Article
Nutrition & Dietetics
Yue Guo, Jing Zou, Xingfeng Xu, Huimin Zhou, Xiuting Sun, Lingling Wu, Shaozhao Zhang, Xiangbin Zhong, Zhenyu Xiong, Yifen Lin, Yiquan Huang, Zhimin Du, Xinxue Liao, Xiaodong Zhuang
Summary: The study found that plasma butyric acid levels and HIF3A mRNA expression were decreased in DCM patients, while 3 CpGs in HIF3A intron 1 were highly methylated. Interestingly, butyric acid levels correlated positively with HIF3A levels, while showing a negative correlation with methylation rates at CpG 6 in HIF3A intron 1.
CLINICAL NUTRITION
(2021)
Article
Food Science & Technology
Xin Li, Jiachen Liang, Wenjie Gao, Yi Zhang, Hongliang Zeng, Baodong Zheng
Summary: In this study, the effects of butyrylated lotus seed starch (LSB) on small intestinal bacteria and SCFA levels in mice were investigated. The results showed that LSB improved small intestine morphology, promoted the abundance of beneficial bacteria, and suppressed harmful genera. This study provides a foundation for designing functional dietary fibers that can induce high levels of butyric acid production.
Article
Nutrition & Dietetics
Carmen Hernandez-Martinez, Josefa Canals, Nuria Voltas, Francisco Martin-Lujan, Victoria Arija
Summary: This study investigates the relationship between prenatal levels of short-chain fatty acids (SCFA) in maternal serum and infant cognitive development and temperament. The results suggest that lower levels of acetic, butyric and isobutyric acid are associated with better language and psychomotor development, while medium levels of propionic acid are related to better scores for development, mood and temperament in infants.
Article
Microbiology
Marco Calvigioni, Andrea Bertolini, Simone Codini, Diletta Mazzantini, Adelaide Panattoni, Mariacristina Massimino, Francesco Celandroni, Riccardo Zucchi, Alessandro Saba, Emilia Ghelardi
Summary: In this study, nine common probiotic strains were tested for their ability to secrete short-chain fatty acids (SCFAs) using a sensitive and specific HPLC-MS-MS method. All tested microorganisms were shown to secrete acetic acid, with only B. clausii and S. boulardii additionally able to produce propionic and butyric acids. This experimental approach contributes to the characterization of probiotics as SCFA-producing organisms and has implications for addressing SCFA deficiency.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Meritxell Sadurni, Ana Cristina Barroeta, Cinta Sol, Monica Puyalto, Lorena Castillejos
Summary: This study evaluated the intestinal release of butyric acid in broiler chickens supplemented with protected sodium butyrate, showing a slow and gradual release in the distal ileum. This research provides valuable insights into the intestinal delivery of butyric acid as a feed additive for broiler chickens.
Article
Engineering, Biomedical
Babita Shashni, Yuya Tajika, Yutaka Ikeda, Yuji Nishikawa, Yukio Nagasaki
Summary: The prevalence of non-alcoholic steatohepatitis (NASH) is increasing worldwide, and cost-effective therapeutic interventions are needed. Gut microbial dysbiosis, particularly a decrease in short-chain fatty acids (SCFA)-producing microbiota, has been linked to NASH pathogenesis. This study designed SCFA-based prodrugs that self-assembled in aqueous media to improve the therapeutic efficacy of SCFAs. NanoSCFA, particularly NanoBA, showed remarkable potential in ameliorating fatty liver disease, reducing hepatic lipogenesis and fibrosis, with negligible adverse effects. Mechanistic studies revealed that NanoBA restored the nuclear expression of PPAR alpha, a transcriptional factor regulating fatty acid oxidation, reflecting the therapeutic effects of NanoBA.
Article
Microbiology
Yi Wang, Lakshman P. Samaranayake, Gary A. Dykes
Summary: The study demonstrated the impact of tea extracts on the physicochemical properties of Actinomyces naeslundii cells and their influence on biofilm formation. The established model showed that changes in cell surface hydrophobicity and charge played critical roles in bacterial auto-aggregation and attachment, correlating with subsequent biofilm development. This modeling approach can be applied to other microbial colonization systems to predict biofilm formation and study the role of cell surface physicochemical properties in biofilm development.
