Pre-clinical efficacy of PU-H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma

Effect of inhibition of the Ubiquitin-Proteasome System and Hsp90 on growth and survival of Rhabdomyosarcoma cells in vitro

(2012) Marica Peron et al.   BMC CANCER

A TARBP2-Dependent miRNA Expression Profile Underlies Cancer Stem Cell Properties and Provides Candidate Therapeutic Reagents in Ewing Sarcoma

(2012) Claudio De Vito et al.   CANCER CELL

R1507, a Monoclonal Antibody to the Insulin-Like Growth Factor 1 Receptor, in Patients With Recurrent or Refractory Ewing Sarcoma Family of Tumors: Results of a Phase II Sarcoma Alliance for Research Through Collaboration Study

(2011) Alberto S. Pappo et al.   JOURNAL OF CLINICAL ONCOLOGY

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

(2011) Kamalika Moulick et al.   Nature Chemical Biology

Efficacy of and resistance to anti-IGF-1R therapies in Ewing's sarcoma is dependent on insulin receptor signaling

(2011) C Garofalo et al.   ONCOGENE

The Hsp90 inhibitor IPI-504 overcomes bortezomib resistance in mantle cell lymphoma in vitro and in vivo by down-regulation of the prosurvival ER chaperone BiP/Grp78

(2010) G. Roue et al.   BLOOD

EWS/FLI1 Oncogene Activates Caspase 3 Transcription and Triggers Apoptosis In vivo

(2010) E. J. Sohn et al.   CANCER RESEARCH

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Oncogenic Partnerships: EWS-FLI1 Protein Interactions Initiate Key Pathways of Ewing's Sarcoma

(2010) H. V. Erkizan et al.   CLINICAL CANCER RESEARCH

Benign Mesenchymal Stromal Cells in Human Sarcomas

(2010) A. Morozov et al.   CLINICAL CANCER RESEARCH

HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans

(2010) Sachie Marubayashi et al.   JOURNAL OF CLINICAL INVESTIGATION

Outcomes for Children and Adolescents With Cancer: Challenges for the Twenty-First Century

(2010) Malcolm A. Smith et al.   JOURNAL OF CLINICAL ONCOLOGY

A Technical Assessment of the Utility of Reverse Phase Protein Arrays for the Study of the Functional Proteome in Non-microdissected Human Breast Cancers

(2010) Bryan T. Hennessy et al.   Clinical Proteomics

Molecular characterization of commonly used cell lines for bone tumor research: A trans-European EuroBoNet effort

(2009) Laura Ottaviano et al.   GENES CHROMOSOMES & CANCER

The novel HSP90 inhibitor STA-1474 exhibits biologic activity against osteosarcoma cell lines

(2009) Jennifer K. McCleese et al.   INTERNATIONAL JOURNAL OF CANCER

A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6–dependent B cell lymphomas

(2009) Leandro C Cerchietti et al.   NATURE MEDICINE

A Molecular Function Map of Ewing's Sarcoma

(2009) Maximilian Kauer et al.   PLoS One

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

(2009) E. Caldas-Lopes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Pivotal Role for Heat Shock Protein 90 in Ewing Sarcoma Resistance to Anti-Insulin-like Growth Factor 1 Receptor Treatment: In vitro and In vivo Study

(2008) A. S. Martins et al.   CANCER RESEARCH