Activation of TRPA1 by Membrane Permeable Local Anesthetics

The dilated TRPA1 channel pore state is blocked by amiloride and analogues

(2011) Tue G. Banke   BRAIN RESEARCH

Continuous Subcutaneous Instillation of Bupivacaine Compared to Saline Reduces Interleukin 10 and Increases Substance P in Surgical Wounds After Cesarean Delivery

(2010) Brendan Carvalho et al.   ANESTHESIA AND ANALGESIA

Pungent General Anesthetics Activate Transient Receptor Potential-A1 to Produce Hyperalgesia and Neurogenic Bronchoconstriction

(2010) Helge Eilers et al.   ANESTHESIOLOGY

Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents

(2010) Romina Nassini et al.   FASEB JOURNAL

The General Anesthetic Propofol Excites Nociceptors by Activating TRPV1 and TRPA1 Rather than GABAAReceptors

(2010) Michael J. M. Fischer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPA1 activation by lidocaine in nerve terminals results in glutamate release increase

(2009) Lian-Hua Piao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

High Concentrations of Morphine Sensitize and Activate Mouse Dorsal Root Ganglia via TRPV1 and TRPA1 Receptors

(2009) Alexander B Forster et al.   Molecular Pain

Nociceptive Signals Induce Trafficking of TRPA1 to the Plasma Membrane

(2009) Manuela Schmidt et al.   NEURON

Comparison of Injection Pain of Articaine and Lidocaine in Eyelid Surgery

(2009) Eric A. Steele et al.   OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY

A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma

(2009) A. I. Caceres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain

(2008) Shenglan Wang et al.   BRAIN

Identification of Transmembrane Domain 5 as a Critical Molecular Determinant of Menthol Sensitivity in Mammalian TRPA1 Channels

(2008) B. Xiao et al.   JOURNAL OF NEUROSCIENCE

General Anesthetics Sensitize the Capsaicin Receptor Transient Receptor Potential V1

(2008) P. M. Cornett et al.   MOLECULAR PHARMACOLOGY

TRPV1 shows dynamic ionic selectivity during agonist stimulation

(2008) Man-Kyo Chung et al.   NATURE NEUROSCIENCE

Transient receptor potential channels: targeting pain at the source

(2008) Ardem Patapoutian et al.   NATURE REVIEWS DRUG DISCOVERY

Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators

(2008) Yuji Karashima et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

General anesthetics activate a nociceptive ion channel to enhance pain and inflammation

(2008) J. A. Matta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA