Article
Orthopedics
D. Chao, H. Tran, Q. H. Hogan, B. Pan
Summary: GFS produces analgesia in MIA-OA rats at least in part by producing blockade of afferent inputs, possibly also by blocking efferent activity from the dorsal horn.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Neurosciences
Jiliang Wen, Zhenghao Chen, Si Wang, Mengmeng Zhao, Shaoyong Wang, Shengtian Zhao, Xiulin Zhang
Summary: As animals age, the electrical properties of bladder afferents undergo differential changes, with a decrease in excitability potentially contributing to reductions in bladder sensory function.
Article
Immunology
Juping Xing, Hongji Wang, Lisha Chen, Hanxi Wang, Huan Huang, Jiabao Huang, Changshui Xu
Summary: This study investigated the role of Cx43 in neuropathic pain mediated by the P2X4 receptor in rats with chronic constriction injury (CCI). The results showed that blocking Cx43 can alleviate neuropathic pain in CCI rats through the P2X4, p38, ERK, and NF-kB signaling pathways. These findings suggest that Cx43 may be a promising therapeutic target for the development of novel pharmacological agents in the management of neuropathic pain.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Dandan Yue, Zihan Zheng, Weiwei Fan, Lizhong Zhu, Dan Lin, Man Lu, Wenjing Ji, Peng Cao, Xiaoyan Sun, Chunping Hu
Summary: SXS may have an effect on inhibiting ectopic tissue growth, enhancing pain thresholds, reducing nerve fiber density and inflammatory factor expression, and alleviating inflammatory cell infiltration in the dorsal root ganglion of animals with endometriosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Cell Biology
Bin Pan, Di Guo, Li Jing, Ke Li, Xin Li, Gen Li, Xiao Gao, Zhi-Wen Li, Wei Zhao, Hu Feng, Meng-Han Cao
Summary: This study reveals the role of lncRNA Pvt1 in the repair of peripheral nerve injury and highlights it as a potential treatment target. The findings show that Pvt1 increases c-Jun expression through sponging miRNA-214, enhancing the proliferation and migration of Schwann cells, and improving the regeneration of injured sciatic nerves and locomotor function in mice.
NEURAL REGENERATION RESEARCH
(2023)
Article
Neurosciences
Hong-Jun Wang, Fu-Chao Zhang, Timothy W. Xu, Yu-Cheng Xu, Yuan-Qing Tian, Yan-Yan Wu, Ji-Tian Xu, Shufen Hu, Guang-Yin Xu
Summary: The aim of this study was to investigate the mechanism of how DNMT1 mediates the analgesic effect of folic acid (FA) on gastric hypersensitivity (GHS) induced by prenatal maternal stress (PMS). The expression of DNMT1, DNMT3a, DNMT3b, and ASIC1 were detected and the effect of FA and DNMT1 on GHS and neuronal excitability were explored.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biophysics
Liling Zhang, Qi Han, Shiyu Chen, Di Suo, Luzhong Zhang, Guicai Li, Xin Zhao, Yumin Yang
Summary: Mechanical property is crucial for neural tissue regeneration, and hydrogels with an elastic modulus of 5.1 kPa were found to be optimal for DRG proliferation and differentiation in this study. The upregulation of specific genes and proteins on these hydrogels suggests a potential mechanism for the effect of material stiffness on neural tissue regeneration. This research provides valuable insights for the design and development of nerve grafts with improved repair performance.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Yueying Wang, Chenxi Li, Jingming Xing, Yan Zhu, Minghao Sun, Sui Yin, Jianming Liu, Lifang Zou, Shangdong Liang, Shuangmei Liu
Summary: This study found that neohesperidin can alleviate neuropathic pain by reducing P2X4R expression and inhibiting satellite glial cells activation.
NEUROCHEMICAL RESEARCH
(2023)
Article
Neurosciences
Stephanie Shiers, James J. Sahn, Theodore J. Price
Summary: Mitogen activated protein kinase interacting kinases (MNK) 1 and 2 play a crucial role in mRNA translation by phosphorylating eukaryotic translation initiation factor (eIF) 4E. They are downstream targets of MAPKs, ERK, and p38. MNKs are involved in sensitizing nociceptors in the DRG and TG, and both MNK1 and MNK2 are expressed in these regions in mice and humans. Our study confirms the expression of MNK1 and MNK2 in human nociceptors, suggesting their potential as therapeutic targets for pain management.
