Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells

Pancreatic cancer

(2011) Audrey Vincent et al.   LANCET

Synthesis and cytotoxicity of novel indirubin-5-carboxamides

(2010) Xinlai Cheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeted Inhibition of Src Kinase Signaling Attenuates Pancreatic Tumorigenesis

(2010) Nagathihalli S. Nagaraj et al.   MOLECULAR CANCER THERAPEUTICS

Phenotype and Genotype of Pancreatic Cancer Cell Lines

(2010) Emily L. Deer et al.   PANCREAS

A new regulatory switch in a JAK protein kinase

(2010) Vickie Tsui et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors

(2009) Michael Hedvat et al.   CANCER CELL

Sustained Src Inhibition Results in Signal Transducer and Activator of Transcription 3 (STAT3) Activation and Cancer Cell Survival via Altered Janus-Activated Kinase-STAT3 Binding

(2009) B. Sen et al.   CANCER RESEARCH

Src kinases as therapeutic targets for cancer

(2009) Lori C. Kim et al.   Nature Reviews Clinical Oncology

Epidemiology of pancreatic cancer: an overview

(2009) Sara Raimondi et al.   Nature Reviews Gastroenterology & Hepatology

Myeloproliferative disorders

(2008) R. L. Levine et al.   BLOOD