Article
Medicine, Research & Experimental
Lucila Cere, Maria G. Sedlmeier, Mariana Semeniuk, Marcelo G. Luquita, Daniel Frances, Maria T. Ronco, Juan Pablo Rigalli, Maria L. Ruiz, Viviana A. Catania
Summary: This study investigates the modulation of hepatic P-gp by PRL in hyperprolactinemic states, demonstrating increased expression and activity of P-gp in lactating post-partum rats and ovariectomized rats treated with PRL. The research also shows a transcriptional up-regulation of P-gp by PRL in primary hepatocyte cultures, suggesting a potential impact on the pharmacokinetics of xenobiotics substrates of P-gp in hyperprolactinemic situations.
Article
Geriatrics & Gerontology
Shuyuan Yang, Ying Wan, Na Wu, Lu Song, Zhihua Liu, Jiahao Zhao, Ying Liu, Zhenguo Liu, Jing Gan
Summary: The study shows that L-dopa can restore circadian rhythm disturbances in PD rats by regulating the D1R-ERK1/2-mTOR pathway, improving irregular fluctuations in blood pressure and temperature.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Public, Environmental & Occupational Health
Lale Susan Karakis, Huseyin Kiyak, Berfin Okmen, Cagdas Ozdemir, Engin Turkgeldi
Summary: This study aimed to investigate the impact of subclinical hypothyroidism on fertility. The results showed that in women with unexplained infertility, serum TSH levels between 2.5 and 4.5 mIU/L were not associated with lower pregnancy rates compared to TSH levels between 0.3 and 2.5 mIU/L.
Article
Biotechnology & Applied Microbiology
Atefeh Nadalizadeh Ghannad, Hassan Marashi, Alireza Seifi, Fereshte Moshiri
Summary: This study aimed to investigate the callus induction and shoot regeneration using stem and leaf explants of the Ohadi and UCB-1 pistachio cultivars for rootstock production. Different plant growth regulators and media were tested for callus induction and regeneration. Results showed that stems had a higher callus induction and shoot regeneration rate compared to leaves, and the Ohadi cultivar had a higher efficiency in callus induction and shoot generation compared to UCB-1. These findings may be useful for future pistachio genetic transformation.
PLANT BIOTECHNOLOGY REPORTS
(2022)
Article
Otorhinolaryngology
Priscila Feliciano de Oliveira, Beatriz Barros Santos Trindade, Paloma Fonseca Martins Reis, Tamara Figueiredo do Carmo Santos, Julio Cesar Santana Alves, Demetrius Silva de Santana, Daniel Badaue-Passos
Summary: Perinatal hypothyroidism has a negative impact on the auditory function of adult offspring in rats, resulting in irreversible damage to cochlear function.
INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY
(2022)
Article
Chemistry, Medicinal
Ali Pourmotabbed, Razieh Naghizadeh, Farshad Moradpour, Mozhgan Veisi, Seyed Ershad Nedaei, Fatemeh Zarei, Zahra Salimi
Summary: The study investigates the effects of kindling during pregnancy on long-term potentiation (LTP) induction and the role of M1 muscarinic acetylcholine receptors in the hippocampus of male offspring. It found that recurrent seizures during pregnancy impair fEPSP-LTP induction and abnormal development of the M1 muscarinic receptor in the hippocampus.
RESEARCH IN PHARMACEUTICAL SCIENCES
(2023)
Article
Veterinary Sciences
Zahraa Q. Alhahawachee, Ghada A. Taqa, Luma I. Al-Allaf
Summary: This study aimed to explore the ameliorating effect of Ashwagandha Roots extract in male rats with early postnatal hypothyroidism. The results showed that oral administration of Ashwagandha Roots extract had a better effect on hypothyroidism and related brain maturation damage compared to levothyroxine.
EGYPTIAN JOURNAL OF VETERINARY SCIENCE
(2023)
Article
Chemistry, Medicinal
Mhatre Bhakti, Marar Thankamani
Summary: Mitochondrial dysfunction induced by MTX can be mitigated by Noni fruit extract. Noni extract shows significant protective effect on liver injury induced by MTX, suggesting it may be a safer combination in cancer therapy. Nutraceutical supplements like antioxidants in Noni can alleviate liver toxicity effectively and safely.
INTERNATIONAL JOURNAL OF LIFE SCIENCE AND PHARMA RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Alaa Fahmawi, Mohammad S. Khalifeh, Karem H. Alzoubi, Abeer M. Rababa'h
Summary: Sleep deprivation, both acute and chronic, has significant effects on immune factors, with changes observed in IL-1 beta, IL-9, and TNF-alpha levels.
CURRENT MOLECULAR PHARMACOLOGY
(2023)
Article
Plant Sciences
Ahmad S. Alkofahi, Karem H. Alzoubi, Majed M. Masadeh, Zaina Abu Rashed
Summary: The aim of this study was to assess the efficacy of various fractions from selected plant extracts in inhibiting the growth of H. pylori strains. Ethanol extracts showed the highest ability to inhibit H. pylori growth. The chloroform fraction from A. inculata, I. viscose, and ethanol extracts from M. vulgare and T. stans showed the highest activity against H. pylori strains.
