Article
Anesthesiology
Vaniely Kaliny Pinheiro de Queiroz, Alexandre Magno da Nobrega Marinho, Guilherme Antonio Moreira de Barros
Summary: The 5% lidocaine patch was effective in reducing pain scores in the first 36 hours after cesarean section, but did not impact opioid consumption, quality of recovery, or occurrence of adverse effects.
JOURNAL OF CLINICAL ANESTHESIA
(2021)
Review
Chemistry, Medicinal
Marion Voute, Veronique Morel, Gisele Pickering
Summary: Topical lidocaine is a safe and effective option for pain management, with proven efficacy in various pain conditions. It can be used alone or in conjunction with systemic drugs and non-pharmacological approaches for optimized pain management and multimodal analgesia.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Anesthesiology
Marko S. Todorovic, Karen Frey, Robert A. Swarm, Michael Bottros, Lesley Rao, Danielle Tallchief, Kristin Kraus, Kathleen Meacham, Kristopher Bakos, Xiaowei Zang, Jong Bong Lee, Leonid Kagan, Simon Haroutounian
Summary: Intravenous lidocaine can alleviate painful diabetic peripheral neuropathy (DPN), but quantitative sensory testing (QST) cannot predict treatment response.
CLINICAL JOURNAL OF PAIN
(2022)
Article
Anesthesiology
Etienne Vachon-Presseau, Taha B. Abdullah, Sara E. Berger, Lejian Huang, James W. Griffith, Thomas J. Schnitzer, A. Vania Apkarian
Summary: This study validates a biosignature model that can predict placebo response in chronic pain patients at a group level, while successfully distinguishing between placebo and active treatment responses.
Article
Chemistry, Medicinal
Xuehai Guan, Ziyin Jiao, Xiaofang Gong, Huiyu Cao, Susu Liu, Hongmeng Lan, Xiaofang Huang, Yanmeng Tan, Bing Xu, Chengxin Lin
Summary: Pre-treatment with remimazolam can reduce the incidence and intensity of propofol-induced injection pain in abortion or curettage patients, with effects equivalent to lidocaine but with fewer adverse effects.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Obstetrics & Gynecology
Yaakov Melcer, Maya Nimrodi, Orna Levinsohn-Tavor, Maayan Gal-Kochav, Marina Pekar-Zlotin, Ron Maymon
Summary: Flushing the uterine cavity with lidocaine before HyFoSy significantly reduces procedure-related pain and has no side effects, making it an easily applied and cost-effective intervention that may improve patient compliance.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2021)
Article
Anesthesiology
Hao Guo, Tingting Ao, Jiagao Wang, Xi Zhang, Junwei Zheng, Yun Xiao, Rui Xue, Prakash Kalika, Ran Ran
Summary: Perioperative dexmedetomidine combined with lidocaine infusion can effectively relieve postoperative pain and improve recovery in patients undergoing thyroidectomy.
CLINICAL JOURNAL OF PAIN
(2022)
Article
Pharmacology & Pharmacy
Yue-Li Sun, Min Yao, Yue-Feng Zhu, Meng-Chen Yin, Jin-Tao Liu, Xin Chen, Jin Huang, Yu-Xiang Dai, Wen-Hao Wang, Zeng-Bin Ma, Yong-Jun Wang, Xue-Jun Cui
Summary: The study suggests that patients with shorter disease duration are more likely to overestimate their pain severity in neck pain treatment, due to their limited experience in pain perception, tolerance, and analgesia expectation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Ming Xia, Qingfeng Wei, Qin Zhang, Hong Jiang
Summary: This study suggests that perioperative intravenous lidocaine infusion can reduce the incidence of chronic postoperative pain in breast cancer patients and is effective in relieving acute postoperative pain.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Ming Xia, Qingfeng Wei, Qin Zhang, Hong Jiang
Summary: The study found that perioperative intravenous lidocaine infusion significantly reduces the incidence of chronic postoperative pain in breast cancer patients and effectively relieves acute postoperative pain.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Erin Bussin, Brian Cairns, Tommy Gerschman, Michael Fredericson, Jim Bovard, Alex Scott
Summary: This study found that a 4-week course of topical diclofenac for Achilles tendinopathy did not lead to better clinical outcomes compared to placebo. The improvements in VISA-A score in both groups were marginal and did not meet the minimum clinically important difference.
