标题
Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease
作者
关键词
Alzheimer’s disease, Synaptic loss, Aβ oligomers, Cognitive decline, Calcium, NMDA receptors, PSD-95, Mitochondrial dysfunction, Tau hyperphosphorylation, Aberrant neuronal network activity
出版物
Molecular Neurodegeneration
Volume 9, Issue 1, Pages 48
出版商
Springer Nature
发表日期
2014-11-14
DOI
10.1186/1750-1326-9-48
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Hsp90 Chaperone Inhibitor 17-AAG Attenuates A -Induced Synaptic Toxicity and Memory Impairment
- (2014) Y. Chen et al. JOURNAL OF NEUROSCIENCE
- Differential Effects of Synaptic and Extrasynaptic NMDA Receptors on A -Induced Nitric Oxide Production in Cerebrocortical Neurons
- (2014) E. Molokanova et al. JOURNAL OF NEUROSCIENCE
- EphA4 Activation of c-Abl Mediates Synaptic Loss and LTP Blockade Caused by Amyloid-β Oligomers
- (2014) Lina M. Vargas et al. PLoS One
- Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer’s disease
- (2014) Amy K. Y. Fu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- C2 Domains as Protein-Protein Interaction Modules in the Ciliary Transition Zone
- (2014) Kim Remans et al. Cell Reports
- Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription
- (2013) Scott D. Ryan et al. CELL
- Synaptic Protein 1-Takusan Mitigates Amyloid- -Induced Synaptic Loss via Interaction with Tau and Postsynaptic Density-95 at Postsynaptic Sites
- (2013) N. Nakanishi et al. JOURNAL OF NEUROSCIENCE
- Memantine Rescues Transient Cognitive Impairment Caused by High-Molecular-Weight A Oligomers But Not the Persistent Impairment Induced by Low-Molecular-Weight Oligomers
- (2013) C. P. Figueiredo et al. JOURNAL OF NEUROSCIENCE
- Aberrant Protein S-Nitrosylation in Neurodegenerative Diseases
- (2013) Tomohiro Nakamura et al. NEURON
- A induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss
- (2013) M. Talantova et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Human LilrB2 Is a -Amyloid Receptor and Its Murine Homolog PirB Regulates Synaptic Plasticity in an Alzheimer's Model
- (2013) T. Kim et al. SCIENCE
- Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimers Disease
- (2012) Suzanne M. de la Monte Current Alzheimer Research
- Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage
- (2012) M. Manczak et al. HUMAN MOLECULAR GENETICS
- Regulation of Mitochondrial Transport and Inter-Microtubule Spacing by Tau Phosphorylation at the Sites Hyperphosphorylated in Alzheimer's Disease
- (2012) K. Shahpasand et al. JOURNAL OF NEUROSCIENCE
- Appoptosin is a Novel Pro-Apoptotic Protein and Mediates Cell Death in Neurodegeneration
- (2012) H. Zhang et al. JOURNAL OF NEUROSCIENCE
- The Secreted Wnt Antagonist Dickkopf-1 Is Required for Amyloid -Mediated Synaptic Loss
- (2012) S. A. Purro et al. JOURNAL OF NEUROSCIENCE
- Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model
- (2012) P. E. Sanchez et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tau Accumulation Causes Mitochondrial Distribution Deficits in Neurons in a Mouse Model of Tauopathy and in Human Alzheimer's Disease Brain
- (2011) Katherine J. Kopeikina et al. AMERICAN JOURNAL OF PATHOLOGY
- Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment
- (2011) Suzanne Craft ARCHIVES OF NEUROLOGY
- Managing Cognitive Dysfunction through the Continuum of Alzheimerʼs Disease
- (2011) Julien Delrieu et al. CNS DRUGS
- Combination Therapy for Alzheimerʼs Disease
- (2011) Laxeshkumar Patel et al. DRUGS & AGING
- Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage
- (2011) Maria Manczak et al. HUMAN MOLECULAR GENETICS
- Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease
- (2011) M. J. Calkins et al. HUMAN MOLECULAR GENETICS
- Tau Protein Is Required for Amyloid -Induced Impairment of Hippocampal Long-Term Potentiation
- (2011) O. A. Shipton et al. JOURNAL OF NEUROSCIENCE
- Soluble A Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors
- (2011) S. Li et al. JOURNAL OF NEUROSCIENCE
- Amyloid- /Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease
- (2011) E. D. Roberson et al. JOURNAL OF NEUROSCIENCE
- AD synapses contain abundant Aβ monomer and multiple soluble oligomers, including a 56-kDa assembly
- (2011) Sophie Sokolow et al. NEUROBIOLOGY OF AGING
- S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by -amyloid peptide
- (2011) J. Qu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Soluble amyloid -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration
- (2011) M. Jin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models
- (2010) Lars M. Ittner et al. CELL
- Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization
- (2010) Zheng Li et al. CELL
- N-Methyl-d-aspartate receptors are required for synaptic targeting of Alzheimer’s toxic amyloid-β peptide oligomers
