Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention

Peripheral Blood CD38 Bright CD8+ Effector Memory T Cells Predict Acute Graft-versus-Host Disease

(2015) Pooja Khandelwal et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRβ repertoire

(2015) Yvonne Suessmuth et al.   BLOOD

Plasma biomarkers of acute GVHD and nonrelapse mortality: predictive value of measurements before GVHD onset and treatment

(2015) G. B. McDonald et al.   BLOOD

The Allo- and Viral-Specific Immunosuppressive Effect of Belatacept, but Not Tacrolimus, Attenuates With Progressive T Cell Maturation

(2014) H. Xu et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The addition of sirolimus to tacrolimus/methotrexate GVHD prophylaxis in children with ALL: a phase 3 Children’s Oncology Group/Pediatric Blood and Marrow Transplant Consortium trial

(2014) Michael A. Pulsipher et al.   BLOOD

CD8-predominant T-cell CNS infiltration accompanies GVHD in primates and is improved with immunoprophylaxis

(2014) S. Kaliyaperumal et al.   BLOOD

Fecal Level of Calprotectin Identifies Histologic Inflammation in Patients With Ulcerative Colitis in Clinical and Endoscopic Remission

(2014) Jordi Guardiola et al.   Clinical Gastroenterology and Hepatology

Does fecal calprotectin predict short-term relapse after stopping TNFα-blocking agents in inflammatory bowel disease patients in deep remission?

(2014) Pauliina Molander et al.   Journal of Crohns & Colitis

Microbial exposure alters HIV-1-induced mucosal CD4+ T cell death pathways Ex vivo

(2014) Amanda K Steele et al.   Retrovirology

In Vivo T Cell Costimulation Blockade with Abatacept for Acute Graft-versus-Host Disease Prevention: A First-in-Disease Trial

(2013) Divya T. Koura et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Inhibiting retinoic acid signaling ameliorates graft-versus-host disease by modifying T-cell differentiation and intestinal migration

(2013) K. Aoyama et al.   BLOOD

Allogeneic T cell responses are regulated by a specific miRNA-mRNA network

(2013) Yaping Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Blockade of individual Notch ligands and receptors controls graft-versus-host disease

(2013) Ivy T. Tran et al.   JOURNAL OF CLINICAL INVESTIGATION

Phase II Study of Alisertib, a Selective Aurora A Kinase Inhibitor, in Relapsed and Refractory Aggressive B- and T-Cell Non-Hodgkin Lymphomas

(2013) Jonathan W. Friedberg et al.   JOURNAL OF CLINICAL ONCOLOGY

Serum calprotectin as a biomarker for Crohn's disease

(2013) M.-A. Meuwis et al.   Journal of Crohns & Colitis

The Nlrp3 inflammasome regulates acute graft-versus-host disease

(2013) Dragana Jankovic et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential expression of aurora-A kinase in T-cell lymphomas

(2013) Rashmi Kanagal-Shamanna et al.   MODERN PATHOLOGY

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ST2 as a Marker for Risk of Therapy-Resistant Graft-versus-Host Disease and Death

(2013) Mark T. Vander Lugt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of hedgehog signaling for the treatment of murine sclerodermatous chronic graft-versus-host disease

(2012) P. Zerr et al.   BLOOD

Discovery and validation of graft-versus-host disease biomarkers

(2012) S. Paczesny   BLOOD

Blockade of Lymphocyte Chemotaxis in Visceral Graft-versus-Host Disease

(2012) Ran Reshef et al.   NEW ENGLAND JOURNAL OF MEDICINE

PANTHER in 2013: modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees

(2012) Huaiyu Mi et al.   NUCLEIC ACIDS RESEARCH

Hedgehog Pathway Inhibitors - Current Status and Future Prospects

(2012) Asfandyar Sheikh et al.   Infectious Agents and Cancer

Nonhuman Primate Transplant Models Finally Evolve: Detailed Immunogenetic Analysis Creates New Models and Strengthens the Old