Article
Anesthesiology
Yan-Yan Wu, Qian Wang, Ping-An Zhang, Cheng Zhu, Guang-Yin Xu
Summary: There is mounting evidence that microRNAs (miRNAs) have critical roles in various pathophysiological conditions and diseases. However, the physiological impact of extracellular miRNAs on disease-related ion channels is largely unknown. In this study, miR-1306-3p was found to stimulate action potentials and inward currents in rat dorsal root ganglion (DRG) neurons. These effects were inhibited by the P2X3 receptor inhibitor A317491 or after knocking down P2X3Rs in DRG neurons. Specific interaction sites on the extracellular domain of P2X3Rs were identified as the miR-1306-3p binding sites. Intrathecal injection of miR-1306-3p induced visceral pain in rats while intrathecal application of a miR-1306-3p inhibitor and A317491 alleviated chronic visceral pain in a rat model.
Article
Cell Biology
Jimena Perez-Sanchez, Steven J. Middleton, Luke A. Pattison, Helen Hilton, Mosab Ali Awadelkareem, Sana R. Zuberi, Maria B. Renke, Huimin Hu, Xun Yang, Alex J. Clark, Ewan St John Smith, David L. Bennett
Summary: Hyperexcitability in sensory neurons plays a key role in neuropathic pain, and the chemogenetic system PSAM(4)-GlyR can effectively suppress this hyperexcitability and produce reversible effects in both mouse and human sensory neurons. This system has great potential for application in pain treatment.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Jun Xue, Yadong Liu, Sichong Zhang, Liucheng Ding, Baixin Shen, Yunpeng Shao, Zhongqing Wei
Summary: Caffeine improves bladder function in rats with diabetes mellitus by reducing cellular apoptosis in the dorsal root ganglion, increasing the expression levels of nerve growth factor, brain-derived neurotrophic factor, and calcitonin gene-related peptide in bladder tissue.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Feng-Ming Zhang, Bing Wang, Han Hu, Ying-Ying Zhang, Hao-Hao Chen, Zuo-Jie Jiang, Mei-Xing Zeng, Xing-Jun Liu
Summary: Signaling by the TGF-beta superfamily is important for neural development and pain processing. In this study, the transcriptional profile of the TGF-beta superfamily members in lumbar DRGs of rats with chronic inflammatory pain was found to be downregulated. Specifically, the signaling of activin/inhibin and BMP/GDF families dramatically decreased. Additionally, peripherally pre-local administration of activins worsened acute inflammatory pain, while activin C improved persistent inflammatory pain by inhibiting astrocyte activation.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Cell Biology
Bo Pang, Ling Qiao, Shaoxin Wang, Xin Guo, Yun Xie, Liping Han
Summary: MiR-214-3p alleviated diabetes-induced nerve injury, pathological lesions, cell apoptosis, and inflammation in DRG through regulating Nav1.3 and TLR4 in STZ-induced rats. These findings suggest novel therapeutic targets for clinical treatment of diabetic neuropathy.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Toxicology
Daisuke Kigami, Mark T. Butt, Danielle L. Brown, Masahiro Matsumoto, Hiroyuki Ito
Summary: ASP7962 is a small molecule inhibitor targeting the NGF receptor TrkA. The study showed that ASP7962 did not cause any detectable dysfunction in the nervous system, but could induce reversible neuronal atrophy.