- (2010) Helena Decker et al. JOURNAL OF NEUROCHEMISTRY
- Memantine Preferentially Blocks Extrasynaptic over Synaptic NMDA Receptor Currents in Hippocampal Autapses
- (2010) P. Xia et al. JOURNAL OF NEUROSCIENCE
- A -Mediated NMDA Receptor Endocytosis in Alzheimer's Disease Involves Ubiquitination of the Tyrosine Phosphatase STEP61
- (2010) P. Kurup et al. JOURNAL OF NEUROSCIENCE
- A Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines
- (2010) H. Zempel et al. JOURNAL OF NEUROSCIENCE
- Transnitrosylation of XIAP Regulates Caspase-Dependent Neuronal Cell Death
- (2010) Tomohiro Nakamura et al. MOLECULAR CELL
- Reversing EphB2 depletion rescues cognitive functions in Alzheimer model
- (2010) Moustapha Cissé et al. NATURE
- Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
- (2010) Jorge J Palop et al. NATURE NEUROSCIENCE
- Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease
- (2010) Marcello D'Amelio et al. NATURE NEUROSCIENCE
- Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5
- (2010) Marianne Renner et al. NEURON
- Transsynaptic Progression of Amyloid-β-Induced Neuronal Dysfunction within the Entorhinal-Hippocampal Network
- (2010) Julie A. Harris et al. NEURON
- Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration
- (2010) Brian R. Hoover et al. NEURON
- Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model
- (2010) H. Du et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport: Fig. 1
- (2010) Keith A. Vossel et al. SCIENCE
- Inhibition of Calcineurin-mediated Endocytosis and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Prevents Amyloid β Oligomer-induced Synaptic Disruption
- (2009) Wei-Qin Zhao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- β-Amyloid Impairs AMPA Receptor Trafficking and Function by Reducing Ca2+/Calmodulin-dependent Protein Kinase II Synaptic Distribution
- (2009) Zhenglin Gu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease
- (2009) Maria Cristina Rosi et al. JOURNAL OF NEUROCHEMISTRY
- Amyloid -Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy
- (2009) R. Minkeviciene et al. JOURNAL OF NEUROSCIENCE
- Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease
- (2009) X. Wang et al. JOURNAL OF NEUROSCIENCE
- NMDA receptor-dependent signaling pathways that underlie amyloid β-protein disruption of LTP in the hippocampus
- (2009) Ghiam Yamin JOURNAL OF NEUROSCIENCE RESEARCH
- The Insulin/Akt Signaling Pathway Is Targeted by Intracellular β-Amyloid
- (2009) Han-Kyu Lee et al. MOLECULAR BIOLOGY OF THE CELL
- Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers
- (2009) Juha Laurén et al. NATURE
- Emerging roles of Wnts in the adult nervous system
- (2009) Nibaldo C. Inestrosa et al. NATURE REVIEWS NEUROSCIENCE
- Epileptic Seizures in AD Patients
- (2009) A. J. Larner NEUROMOLECULAR MEDICINE
- Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake
- (2009) Shaomin Li et al. NEURON
- Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
- (2009) J. Yao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers
- (2009) Fernanda G. De Felice et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury
- (2009) Dong-Hyung Cho et al. SCIENCE
- Caspase-3 Is Enriched in Postsynaptic Densities and Increased in Alzheimer's Disease
- (2008) Natalia Louneva et al. AMERICAN JOURNAL OF PATHOLOGY
- Co-Localization of Amyloid Beta and Tau Pathology in Alzheimer's Disease Synaptosomes
- (2008) Jeffrey A. Fein et al. AMERICAN JOURNAL OF PATHOLOGY
- Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior
- (2008) Dennis J. Selkoe BEHAVIOURAL BRAIN RESEARCH
- DKK1 Antagonizes Wnt Signaling without Promotion of LRP6 Internalization and Degradation
- (2008) Mikhail V. Semënov et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Amyloid-β Binds to the Extracellular Cysteine-rich Domain of Frizzled and Inhibits Wnt/β-Catenin Signaling
- (2008) Margaret H. Magdesian et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease
- (2008) Heng Du et al. NATURE MEDICINE
- Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
- (2008) Ganesh M Shankar et al. NATURE MEDICINE
- Mitochondrial fragmentation in neurodegeneration
- (2008) Andrew B. Knott et al. NATURE REVIEWS NEUROSCIENCE
- Co-occurrence of Alzheimer's disease β-amyloid and tau pathologies at synapses
- (2008) Reisuke H. Takahashi et al. NEUROBIOLOGY OF AGING
- Mitochondria in Neuroplasticity and Neurological Disorders
- (2008) Mark P. Mattson et al. NEURON
- Amyloid- overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
- (2008) X. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease
- (2008) P. Hemachandra Reddy et al. TRENDS IN MOLECULAR MEDICINE
- Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers
- (2007) Fernanda G. De Felice et al. NEUROBIOLOGY OF AGING
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