Article
Biotechnology & Applied Microbiology
Xu Han, Jialin Hao, Suling Ding, En-Hua Wang, Liang Wang
Summary: Bronchiolar adenoma (BA) is typically considered a benign tumor, but recent studies have suggested potential malignant characteristics at the genetic level. This case report highlights a BA case harboring the same genetic mutation as adjacent invasive mucinous adenocarcinoma (IMA), indicating a possible malignant transformation from BA to IMA.
ONCOTARGETS AND THERAPY
(2021)
Review
Cell Biology
Wei-Chin Chang, Yu Zhi Zhang, Andrew G. Nicholson
Summary: This article reviews recent updates on the histopathological, clinical, and molecular features of invasive mucinous adenocarcinoma (IMA), emphasizing its differences in therapeutic approaches compared to nonmucinous adenocarcinomas. The article also highlights unresolved issues that can guide future studies.
Article
Oncology
Chang Woo Kim, Jae Myung Cha, Min Seob Kwak
Summary: In colorectal cancer, patients with mucinous adenocarcinoma (MAC) have a poorer prognosis compared to those with traditional adenocarcinoma (TAC), especially in Stage II. The study findings suggest that identifying potential biomarkers and biological pathways can be useful in predicting the prognosis of colorectal cancer.
Article
Respiratory System
Dongyu Cui, Shaonan Xie, Qingyi Liu
Summary: This study aimed to compare the surgical prognosis and prognosis-related risk factors between pulmonary invasive mucinous adenocarcinoma (IMA) and non-mucinous invasive adenocarcinoma (NMA). The results showed that there was no significant difference in overall survival (OS) between patients with IMA and NMA after surgical treatment. Age, sex, and radiation treatment were identified as independent predictors of patient OS.
BMC PULMONARY MEDICINE
(2023)
Article
Medicine, General & Internal
Xu-Ling Liu, Cheng-Feng Miao, Min Li, Peng Li
Summary: This study identified bronchiolar adenoma and ciliated muconodular papillary tumor as rare tumors with bilayered cell proliferation and continuous expression of p40 and CK5/6 in the basal cell layer. Diagnosis is difficult due to limited knowledge and morphological similarities to malignant tumors, especially based on histopathology of intraoperative frozen sections. These tumors are now considered benign, with few cases reported of malignant transformation.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Oncology
Yuming Wang, Yike Gao, Zhiwen Zhang, Zixin Zhang, Anqi Wang, Kun Zhao, Miao Zhang, Sumei Zhang, Mei Li, Jian Sun, Dan Guo, Zhiyong Liang
Summary: In this study, the expression of claudin18.2 was found to be significantly higher in pulmonary invasive mucinous adenocarcinoma (IMA) patients and was associated with low invasive capacity. Therefore, this protein may serve as a promising therapeutic target and should be further investigated in IMA patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biology
Fang-Jie Hu, Ying-Jie Li, Li Zhang, Deng-Bo Ji, Xin-Zhi Liu, Yong-Jiu Chen, Lin Wang, Ai-Wen Wu
Summary: A single-cell RNA sequencing analysis reveals molecular differences between mucinous adenocarcinoma and classical adenocarcinoma, providing insight into these two subtypes of colorectal cancer. Mucinous adenocarcinoma, a unique histological subtype, responds poorly to chemoradiotherapy and its prognosis compared to classical adenocarcinoma is controversial. The study findings show that mucinous adenocarcinoma cells exhibit goblet cell-like properties and express higher levels of goblet cell markers than classical adenocarcinoma cells. TFF3 and possibly RPS4X play essential roles in the transcriptional regulation of these molecules and the development of the mucinous adenocarcinoma mucus phenotype.
COMMUNICATIONS BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Takuya Matsui, Noriaki Sakakura, Shin Koyama, Keita Nakanishi, Eiichi Sasaki, Seiichi Kato, Waki Hosoda, Yoshiko Murakami, Hiroaki Kuroda, Yasushi Yatabe
Summary: Invasive mucinous adenocarcinoma (IMA) is a rare subtype of invasive lung adenocarcinoma with differences in lymph node metastasis and KRAS mutations compared to non-IMA. Patients with IMA have a higher rate of intrapulmonary recurrence postoperatively, leading to significantly worse prognosis among those with lung recurrence compared to non-IMA patients. Overall survival rates at 5 years did not differ significantly between the two groups.