FEMS MICROBIOLOGY ECOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Meritxell Sadurni, Ana Cristina Barroeta, Roser Sala, Cinta Sol, Monica Puyalto, Lorena Castillejos
Summary: This study investigated the effect of a feed additive on broiler gut health and found that it could reinforce the gut barrier, especially in birds with coccidiosis.
Article
Agricultural Engineering
Shin Myung Kim, Jee Young Kim, Jaewon Park, Eun Hee Bae, Jae-Shin Kang, Ka Young Kim, Yoon-E Choi
Summary: Cyanobacteria-derived biofuels can be produced efficiently by mixotrophic cultivation using volatile fatty acids as a low-cost carbon source. Butyric acid was found to be more effective than acetic acid in enhancing cell growth and increasing biodiesel and bioethanol production. The study contributes to the potential commercialization of carbon-neutral fuels derived from cyanobacteria and the development of a circular bioeconomy.
BIORESOURCE TECHNOLOGY
(2023)
Review
Fisheries
Mariana Palma, Leonardo J. Magnoni, Sofia Morais, Ivan Viegas
Summary: Short-chain fatty acids, including tributyrin, have been studied for their potential benefits as dietary supplements in aquaculture, particularly for carnivorous species, to optimize plant-based feeds.
REVIEWS IN AQUACULTURE
(2023)
Review
Biochemistry & Molecular Biology
Serena Coppola, Carmen Avagliano, Antonio Calignano, Roberto Berni Canani
Summary: Obesity is a global public health issue associated with various comorbidities, including diabetes and cardiovascular diseases. The changes in gut microbiota play a key role in the development of obesity, and butyrate may have potential in alleviating obesity and related comorbidities.
Article
Engineering, Environmental
Peng Yu, Menghan Wu, Wanyin Bao, Hui Wang
Summary: In this study, three different inoculants (active sludge, pit mud and mixture of sludge and pit mud) were used to produce medium-chain fatty acids (MCFA) from food waste with ethanol as electron donor. The results showed that the mixed inoculum of sludge and pit mud produced the highest MCFA concentration. Microbial community analysis revealed the key genera involved in MCFA production. Metagenomic analysis identified the fatty acid biosynthesis pathway as the main pathway for MCFA synthesis. Overall, this study provides new strategies and insights for MCFA production.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Andrew N. Carley, Santosh K. Maurya, Matthew Fasano, Yang Wang, Craig H. Selzman, Stavros G. Drakos, E. Douglas Lewandowski
Summary: The study revealed that short-chain fatty acids (SCFAs) are oxidized more readily than ketones in failing hearts, serving as a potential unexplored carbon source for energy production. Despite both SCFAs and ketones bypassing reduced CPT1 activity, SCFAs show higher oxidation rates and may represent a promising alternative energy substrate for failing hearts.
Article
Fisheries
Leonardo Julian Magnoni, Francisca Silva-Brito, Thais Cavalheri, Carlos Espirito-Santo, Mariana Palma, Rodrigo Ozorio, Stephane Panserat, Sofia Morais, Ivan Viegas
Summary: Results showed that dietary supplementation with 0.1% and 0.2% TBT could improve immune and antioxidant responses in rainbow trout, respectively, without significant effects on growth performance and feed efficiency.
