Article
Environmental Sciences
Xue Wen, Man Zhu, Zehua Li, Tao Li, Xuewen Xu
Summary: This study explores the effects of BPA on wound repair and finds that dietary intake of BPA delays wound healing, while wound application of BPA accelerates skin regeneration. This is because BPA up-regulates the expression of ERβ in the wound area, and enhances the function of fibroblasts to promote wound repair. For diabetic patients, application of BPA on wounds significantly speeds up wound healing without significant adverse effects on ovarian hormone levels.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Endocrinology & Metabolism
Fernando Lizcano
Summary: Women are more susceptible to cardiovascular risks such as obesity and diabetes after menopause due to constitutional changes. Estrogens and androgens play a role in controlling fat distribution and regulating hunger and satiety. The absence of estrogen during menopause is the main factor contributing to cardiovascular alterations in women. The mechanisms by which estrogens regulate energy metabolism are not fully understood, but they involve specific receptors in the steroid receptor superfamily.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Oncology
Silvia Belluti, Carol Imbriano, Livio Casarini
Summary: This review summarizes the mechanisms of action of ERα and ERβ in prostate cancer and promising future therapies.
Article
Dermatology
Jennifer M. McCracken, Swathi Balaji, Sundeep G. Keswani, Julie C-E Hakim
Summary: A novel murine model of full-thickness vaginal wound healing was designed and validated to study the impact of estrogen signaling-driven healing kinetics, inflammation, and neovascularization. Accelerated vaginal mucosal repair potentially regulated by estrogen signaling through ER alpha was observed, providing a cellular and molecular foundation for understanding healing responses to injury in the vagina.
ADVANCES IN WOUND CARE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Isabela Ribeiro Madalena, Guido Artemio Maranon-Vasquez, Marjorie Ayumi Omori, Emerson Tavares de Sousa, Heitor Albergoni da Silveira, Jorge Esquiche Leon, Flares Baratto-Filho, Sandra Yasuyo Fukada Alves, Maria Bernadete Sasso Stuani, Paulo Nelson-Filho, Christian Kirschneck, Erika Calvano Kuechler
Summary: The aim of this study was to assess the effects of estrogen deficiency on tooth eruption rate (TER) and gene expression of estrogen receptor alpha and beta (ER alpha and ER beta) in a rat model. The results showed that estrogen deficiency decreased TER in teeth under impeded condition and increased gene expression of ER beta in the odontogenic region of teeth with continuous formation.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Vrisiis Kofina, Mutlu Demirer, Barbaros S. Erdal, Timothy D. Eubank, Vedat O. Yildiz, Dimitris N. Tatakis, Binnaz Leblebicioglu
Summary: This study found that a history of bone grafting alters the healing response of soft tissues following implant placement surgery. Soft tissue closure was slower in grafted bone (GG) areas, and blood perfusion recovery was slower in GG sites.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Biology
Sylwia Lewoniewska, Ilona Oscilowska, Antonella Forlino, Jerzy Palka
Summary: The estrogen receptor status and the availability of estrogen affect the survival and apoptosis of breast cancer cells through the mitochondrial enzyme PRODH/POX. ERα stimulates cell proliferation while ERβ has anti-proliferative and pro-apoptotic activity. Estrogens can upregulate prolidase activity and collagen biosynthesis, limiting proline availability for PRODH/POX-dependent apoptosis in ER-positive breast cancer cells.
Article
Environmental Sciences
Juan P. Munoz, Rocio Araya-Osorio, Raul Mera-Adasme, Gloria M. Calaf
Summary: Recent reports have questioned the safety of glyphosate, the active ingredient in several herbicide formulations, suggesting that it may act as an endocrine disruptor by promoting estrogenic activity. This study aimed to investigate the mechanism by which glyphosate induces estrogenic effects using breast cancer cell line models. The results showed that high concentrations of glyphosate mimic the effects of estrogen, leading to the activation of estrogen receptor alpha and enhanced cell proliferation.