(2011) L. S. Kean et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Evaluation of a Droplet Digital Polymerase Chain Reaction Format for DNA Copy Number Quantification

(2011) Leonardo B. Pinheiro et al.   ANALYTICAL CHEMISTRY

Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease

(2011) J. L. M. Ferrara et al.   BLOOD

Characterization of Alisertib (MLN8237), an Investigational Small-Molecule Inhibitor of Aurora A Kinase Using Novel In Vivo Pharmacodynamic Assays

(2011) M. G. Manfredi et al.   CLINICAL CANCER RESEARCH

Tight Regulation of Memory CD8+ T Cells Limits Their Effectiveness during Sustained High Viral Load

(2011) Erin E. West et al.   IMMUNITY

Immunogenetic Management Software: a new tool for visualization and analysis of complex immunogenetic datasets

(2011) Z. P. Johnson et al.   IMMUNOGENETICS

Increased interleukin-10 production by ASC-deficient CD4+ T cells impairs bystander T-cell proliferation

(2011) Sharmal Narayan et al.   IMMUNOLOGY

Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells

(2011) Jonathan Sprent et al.   NATURE IMMUNOLOGY

Systems biology of vaccination for seasonal influenza in humans

(2011) Helder I Nakaya et al.   NATURE IMMUNOLOGY

Low levels of SIV infection in sooty mangabey central memory CD4+ T cells are associated with limited CCR5 expression

(2011) Mirko Paiardini et al.   NATURE MEDICINE

A Phase III Study of Belatacept-based Immunosuppression Regimens versus Cyclosporine in Renal Transplant Recipients (BENEFIT Study)

(2010) F. Vincenti et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Experience with a Novel Efalizumab-Based Immunosuppressive Regimen to Facilitate Single Donor Islet Cell Transplantation

(2010) N. A. Turgeon et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Blockade of interleukin-23 signaling results in targeted protection of the colon and allows for separation of graft-versus-host and graft-versus-leukemia responses

(2010) R. Das et al.   BLOOD

GVHD after haploidentical transplantation: a novel, MHC-defined rhesus macaque model identifies CD28- CD8+ T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression

(2010) W. P. Miller et al.   BLOOD

Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease

(2010) Y. Zhang et al.   BLOOD

DeathBase: a database on structure, evolution and function of proteins involved in apoptosis and other forms of cell death

(2010) J Díez et al.   CELL DEATH AND DIFFERENTIATION

Independent filtering increases detection power for high-throughput experiments

(2010) R. Bourgon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elafin Is a Biomarker of Graft-Versus-Host Disease of the Skin

(2010) S. Paczesny et al.   Science Translational Medicine

Large scale analysis of positional effects of single-base mismatches on microarray gene expression data

(2010) Fenghai Duan et al.   BioData Mining

Homeostatic proliferation and survival of naïve and memory T cells

(2009) Onur Boyman et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4+ T Cells

(2009) Gang Wei et al.   IMMUNITY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Sirolimus, Tacrolimus, and Low-Dose Methotrexate as Graft-versus-Host Disease Prophylaxis in Related and Unrelated Donor Reduced-Intensity Conditioning Allogeneic Peripheral Blood Stem Cell Transplantation

(2008) Edwin P. Alyea et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

A biomarker panel for acute graft-versus-host disease

(2008) S. Paczesny et al.   BLOOD

What is principal component analysis?

(2008) Markus Ringnér   NATURE BIOTECHNOLOGY

Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

(2008) Troy D Querec et al.   NATURE IMMUNOLOGY

HLA-Mismatched Renal Transplantation without Maintenance Immunosuppression

(2008) Tatsuo Kawai et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reactome knowledgebase of human biological pathways and processes

(2008) L. Matthews et al.   NUCLEIC ACIDS RESEARCH