ANNALS OF THORACIC SURGERY
(2021)
Article
Gastroenterology & Hepatology
Yasuhiko Mizuguchi, Yusaku Tanaka, Hourin Cho, Masau Sekiguchi, Hiroyuki Takamaru, Masayoshi Yamada, Taku Sakamoto, Takahisa Matsuda, Taiki Hashimoto, Shigeki Sekine, Yutaka Saito
Summary: The study evaluated the endoscopic features of isolated and TSA-associated SuSAs, finding that they exhibit several characteristic features on white-light and image-enhanced endoscopy, with diminutive lesions overlapping with hyperplastic polyps. However, the endoscopic diagnosis of larger and TSA-associated SuSAs may be feasible.
DIGESTIVE ENDOSCOPY
(2022)
Article
Oncology
Luigi Tornillo, Frank Serge Lehmann, Andrea Garofoli, Viola Paradiso, Charlotte K. Y. Ng, Salvatore Piscuoglio
Summary: The study defined the genomic landscape of serrated lesions of the colorectum using high-depth targeted sequencing, revealing similarities in somatic mutations between SSL/D and TSA, with the BRAF hotspot mutation driving the disease. TA, on the other hand, showed a distinct constellation of somatic mutations, such as ARID1A loss of function.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pathology
Eiichi Sasaki, Katsuhiro Masago, Yoshihito Kogure, Shiro Fujita, Akari Iwakoshi, Hiroaki Kuroda, Toyonori Tsuzuki, Koji Tsuta, Hirokazu Matsushita, Masahide Oki
Summary: This study reported two cases of mucous gland adenoma (MGA) and compared their morphological, immunohistochemical, and molecular profiles with 19 pulmonary tumors of different histological types. The results showed that MGA had a specific RNA expression profile and NKX3.1 immunohistochemistry could differentiate MGA from other histologic mimics. The findings suggest that MGA is a neoplastic counterpart of mucinous bronchial glands and NKX3.1 immunohistochemistry can be used as a sensitive and specific ancillary marker for the diagnosis of MGA.
Article
Oncology
Jae Eun Lee, Yoon Young Choi, Ji Yeong An, Ki Tae Kim, Su-Jin Shin, Jae-Ho Cheong
Summary: Mucinous gastric adenocarcinoma (MGC) has distinctive clinico-pathologic characteristics compared to non-mucinous GC (NMGC), and is frequently associated with high microsatellite instability (MSI-H) while mutually exclusive to Epstein-Barr virus type. MGC shows a better prognosis than NMGC, but there is no clear benefit from postoperative chemotherapy.
Article
Surgery
Rui-Qi Zou, Hai-Jie Hu, Fei Liu, Tian-Run Lv, Jun-Ke Wang, Parbatraj Regmi, Fu-Yu Li
Summary: Clinicopathological features and surgical outcomes differ significantly between gallbladder mucinous adenocarcinoma (GBMAC) and conventional gallbladder adenocarcinoma (GBAC). GBMAC exhibits more aggressive biological behaviors and poorer survival outcomes even after curative surgery, with the presence of signet-ring cell component indicating worse prognosis.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Oncology
Yuan-Tzu Lan, Shih-Ching Chang, Pei-Ching Lin, Chun-Chi Lin, Hung-Hsin Lin, Shen-Chieh Huang, Chien-Hsing Lin, Wen-Yi Liang, Wei-Shone Chen, Jeng-Kai Jiang, Jen-Kou Lin, Shung-Haur Yang
Summary: The prognosis and molecular differences between mucinous adenocarcinoma (MAC) and non-mucinous adenocarcinoma (NMAC) in colorectal cancer (CRC) are controversial. Genetic alterations are distinct between MAC and NMAC, with tumor location having an impact on genetic alterations and patient prognosis in MAC and NMAC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pathology
Moonsik Kim, Jinha Hwang, Kyung A. Kim, Sohyun Hwang, Hye-Jeong Lee, Ji Ye Jung, Jin Gu Lee, Yoon Jin Cha, Hyo Sup Shim
Summary: Multifocal invasive mucinous adenocarcinoma (IMA) of the lung exhibits low tumor mutational burden with intra-tumor heterogeneity and diverse mutation signatures, suggesting potential multicentric origins from different primary lesions. Further studies are needed to determine the clinical significance of the genomic characteristics of IMAs in expanded cohorts.
Review
Oncology
Plabon Kumar Das, Joti Saha, Suja Pillai, Alfred K-Y Lam, Vinod Gopalan, Farhadul Islam
Summary: This study highlights the significant role of estrogens and their receptors, particularly ERβ, in the pathogenesis of colorectal carcinoma (CRC). Understanding the underlying mechanisms of estrogen and its receptors in CRC pathogenesis could offer new insights for therapeutic development.
Article
Medicine, General & Internal
Zaw Thet, Alfred K. Lam, Tony Pham, Shu-Kay Ng, Jason C. Steel, Sirena Sawhney, Carolina T. Arellano, Soe Yu Aung, Thin Han, Dwarakanathan Ranganathan, George John, Christina Pepito, Tamlyn Rautenberg, Tien K. Khoo
Summary: This study evaluated the clinical and economic burden of benign and malignant skin lesions in renal transplant recipients in Australia using Medicare data. The results showed that 40% of patients were diagnosed with benign skin lesions, 38% with nonmelanoma skin carcinoma (NMSC), and 2% with melanoma during a 2-year follow-up. The total direct costs to Medicare were $48,806 Australian Dollars, indicating a significant burden in the renal transplantation setting.
INTERNAL MEDICINE JOURNAL
(2023)
Review
Otorhinolaryngology
Sharmin Aktar, Hooman Baghaie, Farhadul Islam, Vinod Gopalan, Alfred King-Yin Lam
Summary: This review examines the current status of circulating tumor cells (CTCs) in patients with head and neck squamous cell carcinomas (HNSCC), highlighting their diagnostic and prognostic value. Various analysis approaches, such as single-CTC analysis and identifying phenotypic surface markers, have shown promise in predicting disease progression and treatment efficacy. However, limitations in CTC detection and characterization methods remain.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Review
Medicine, General & Internal
Louise Clarkson, Laura Hart, Alfred K. K. Lam, Tien K. K. Khoo
Summary: This review examined the effectiveness of deprescribing interventions within specialist outpatient clinics for patients aged 60 and older. Nineteen studies showed that implementing deprescribing interventions in certain clinic settings can significantly reduce medication load, but with limited study quality and the need for further research.
CURRENT MEDICAL RESEARCH AND OPINION
(2023)
Article
Biochemistry & Molecular Biology
Sharmin Aktar, Faysal Bin Hamid, Sujani Madhurika Kodagoda Gamage, Tracie Cheng, Nahal Parkneshan, Cu Tai Lu, Farhadul Islam, Vinod Gopalan, Alfred King-yin Lam
Summary: Information on genetic alterations of driver cancer genes in circulating tumor cells (CTCs) and their immune microenvironment can be used as a real-time monitoring platform for translational applications. This study investigated gene expression profiling in CTCs and peripheral blood mononuclear cells (PBMCs) of colorectal carcinoma (CRC) patients. The presence of higher numbers of CTCs was correlated with advanced cancer stages and adenocarcinoma subtypes. Patients with lower numbers of CTCs had higher expression of KRAS, which was negatively correlated with tumor perforation and distant metastasis. CTLA-4 was highly expressed in both CTCs and PBMCs and positively correlated with KRAS in CTCs. Dysregulation of KRAS in CTCs may alter the expression of CTLA-4, providing insights into therapeutic target selection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ghazaleh Pourali, Nima Zafari, Hamid Fiuji, Jyotsna Batra, Elham Nazari, Majid Khazaei, Seyed Mahdi Hassanian, Mahrou Vahabi, MohammadAli Kiani, Majid Ghayour-Mobarhan, Godefridus J. Peters, Gordon A. Ferns, Alfred King-yin Lam, Elisa Giovannetti, Amir Avan
Summary: There is a complex interaction between pro-tumoural and anti-tumoural networks in the tumour microenvironment (TME). Understanding these interactions within the TME is crucial for the development of innovative cancer treatments. Extracellular vesicles (EVs) serve as carriers of various materials and play a vital role in the communication between tumour cells and non-tumour cells. This review summarizes recent findings regarding the involvement of EVs in the metabolic reprogramming of gastrointestinal cancers and highlights potential therapeutic approaches.
CYTOKINE & GROWTH FACTOR REVIEWS
(2023)
Correction
Biochemistry & Molecular Biology
Sharmin Aktar, Faysal Bin Hamid, Sujani Madhurika Kodagoda Gamage, Tracie Cheng, Nahal Pakneshan, Cu Tai Lu, Farhadul Islam, Vinod Gopalan, Alfred King-yin Lam
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Fatemeh Khojasteh-Leylakoohi, Reza Mohit, Nima Khalili-Tanha, Alireza Asadnia, Hamid Naderi, Ghazaleh Pourali, Zahra Yousefli, Ghazaleh Khalili-Tanha, Majid Khazaei, Mina Maftooh, Mohammadreza Nassiri, Seyed Mahdi Hassanian, Majid Ghayour-Mobarhan, Gordon A. Ferns, Soodabeh Shahidsales, Alfred King-yin Lam, Elisa Giovannetti, Elham Nazari, Jyotsna Batra, Amir Avan
Summary: This study utilized bioinformatics and machine learning methods to identify and validate differentially expressed genes and microRNAs associated with pancreatic ductal adenocarcinoma (PDAC). The results demonstrated the prognostic and diagnostic value of these genes and microRNAs in PDAC.
SCIENTIFIC REPORTS
(2023)
Article
Genetics & Heredity
Sharmin Aktar, Farhadul Islam, Tracie Cheng, Sujani Madhurika Kodagoda Gamage, Indra Neil Choudhury, Md Sajedul Islam, Cu Tai Lu, Faysal Bin Hamid, Hirotaka Ishida, Ichiro Abe, Nan Xie, Vinod Gopalan, Alfred K. Lam
Summary: This study investigated the genomic variations of KRAS in circulating tumour cells (CTCs) and matched colorectal carcinoma (CRC) tissues. The results showed differences in KRAS mutations between CTCs and CRC tissues. Patients with KRAS mutations in CTCs were more likely to have poorly differentiated tumors and lymph node metastasis. These findings suggest the genetic basis of KRAS as a potential target for immunotherapy.
Article
Oncology
Maryam Alaei, Seyedeh Elnaz Nazari, Ghazaleh Pourali, AliReza Asadnia, Mehrdad Moetamani-Ahmadi, Hamid Fiuji, Hamid Tanzadehpanah, Fereshteh Asgharzadeh, Fatemeh Babaei, Fatemeh Khojasteh-Leylakoohi, Ibrahim Saeed Gataa, Mohammad Ali Kiani, Gordon A. Ferns, Alfred King-yin Lam, Seyed Mahdi Hassanian, Majid Khazaei, Elisa Giovannetti, Amir Avan
Summary: In this study, the potential of targeting the enzyme cytochrome P450 (CYP450) using lopinavir/ritonavir in colorectal cancer (CRC) was explored. Experimental methods were employed to assess the effects of lopinavir/ritonavir on CRC, and it was found that inhibiting CYP450 reduced cell proliferation, induced cell death, and suppressed cell migration. Lopinavir/ritonavir also inhibited tumor growth and fibrosis. These findings suggest that targeting CYP450 with lopinavir/ritonavir has therapeutic potential in CRC and further research in this area is needed.
Article
Oncology
Alireza Asadnia, Elham Nazari, Ladan Goshayeshi, Nima Zafari, Mehrdad Moetamani-Ahmadi, Lena Goshayeshi, Haneih Azari, Ghazaleh Pourali, Ghazaleh Khalili-Tanha, Mohammad Reza Abbaszadegan, Fatemeh Khojasteh-Leylakoohi, Mohammadjavad Bazyari, Mir Salar Kahaei, Elnaz Ghorbani, Majid Khazaei, Seyed Mahdi Hassanian, Ibrahim Saeed Gataa, Mohammad Ali Kiani, Godefridus J. Peters, Gordon A. Ferns, Jyotsna Batra, Alfred King-yin Lam, Elisa Giovannetti, Amir Avan
Summary: This study identified genetic variants and differentially expressed genes in colorectal cancer patients using genome-wide DNA and RNA sequencing. ASPHD1 and ZBTB12 genes were identified as potential prognostic markers, and two novel genetic variants were found to potentially regulate gene expression. These findings provide a proof of concept for the evaluation of emerging biomarkers in colorectal cancer.