Article
Oncology
Ashley V. Ward, Shawna B. Matthews, Lynsey M. Fettig, Duncan Riley, Jessica Finlay-Schultz, Kiran V. Paul, Matthew Jackman, Peter Kabos, Paul S. MacLean, Carol A. Sartorius
Summary: This study evaluated the impact of estrogens and progestins on breast cancer cell metabolism and found that combination hormone treatment increases glucose metabolism and fat storage, promoting tumor progression. Targeting hormone-regulated metabolism may be a potential therapeutic strategy for ER+PR+ breast cancer.
Article
Biochemistry & Molecular Biology
Dongying Zhang, Qianqian Ouyang, Zhang Hu, Sitong Lu, Weiyan Quan, Puwang Li, Yu Chen, Sidong Li
Summary: Chitosan-based thermosensitive hydrogels incorporating integral active oyster peptide microspheres were studied for wound healing applications with promising results in accelerating cell migration and promoting fast wound healing in a mouse model. Safety evaluation demonstrated the biocompatibility of the hydrogel, indicating its potential as a medical dressing for wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Agriculture, Dairy & Animal Science
Vasileia Angelou, Dimitra Psalla, Chrysostomos Dovas, George M. Kazakos, Christina Marouda, Kyriakos Chatzimisios, Zacharenia Kyrana, Evangelia Moutou, Maria Karayannopoulou, Lysimachos G. Papazoglou
Summary: This study investigated the efficacy of autologous platelet-rich plasma (PRP) infiltration in open wounds in cats. The results showed that PRP infiltration promoted faster and better wound healing, as well as improved perfusion. This is the first study to focus on the topical application of PRP in treating open wounds in laboratory cats, and the results are encouraging, demonstrating faster healing in the PRP group.
Article
Biology
Juan P. Munoz, Gloria M. Calaf
Summary: Acetylcholine (ACh) can activate the MAPK/ERK and PI3K/Akt pathways, induce p-ERα expression and nuclear translocation in breast cancer cell lines. However, ACh and 17β-estradiol have different mechanisms of action, and ACh can enhance cell viability and induce overexpression of specific EMT markers.
Review
Pharmacology & Pharmacy
Jiaqi Yao, Yiran Tao, Zelin Hu, Junjie Li, Ziyi Xue, Ya Zhang, Yi Lei
Summary: This paper provides a comprehensive review of ER's structural functions and highlights the recent advancements in novel drugs targeting ER, namely SERD and SERCA, focusing on their structural optimization strategies and future directions. It also discusses the therapeutic potential and challenges of these drugs in breast cancer and other ER-related diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Chemistry, Medicinal
Shasha Jia, Xueya Wang, Guowei Wang, Xiaojing Wang
Summary: Soft tissue damage stimulates the release of catecholamine hormones which bind to beta-adrenergic receptors on the cell membrane surface, impairing soft tissue wound healing. Beta-blockers inhibit this activation and accelerate wound healing by reducing inflammation, promoting cell migration, and inhibiting bacterial effects. They are being studied for their efficacy in various soft tissue wound repair applications, but further investigation into their mechanisms of action is necessary.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Endocrinology & Metabolism
Holly N. Wilkinson, Benjamin Reubinoff, David Shveiky, Matthew J. Hardman, Ofra Ben Menachem-Zidon
Summary: Pelvic organ prolapse is a common disorder that significantly affects women's quality of life. Age-related deficiency of Arginase 1 has been identified as a potential factor contributing to delayed vaginal healing. This study found that inhibiting Arginase 1 expression led to delayed scratch-wound closure in vaginal epithelial cells, while activating Arginase 1 accelerated healing in aged rat vaginal wounds. Targeting age-related Arginase 1 deficiency may be a viable therapeutic strategy to promote vaginal healing in pelvic organ prolapse patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Francesca Bugli, Federica Massaro, Francesco Buonocore, Paolo Roberto Saraceni, Stefano Borocci, Francesca Ceccacci, Cecilia Bombelli, Maura Di Vito, Rosalba Marchitiello, Melinda Mariotti, Riccardo Torelli, Maurizio Sanguinetti, Fernando Porcelli
