BRCA2 inhibition enhances cisplatin-mediated alterations in tumor cell proliferation, metabolism, and metastasis

Causes of Genome Instability

(2013) Andrés Aguilera et al.   Annual Review of Genetics

SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism

(2013) Seung Min Jeong et al.   CANCER CELL

Outcome of metastatic breast cancer in selected women with or without deleterious BRCA mutations

(2013) S. Bayraktar et al.   CLINICAL & EXPERIMENTAL METASTASIS

KISS1R Induces Invasiveness of Estrogen Receptor-Negative Human Mammary Epithelial and Breast Cancer Cells

(2013) Donna Cvetković et al.   ENDOCRINOLOGY

Integrated genomic characterization of endometrial carcinoma

(2013) Gad Getz et al.   NATURE

The causes and consequences of genetic heterogeneity in cancer evolution

(2013) Rebecca A. Burrell et al.   NATURE

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Inhibition of BRCA2 and Thymidylate Synthase Creates Multidrug Sensitive Tumor Cells via the Induction of Combined “Complementary Lethality”

(2013) Mateusz Rytelewski et al.   Molecular Therapy-Nucleic Acids

Cancer treatment according to BRCA1 and BRCA2 mutations

(2012) Kara N. Maxwell et al.   Nature Reviews Clinical Oncology

In Vitro and In Vivo Prostate Cancer Metastasis and Chemoresistance Can Be Modulated by Expression of either CD44 or CD147

(2012) Jingli Hao et al.   PLoS One

Chemosensitivity and outcome of BRCA1- and BRCA2-associated ovarian cancer patients after first-line chemotherapy compared with sporadic ovarian cancer patients

(2011) P. M. L. H. Vencken et al.   ANNALS OF ONCOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Association of BRCA1 and BRCA2 Mutations With Survival, Chemotherapy Sensitivity, and Gene Mutator Phenotype in Patients With Ovarian Cancer

(2011) Da Yang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Insight into the heterogeneity of breast cancer through next-generation sequencing

(2011) Hege G. Russnes et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk

(2011) E Arpaia et al.   ONCOGENE

Real-Time Monitoring of Cisplatin-Induced Cell Death

(2011) Hamed Alborzinia et al.   PLoS One

Early reduction of glucose uptake after cisplatin treatment is a marker of cisplatin sensitivity in ovarian cancer

(2010) Tomomi Egawa-Takata et al.   CANCER SCIENCE

The mutation spectrum revealed by paired genome sequences from a lung cancer patient

(2010) William Lee et al.   NATURE

Prolonged survival in a patient with BRCA2 associated metastatic pancreatic cancer after exposure to camptothecin: a case report and review of literature

(2009) Edward James et al.   ANTI-CANCER DRUGS

Functional Restoration of BRCA2 Protein by Secondary BRCA2 Mutations in BRCA2-Mutated Ovarian Carcinoma

(2009) W. Sakai et al.   CANCER RESEARCH

A comprehensive catalogue of somatic mutations from a human cancer genome

(2009) Erin D. Pleasance et al.   NATURE

Restoration of CAPAN-1 cells with functional BRCA2 provides insight into the DNA repair activity of individuals who are heterozygous for BRCA2 mutations

(2008) Jeffrey T. Holt et al.   CANCER GENETICS AND CYTOGENETICS

Drug Resistance Caused by Reversion Mutation

(2008) A. Ashworth   CANCER RESEARCH

Platinum Resistance: The Role of DNA Repair Pathways

(2008) L. P. Martin et al.   CLINICAL CANCER RESEARCH