Cytosolic Phospholipase A2 Facilitates Oligomeric Amyloid-β Peptide Association with Microglia via Regulation of Membrane-Cytoskeleton Connectivity

Endocytic uptake of monomeric amyloid-β peptides is clathrin- and dynamin-independent and results in selective accumulation of Aβ(1–42) compared to Aβ(1–40)

(2017) Emelie Wesén et al.   Scientific Reports

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

Lithium activates brain phospholipase A2 and improves memory in rats: implications for Alzheimer’s disease

(2015) Fábio B. Mury et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

The role of cytosolic phospholipase A2α in amyloid precursor protein induction by amyloid beta1-42: implication for neurodegeneration

(2015) Chen Sagy-Bross et al.   JOURNAL OF NEUROCHEMISTRY

Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway

(2015) Dennis Y. Chuang et al.   Journal of Neuroinflammation

The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer's disease

(2015) Megan M. Varnum et al.   NEUROBIOLOGY OF AGING

Minocycline attenuates Aβ oligomers-induced pro-inflammatory phenotype in primary microglia while enhancing Aβ fibrils phagocytosis

(2015) Ismail Amr El-Shimy et al.   NEUROSCIENCE LETTERS

Microglial Aβ Receptors in Alzheimer’s Disease

(2014) Yang Yu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Cytosolic phospholipase A2  drives recycling through the clathrin-independent endocytic route

(2014) M. Capestrano et al.   JOURNAL OF CELL SCIENCE

IL-4-Induced Selective Clearance of Oligomeric  -Amyloid Peptide1-42 by Rat Primary Type 2 Microglia

(2014) E. Shimizu et al.   JOURNAL OF IMMUNOLOGY

Aspirin-Triggered Lipoxin A4 Stimulates Alternative Activation of Microglia and Reduces Alzheimer Disease–Like Pathology in Mice

(2013) Rodrigo Medeiros et al.   AMERICAN JOURNAL OF PATHOLOGY

Scara1 deficiency impairs clearance of soluble amyloid-β by mononuclear phagocytes and accelerates Alzheimer’s-like disease progression

(2013) Dan Frenkel et al.   Nature Communications

Regulation of the Golgi complex by phospholipid remodeling enzymes

(2012) Kevin D. Ha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice

(2012) Ana María Martín-Moreno et al.   Journal of Neuroinflammation

A comparative review of cell culture systems for the study of microglial biology in Alzheimer’s disease

(2012) Branden Stansley et al.   Journal of Neuroinflammation

Integrating Cytosolic Phospholipase A2 with Oxidative/Nitrosative Signaling Pathways in Neurons: A Novel Therapeutic Strategy for AD

(2012) Grace Y. Sun et al.   MOLECULAR NEUROBIOLOGY

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

A PLA1-2 punch regulates the Golgi complex

(2012) Marie E. Bechler et al.   TRENDS IN CELL BIOLOGY

cPLA2α-mediated actin rearrangements downstream of the Akt signaling is required for Cronobacter sakazakii invasion into brain endothelial cells

(2011) Dong-Xin Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of phospholipase A2 in rat brain decreases the levels of total Tau protein

(2011) Evelin L. Schaeffer et al.   JOURNAL OF NEURAL TRANSMISSION

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Mechanism mediating oligomeric Aβ clearance by naïve primary microglia

(2011) Cheng-Ning Yang et al.   NEUROBIOLOGY OF DISEASE

Inhibition of phospholipase A2 in rat brain modifies different membrane fluidity parameters in opposite ways

(2011) Evelin L. Schaeffer et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Novel role of cPLA2α in membrane and actin dynamics

(2010) Maarten Moes et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Interplay of proteins and lipids in generating membrane curvature

(2010) Todd R Graham et al.   CURRENT OPINION IN CELL BIOLOGY

The role of microglia in amyloid clearance from the AD brain

(2010) C. Y. Daniel Lee et al.   JOURNAL OF NEURAL TRANSMISSION

NAD(P)H oxidase-mediated reactive oxygen species production alters astrocyte membrane molecular order via phospholipase A2

(2009) Donghui Zhu et al.   BIOCHEMICAL JOURNAL

Regulatory role of cytosolic phospholipase A2α in NADPH oxidase activity and in inducible nitric oxide synthase induction by aggregated Aβ1-42in microglia

(2009) I. Szaingurten-Solodkin et al.   GLIA

CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar A -Stimulated Microglial Activation

(2009) E. G. Reed-Geaghan et al.   JOURNAL OF NEUROSCIENCE

Microglia Mediate the Clearance of Soluble A  through Fluid Phase Macropinocytosis

(2009) S. Mandrekar et al.   JOURNAL OF NEUROSCIENCE

Mediation, Modulation, and Consequences of Membrane-Cytoskeleton Interactions

(2008) Gary J. Doherty et al.   Annual Review of Biophysics

Amyloid-β peptide induces temporal membrane biphasic changes in astrocytes through cytosolic phospholipase A2

(2008) Jacob B. Hicks et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2in cortical neurons

(2008) Phullara B. Shelat et al.   JOURNAL OF NEUROCHEMISTRY

Dynamics of the Microglial/Amyloid Interaction Indicate a Role in Plaque Maintenance

(2008) T. Bolmont et al.   JOURNAL OF NEUROSCIENCE

Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease

(2008) Rene O Sanchez-Mejia et al.   NATURE NEUROSCIENCE