Article
Biochemistry & Molecular Biology
Bindu D. Paul
Summary: Cysteine plays important roles in cellular processes and signaling cascades, and abnormal cysteine and H2S metabolism are associated with Huntington's disease.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Kangdi Hu, Xiangjun Peng, Gaifang Yao, Zhilin Zhou, Feng Yang, Wanjie Li, Yuqi Zhao, Yanhong Li, Zhuo Han, Xiaoyan Chen, Hua Zhang
Summary: The study revealed the important role of H2S-generating enzyme LCD1 in regulating leaf senescence in tomato. Overexpression of LCD1 delayed leaf senescence, while its deletion accelerated the process. The expression of LCD1 was correlated with chlorophyll degradation, ROS accumulation, and the expression of senescence-related genes, providing insight into the physiological functions of LCD1 in tomato leaf senescence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lixia Hou, Zhaoxia Wang, Guangxia Gong, Ying Zhu, Qing Ye, Songchong Lu, Xin Liu
Summary: This study reveals that hydrogen sulfide (H2S) plays an important role in alleviating manganese (Mn) stress in Arabidopsis. H2S reduces Mn content, decreases reactive oxygen species accumulation, and enhances antioxidant enzyme activity, thereby mitigating the inhibitory effect of Mn stress on Arabidopsis seedling growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Heng Zhou, Yin Zhou, Feng Zhang, Wenxue Guan, Ye Su, Xingxing Yuan, Yanjie Xie
Summary: The OsLCD1 gene enhances H2S production in rice and confers drought tolerance. Additionally, endogenous H2S production regulates nitrate reductase activity and influences rice drought tolerance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Horticulture
Zhiqiang Liu, Juanjuan Qu, Liping Zhang, Xin Liu, Guangdong Yang, Yanxi Pei
Summary: The study identified CsaLCD and CsaDES2 as the main enzymes responsible for endogenous H2S production in cucumber, playing a crucial role in H2S generation during stress responses.
SCIENTIA HORTICULTURAE
(2021)
Article
Multidisciplinary Sciences
Daniel Vojtovic, Lenka Luhova, Marek Petrivalsky
Summary: Studies have revealed the importance of DES in modulating H2S production, particularly in response to biotic and abiotic stress stimuli. Mutants of the model plant Arabidopsis thaliana have uncovered the molecular mechanisms of H2S as a signaling and defense molecule in plant-pathogen interactions. H2S signaling pathways, including S-persulfidation of protein cysteines, play a crucial role in activating downstream components of the H2S signaling pathway.
JOURNAL OF ADVANCED RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Sunil Jamuna Tripathi, Suwarna Chakraborty, Emiko Miller, Andrew A. Pieper, Bindu D. Paul
Summary: The gaseous neurotransmitter hydrogen sulfide (H2S) exerts neuroprotective effects in the brain through post-translational modification of cysteine residues by sulfhydration. It cannot be stored in vesicles due to its gaseous nature and is either synthesized or released from endogenous stores. Sulfhydration has both specific and general neuroprotective effects and is diminished in neurodegenerative disorders, while excessive cellular H2S is linked to certain forms of neurodegenerative disease. This review explores the role of H2S in signaling across various neurodegenerative diseases and age-related neurodegeneration.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maria A. Munoz-Vargas, Javier Lopez-Jaramillo, Salvador Gonzalez-Gordo, Alberto Paradela, Jose M. Palma, Francisco J. Corpas
Summary: This study aims to analyze the interrelationship between nitric oxide (NO) and hydrogen sulfide (H2S) during pepper fruit ripening. The results show that the activity of H2S-generating enzymes LCD and DCD is downregulated during ripening, but it can be reversed by NO treatment. These findings enhance our understanding of the relationship between NO and H2S during pepper fruit ripening.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Maria A. Munoz-Vargas, Salvador Gonzalez-Gordo, Jose M. Palma, Francisco J. Corpas