Article
Medicine, General & Internal
Dariusz Gajniak, Konrad Mendrala, Tomasz Cyzowski, Michal Polak, Danuta Gierek, Lukasz J. Krzych
Summary: The study aimed to determine the opioid consumption in patients receiving continuous lidocaine infusion during perioperative period. The results showed that lidocaine infusion as an adjunct to standard perioperative analgesia could effectively decrease opioid consumption by more than 20% during the first 24 h after surgery in high-risk vascular surgery, with no serious adverse effects noted during the study period.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Emergency Medicine
Farhad Heydari, Sanaz Khalilian, Keihan Golshani, Saeed Majidinejad, Babak Masoumi, Abaris Massoumi
Summary: This study demonstrated that local cutaneous ketamine is as effective as EMLA in relieving pain during venipuncture. While there was no significant difference in pain relief between the two interventions, itching and irritation were more common with EMLA.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Urology & Nephrology
Ahmed M. Tawfik, Mohammed H. Radwan, Mohammed Abdulmonem, Mohammed Abo-Elenen, Samir A. Elgamal, Mohammed O. Aboufarha
Summary: This study aimed to evaluate the clinical outcomes of using the PDE-5 inhibitor tadalafil 5 mg OD for the management of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). The results showed that tadalafil significantly improved the symptoms in various domains of CP/CPPS compared to placebo. Approximately 50.8% of patients in the tadalafil group showed clinically significant improvement. However, there was weak correlation between tadalafil-induced changes in IIEF-5 scores and the improvement in quality of life.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Medicine, General & Internal
Yayun Lu, Yaping Gu, Lihua Liu, Xuefeng Tang, Qing Xia, Zhiyue Xu
Summary: The study indicates that using dexmedetomidine in combination with propofol induction at low temperature can effectively alleviate the occurrence and severity of injection pain in oral and maxillofacial surgery.
FRONTIERS IN MEDICINE
(2021)
Article
Neurosciences
Wenjie Ren, Maria Virginia Centeno, Sara Berger, Ying Wu, Xiaodong Na, Xianguo Liu, Jyothisri Kondapalli, A. Vania Apkarian, Marco Martina, D. James Surmeier
NATURE NEUROSCIENCE
(2016)
Article
Neurosciences
Pascal Tetreault, Marwan N. Baliki, Alexis T. Baria, William R. Bauer, Thomas J. Schnitzer, A. Vania Apkarian
HUMAN BRAIN MAPPING
(2018)
Article
Clinical Neurology
A. Vania Apkarian
Article
Neurosciences
Bogdan Petre, Souraya Torbey, James W. Griffith, Gildasio De Oliveira, Kristine Herrmann, Ali Mansour, Alex T. Baria, Marwan N. Baliki, Thomas J. Schnitzer, Apkar Vania Apkarian
HUMAN BRAIN MAPPING
(2015)
Article
Multidisciplinary Sciences
Adiel Mallik, Mona Lisa Chanda, Daniel J. Levitin
SCIENTIFIC REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Etienne Vachon-Presseau, Sara E. Berger, Taha B. Abdullah, James W. Griffith, Thomas J. Schnitzer, A. Vania Apkarian
Article
Multidisciplinary Sciences
Joana Barroso, Kenta Wakaizumi, Diane Reckziegel, Joao Pinto-Ramos, Thomas Schnitzer, Vasco Galhardo, A. Vania Apkarian
Article
Neurosciences
Lili Yang, Bo Wu, Linyu Fan, Shishi Huang, Andrew D. Vigotsky, Marwan N. Baliki, Zhihan Yan, A. Vania Apkarian, Lejian Huang
Summary: The study found that dissimilarity of functional connectivity can uncover the influence of participant's motion on fMRI data quality, and this relationship is independent of population, scanner, and preprocessing method. Excluding high-motion participants and how it affects this association is a new strategy for group-level QC following preprocessing.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Joana Barroso, Kenta Wakaizumi, Ana Mafalda Reis, Marwan Baliki, Thomas J. Schnitzer, Vasco Galhardo, Apkar Vania Apkarian
Summary: The study found that in patients with osteoarthritis, the brain network architecture reorganizes at both global and local levels. Network connectivity related to pain intensity in OA is dissociated from major hub disruptions. This challenges the extent of dependence of OA pain on nociceptive signaling.
