Article
Microbiology
Shuai Shao, Chunli Li, Luyao Zhao, Yuanxing Zhang, Kaiyu Yin, Qiyao Wang
Summary: In Edwardsiella piscicida, iron uptake systems are co-regulated by the ferric uptake regulator (Fur), while the response regulator EsrB activates the expression of virulence systems and iron uptake systems to mitigate iron shortage. The interaction between Fur and EsrB is essential for bacterial fitness during infection and survival in seawater environments.
MICROBIOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Kazuyoshi Muranishi, Koichiro Ishimori, Takeshi Uchida
Summary: The expression of the nik operon in Vibrio cholerae is regulated by both iron and heme, with Fur binding to the Fur box in the presence of Fe2+ to mediate the expression. Ni2+ does not induce the expression of Fur box genes. The nik operon-encoded protein VCA1098 also binds heme.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Ecology
Wen Liu, Feng-Juan Yang, Yong-Ling Zhou, Yi-Yong Li, Hui Liu, A. Dan
Summary: A plant-biofilm oxidation ditch (PBOD) scheme was proposed to overcome the poor phosphorus removal capacity of oxidation ditches in China. The results showed that the combination of aeration and plants effectively enhanced the capacity of PBOD for sewage purification and phosphorus removal by promoting the change of Fe2+ into Fe3+. Different plant species had different roles in phosphorus removal, with Canna generalis absorbing more phosphorus in plant tissue and Zizania caduciflora adsorbing more phosphorus on the root surface.
ECOLOGICAL ENGINEERING
(2023)
Article
Microbiology
Haihong Jia, Nannan Song, Yue Ma, Fengyu Zhang, Yingying Yue, Weiwei Wang, Cuiling Li, Hui Li, Qi Wang, Lichuan Gu, Bingqing Li
Summary: This study reveals a novel regulation process of iron acquisition mediated by UMPylator YdiU, which inhibits the binding of Fur to target DNA and activates the expression of iron uptake genes. This process is crucial for Salmonella survival within host cells and evasion of host nutritional immunity.
Article
Biochemistry & Molecular Biology
Xu Yang, Yiqun Wang, Guiyang Liu, Zixin Deng, Shuangjun Lin, Jianting Zheng
Summary: The molecular mechanism of transcription activation by ScZur in Streptomyces coelicolor has been deciphered through cryo-EM structures and biochemical assays. ScZur binds to Zur-box sequences and interacts with Sc RNA polymerase and promoter DNA. These interactions are crucial for the transcription initiation of housekeeping genes in Streptomyces coelicolor.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Emma Sevilla, M. Teresa Bes, M. Luisa Peleato, Maria F. Fillat
Summary: Proteins belonging to the FUR family, aside from the canonical Fur paralog, play crucial roles in bacterial metabolism, stress defenses, and host-pathogen interactions. Members such as Zur, Irr, BosR, and PerR are essential for virulence, while Nur and Mur contribute significantly to controlling nickel and manganese homeostasis. The diversity in coregulatory metals and action mechanisms of these proteins set them apart from the canonical Fur paralog.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Fenmei Liu, Zihui Su, Peng Chen, Xiaolin Tian, Lijie Wu, Dong-Jie Tang, Peifang Li, Haiteng Deng, Pengfei Ding, Qiang Fu, Ji-Liang Tang, Zhenhua Ming
Summary: This study reports the structure and activation mechanism of the zinc uptake regulator in Xanthomonas campestris pv. campestris, highlighting the essential role of zinc atom binding in driving conformational changes.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Fisheries
Moamer A. H. Ahmed, Jingxiao Cai, Yuanxing Zhang, Kaiyu Yin, Qiyao Wang, Shuai Shao
Summary: This study reveals a new role of the BasS-BasR two-component system in virulence regulation and iron uptake in Edwardsiella piscicida, providing valuable insights into bacterial pathogenesis.
Article
Engineering, Environmental
Yi Xu, Shihong Yang, Guoxiang You, Jun Hou
Summary: Zero valent iron (ZVI) has been shown to reduce antibiotic resistance genes (ARGs) in microbes by inhibiting horizontal transfer of ARGs and decreasing proliferation of resistant strains. However, a higher dosage of 20 g/L ZVI had negligible effects on ARGs reduction, possibly due to iron-catalyzed oxidative damage and reduced physiological activity.
Article
Environmental Sciences
Aiting Li, Yingying Lu, Da Zhen, Ziheng Guo, Gejiao Wang, Kaixiang Shi, Shuijiao Liao
Summary: The presence of Enterobacter sp. E1 significantly affects the accumulation of arsenic in Pteris vittata by promoting plant growth and dissolving soil arsenic. The strain E1 increases the water-soluble and exchangeable arsenic while reducing the Fe-bound arsenic in the soil. Additionally, the strain E1 has a positive effect on microbial diversity and soil enzymatic activities with low ecological risks.
