Article
Medicine, Research & Experimental
Jishang Huang, Zhixi Chen, Zhenyu Wu, Xunlu Xie, Shiwei Liu, Weihao Kong, Jianguo Zhou
Summary: The study found that geniposide can stimulate autophagy and protect against the development of osteoarthritis by activating the GLP-1R/AMPK/mTOR signaling pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Environmental Sciences
Chaiqin Lei, Jianzhao Liao, Quanwei Li, Jian Shi, Hui Zhang, Jianying Guo, Qingyue Han, Lianmei Hu, Ying Li, Jiaqiang Pan, Zhaoxin Tang
Summary: The accumulation of copper in the hypothalamus can cause mitochondrial dysfunction, induce mitochondria-mediated apoptosis, and activate the AMPK-mTOR pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Medicine, Research & Experimental
Letycia dos Santos Neves, Renata Kelly Gomes Oliveira, Lucimeire Santana dos Santos, Ingrid Oliveira Ribeiro, Jairza Maria Barreto Barreto-Medeiros, Rhowena Jane Barbosa Matos
Summary: This systematic review discusses the relationship between AMPK and hypothalamic neuropeptides in controlling eating behavior. The study found that a decrease in AMPK activity is associated with a decrease in food intake, and glucose, thyroid hormones, estradiol, leptin, and ghrelin can modulate AMPK activity.
Article
Biochemistry & Molecular Biology
Patricia Seoane-Collazo, Amparo Romero-Pico, Eva Rial-Pensado, Laura Linares-Pose, Anxela Estevez-Salguero, Johan Ferno, Ruben Nogueiras, Carlos Dieguez, Miguel Lopez
Summary: Nicotine exerts a marked negative energy balance through regulation of brown adipose tissue and white adipose tissue, mainly controlled at the central level by modulation of hypothalamic neuropeptide systems and AMPK. The study reveals that the kappa opioid receptor signaling plays a crucial role in mediating the effects of nicotine on body weight loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Daewon Han, Deokryong Kim, Haeil Kim, Jeonga Lee, Jungmook Lyu, Jong-Seok Kim, Jongdae Shin, Jeong Sig Kim, Do Kyung Kim, Hwan-Woo Park
Summary: In this study, it was found that Methylsulfonylmethane (MSM) can enhance the autophagy flux through the AMPK/mTOR/ULK1 pathway, improving hepatic steatosis and potentially serving as a treatment for obesity-related MAFLD.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Eva Rial-Pensado, Oscar Freire-Agulleiro, Marcos Rios, Deng Fu Guo, Cristina Contreras, Patricia Seoane-Collazo, Sulay Tovar, Ruben Nogueiras, Carlos Dieguez, Kamal Rahmouni, Miguel Lopez
Summary: This study investigates the role of bone morphogenetic protein 8B (BMP8B) in energy homeostasis and the molecular mechanisms underlying it, particularly in the context of obesity. The researchers found that obesity induced resistance to the central actions of BMP8B on energy balance, which was attributed to the lack of effects on AMP-activated protein kinase (AMPK) signaling, decreased BMP receptors signaling, and reduced expression of Bardet-Biedl Syndrome 1 (BBS1) protein in the hypothalamus. The involvement of BBS1 in this process was demonstrated through the lack of response to BMP8B in mice with a single disease-causing mutation in the Bbs1 gene.
MOLECULAR METABOLISM
(2022)
Review
Pharmacology & Pharmacy
Hiroaki Ueno, Weidong Zhang, Masamitsu Nakazato
Summary: Obesity and obesity-related diseases are global pandemics. Peptide chemistry and molecular biology have identified peptides that regulate appetite and energy metabolism. Peptide-related drugs have powerful anti-obesity effects with fewer adverse effects. Liraglutide and other candidates have been developed as anti-obesity drugs, and hybrid peptides have been designed to enhance appetite suppression.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Neurosciences
Yong Li, Yujie Cheng, Yuan Zhou, Hongmei Du, Cui Zhang, Zhentao Zhao, Yuenan Chen, Zhongnan Zhou, Jinyu Mei, Wenning Wu, Ming Chen
Summary: The study revealed that high-fat diet induced metabolic disorders, depression, and anxiety-like behaviors in mice. The high-fat diet inhibited AMPK phosphorylation and promoted mTOR phosphorylation, with rapamycin treatment showing improvement in these effects.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pengjiao Xi, Wenjuan Zhu, Yan Zhang, Meng Wang, Huimin Liang, Haomin Wang, Derun Tian
Summary: The study reveals the significant role of hypothalamic TRPV4 in obesity. Overexpressed hypothalamic TRPV4 leads to weight gain, fat accumulation, and hepatic steatosis, while reducing central inflammation induced by high-fat diet. This suggests that hypothalamic TRPV4 could serve as a potential target for therapeutic intervention against obesity.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Endocrinology & Metabolism
Ilaria Coppola, Bas Brouwers, Leanne Walker, Ceyhun Alar, Sandra Meulemans, Anne White, Bruno Ramos-Molina, John W. M. Creemers
Summary: This study investigates the role of FURIN in hypothalamic neurons controlling glucose and feeding. The researchers found that FURIN plays an important role in the cleavage of POMC and is involved in the regulation of feeding behavior and glucose homeostasis. The deletion of FURIN in mice resulted in hyperphagia, increased body weight, and altered POMC processing. These findings challenge the previous understanding of POMC cleavage and have implications for understanding the mechanisms of glucose and feeding regulation.
