Article
Multidisciplinary Sciences
Jo Otsuji, Yoshinori Hayashi, Suzuro Hitomi, Chihiro Soma, Kumi Soma, Ikuko Shibuta, Koichi Iwata, Tetsuo Shirakawa, Masamichi Shinoda
Summary: Whisker pad skin incision in infancy causes the prolongation of mechanical allodynia after re-incision in adulthood. The sex difference in re-incision-induced mechanical allodynia in the orofacial region is not fully understood. In rats that experienced neonatal injury in the whisker pad skin, the mechanical allodynia in the whisker pad was significantly prolonged after re-incision in adulthood, with no significant sex differences observed in the duration of mechanical allodynia.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Sonja Lj Joksimovic, Nathan Lamborn, Vesna Jevtovic-Todorovic, Slobodan M. Todorovic
Summary: The study investigated the analgesic potential of the endogenous antioxidant molecule alpha-lipoic acid (ALA) in a postsurgical pain model, demonstrating significant reduction in mechanical hyperalgesia and spontaneous postsurgical pain. The findings suggest further investigation into the analgesic properties and mechanisms of action of ALA in surgical patients.
Article
Neurosciences
Ting-Chun Lin, Yi-Chieh Tsai, Yun-An Chen, Tai-Horng Young, Chung-Che Wu, Yung-Hsiao Chiang, Chia-Hsin Kao, Abel Po-Hao Huang, Yi-Hua Hsu, Kai-Yun Chen, Li-Kai Tsai
Summary: This study investigated the role of brain-derived neurotrophic factor (BDNF) in post-ICH neurogenesis using a rodent model and patients with ICH. The results showed that the BDNF concentration in cerebrospinal fluid (CSF) was positively correlated with neurogenesis-promoting capacity. This suggests that BDNF plays an important role in regulating neurogenesis after ICH.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Anesthesiology
Max Grayson, Dominic Arris, Ping Wu, Jaclyn Merlo, Tarek Ibrahim, Chang Fang-Mei, Vanessa Valenzuela, Shilpa Ganatra, Shivani Ruparel
Summary: This study found that BDNF signaling is elevated in oral tumor biopsies and may contribute to cancer-induced pain. Blocking TrkB receptor activity can reverse tumor-induced pain-like behaviors. This discovery suggests a peripheral role for BDNF signaling in oral cancer pain.
Review
Clinical Neurology
Andrea Ballesio, Andrea Zagaria, Davide Gusmeo Curti, Rosalyn Moran, Peter J. Goadsby, Ivana Rosenzweig, Caterina Lombardo
Summary: The brain-derived neurotrophic factor (BDNF) is considered a transdiagnostic biomarker for mental disorders and is associated with emotional and cognitive functioning. A systematic review and meta-analysis of case-control studies were conducted to examine the levels of peripheral BDNF in individuals with insomnia. The results showed that subjects with insomnia had lower BDNF levels compared to healthy controls. However, the interpretation of the results should be cautious due to the small sample size, cross-sectional nature of the measurement, and high heterogeneity of the included data.
SLEEP MEDICINE REVIEWS
(2023)
Article
Clinical Neurology
Jessica A. Harder, Raina N. Fichorova, Akanksha Srivastava, Aleta Wiley, Katherine E. Burdick, Joseph J. Locascio, Hadine Joffe
Summary: This study found that BDNF levels are positively correlated with the severity of mood symptoms in women with perimenopausal depression symptoms, resembling the pattern seen in hormonally-sensitive PMDD. This suggests the presence of a hormonally-sensitive mood disorder biomarker profile distinct from that of major depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Timothy J. Ness, Cary DeWitte, Alan Randich
Summary: This study investigated the role of CRFR2 in bladder hyperalgesia secondary to neonatal bladder inflammation and acute bladder re-inflammation as an adult, suggesting the therapeutic value of CRFR2 antagonists in the treatment of painful bladder disorders.