Summary: The increasing resistance of fungi to antibiotics is a severe challenge in public health, and newly effective drugs are required. In this study, a promising lipopeptide was found to exhibit broad-spectrum antifungal activity against relevant pathogen fungi, including multidrug-resistant ones, both in vitro and in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Rachel A. Crompton, Helen Williams, Laura Campbell, Lim Hui Kheng, Charis Saville, David M. Ansell, Adam Reid, Jason Wong, Leah A. Vardy, Matthew J. Hardman, Sheena M. Cruickshank
Summary: Nonhealing wounds represent a significant clinical challenge with limited treatment options. This study reveals a previously unknown intrinsic role of epidermal ARG1 in cutaneous wound healing, highlighting the potential of targeting epidermal ARG1 and its downstream mediators as therapeutic strategies for wound repair.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Correction
Pharmacology & Pharmacy
Alessandro Villa, Electra Brunialti, Jessica Dellavedova, Clara Meda, Monica Rebecchi, Matteo Conti, Lorena Donnici, Angelo Reggiani, Vincenzo Lionetti, Paolo Ciana, Raffaele De Francesco
PHARMACOLOGICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Fabrizio Vetica, Fabiana Pandolfi, Luca Pettazzoni, Francesca Leonelli, Martina Bortolami
Summary: This review outlines the methodological and stereochemical features of organocatalytic stereoselective synthesis of bicyclic ketones since 1971, focusing on the structural features of catalysts and reaction conditions.
Article
Biochemistry & Molecular Biology
Alessandra Oberto, Ilaria Bertocchi, Angela Longo, Sara Bonzano, Silvia Paterlini, Clara Meda, Sara Della Torre, Paola Palanza, Adriana Maggi, Carola Eva
Summary: Conditional inactivation of the Npy1r gene in forebrain principal neurons leads to a sexually dimorphic phenotype in mice, with male mice showing more significant effects than females. Additionally, the conditional deletion of the Npy1r gene in male mice increases susceptibility to obesity when exposed to a high-fat diet. In female mice, the conditional deletion of the Npy1r gene increases body weight and subcutaneous white adipose tissue weight in both standard diet and high-fat diet-fed ovariectomized females, possibly mediated by the NPY-Y1R's ability to protect the brain against neuroinflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Iqra Fatima, Guodong Chen, Natalia Botchkareva, Andrey A. Sharov, Daniel Thornton, Holly N. Wilkinson, Matthew J. Hardman, Andreas Grutzkau, Joao Pedro de Magalhaes, Andrei Seluanov, Ewan St J. Smith, Vera Gorbunova, Andrei N. Mardaryev, Chris G. Faulkes, Vladimir A. Botchkarev
Summary: Naked mole-rats show similar skin aging characteristics to humans, including a decrease in epidermal thickness and keratinocyte proliferation. However, interestingly, the expression levels of several longevity-associated and tumor-suppressor genes are increased in aged naked mole-rat skin. These findings provide a basis for using naked mole-rats as a model organism to study the biology and disease resistance of human skin.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Chemistry, Organic
Leonardo Straminelli, Francesco Vicentini, Antonio Di Sabato, Carmela Maria Montone, Chiara Cavaliere, Kari Rissanen, Francesca Leonelli, Fabrizio Vetica
Summary: A highly stereoselective procedure for the synthesis of spiro-polycyclic oxindoles bearing five contiguous stereogenic centers including two tetrasubstituted carbons has been developed. The sequence involves sequential organocatalysis using a pyrrolidine-based organocatalyst and DBU, resulting in an atom-economical Michael-domino Michael/aldol reaction sequence. The reaction yielded variously functionalized spiro-decalin oxindoles with excellent stereoselectivity (>99:1 dr, up to 92% ee).
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Clara Meda, Arianna Dolce, Elisabetta Vegeto, Adriana Maggi, Sara Della Torre
Summary: Non-alcoholic fatty liver disease (NAFLD) is a widespread health issue that is associated with other cardiometabolic diseases. This study found that adropin, a hepatokine, may be regulated in a sex-specific manner through estrogen receptor alpha (ERα) and could potentially be used as an approach to limit or prevent NAFLD.