MOLECULAR METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Aristea Psilopanagioti, Sofia Nikou, Souzana Logotheti, Marina Arbi, Dionysios V. Chartoumpekis, Helen Papadaki
Summary: The study focuses on the expression of GLP-1R in the human hypothalamus and its relationship with BMI. The results suggest that GLP-1R may play a role in regulating energy balance in the human hypothalamus, particularly in the LH region, which is associated with appetite and reward. The study also indicates a potential interaction between GLP-1R and nucleobindin-2/nesfatin-1 in signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Peerachat Veeraphan, Warinthorn Chavasiri, Chatchai Muanprasat, Varanuj Chatsudthipong, Chaowalit Yuajit
Summary: The study showed that a chalcone derivative, CHAL-005, inhibited the growth of MDCK cysts in a dose-dependent manner without cytotoxicity. CHAL-005 also affected various signaling pathways, including CFTR expression, ERK1/2 and mTOR/S6K phosphorylation levels, and activated AMPK expression. These findings indicate that CHAL-005 could be a promising drug candidate for polycystic kidney disease intervention.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2021)
Article
Cell Biology
Anthony Estienne, Alice Bongrani, Christelle Rame, Patrycja Kurowska, Klaudia Blaszczyk, Agnieszka Rak, Pierre-Henri Ducluzeau, Pascal Froment, Joelle Dupont
Summary: Energy metabolism in females can influence reproductive function by modulating the Hypothalamic Pituitary Ovarian axis. Hormones, neuropeptides, and metabolites play important roles as signals between energy balance and reproduction. The enzymes mTOR, AMPK, and SIRT1 are key players in normal female fertility and may be involved in reproductive disorders associated with metabolic complications like PCOS and POF.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Eun Roh, Kyung Mook Choi
Summary: The brain monitors and integrates metabolic signals, including gut hormones, to regulate energy homeostasis. Gut-brain communication is also facilitated by the vagus nerve. Advances in our understanding of this communication have potential for the development of effective anti-obesity medications. This review comprehensively explores the central regulation of energy balance and the application of gut hormones in anti-obesity drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Gamal A. Salem, Amany Abdel-Rahman Mohamed, Safaa I. Khater, Ahmed E. Noreldin, Manal Alosaimi, Wafa S. Alansari, Ghalia Shamlan, Areej A. Eskandrani, Marwa Mahmoud Awad, Rehab Ahmed Ahmed El-Shaer, Mohamed A. Nassan, Mahmoud Mostafa, Tarek Khamis
Summary: This research explores the potential of nano-liposomal formulated Lycopene (LipLyco) in preventing the development of obesity and insulin resistance, both of which contribute to Non-alcoholic fatty liver (NAFL). The study demonstrates that Lip-Lyco exhibits various beneficial effects such as antioxidant, anti-inflammatory, hypoglycemic, antiapoptotic, autophagyinducing, and Hedgehog signaling inhibitory effects, making it a promising therapeutic agent for NAFL disease.
Article
Biochemistry & Molecular Biology
Ana Perez-Garcia, Pilar Dongil, Veronica Hurtado-Carneiro, Enrique Blazquez, Carmen Sanz, Elvira Alvarez
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2018)
Article
Multidisciplinary Sciences
P. Dongil, A. Perez-Garcia, V. Hurtado-Carneiro, C. Herrero-de-Dios, E. Blazquez, E. Alvarez, C. Sanz
SCIENTIFIC REPORTS
(2018)
Article
Anatomy & Morphology
Elena Gine, Carmen Martinez, Carmen Sanz, Cristina Nombela, Fernando de Castro
FRONTIERS IN NEUROANATOMY
(2019)
Article
Cell Biology
Pilar Dongil, Ana Perez-Garcia, Veronica Hurtado-Carneiro, Carmen Herrero-de-Dios, Elvira Alvarez, Carmen Sanz
Review
Endocrinology & Metabolism
Veronica Hurtado-Carneiro, Ana Perez-Garcia, Elvira Alvarez, Carmen Sanz
FRONTIERS IN ENDOCRINOLOGY
(2020)
Article
Nutrition & Dietetics
Ana Perez-Garcia, Veronica Hurtado-Carneiro, Carmen Herrero-De-Dios, Pilar Dongil, Jose Enrique Garcia-Maurino, Maria Dolores Sanchez, Carmen Sanz, Elvira Alvarez
Summary: GLP-1 and PASK play a crucial role in regulating glucose and energy homeostasis, affecting hepatic glycogen metabolism. The study using a murine model revealed that PASK mediates the effect of exendin-4 on hepatic glycogen metabolism in response to different nutritional states. Results showed that both exendin-4 and fasting can influence Pask expression, leading to abnormal glycogen accumulation in the liver.
Review
Biochemistry & Molecular Biology
Veronica Hurtado-Carneiro, Pilar Dongil, Ana Perez-Garcia, Elvira alvarez, Carmen Sanz
Summary: The liver's high metabolic activity generates reactive oxygen species through oxidative phosphorylation, but it also has potent antioxidant mechanisms. PASK regulates critical liver protein expression during fasting/feeding changes, preventing high-fat diet-induced obesity and diabetes development.