nanoparticles and emphasize the need to consider the presence of single atoms and small clusters in the characterization of nanoparticle systems.
Article
Biochemistry & Molecular Biology
Magdalena Szota, Katarzyna Reczynska-Kolman, Elzbieta Pamula, Olga Michel, Julita Kulbacka, Barbara Jachimska
Summary: Two generations of PAMAM dendrimers were studied as potential carriers for the anticancer drug 5-fluorouracil, with results showing that the protonation degree of starting components is crucial for complex formation. The system was able to attach a number of 5FU molecules per dendrimer molecule, and cytotoxicity tests demonstrated a significant decrease in cell viability for malignant cell lines when exposed to PAMAM-5FU complexes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Siva P. Kambhampati, Imran A. Bhutto, Tony Wu, Katie Ho, D. Scott McLeod, Gerard A. Lutty, Rangaramanujam M. Kannan
Summary: The study demonstrates a potential systemic therapy approach for selectively targeting and inhibiting the progression of AMD, showing promising efficacy in animal models and human postmortem studies.
JOURNAL OF CONTROLLED RELEASE
(2021)