AQUACULTURE REPORTS
(2023)
Article
Nutrition & Dietetics
Jerusa Brignardello, Sofia Fountana, Joram Matthias Posma, Edward S. Chambers, Jeremy K. Nicholson, Julien Wist, Gary Frost, Isabel Garcia-Perez, Elaine Holmes
Summary: This study investigated the temporal changes in SCFA concentrations in response to two contrasting diets using a novel GC-MS method. The results showed that the unhealthy diet was associated with lower concentrations of certain SCFAs and higher concentrations of lactic acid. The study highlighted the importance of standardizing the timing of SCFA measurements in dietary studies.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Dentistry, Oral Surgery & Medicine
Taketo Kawarai, Naoki Narisawa, Saori Yoneda, Yoshiaki Tsutsumi, Jun Ishikawa, Yasutaka Hoshino, Hidenobu Senpuku
ARCHIVES OF ORAL BIOLOGY
(2016)
Article
Dentistry, Oral Surgery & Medicine
Hidenobu Senpuku, Hideo Yonezawa, Saori Yoneda, Itaru Suzuki, Ryo Nagasawa, Naoki Narisawa
MOLECULAR ORAL MICROBIOLOGY
(2018)
Article
Food Science & Technology
Aya Iwamoto, Tomoyo Nakamura, Naoki Narisawa, Yukimasa Kawasaki, Shin Abe, Yasuyoshi Torii, Hidenobu Senpuku, Fumio Takenaga
FOOD SCIENCE AND TECHNOLOGY RESEARCH
(2018)
Article
Biotechnology & Applied Microbiology
Ayako Ogawa, Soichi Furukawa, Shuhei Fujita, Jiro Mitobe, Taketo Kawarai, Naoki Narisawa, Tsuyoshi Sekizuka, Makoto Kuroda, Kuniyasu Ochiai, Hirokazu Ogihara, Saori Kosono, Saori Yoneda, Haruo Watanabe, Yasushi Morinaga, Hiroshi Uematsu, Hidenobu Senpuku
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2011)
Article
Microbiology
Naoki Narisawa, Taketo Kawarai, Naomi Suzuki, Yutaka Sato, Kuniyasu Ochiai, Makoto Ohnishi, Haruo Watanabe, Hidenobu Senpuku
JOURNAL OF BACTERIOLOGY
(2011)
Article
Multidisciplinary Sciences
Tatsuya Ohsumi, Shoji Takenaka, Rika Wakamatsu, Yuuki Sakaue, Naoki Narisawa, Hidenobu Senpuku, Hayato Ohshima, Yutaka Terao, Takashi Okiji
Article
Dentistry, Oral Surgery & Medicine
Norihiko Kanaguchi, Naoki Narisawa, Tatsuro Ito, Yosuke Kinoshita, Yasuka Kusumoto, Osamu Shinozuka, Hidenobu Senpuku
Article
Food Science & Technology
Mayuka Ikeda, Naoki Narisawa, Shin Abe, Yasuyoshi Torii, Fumio Takenaga
JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY-NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI
(2018)
Article
Immunology
Tomoyo Nakamura, Yusuke Iwabuchi, Satoru Hirayama, Naoki Narisawa, Fumio Takenaga, Ryoma Nakao, Hidenobu Senpuku
MICROBIAL PATHOGENESIS
(2020)
Article
Microbiology
Tomoyo Nakamura, Hideo Yonezawa, Taketo Kawarai, Naoki Narisawa, Hidenobu Senpuku
Summary: In this study, the effect of xylitol and funoran on biofilm formation by Streptococcus mutans, a cariogenic bacteria, was investigated. It was found that funoran had an effect on biofilm formation, while xylitol did not strongly affect it. The combination of xylitol and funoran strongly inhibited biofilm formation. These findings suggest that this combination could be useful in reducing oral biofilm formation in individuals with decreased saliva production, such as the elderly.
ARCHIVES OF MICROBIOLOGY
(2022)
Article
Food Science & Technology
Manami Kimijima, Kengo Mandokoro, Yuki Ichikawa, Mizuki Tokumaru, Naoki Narisawa, Fumio Takenaga
Summary: This study evaluated the genetic and enzymatic characteristics of Bacillus subtilis obtained from commercial honey and found that these strains are suitable for natto fermentation. The results indicate that honey is a potential source of B. subtilis natto for the food industry.
FOOD SCIENCE AND TECHNOLOGY RESEARCH
(2022)
Article
Food Science & Technology
Tomoki Yokoyama, Tomoyo Nakamura, Manami Kimijima, Kengo Mandokoro, Mizuki Tokumaru, Ayami Takatsuka, Naoki Narisawa, Rika Kobayashi, Fumio Takenaga
Summary: The study demonstrates that Subtilisin NAT found in natto plays a crucial role in inhibiting the biofilm formation of Streptococcus mutans. Mutations in the Subtilisin NAT gene resulted in reduced protease activity and gamma-PGA levels, leading to a decrease in the inhibitory effect on biofilm formation.
FOOD SCIENCE AND TECHNOLOGY RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Taketo Kawarai, Naoki Narisawa, Yusuke Suzuki, Ryo Nagasawa, Hidenobu Senpuku
JOURNAL OF ORAL BIOSCIENCES
(2016)
Review
Dentistry, Oral Surgery & Medicine
Naoki Narisawa
JOURNAL OF ORAL BIOSCIENCES
(2010)