Article
Chemistry, Physical
Marco Fuse, Giovanna Longhi, Giuseppe Mazzeo, Stefano Stranges, Francesca Leonel, Giorgia Aquila, Enrico Bodo, Bruno Brunetti, Carlo Bicchi, Cecilia Cagliero, Julien Bloino, Sergio Abbate
Summary: In this study, the VCD and IR spectra of chiral isomers of methyloxirane and methylthiirane were reinvestigated using experimental and theoretical approaches. Anharmonic corrections were taken into account to better understand the active anharmonic modes and the role of mechanical and electrical anharmonicity in determining the intensities of VCD and IR/NIR data.
JOURNAL OF PHYSICAL CHEMISTRY A
(2022)
Article
Chemistry, Physical
Alessandro Triolo, Vitaly V. Chaban, Fabrizio Lo Celso, Francesca Leonelli, Michael Vogel, Elisa Steinrucken, Alessandra Del Giudice, Carlo Ottaviani, James A. Kenar, Olga Russina
Summary: Dialkyl carbonates with short-medium alkyl length, also known as oleochemical carbonates, have attractive properties and a wide range of applications. However, their chemical physical properties and microscopic correlations are not well understood. In this study, we explored the temperature dependence of these properties and the microscopic morphology of DACs. Our findings reveal a distinct degree of mesoscopic spatial segregation and the role of carbonate moieties in driving weak hydrogen bonding interactions and alkyl chain alignment. These findings have implications for the potential applications of DACs in separation, catalysis, and lubrication fields.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Biochemistry & Molecular Biology
Annalisa Masi, Francesca Leonelli, Viviana Scognamiglio, Giulia Gasperuzzo, Amina Antonacci, Michael A. Terzidis
Summary: This article focuses on the importance of C. reinhardtii microalgae in understanding photosynthetic and metabolic processes in plants and eukaryotes. It also highlights the potential of C. reinhardtii as a biochemical factory for producing valuable biomolecules that directly impact human health and nutrition. The review discusses recent advances in the field, along with limitations and challenges, and explores the future applications of C. reinhardtii biomass and processed products in nutraceuticals and food supplements. The article underscores the increasing need for environmentally and economically sustainable production of high-value biomolecules and the important role of C. reinhardtii.
Article
Biochemistry & Molecular Biology
Elisa Sturabotti, Fabrizio Vetica, Giorgia Toscano, Andrea Calcaterra, Andrea Martinelli, Luisa Maria Migneco, Francesca Leonelli
Summary: A study was conducted on the amidation conditions of N-acetyl-l-phenylalanine using TBTU and various bases for the synthesis of NAPA, a potential drug for joints diseases. The diastereoselective amidation reaction with 1,3,4,6-tetra-O-acetyl-beta-d-glucosamine showed racemization, but the use of pyridine as base showed potential for reducing racemization. Stereochemical retention under amidation conditions was studied in detail through control experiments.
Article
Polymer Science
Luca Pettazzoni, Francesca Leonelli, Andrea Giacomo Marrani, Luisa Maria Migneco, Fabrizio Vetica, Lorenzo Celio, Valerio Napoleone, Sara Alfano, Andrea Colecchia, Francesco Amato, Valerio Di Lisio, Andrea Martinelli
Summary: In the last decade, there has been an increasing number of studies on the application of dynamic covalent chemistry in polymeric materials, due to the unique properties of these materials such as reprocessability, recyclability, and self-healing. This research focuses on the synthesis and characterization of a dynamic covalent chemistry-based polymer, which is reprocessable and self-healable. The polymer also shows strong interaction with copper surfaces through stable Cu-S bonds. Furthermore, the study investigates its potential application as a solvent-free reusable adhesive for copper.
Article
Cell Biology
Electra Brunialti, Alessandro Villa, Marco Toffoli, Sara Lucas Del Pozo, Nicoletta Rizzi, Clara Meda, Adriana Maggi, Anthony H. V. Schapira, Paolo Ciana
Summary: Microglia are heterogenous cells in the nervous system that have distinct populations contributing to specific processes, including neuroprotection. Our study found that male microglia tend to have a more pro-inflammatory phenotype, while female microglia are more sensitive to glucocerebrosidase inhibition. Furthermore, glucocerebrosidase inhibition impaired the ability of female microglia to enhance the Nrf2-dependent detoxification pathway in neurons.