Summary: The study revealed variations in endogenous hydrogen sulfide (H2S) content and emission among different plants, with the highest levels found in Allium species. The activity of L-cysteine desulfhydrase (LCD) correlated positively with H2S content in plants, particularly in Allium species, suggesting potential health benefits associated with consuming these plants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Jing Zhang, Heng Zhou, Mingjian Zhou, Zhenglin Ge, Feng Zhang, Christine H. Foyer, Xingxing Yuan, Yanjie Xie
Summary: The study revealed that in Arabidopsis, dehydration-induced expression of DES1 is regulated by ABA, and ABA-deficient mutants show abolished DES1 expression under dehydration. Complementation of ABA3 or ABA treatment can rescue DES1 expression and wilting phenotype in ABA-deficient mutants. Additionally, coordinated synthesis of ABA and DES1 is required for drought-induced stomatal closure in Arabidopsis.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Sofia-Iris Bibli, Jiong Hu, Mario Looso, Andreas Weigert, Corina Ratiu, Janina Wittig, Maria Kyriaki Drekolia, Lukas Tombor, Voahanginirina Randriamboavonjy, Matthias S. Leisegang, Philipp Goymann, Fredy Delgado Lagos, Beate Fisslthaler, Sven Zukunft, Anastasia Kyselova, Alberto Fernando Oliveira Justo, Juliana Heidler, Diamantis Tsilimigras, Ralf P. Brandes, Stefanie Dimmeler, Andreas Papapetropoulos, Stefan Knapp, Stefan Offermanns, Ilka Wittig, Stephen L. Nishimura, Fragiska Sigala, Ingrid Fleming
Summary: This study investigated the S-sulfhydrome in human endothelial cells and found that S-sulfhydration plays a crucial role in regulating endothelial cell functions, especially in integrins and mechanotransduction. Impaired S-sulfhydration was associated with vascular dysfunction, while H2Sn supplementation improved vascular reactivity, suggesting a potential therapeutic target for vascular diseases.
Article
Biochemistry & Molecular Biology
Dalila G. F. Fernandes, Joao Nunes, Catarina S. Tome, Karim Zuhra, Joao M. F. Costa, Alexandra M. M. Antunes, Alessandro Giuffre, Joao B. Vicente
Summary: Gasotransmitters hydrogen sulfide, nitric oxide, and carbon monoxide play critical roles in human physiology by mediating signal transduction through interaction with protein targets. Research shows that S-nitrosation can inhibit hydrogen sulfide production through affecting various protein cysteine residues, highlighting a new mechanism of crosstalk between gasotransmitters.
Article
Biochemistry & Molecular Biology
Sofia-Iris Bibli, Ingrid Fleming
Summary: This article discusses the impact of changes in oxidative balance on cellular physiology and adaptation, with a focus on the sensitivity of endothelial cells to reactive oxygen species and the role of oxidative modifications in regulating protein function. Persulfidation, a newly identified reversible oxidation modification, plays a crucial role in maintaining cellular redox homeostasis.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Tingting Bu, Jing Lan, Inseong Jo, Jie Zhang, Xue Bai, Shanru He, Xiaoling Jin, Lulu Wang, Yu Jin, Xiaoyu Jin, Liying Zhang, Hailong Piao, Nam-Chul Ha, Chunshan Quan, Ki Hyun Nam, Yongbin Xu
Summary: This study discovered that the pathogen Fusobacterium nucleatum, which is associated with destructive periodontal disease and colorectal cancer, has four genes that produce hydrogen sulfide, which helps protect against oxidative stress. By examining the structure and conducting inhibitor screening, two natural compounds were found to selectively inhibit the production of hydrogen sulfide by Fn1419. This research revealed the molecular mechanism of Fn1419 and identified a new potential inhibitor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chenghua Luo, Dengyu Ji, Yan Li, Yan Cao, Shangyue Zhang, Wenjing Yan, Ke Xue, Jiayin Chai, Ye Wu, Huirong Liu, Wen Wang
Summary: This study revealed a new mechanism of post-translational modification of Sp1/CSE, investigated the specific effects of homocysteine metabolism disorder on H2S deficiency, and proposed therapeutic strategies involving restoring S-sulfhydration and blocking nitration.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)