Article
Neurosciences
Isabel Perez-Santos, Nicola Palomero-Gallagher, Karl Zilles, Carmen Cavada
Summary: The study reveals that Noradrenaline (NA) plays important roles in modulating thalamic functions related to consciousness, emotion, cognition, and executive functions, with different levels of innervation and receptor densities across thalamic nuclei. The findings suggest a close relationship between NA axonal densities and Alpha adrenoceptor densities in the thalamus.
Article
Immunology
Song Cao, Daniel W. Fisher, Guadalupe Rodriguez, Tian Yu, Hongxin Dong
Summary: The study found that in APP/PS1 mice, there was increased expression of inflammatory cytokines and microglial activation in the cortex, hippocampus, and spinal cord. Additionally, there was more evident loss of LC-NE neurons and fibers, as well as reduced NET expression, in the APP/PS1 mice compared to wild-type mice.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Juan Li, Yiyong Wei, Junli Zhou, Helin Zou, Lulin Ma, Chengxi Liu, Zhi Xiao, Xingfeng Liu, Xinran Tan, Tian Yu, Song Cao
Summary: Selective activation of the LC:SC pathway alleviates neuropathic pain in mice by increasing noradrenaline release and reducing neuroinflammation of astrocytes and microglia in the spinal dorsal horn.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Neurosciences
Alexia Montalant, Ole Kiehn, Jean-Francois Perrier
Summary: Spinal cord astrocytes respond to dopamine and noradrenaline with compartmentalized calcium responses that start in endfeet. Dopamine induces localized responses, while noradrenaline triggers stronger, spreading responses. These findings expand our understanding of astrocyte-neurotransmitter interactions and their roles in central nervous system physiology.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Review
Medicine, General & Internal
Agoston Patthy, Janos Murai, Janos Hanics, Anna Pinter, Peter Zahola, Tomas G. M. Hokfelt, Tibor Harkany, Alan Alpar
Summary: Alzheimer's disease (AD) is a devastating neurodegenerative disorder for which an effective therapy has yet to be found. Research suggests that early damage to the ascending monoaminergic system in the brainstem may be an early sign and potential trigger of AD. In addition, cortical malfunction and local neurohistopathology are also related to the progression of AD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Mingqian Fang, Yu Li, Zhiyi Liao, Gan Wang, Qiqi Cao, Ya Li, Yong Duan, Yanbing Han, Xinyi Deng, Feilong Wu, Peter Muiruri Kamau, Qiumin Lu, Ren Lai
Summary: This study reveals that the acute-phase protein lipopolysaccharide-binding protein (LBP) inhibits monoamine biosynthesis, contributing to depressive features. Increased LBP expression has been observed in individuals with depression and by diverse stress challenges in mice. Targeting LBP may be a potential treatment for some individuals with depression.
Article
Biochemistry & Molecular Biology
Yuying Huang, Hong Chen, Shao-Rui Chen, Hui -Lin Pan
Summary: Antidepressants are effective for treating chronic neuropathic pain by inhibiting glutamatergic input through activation of α1 and α2 adrenergic receptors.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Yuying Huang, Hong Chen, Shao-Rui Chen, Hui-Lin Pan
Summary: Antidepressants, such as duloxetine and amitriptyline, are effective for treating chronic neuropathic pain by inhibiting norepinephrine and serotonin transporters and activating alpha 1-and alpha 2-adrenergic receptors in the spinal cord. This study provides important insights into the mechanism of action of antidepressants in alleviating neuropathic pain and can inform the development of improved treatment strategies.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Neurosciences
Nanna Bertin Markussen, Rasmus West Knopper, Stine Hasselholt, Christian Stald Skoven, Jens Randel Nyengaard, Leif Ostergaard, Brian Hansen
Summary: The Locus Coeruleus (LC) is a brainstem region that supplies noradrenaline to key brain structures and affects various behaviors and physiological phenomena. Its dysfunction may play a role in neurodegenerative diseases. Animal models with LC dysfunction are essential for understanding its function and role in diseases.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Clinical Neurology
Tatyana Strekalova, Evgeniy Svirin, Jonas Waider, Anna Gorlova, Raymond Cespuglio, Allan Kalueff, Igor Pomytkin, Angelika G. Schmitt-Boehrer, Klaus-Peter Lesch, Daniel C. Anthony
Summary: Gene-environment interaction determines vulnerability to stress-related neuropsychiatric disorders, with Tph2 gene variants linked to increased impulsivity and aggression. Tph2+/- mice exhibit increased aggression, reduced sociability, and altered brain metabolism of serotonin, dopamine, and norepinephrine after predator stress exposure, showing resilience to stress. This study highlights how GxE interaction studies can reveal genetically determined predispositions and uncover latent behaviors.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Adeline Orts-Del'Immagine, Mahalakshmi Dhanasekar, Francois-Xavier Lejeune, Julian Roussel, Claire Wyart
Summary: The study found that following acousto-vestibular stimulation, calcium waves in glial cells are initiated by noradrenergic neurons in the brainstem and propagate bidirectionally through the spinal cord and rostrally into the hindbrain. This process may be triggered by alpha-adrenergic receptors, indicating a recruitment of neurons in response to AV stimuli.
Article
Cell Biology
Tadayuki Ishibashi, Daichi Sueto, Yu Yoshikawa, Keisuke Koga, Ken Yamaura, Makoto Tsuda
Summary: This study identified an inhibitory interneuron subset in the spinal dorsal horn that is depolarized by noradrenaline (NA) and showed that alpha(1B)-adrenoceptors (ARs) and AAV-NpyP(+) neurons are critical targets for spinal NA and necessary for the therapeutic effect of duloxetine on neuropathic pain.
Article
Neurosciences
Fei Zeng, Yan Fan, Russell W. Brown, Wesley Drew Gill, Jennifer B. Price, Thomas C. Jones, Meng-Yang Zhu
Summary: This study found that enhancing noradrenergic activity in the brain can improve the function of dopaminergic neurons in aged animals, potentially indicating biochemical therapeutic benefits but not necessarily behavioral improvements.
Article
Virology
George Mpekoulis, Vassilina Tsopela, Anna Chalari, Katerina Kalliampakou, Georgios Panos, Efseveia Frakolaki, Raphaela S. Milona, Diamantis C. Sideris, Dido Vassilacopoulou, Niki Vassilaki
Summary: This study reveals the association between catecholamine biosynthesis/metabolism and Dengue virus replication. The production and uptake of biogenic amines impede DV replication, while the virus reduces catecholamine biosynthesis, metabolism, and transport. Altering the expression of L-Dopa decarboxylase (DDC) enhances virus replication, suggesting a negative effect of DDC on DV. In addition, the study demonstrates that dopamine uptake, rather than dopamine signaling, is responsible for the negative effect on DV.
Article
Materials Science, Biomaterials
Zhenzhen Lu, Boon Mian Teo, Rico F. Tabor
Summary: This review discusses the application of polynorepinephrine (PNE) as an alternative to polydopamine (PDA) with equivalent or better performance. PNE offers a thinner and smoother coating surface, enhancing resistance to fouling, cell adhesion capability, surface hydrophilicity, and biomolecule immobilization. Additionally, PNE shows potential as a biosensor due to its bioconjugation and molecular recognition ability.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)