IGF-1 Intranasal Administration Rescues Huntington's Disease Phenotypes in YAC128 Mice

Mitochondrial-Associated Metabolic Changes and Neurodegeneration in Huntingtons Disease - from Clinical Features to the Bench

(2012) Tatiana R. Rosenstock et al.   CURRENT DRUG TARGETS

Bioenergetic dysfunction in Huntington's disease human cybrids

(2011) I. Luisa Ferreira et al.   EXPERIMENTAL NEUROLOGY

IGF-1 protects against diabetic features in an in vivo model of Huntington's disease

(2011) A.I. Duarte et al.   EXPERIMENTAL NEUROLOGY

IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease

(2011) Marianna Sadagurski et al.   JOURNAL OF CLINICAL INVESTIGATION

Intranasal administration of insulin-like growth factor-1 protects against lipopolysaccharide-induced injury in the developing rat brain

(2011) Z. Cai et al.   NEUROSCIENCE

Diabetes mellitus in Huntington disease

(2010) Lindsay A. Farrer   CLINICAL GENETICS

Mitochondrial-dependent apoptosis in Huntington's disease human cybrids

(2010) Ildete L. Ferreira et al.   EXPERIMENTAL NEUROLOGY

Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression

(2010) M. A. Pouladi et al.   HUMAN MOLECULAR GENETICS

Phosphorylation of Huntingtin at Ser421 in YAC128 Neurons Is Associated with Protection of YAC128 Neurons from NMDA-Mediated Excitotoxicity and Is Modulated by PP1 and PP2A

(2010) M. Metzler et al.   JOURNAL OF NEUROSCIENCE

High insulinlike growth factor I is associated with cognitive decline in Huntington disease

(2010) N. Saleh et al.   NEUROLOGY

Insulin-stimulated translocation of GLUT4 to the plasma membrane in rat hippocampus is PI3-kinase dependent

(2009) C.A. Grillo et al.   BRAIN RESEARCH

Low levels of insulin-like growth-factor-binding protein-1 (IGFBP-1) are prospectively associated with the incidence of type 2 diabetes and impaired glucose tolerance (IGT): The Söderåkra Cardiovascular Risk Factor Study

(2009) U. Petersson et al.   DIABETES & METABOLISM

Huntington’s Disease Does Not Appear to Increase the Risk of Diabetes Mellitus

(2009) T. W. Boesgaard et al.   JOURNAL OF NEUROENDOCRINOLOGY

The gene coding for PGC-1α modifies age at onset in Huntington's Disease

(2009) Patrick Weydt et al.   Molecular Neurodegeneration

Abnormalities of IGF-I signaling in the pathogenesis of diseases of the bone, brain, and fetoplacental unit in humans

(2008) Luigi Laviola et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glucose Homeostasis in Huntington Disease

(2008) Nebojša M. Lalić et al.   ARCHIVES OF NEUROLOGY

Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease

(2008) Leah R Hanson et al.   BMC NEUROSCIENCE

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

(2008) Emilie Colin et al.   EMBO JOURNAL

Mechanisms of neurodegeneration in Huntington’s disease

(2008) Joana M. Gil et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The metabolic profile of early Huntington's disease- a combined human and transgenic mouse study

(2008) Anna O.G. Goodman et al.   EXPERIMENTAL NEUROLOGY

Increased glucose metabolism and ATP level in brain tissue of Huntington’s disease transgenic mice

(2008) Judit Oláh et al.   FEBS Journal

Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons

(2008) Diana Zala et al.   HUMAN MOLECULAR GENETICS

N-Terminal Mutant Huntingtin Associates with Mitochondria and Impairs Mitochondrial Trafficking

(2008) A. L. Orr et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments

(2008) Simon C. Warby et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease

(2008) Hua Zhang et al.   NEUROBIOLOGY OF DISEASE

Mutant huntingtin and mitochondrial dysfunction

(2008) Ella Bossy-Wetzel et al.   TRENDS IN NEUROSCIENCES