Overexpression of ALS-Associated p.M337V Human TDP-43 in Mice Worsens Disease Features Compared to Wild-type Human TDP-43 Mice
出版年份 2013 全文链接
标题
Overexpression of ALS-Associated p.M337V Human TDP-43 in Mice Worsens Disease Features Compared to Wild-type Human TDP-43 Mice
作者
关键词
Amyotrophic lateral sclerosis, Frontotemporal lobar degeneration, <em class=EmphasisTypeItalic >TARDBP</em>, Transgenic mice, Ubiquitin
出版物
MOLECULAR NEUROBIOLOGY
Volume 48, Issue 1, Pages 22-35
出版商
Springer Nature
发表日期
2013-03-09
DOI
10.1007/s12035-013-8427-5
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction
- (2012) Ashley Cannon et al. ACTA NEUROPATHOLOGICA
- Locus-specific mutation databases for neurodegenerative brain diseases
- (2012) Marc Cruts et al. HUMAN MUTATION
- TDP-43 Potentiates Alpha-synuclein Toxicity to Dopaminergic Neurons in Transgenic Mice
- (2012) Tian Tian et al. International Journal of Biological Sciences
- Requirements for Stress Granule Recruitment of Fused in Sarcoma (FUS) and TAR DNA-binding Protein of 43 kDa (TDP-43)
- (2012) Eva Bentmann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulated protein aggregation: stress granules and neurodegeneration
- (2012) Benjamin Wolozin Molecular Neurodegeneration
- The role of mutant TAR DNA-binding protein 43 in amyotrophic lateral sclerosis and frontotemporal lobar degeneration: Table 1
- (2011) Jonathan Janssens et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments
- (2011) Vivek Swarup et al. BRAIN
- Delineation of the Core Aggregation Sequences of TDP-43 C-Terminal Fragment
- (2011) Akash Saini et al. CHEMBIOCHEM
- Regulation of Autophagy by Neuropathological Protein TDP-43
- (2011) Jayarama Krishnan Bose et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A “Two-hit” Hypothesis for Inclusion Formation by Carboxyl-terminal Fragments of TDP-43 Protein Linked to RNA Depletion and Impaired Microtubule-dependent Transport
- (2011) G. Scott Pesiridis et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice
- (2011) Lionel M. Igaz et al. JOURNAL OF CLINICAL INVESTIGATION
- Progranulin and TDP-43: Mechanistic Links and Future Directions
- (2011) Samir Kumar-Singh JOURNAL OF MOLECULAR NEUROSCIENCE
- Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice
- (2011) Ya-Fei Xu et al. Molecular Neurodegeneration
- Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
- (2011) Han-Xiang Deng et al. NATURE
- RNA-binding proteins with prion-like domains in ALS and FTLD-U
- (2011) Aaron D. Gitler et al. Prion
- TDP-43 regulates its mRNA levels through a negative feedback loop
- (2010) Youhna M Ayala et al. EMBO JOURNAL
- ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import
- (2010) Dorothee Dormann et al. EMBO JOURNAL
- Identification of Neuronal RNA Targets of TDP-43-containing Ribonucleoprotein Complexes
- (2010) Chantelle F. Sephton et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U
- (2010) Kuen-Jer Tsai et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Increased caspase activation and decreased TDP-43 solubility in progranulin knockout cortical cultures
- (2010) Gernot Kleinberger et al. JOURNAL OF NEUROCHEMISTRY
- Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice
- (2010) Y.-F. Xu et al. JOURNAL OF NEUROSCIENCE
- Progressive motor weakness in transgenic mice expressing human TDP-43
- (2010) Nancy R. Stallings et al. NEUROBIOLOGY OF DISEASE
- Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue
- (2010) Liqun Liu-Yesucevitz et al. PLoS One
- Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice
- (2010) X. Shan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration
- (2010) Hans Wils et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The multiple roles of TDP-43 in pre-mRNA processing and gene expression regulation
- (2010) Emanuele Buratti et al. RNA Biology
- The ubiquitin proteasome system in neuropathology
- (2009) Norman L. Lehman ACTA NEUROPATHOLOGICA
- Synaptogenesis in the developing mouse visual cortex
- (2009) Mingshan Li et al. BRAIN RESEARCH BULLETIN
- Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43
- (2009) Takashi Nonaka et al. HUMAN MOLECULAR GENETICS
- Expression of TDP-43 C-terminal Fragmentsin VitroRecapitulates Pathological Features of TDP-43 Proteinopathies
- (2009) Lionel M. Igaz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity
- (2009) Brian S. Johnson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Amyotrophic lateral sclerosis, frontotemporal dementia and beyond: the TDP-43 diseases
- (2009) Felix Geser et al. JOURNAL OF NEUROLOGY
- Sporadic amyotrophic lateral sclerosis: Widespread multisystem degeneration with TDP-43 pathology in a patient after long-term survival on a respirator
- (2009) Yasushi Nishihira et al. NEUROPATHOLOGY
- Degradation of TDP-43 and its pathogenic form by autophagy and the ubiquitin-proteasome system
- (2009) Xiaoju Wang et al. NEUROSCIENCE LETTERS
- TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration
- (2009) I. Wegorzewska et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity
- (2009) Y.-J. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Enrichment of C-Terminal Fragments in TAR DNA-Binding Protein-43 Cytoplasmic Inclusions in Brain but not in Spinal Cord of Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
- (2008) Lionel M. Igaz et al. AMERICAN JOURNAL OF PATHOLOGY
- Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
- (2008) Masato Hasegawa et al. ANNALS OF NEUROLOGY
- TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
- (2008) J. Sreedharan et al. SCIENCE
- Novel Mutations in TARDBP (TDP-43) in Patients with Familial Amyotrophic Lateral Sclerosis
- (2008) Nicola J. Rutherford et al. PLoS Genetics
- Intraneuronal amyloid β and reduced brain volume in a novel APP T714I mouse model for Alzheimer's disease
- (2006) Bianca Van Broeck et al. NEUROBIOLOGY OF AGING
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