Endoplasmic reticulum stress and cell death in mTORC1-overactive cells is induced by nelfinavir and enhanced by chloroquine

Does bafilomycin A1block the fusion of autophagosomes with lysosomes?

(2014) Daniel J. Klionsky et al.   Autophagy

The HIV Protease Inhibitor Nelfinavir Down-Regulates RET Signaling and Induces Apoptosis in Medullary Thyroid Cancer Cells

(2014) Yevgeniya Kushchayeva et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells

(2013) Tianliang Li et al.   Autophagy

A phase I study of nelfinavir concurrent with temozolomide and radiotherapy in patients with glioblastoma multiforme

(2013) Michelle Alonso-Basanta et al.   JOURNAL OF NEURO-ONCOLOGY

Identification of endoplasmic reticulum stress-inducing agents by antagonizing autophagy: a new potential strategy for identification of anti-cancer therapeutics in B-cell malignancies

(2013) Emilia Mahoney et al.   LEUKEMIA & LYMPHOMA

Nelfinavir and bortezomib inhibit mTOR activity via ATF4-mediated sestrin-2 regulation

(2013) Ansgar Brüning et al.   Molecular Oncology

Integrated molecular analysis of clear-cell renal cell carcinoma

(2013) Yusuke Sato et al.   NATURE GENETICS

Phase I trial of the combination of the Akt inhibitor nelfinavir and chemoradiation for locally advanced rectal cancer

(2013) Jeroen Buijsen et al.   RADIOTHERAPY AND ONCOLOGY

Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy

(2012) Paola Maycotte et al.   Autophagy

Phase I study of nelfinavir in liposarcoma

(2012) Janet Pan et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors

(2012) Simmy Thomas et al.   CANCER LETTERS

Molecular Therapies for Tuberous Sclerosis and Neurofibromatosis

(2012) David Neal Franz et al.   Current Neurology and Neuroscience Reports

The human immunodeficiency virus-1 protease inhibitor nelfinavir impairs proteasome activity and inhibits the proliferation of multiple myeloma cells in vitro and in vivo

(2012) C. Bono et al.   HAEMATOLOGICA

The dual PI3K/mTOR inhibitor NVP-BEZ235 and chloroquine synergize to trigger apoptosisviamitochondrial-lysosomal cross-talk

(2012) Christian Seitz et al.   INTERNATIONAL JOURNAL OF CANCER

A Phase I Trial of the HIV Protease Inhibitor Nelfinavir with Concurrent Chemoradiotherapy for Unresectable Stage IIIA/IIIB Non-small Cell Lung Cancer: A Report of Toxicities and Clinical Response

(2012) Ramesh Rengan et al.   Journal of Thoracic Oncology

A Phase I Study of Erlotinib and Hydroxychloroquine in Advanced Non–Small-Cell Lung Cancer

(2012) Sarah B. Goldberg et al.   Journal of Thoracic Oncology

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

(2012) Christian C. Dibble et al.   MOLECULAR CELL

Suppression of autophagy exacerbates Mefloquine-mediated cell death

(2012) Ji Hyun Shin et al.   NEUROSCIENCE LETTERS

Emerging Treatments in the Management of Tuberous Sclerosis Complex

(2012) Michael H. Kohrman   PEDIATRIC NEUROLOGY

Chloroquine-Mediated Lysosomal Dysfunction Enhances the Anticancer Effect of Nutrient Deprivation

(2012) Ljubica Harhaji-Trajkovic et al.   PHARMACEUTICAL RESEARCH

Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling

(2012) Christian Appenzeller-Herzog et al.   TRENDS IN CELL BIOLOGY

ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding

(2011) Elaine A. Dunlop et al.   Autophagy

Gadd34 induces autophagy through the suppression of the mTOR pathway during starvation

(2011) Mohammad Nizam Uddin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

PI3K/mTORC1 activation in hamartoma syndromes: Therapeutic prospects

(2011) Vera P. Krymskaya et al.   CELL CYCLE

Salermide up-regulates death receptor 5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cells

(2011) Guangbo Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest

(2011) Ian G. Ganley et al.   MOLECULAR CELL

A Systematic Study of Gene Mutations in Urothelial Carcinoma; Inactivating Mutations in TSC2 and PIK3R1

(2011) Gottfrid Sjödahl et al.   PLoS One

Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent

(2011) A. Parkhitko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors

(2011) Y. Jiao et al.   SCIENCE

Mammalian target of rapamycin and head and neck squamous cell carcinoma

(2011) Yu-Min Liao et al.   Head and Neck Optical Diagnostics Society

Validation and toxicity of PI3K/Akt pathway inhibition by HIV protease inhibitors in humans

(2010) John P. Plastaras et al.   CANCER BIOLOGY & THERAPY

The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis

(2010) Y J Kang et al.   CELL DEATH AND DIFFERENTIATION

Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase

(2010) You-Tong Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Spectrum of Phosphatidylinositol 3-Kinase Pathway Gene Alterations in Bladder Cancer

(2009) F. M. Platt et al.   CLINICAL CANCER RESEARCH

Chloroquine and its analogs: A new promise of an old drug for effective and safe cancer therapies

(2009) V. Raja Solomon et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tuberous Sclerosis Complex Activity Is Required to Control Neuronal Stress Responses in an mTOR-Dependent Manner

(2009) A. Di Nardo et al.   JOURNAL OF NEUROSCIENCE

Induction of endoplasmic reticulum stress response by TZD18, a novel dual ligand for peroxisome proliferator-activated receptor  / , in human breast cancer cells

(2009) C. Zang et al.   MOLECULAR CANCER THERAPEUTICS

Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis

(2008) Umut Ozcan et al.   MOLECULAR CELL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL