Article
Reproductive Biology
Maho Shimizu, Keitaro Yamanaka, Maho Azumi, Masako Tomimoto, Keiichi Washio, Ryosuke Takahashi, Satoshi Nagamata, Yuka Murata, Yui Yamasaki, Yoshito Terai
Summary: The case presented a patient with SEIC accompanied by serous ovarian carcinoma and lymph node metastasis. The difficulty in identifying the primary lesion was highlighted as both tumors were serous carcinomas. Further development of methods for differentiation between the diseases is needed due to controversial histological diagnostic criteria.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Basem Fares, Liron Berger, Einav Bangiev-Girsh, Reli Rachel Kakun, Dima Ghannam-Shahbari, Yuval Tabach, Yaniv Zohar, Eyal Gottlieb, Ruth Perets
Summary: PAX8 plays a critical antiapoptotic role in uterine serous papillary carcinoma (USPC) by regulating mutated p53 and p21 expression to promote tumor proliferation. Additionally, a genome-wide transcriptome analysis suggests that metabolism and HIF-1alpha-related pathways may mediate the role of PAX8 in USPC.
Article
Pathology
Natalie Banet, Maryam Shahi, Denise Batista, Raluca Yonescu, Edward J. Tanner, Amanda N. Fader, Ashley Cimino-Mathews
Summary: HER-2 targeted therapy shows promising results in HER-2-positive uterine serous carcinoma, but evaluating HER-2 status can be challenging due to intratumoral heterogeneity and discordance between IHC and FISH results, highlighting the need for further research and caution in clinical practice.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Oncology
Puja Dey, Kentaro Nakayama, Sultana Razia, Masako Ishikawa, Tomoka Ishibashi, Hitomi Yamashita, Kosuke Kanno, Seiya Sato, Tohru Kiyono, Satoru Kyo
Summary: This study successfully developed an in vitro carcinogenic model of LGSOCs and found that the mutations of KRAS and PIK3CA play a causative role in LGSOC tumorigenesis. Simultaneous activation of the KRAS/ERK and PIK3CA/AKT signaling pathways is essential for LGSOC development.
Article
Biochemistry & Molecular Biology
Yazmin Brown, Susan Hua, Pradeep S. Tanwar
Summary: High-grade serous ovarian cancer (HGSOC) is a deadly gynaecological cancer with insidious progression. It is now widely accepted that HGSOC originates from the fallopian tube epithelium. This review explores the involvement of the extracellular matrix (ECM) in HGSOC development, including its role in tumourigenesis, metastasis, and drug resistance.
Article
Oncology
Thomas Boerner, Henry S. Walch, Bastien Nguyen, Alexia Iasonos, Qin C. Zhou, Nikolaus Schultz, M. Herman Chui, Rachel N. Grisham, William P. Tew, Roisin E. O'Cearbhaill, Carol Aghajanian, Oliver Zivanovic, Nadeem R. Abu-Rustum, Ginger J. Gardner, Yukio Sonoda, Dennis S. Chi, Kara Long Roche
Summary: This study evaluated the clinical significance and genomic associations of concurrent STIC and HGSC in women undergoing PDS. Findings revealed no significant clinical or genetic differences between +STIC and no-STIC patients, suggesting a comparable, if not identical, disease process. The study provides important insights into the relationship between HGSC and STIC.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Obstetrics & Gynecology
Jung Mi Byun, Hwa Jin Cho, Dae Sim Lee, Hye Kyoung Yoon, Young Nam Kim, Do Hwa Im, Da Hyun Kim, Kyung Bok Lee, Moon Su Sung, Dae Hoon Jeong
Summary: This study aimed to evaluate the proportion of STIC in patients with HGSOC and analyze the STIC-related prognosis. The results showed that 11 out of 76 cases were STIC. BRCA mutations were found in 16.9% of patients with HGSOC. The incidence of STIC in patients with BRCA mutations was higher than in patients without BRCA mutations, but the difference was not statistically significant. There was no significant difference in survival rates with or without STIC. Prophylactic salpingectomy may be useful for prevention of HGSOC.
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2023)
Article
Cell Biology
Pamoda Galhenage, Yunlan Zhou, Erica Perry, Brenda Loc, Kelly Fietz, Sonia Iyer, Ferenc Reinhardt, Tiego Da Silva, Vladimir Botchkarev, Jie Chen, Christopher P. Crum, Robert A. Weinberg, Shailja Pathania
Summary: Clinical and molecular evidence suggests that high-grade serous ovarian cancer primarily originates from the fallopian tube due to distinct differences between fallopian tube epithelial cells and ovarian surface epithelial cells. Fallopian tube cells exhibit heightened replication stress, impaired repair mechanisms, defective checkpoint functionality, and increased tumorigenicity compared to ovarian surface cells. BRCA1 heterozygosity exacerbates these defects and leads to an aggressive tumor phenotype.
Review
Oncology
Lana E. Kandalaft, Denarda Dangaj Laniti, George Coukos
Summary: This review proposes a classification system based on immunophenotypes to explain the failures of existing immunotherapies in high-grade serous ovarian cancers, and suggests that rational therapeutic approaches tailored to each immunophenotype might meet with improved success.
NATURE REVIEWS CANCER
(2022)
Article
Multidisciplinary Sciences
Claudia Marchetti, Marco D'Indinosante, Carolina Bottoni, Chiara Di Ilio, Stefano Di Berardino, Barbara Costantini, Angelo Minucci, Laura Vertechy, Giovanni Scambia, Anna Fagotti
Summary: The study found that NLR is associated with disease distribution in ovarian cancer patients, with those having NLR<4 more likely to undergo primary debulking surgery and have lower surgical complexity scores. Patients with NLR<4 had a longer median Progression-Free Survival (mPFS), and both BRCA-mutated and BRCA-wild type patients with lower NLR had significantly prolonged mPFS compared to those with higher NLR. BRCA mutational status, complete cytoreduction, and NLR<4 were identified as independent factors of prolonged PFS, while BRCA mutational status, complete cytoreductive surgery, NLR<4, and age were predictors of longer Overall Survival (OS).
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Kristie-Ann Dickson, Tao Xie, Christian Evenhuis, Yue Ma, Deborah J. Marsh
Summary: PARP inhibitors have shown efficacy in treating tumors with BRCA gene defects, improving survival outcomes. Variability exists between different PARP inhibitors in terms of chemical structure, toxicity, and cell survival, with acquired resistance being a concerning issue that needs further exploration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Soyoun Rachel Kim, Janet Malcolmson, Xuan Li, Marcus Q. Bernardini, Liat Hogen, Taymaa May
Summary: BRCAm status predicts complete cytoreduction at the time of primary cytoreduction (PCS), with higher likelihood of achieving complete resection in BRCAm HGSC despite similar disease burden and surgical efforts.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Hyunjin Kim, Go Eun Bae, Yoon Yang Jung, Hyun-Soo Kim
Summary: This is a rare case of ovarian mesonephric-like adenocarcinoma (MLA) involving the fimbria and mimicking serous tubal intraepithelial carcinoma (STIC). Immunostaining played a crucial role in differential diagnosis, especially between MLA and high-grade serous carcinoma.
Article
Health Care Sciences & Services
Ana Paula Dergham, Caroline Busatta Vaz de Paula, Seigo Nagashima, Marcia Olandoski, Lucia de Noronha, Vanessa Santos Sotomaior
Summary: Assessment of immunotherapeutic markers in paraffin-embedded samples of advanced serous ovarian carcinoma is feasible and may provide prognostic information.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Sara Corvigno, Jared K. Burks, Wei Hu, Yanping Zhong, Nicholas B. Jennings, Nicole D. Fleming, Shannon N. Westin, Bryan Fellman, Jinsong Liu, Anil K. Sood
Summary: In this study, differences between the immune microenvironment composition of germline BRCA-mutated and BRCA wild-type HGSC were substantial. Tumors with BRCA1 or BRCA2 mutations exhibited a more immunogenic microenvironment with higher levels of CD8(+) and PD-L1(+) cells compared to wild-type BRCA1 and BRCA2 tumors. High numbers of specific immune cells were associated with improved event-free survival in HGSC patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Andra S. Martinikova, Miroslav Stoyanov, Anna Oravetzova, Yannick P. Kok, Shibo Yu, Jana Dobrovolna, Pavel Janscak, Marcel van Vugt, Libor Macurek
Summary: Oncogene-induced replication stress is a major cause of genome instability in cancer cells. This study reveals that increased activity of PPM1D exacerbates replication stress caused by cyclin E1 overexpression, leading to abnormal cell cycle progression and accumulation of DNA copy number alterations. Pharmacological inhibition of PPM1D can alleviate replication stress-induced genome instability.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Alamelu G. Bharadwaj, Meghan E. McLean, Margaret L. Dahn, Hannah F. Cahill, Marie-Claire D. Wasson, Raj Pranap Arun, Olivia L. Walker, Brianne M. Cruickshank, Wasundara Fernando, Jaganathan Venkatesh, Penelope J. Barnes, Gillian Bethune, Gregory Knapp, Lucy K. Helyer, Carman A. Giacomantonio, David M. Waisman, Paola Marcato
Summary: ALDH1A3 regulates the plasminogen activation pathway to promote breast cancer metastasis. Co-expression of ALDH1A3 and tPA is associated with TNBC subtype, high tumor grade, and recurrent metastatic disease.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Nayela N. Chowdhury, Yi Yang, Ananya Dutta, Michelle Luo, Zimu Wei, Sara R. Abrahams, Alexey S. Revenko, Fenil Shah, Lindsey A. Miles, Robert J. Parmer, Bas de Laat, Alisa S. Wolberg, James P. Luyendyk, Melissa L. Fishel, Matthew J. Flick
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal metastatic disease associated with robust activation of the coagulation and fibrinolytic systems. Primary fibrinolytic protease plasminogen promotes PDAC tumor growth and metastatic potential through engaging plasminogen receptors on tumor cells.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Nuria Gendrau-Sanclemente, Agnes Figueras, Kristina Gracova, Alvaro Lahiguera, Elisenda Alsina-Sanchis, Juan A. Marin-Jimenez, August Vidal, Xavier Matias-Guiu, Sergi Fernandez-Gonzalez, Marc Barahona, Lola Marti, Jordi Ponce, Francesc Vinals
Summary: High-grade serous ovarian cancer (HGSOC), the deadliest gynecological malignancy, spreads through transcoelomic dissemination. This study reveals that platelet-derived growth factor receptor beta (PDGFRβ) is essential for the formation of tumorspheres in HGSOC. Inhibition of PDGFRβ blocks the clustering of ovarian cancer cells and prevents peritoneal dissemination.
MOLECULAR ONCOLOGY
(2024)