Meeting Abstract
Transplantation
Ken Chau, Shu Kay Ng, Alfred Lam, Tien Khoo, Dwarakanathan Ranganathan
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Meeting Abstract
Transplantation
Louise Clarkson, Tien Khoo, Alfred Lam, Anthony Griffiths
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Meeting Abstract
Transplantation
Zaw Thet, Thin Han, Leo Francis, Nyi Aung, Ken Chau, Shu Kay Ng, Mar Myint, Jennifer Borg, Alfred Lam, Tien Khoo, Dwarakanathan Ranganathan
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Cell Biology
Hirotaka Ishida, Atsuko Kasajima, Takuro Yamauchi, Ryujiro Akaishi, Shunsuke Ueki, Yusuke Taniyama, Fumiyoshi Fujishima, Tomoyuki Koike, Takashi Kamei, Alfred King-yin Lam, Hironobu Sasano
Summary: Esophageal basaloid squamous cell carcinoma can resemble small cell carcinoma biopsy specimens and cause difficulties in pathology diagnosis. Small cell carcinoma-like features are frequent in biopsies but do not impact patients' outcome. Immunohistochemically, synapto-physin and chromogranin A are consistently negative, while CD56 is expressed in some cases. p16 expression may also be detected in basaloid squamous cell carcinoma.
HISTOLOGY AND HISTOPATHOLOGY
(2023)
Article
Oncology
Andra S. Martinikova, Miroslav Stoyanov, Anna Oravetzova, Yannick P. Kok, Shibo Yu, Jana Dobrovolna, Pavel Janscak, Marcel van Vugt, Libor Macurek
Summary: Oncogene-induced replication stress is a major cause of genome instability in cancer cells. This study reveals that increased activity of PPM1D exacerbates replication stress caused by cyclin E1 overexpression, leading to abnormal cell cycle progression and accumulation of DNA copy number alterations. Pharmacological inhibition of PPM1D can alleviate replication stress-induced genome instability.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Alamelu G. Bharadwaj, Meghan E. McLean, Margaret L. Dahn, Hannah F. Cahill, Marie-Claire D. Wasson, Raj Pranap Arun, Olivia L. Walker, Brianne M. Cruickshank, Wasundara Fernando, Jaganathan Venkatesh, Penelope J. Barnes, Gillian Bethune, Gregory Knapp, Lucy K. Helyer, Carman A. Giacomantonio, David M. Waisman, Paola Marcato
Summary: ALDH1A3 regulates the plasminogen activation pathway to promote breast cancer metastasis. Co-expression of ALDH1A3 and tPA is associated with TNBC subtype, high tumor grade, and recurrent metastatic disease.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Nayela N. Chowdhury, Yi Yang, Ananya Dutta, Michelle Luo, Zimu Wei, Sara R. Abrahams, Alexey S. Revenko, Fenil Shah, Lindsey A. Miles, Robert J. Parmer, Bas de Laat, Alisa S. Wolberg, James P. Luyendyk, Melissa L. Fishel, Matthew J. Flick
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal metastatic disease associated with robust activation of the coagulation and fibrinolytic systems. Primary fibrinolytic protease plasminogen promotes PDAC tumor growth and metastatic potential through engaging plasminogen receptors on tumor cells.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Nuria Gendrau-Sanclemente, Agnes Figueras, Kristina Gracova, Alvaro Lahiguera, Elisenda Alsina-Sanchis, Juan A. Marin-Jimenez, August Vidal, Xavier Matias-Guiu, Sergi Fernandez-Gonzalez, Marc Barahona, Lola Marti, Jordi Ponce, Francesc Vinals
Summary: High-grade serous ovarian cancer (HGSOC), the deadliest gynecological malignancy, spreads through transcoelomic dissemination. This study reveals that platelet-derived growth factor receptor beta (PDGFRβ) is essential for the formation of tumorspheres in HGSOC. Inhibition of PDGFRβ blocks the clustering of ovarian cancer cells and prevents peritoneal dissemination.
MOLECULAR ONCOLOGY
(2024)
