期刊
MOLECULAR ONCOLOGY
卷 5, 期 4, 页码 315-323出版社
WILEY
DOI: 10.1016/j.molonc.2011.07.007
关键词
Aneuploidy; Tetraploidy; p53; Lats2; Genomic instability; Oncogenic H-Ras
类别
资金
- National Cancer Institute [R37 CA40099]
- EC [223151, 201102]
- Flight Attendant Medical Research Institute (FAMRI)
- Dr. Miriam and Sheldon Adelson Medical Research Foundation
- The Robert Bosch Stiftung
- The Lower Saxony-Israeli Association
- Estate of Harold Z. Novak
Aneuploidy, often preceded by tetraploidy, is one of the hallmarks of solid tumors. Indeed, both aneuploidy and tetraploidy are oncogenic occurrences that are sufficient to drive neoplastic transformation and cancer progression. True to form, the tumor suppressor p53 obstructs propagation of these dangerous chromosomal events by either instigating irreversible cell cycle arrest or apoptosis. The tumor suppressor Lats2, along with other tumor inhibitory proteins such as BRCA1/2 and BubR1, are central to p53-dependent elimination of tetraploid cells. Not surprisingly, these proteins are frequently inactivated or downregulated in tumors, synergizing with p53 inactivation to establish an atmosphere of tolerance for a non-diploid state. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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