Review
Biochemistry & Molecular Biology
Timothy J. Cain, Aaron T. Smith
Summary: Iron is essential for life and its acquisition by unicellular pathogens through siderophores is crucial for virulence. Ferric reductases play a key role in reducing Fe3+ to Fe2+ for uptake, but remain poorly understood, highlighting the important connection between Fe3+ reduction and Fe2+ transport.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Swati Kaushik, Jijo Thomas, Vineeta Panwar, Preethi Murugesan, Vianni Chopra, Navita Salaria, Rupali Singh, Himadri Shekar Roy, Rajesh Kumar, Vikas Gautam, Deepa Ghosh
Summary: During the COVID-19 pandemic, the excessive use of antibiotics could lead to an increase in multi-drug resistant bacteria. Magnetic nanoparticle-mediated hyperthermia-induced antimicrobial therapy has shown potential as an antibiotic-free approach for combating bacterial infections.
Article
Plant Sciences
Katarzyna Kozak, Anna Papierniak-Wygladala, Malgorzata Palusinska, Anna Barabasz, Danuta Maria Antosiewicz
Summary: NRAMP genes play an important role in maintaining metal homeostasis in plant cells. In this study, NtNRAMP3, a protein in tobacco, was identified and functionally characterized. The results suggest that NtNRAMP3 may be involved in metal uptake. It is mainly expressed in the xylem of tobacco leaves.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Tianzuo Wang, Jing Wang, Di Zhang, Li Chen, Min Liu, Xinxin Zhang, Wolfgang Schmidt, Wen-Hao Zhang
Summary: Fe deficiency is a limiting factor for plant growth, but the mechanisms regulating Fe acquisition and utilization are not fully known. This study reveals that CIPK12 regulates riboflavin biosynthesis and Fe-deficiency responses in plants, thereby affecting Fe accumulation and photosynthetic efficiency.
PLANT CELL AND ENVIRONMENT
(2023)
Article
Immunology
Md. Maidul Islam, Kyeongmin Kim, Je Chul Lee, Minsang Shin
Summary: Acinetobacter baumannii is a significant nosocomial pathogen with multidrug resistance properties. A novel transcriptional regulator LeuO was identified to be associated with pathogenicity and biofilm formation of A. baumannii.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Isaac S. Gomes-Filho, Josicelia Estrela Tuy Batista, Soraya Castro Trindade, Johelle De Santana Passos-Soares, Eneida de Moraes Marcilio Cerqueira, Teresinha Silveira da Costa, Ana Claudia Morais Godoy Figueiredo, Maria da Conceicao Nascimento Costa, Luis Fernando Fernandes Adan, Gessica Santana Orrico, Edla Carvalho Lima Porto, Rodolfo Macedo Cruz Pimenta, Frank A. Scannapieco, Peter Michael Loomer, Simone Seixas da Cruz
JOURNAL OF PERIODONTAL RESEARCH
(2020)
Article
Dentistry, Oral Surgery & Medicine
Julita Maria F. Coelho, Samilly S. Miranda, Simone S. da Cruz, Soraya C. Trindade, Johelle de S. Passos-Soares, Eneida de M. M. Cerqueira, Maria da Conceicao N. Costa, Ana Claudia M. G. Figueiredo, Alexandre Marcelo Hintz, Mauricio L. Barreto, Gregory J. Seymour, Frank Scannapieco, Isaac Suzart Gomes-Filho
CLINICAL ORAL INVESTIGATIONS
(2020)
Article
Dentistry, Oral Surgery & Medicine
Isaac S. Gomes-Filho, Julita Maria F. Coelho, Samilly S. Miranda, Simone S. Cruz, Soraya C. Trindade, Eneida M. M. Cerqueira, Johelle S. Passos-Soares, Maria Conceicao N. Costa, Maria Isabel P. Vianna, Ana Claudia M. G. Figueiredo, Alexandre Marcelo Hintz, Amanda F. Coelho, Luiz Carlos S. Passos, Mauricio L. Barreto, Frank Scannapieco
JOURNAL OF PERIODONTOLOGY
(2020)
Review
Dentistry, Oral Surgery & Medicine
Manoj J. Mammen, Frank A. Scannapieco, Sanjay Sethi
PERIODONTOLOGY 2000
(2020)
Review
Dentistry, Oral Surgery & Medicine
Frank A. Scannapieco, Eva Gershovich
PERIODONTOLOGY 2000
(2020)
Article
Dentistry, Oral Surgery & Medicine
Isaac Suzart Gomes-Filho, Izadora da S. C. E. Balinha, Simone S. da Cruz, Soraya C. Trindade, Eneida de M. M. Cerqueira, Johelle de S. Passos-Soares, Julita Maria F. Coelho, Ana Marice T. Ladeia, Maria Isabel P. Vianna, Alexandre M. Hintz, Teresinha C. de Santana, Pedro P. dos Santos, Ana Claudia M. G. Figueiredo, Ivana C. O. da Silva, Frank A. Scannapieco, Mauricio L. Barreto, Peter M. Loomer
Summary: The study found a positive association between moderate and severe periodontitis and metabolic syndrome, with adjusted measurements showing that individuals with moderate or severe periodontitis had around two times greater probability of having MetS compared to those without periodontitis, and the chance was greater among participants with severe periodontitis than those with moderate periodontitis.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Isaac Suzart Gomes-Filho, Michelle Teixeira Oliveira, Simone Seixas da Cruz, Eneida de Moraes Marcilio Cerqueira, Soraya Castro Trindade, Graciete Oliveira Vieira, Paulo Henrique Couto Souza, Luis Fernando Fernandes Adan, Alexandre Marcelo Hintz, Johelle de Santana Passos-Soares, Frank Andrew Scannapieco, Peter Michael Loomer, Gregory John Seymour, Ana Claudia Morais Godoy Figueiredo
Summary: The study found a positive association between moderate and severe periodontitis and dyslipidemia.
