期刊
MOLECULAR ONCOLOGY
卷 8, 期 8, 页码 1393-1403出版社
WILEY
DOI: 10.1016/j.molonc.2014.05.010
关键词
lncRNA; Consensus clustering; Colorectal cancer; Gene expression profiling; Somatic copy number alterations; Survival; Gene set enrichment analysis
类别
资金
- Shanghai Natural Science Foundation [13ZR14244000]
- National Natural Science Foundation of China [31371273]
- Nataional Natural Science Foundation of Key Program [81320108024]
- Ministry of Public Health, China [200802094]
- Ministry of Education [20120073110078]
Colorectal cancer (CRC) is a heterogeneous disease in terms of clinical behavior and response to therapy. Increasing evidence suggests that long noncoding RNAs (lncRNAs) are frequently aberrantly expressed in cancers, and some of them have been implicated in CRC biogenesis and prognosis. Using an IncRNA-mining approach, we constructed lncRNAs expression profiles in approximately 888 CRC samples. By applying unsupervised consensus clustering to LncRNA expression profiles, we identified five distinct molecular subtypes of CRC with different biological pathways and phenotypically distinct in their clinical outcome in both univariate and multivariate analysis. The prognostic significance of the lncRNA-based classifier was confirmed in independent patient cohorts. Further analysis revealed that most of the signature lncRNAs positively correlated with somatic copy number alterations (SCNAs). This lncRNAs-based classification schema thus provides a molecular classification applicable to individual tumors that has implications to influence treatment decisions. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据