TOXICOLOGY LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Hongping Wu, Bingbing Zhang, Hongwei Yu, Zhanggui Hu, Jiyang Wang, Yicheng Wu, P. Shiv Halasyamani
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Chemistry, Inorganic & Nuclear
Haonan Liu, Hongping Wu, Hongwei Yu, Zhanggui Hu, Jiyang Wang, Yicheng Wu
INORGANIC CHEMISTRY
(2020)
Article
Materials Science, Multidisciplinary
Jingjing Xu, Hongping Wu, Hongwei Yu, Zhanggui Hu, Jiyang Wang, Yicheng Wu
SCIENCE CHINA-MATERIALS
(2020)
Article
Chemistry, Inorganic & Nuclear
Ming Wen, Hongping Wu, Hongwei Yu, Xiaohong Wu
JOURNAL OF SOLID STATE CHEMISTRY
(2020)
Article
Endocrinology & Metabolism
Eu Jeong Ku, Dong-Hwa Lee, Hyun Jeong Jeon, Frank Park, Tae Keun Oh
Summary: Psychometric analysis on type 2 diabetic patients in South Korea showed a direct association between positive attitudes towards insulin therapy and HbA1c levels, while there was no significant link between insulin cost and HbA1c levels. This suggests the need for continued education to promote a positive psychology towards insulin use in T2D patients.
Article
Chemistry, Medicinal
Rajib Bhuniya, Xinrui Yuan, Longchuan Bai, Kathryn L. Howie, Rui Wang, Wei Li, Frank Park, Chao-Yie Yang
Summary: CDC20 overexpression is associated with poor prognosis in breast and other cancers. By designing new CDC20 inhibitors and improving their chemical structure, the antitumor activity can be enhanced. The most effective inhibitor, 22, shows promise for further development.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Medicine, Research & Experimental
Taketsugu Hama, Prashanth K. B. Nagesh, Pallabita Chowdhury, Bob M. Moore, Murali M. Yallapu, Kevin R. Regner, Frank Park
Summary: The study demonstrates that thyroid receptor interacting protein 13 (TRIP13) may play a crucial role in protecting proximal tubules from DNA damage caused by cisplatin. Restoring TRIP13 activity could effectively reduce nephrotoxic damage and protect the kidney.
Editorial Material
Cell Biology
Frank Park
PHYSIOLOGICAL GENOMICS
(2022)
Meeting Abstract
Physiology
Jada Williams, Ravi Kumar, Jeremiah Afolabi, Frank Park, Adebowale Adebiyi
Article
Biochemistry & Molecular Biology
Jada D. Williams, Ravi Kumar, Jeremiah M. Afolabi, Frank Park, Adebowale Adebiyi
Summary: Individuals with sickle cell disease (SCD) are at a greater risk of rhabdomyolysis, a potentially life threatening condition resulting from the breakdown of skeletal muscle fibers. This study demonstrates that oxidative stress driven by renal iron accumulation amplifies rhabdomyolysis-induced acute kidney injury (AKI) in SCD mice.
FREE RADICAL RESEARCH
(2023)
Article
Physiology
Mallory Swanson, Jiyoung Yun, Daniel M. Collier, Connor Seif, Chao-Yie Yang, Kevin R. Regner, Frank Park
Summary: The expression levels and distribution of CDC20 in the kidney are influenced by injurious stimuli, and inhibiting CDC20 function can alleviate and reverse kidney injury.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Praveen K. Potukuchi, Hamid Moradi, Frank Park, Cameron Kaplan, Fridtjof Thomas, Ankur A. Dashputre, Keiichi Sumida, Miklos Z. Molnar, Abduzhappar Gaipov, Justin D. Gatwood, Connie Rhee, Elani Streja, Kamyar Kalantar-Zadeh, Csaba P. Kovesdy
Summary: This observational study found no association between cannabis use and the risk of acute kidney injury in patients with advanced chronic kidney disease.
CANNABIS AND CANNABINOID RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Mallory L. Swanson, Kevin R. Regner, Bob M. Moore II, Frank Park
Summary: In this study, a selective CB2 receptor agonist, SMM-295, was found to reduce kidney tissue damage and slow the progression of fibrosis. It exhibited greater effectiveness compared to the genetic knockout of CB2 or administration of a CB2 inverse agonist.
CANNABIS AND CANNABINOID RESEARCH
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Sarah Maxwell, John Malysz, M. Dennis Leo, Wenkuan Xin, Frank Park, Georgi Petkov
Article
Chemistry, Multidisciplinary
Xiaoqing Jiang, Hongping Wu, Hongwei Yu, Zhanggui Hu, Jiyang Wang, Yicheng Wu
CHEMICAL COMMUNICATIONS
(2020)