Review
Medicine, General & Internal
Michal Piotrkowicz, Marlena Janoska-Jazdzik, Tytus Koweszko, Agata Szulc
Summary: Psychotherapy has been shown to lead to changes in brain structure and function, with BDNF identified as a potential research target. Limited studies indicate that BDNF concentration levels may increase after psychotherapy, but the impact of BDNF gene methylation status remains to be explored.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
L. M. C. Puhlmann, R. Linz, S. L. Valk, P. Vrticka, R. Vos de Wael, A. Bernasconi, N. Bernasconi, B. Caldairou, I Papassotiriou, G. P. Chrousos, B. C. Bernhardt, T. Singer, V Engert
Summary: The study found no significant relationship between serum BDNF levels and hippocampal structure volumes in healthy middle-aged adults, and age does not moderate this relationship.
Article
Clinical Neurology
Younjung Lee, Kye-Hyun Kim, Bun-Hee Lee, Yong-Ku Kim
Summary: The study found that pregnancy and postpartum depression can affect BDNF concentration, and the BDNF concentration in the postpartum depression-recovery group significantly increased at 6 weeks postpartum.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Xudan Shi, Chaoqiong Wang, Tengfei Zhao, Mengting Gu, Jinting Yang, Na Sun, Yangyuxin Huang, Yuanyuan Yao, Lina Yu, Min Yan
Summary: This study examined the role of sestrin2 in neonatal incision pain and re-incision enhanced hyperalgesia in adult rats. The results showed that sestrin2 improved mechanical hypersensitivity in neonatal rats and alleviated re-incision-induced enhanced hyperalgesia in adult rats by regulating the AMPK/ERK pathway. Additionally, microglia inhibition only affected enhanced hyperalgesia in adult males, which may be regulated through the sestrin2 mechanism. In conclusion, these sestrin2 data may serve as a potential common molecular target for treating re-incision hyperalgesia in different sexes.
Article
Immunology
Geraldine Gazzo, Meggane Melchior, Andrea Caussaint, Clemence Giere, Vincent Lelievre, Pierrick Poisbeau
Summary: This study showed that early life stress can lead to long-lasting upregulation of chloride importer NKCC1 expression in the cerebrum and spinal cord in rats. This impaired chloride homeostasis, associated with dysfunction in oxytocin signaling and neuro-inflammatory processes, may contribute to the observed sensori-affective phenotype following neonatal maternal separation.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Biology
Massimo Fioranelli, Maria Grazia Roccia, Bianca Przybylek, Maria Luisa Garo
Summary: This systematic review examines the bidirectional relationship between cardiovascular disease (CVD) and depression, with a focus on the potential role of low serum BDNF levels in the development of either disease in the presence of the other. The results suggest a strong association between low serum BDNF levels and the risk of post-stroke depression, but there is limited research on altered serum BDNF levels and other types of CVD, therefore the inverse association between depression and CVD cannot be proven.
Review
Biochemistry & Molecular Biology
Anna Mosiolek, Magdalena Pietrzak, Maria Tabisz, Wiktoria Wojtaszek, Michalina Zabielska, Agnieszka Ostrowska, Pawel Szwed, Jadwiga Mosiolek, Agata Szulc
Summary: This systematic review evaluates the effect of broadly defined cognitive behavioral therapy (CBT) on the levels of brain-derived neurotrophic factor (BDNF) in psychiatric patients. Ten randomized-controlled trials were included, and the results suggest that BDNF levels may be considered as an indicator of cognitive function outcomes in psychotherapy, but no correlation was observed for mindfulness-based practices aimed at reducing stress or improving quality of life.
Article
Nutrition & Dietetics
Risa Takemoto, Seiwa Michihara, Li-Kun Han, Nina Fujita, Ryuji Takahashi
Summary: In this study, it was found that the Kampo medicine Ninjin'yoeito (NYT) effectively alleviates neuropathic pain in rats by increasing pain threshold, reducing spontaneous pain, and decreasing serum BDNF levels. There was also an observed normalization of corticosterone levels after repeated administration of NYT, indicating a potential mechanism for pain relief through stress response regulation.
FRONTIERS IN NUTRITION
(2021)