HUMAN BRAIN MAPPING
(2021)
Article
Anesthesiology
Etienne Vachon-Presseau, Taha B. Abdullah, Sara E. Berger, Lejian Huang, James W. Griffith, Thomas J. Schnitzer, A. Vania Apkarian
Summary: This study validates a biosignature model that can predict placebo response in chronic pain patients at a group level, while successfully distinguishing between placebo and active treatment responses.
Article
Behavioral Sciences
Rami Jabakhanji, Andrew D. D. Vigotsky, Jannis Bielefeld, Lejian Huang, Marwan N. N. Baliki, Giandomenico Iannetti, A. Vania Apkarian
Summary: A growing number of studies claim to decode mental states using multi-voxel decoders of brain activity. However, this study found that the efficacy of these decoders might be overstated, as their patterns were spatially imprecise and redundant, and their performance was similar to brain activity maps used as decoders. Moreover, identification of specific mental states was poor. Additionally, simple and intuitive similarity metrics can explain a large portion of discrimination performance.
Article
Anesthesiology
Camila Bonin Pinto, Jannis Bielefeld, Joana Barroso, Byron Yip, Lejian Huang, Thomas Schnitzer, A. Vania Apkarian
Summary: Chronic pain is a multidimensional pathological state that is associated with distorted brain properties and patients' psychological and physical traits. Different dimensions of pain are related to specific personality traits and brain functional connectivity.
Article
Anesthesiology
Paulo Branco, Sara Berger, Taha Abdullah, Etienne Vachon-Presseau, Guillermo Cecchi, A. Vania Apkarian
Summary: Language use can predict placebo response in patients with chronic pain. A model built on language features was able to predict patients' response to placebo, with responders experiencing an average of 30% pain relief compared to 3% for nonresponders.
Article
Multidisciplinary Sciences
Shogo Tsujikawa, Kaitlyn E. DeMeulenaere, Maria V. Centeno, Shahrzad Ghazisaeidi, Megan E. Martin, Martinna R. Tapies, Mohammad M. Maneshi, Megumi Yamashita, Kenneth A. Stauderman, Apkar V. Apkarian, Michael W. Salter, Murali Prakriya
Summary: Microglial Orai1 channels play a crucial role in the neuroinflammation associated with neuropathic pain. Deletion or inhibition of Orai1 in microglia reduces calcium signaling, inflammatory cytokine production, microglial proliferation, spinal cytokine levels, and excitatory neurotransmission, leading to alleviation of pain hypersensitivity. However, these protective effects seem to be gender-specific, as they are only observed in male mice, highlighting the sexually dimorphic regulation of microglial reactivity and hyperalgesia by Orai1. Overall, these findings demonstrate the importance of Orai1 channels in the pathogenesis of neuropathic pain and underscore the need for considering gender differences in pain research.
Article
Anesthesiology
Joana Barroso, Paulo Branco, Joao Pinto-Ramos, Andrew D. Vigotsky, Ana Mafalda Reis, Thomas J. Schnitzer, Vasco Galhardo, A. Vania Apkarian
Summary: Persistence of osteoarthritis pain after joint replacement surgery is associated with specific subcortical brain volumes and shape deformations. Preoperative anxiety levels, pain duration, and neuropathic pain also contribute to pain outcomes. This challenges the current understanding of osteoarthritis pain mechanisms and suggests new approaches for clinical management and treatment strategies.