Article
Dentistry, Oral Surgery & Medicine
Isaac S. Gomes-Filho, Pedro N. P. Santos, Simone S. Cruz, Ana C. M. G. Figueiredo, Soraya C. Trindade, Ana M. Ladeia, Eneida M. M. Cerqueira, Johelle S. Passos-Soares, Julita M. F. Coelho, Alexandre M. Hintz, Mauricio L. Barreto, Ricardo G. Fischer, Peter M. Loomer, Frank A. Scannapieco
Summary: The study revealed a positive association between periodontitis and a TG/HDL-C ratio >= 2.3, suggesting a potential link to the severity of periodontal disease.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Frank A. Scannapieco, Anna Dongari-Bagtzoglou
Summary: Periodontal disease pathogenesis is dependent on microbial biofilms and host responses, different from microbial dysbiosis pattern observed in other diseases. The microbial diversity in periodontal disease is higher compared to other dysbiotic chronic diseases.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Microbiology
Izumi Mashima, Yu-Chieh Liao, Chieh-Hua Lin, Futoshi Nakazawa, Elaine M. Haase, Yusuke Kiyoura, Frank A. Scannapieco
Summary: The genus Veillonella in the oral microbiome includes eight species with important metabolic pathways utilizing lactate as an energy source. Through a comparative pan-genome analysis, it was found that these species have conserved pathways using carbohydrates other than lactate as an energy source, helping to understand the metabolic network in oral microbiomes.
Article
Public, Environmental & Occupational Health
Dian Baker, Karen K. Giuliano, Madhuli Thakkar-Samtani, Frank A. Scannapieco, Michael Glick, Marcos Restrepo, Lisa J. Heaton, Julie Frantsve-Hawley
Summary: In this 2019 study, hospital records were analyzed to examine the relationship between preventive dental treatment and periodontal therapy prior to hospitalization, and the risk of nonventilator hospital-acquired pneumonia. The results showed that both preventive dental treatment in the 12 months prior and periodontal therapy in the 6 months prior were associated with a reduced risk of NVHAP.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Letter
Dentistry, Oral Surgery & Medicine
Isaac Suzart Gomes-Filho, Simone Seixas da Cruz, Soraya Castro Trindade, Johelle de Santana Passos-Soares, Paulo Cirino Carvalho-Filho, Ana Claudia Morais Godoy Figueiredo, Amanda Oliveira Lyrio, Alexandre Marcelo Hintz, Mauricio Gomes Pereira, Frank Andrew Scannapieco
Review
Dentistry, Oral Surgery & Medicine
Frank A. Scannapieco
Summary: Mirdza E. (Mitzi) Neiders has had a diverse career at the University at Buffalo School of Dental Medicine, serving as a teacher, dentist, researcher, mentor, and role-model to thousands of faculty, students, and patients over the span of nearly 60 years. Being one of the first women on the dental school faculty, she has made significant contributions to dentistry and her community. This article highlights her journey and celebrates her retirement.
Review
Dentistry, Oral Surgery & Medicine
Ricardo Guimaraes Fischer, Isaac Suzart Gomes Filho, Simone Seixas da Cruz, Victor Bento Oliveira, Ronaldo Lira-Junior, Frank Andrew Scannapieco, Rodrigo Otavio Rego
Summary: Over the last five decades, significant progress has been made in understanding the relationship between periodontal diseases and systemic health conditions. This has led to increased interest in Periodontal Medicine and its potential impact on overall health. Further research is needed to explore the potential connections and implications for future advancements in this field.
BRAZILIAN ORAL RESEARCH
(2021)