PAKISTAN JOURNAL OF BOTANY
(2023)
Article
Plant Sciences
Omar F. Khabour, Karem H. Alzoubi, Salwa F. M. Hassanein, Hanin Makhlouf, Farah Alhashimi
Summary: The protective effect of essential oils from Ocimum basilicum, Galium odoratum, and Cymbopogon citratus against oxidative DNA damage in cultured human lymphocytes was investigated in this study. Results showed that G. odoratum oil significantly decreased the biomarker 8-hydroxy deoxyguanosine (8-OHdG) in cultured cells at all examined concentrations, with decreases ranging between 31-39% (p<0.01). C. citratus oil also significantly decreased 8-OHdG at concentrations of 1 and 2 uL/mL, with decreases of 34% and 44% respectively (p<0.05). Similarly, O. basilicum significantly decreased 8-OHdG at concentrations of 1 and 2 uL/mL (p<0.005), with decreases of about 62% at both concentrations. In conclusion, the examined essential oils demonstrated potent antioxidative DNA damage activity in cultured human lymphocytes.
PAKISTAN JOURNAL OF BOTANY
(2023)
Article
Neurosciences
Suzie Y. Rababa'h, Karem H. Alzoubi, Hana Hammad, Laiali Alquraan, Abeer M. Rababa'h
Summary: This study aimed to examine the protective effect of L-Carnitine (L-CAR) on STS-induced changes in serum corticosterone levels, MMP-2, -9, and -12 protein and mRNA expression. The results showed that L-CAR could restore the alterations in corticosterone and MMP-2 and -9 levels induced by STS.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Review
Biochemistry & Molecular Biology
Munazza Ahmed, Ahlam M. Semreen, Waseem El-Huneidi, Yasser Bustanji, Eman Abu-Gharbieh, Mohammad A. Y. Alqudah, Ahmed Alhusban, Mohd Shara, Ahmad Y. Abuhelwa, Nelson C. Soares, Mohammad H. Semreen, Karem H. Alzoubi
Summary: Glioblastoma (GB) is a type of aggressive brain tumor with unclear biology and challenges in diagnosis and prognosis due to its heterogeneity. Omics techniques, including proteomics and metabolomics, have shown promise in understanding the regulatory network of enzymes and metabolites in GB. This review highlights the significant contributions of these tools in GB research and treatment, emphasizing the impact of integrative omics approaches in overcoming therapeutic challenges.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Yousra A. A. Hagyousif, Basma M. M. Sharaf, Ruba A. A. Zenati, Waseem El-Huneidi, Yasser Bustanji, Eman Abu-Gharbieh, Mohammad A. Y. Alqudah, Alexander D. D. Giddey, Ahmad Y. Y. Abuhelwa, Karem H. H. Alzoubi, Nelson C. C. Soares, Mohammad H. H. Semreen
Summary: Skin cancer is the most common type of cancer among the white skin population, and metabolomics technology can be used to evaluate the metabolic profile of human skin cancer, which can be applied in diagnosis and treatment. Different analytical platforms, including GC-MS, LC-MS, and NMR, can be used in metabolomics analysis of skin cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Kamal M. Al-Shami, Wesam S. Ahmed, Karem H. Alzoubi
Summary: This study aims to assess the public's opinions in Jordan toward providing blanket consent for using biospecimens and health records in research. The results showed that although the majority of the public were aware of clinical research, only a small percentage had participated in this type of research. While about half of the participants agreed on blanket consent for the use of clinical samples, a lower percentage agreed on open access to their health records. Privacy concerns and lack of trust in the researcher were cited as major barriers to providing blanket consent.
PATIENT PREFERENCE AND ADHERENCE
(2023)
Article
Medicine, General & Internal
Sawsan Abuhammad, Omar F. Khabour, Karem H. Alzoubi, Shaher Hamaideh, Basheer Y. Khassawneh, Amat Al-Khaleq O. Mehrass, Baha F. Alsmadi, Abdelrahman M. Ababneh
Summary: This study aims to determine the health-related quality of life (HRQoL) of recovered COVID-19 patients and investigates the impact of variables such as infection period, sample demographics, hospitalization history, and chronic disease history on their HRQoL. The results showed that the physical well-being of the participants during COVID-19 was medium, while the psychological well-being was also medium. Multiple regression analysis revealed that female recovered patients who are not working, have a low income, and are married, as well as those who experienced multiple COVID-19 infections, have lower HRQoL compared to other recovered patients. The findings suggest the need for policymakers and healthcare workers to explore effective strategies to improve the HRQoL of COVID-19 patients, especially for elderly patients and those with a history of multiple infections and hospitalizations.
PATIENT PREFERENCE AND ADHERENCE
(2023)
Article
Medicine, General & Internal
Anan S. Jarab, Walid A. Al-Qerem, Hanan Walid Hamam, Karem H. Alzoubi, Shrouq R. Abu Heshmeh, Tareq L. Mukattash, Eman Alefishat
Summary: This study found that 23.5% of patients with heart failure had poor medication adherence. Patients with higher education and no medication-related side effects were more likely to have moderate adherence, while those taking statins or ACEIs/ARBs were more likely to have high adherence. Implementing intervention programs to improve patients' perception of prescribed medications, particularly for those with low educational levels, receiving anticoagulants, and not receiving statins or ACEIs/ARBs, is important.
PATIENT PREFERENCE AND ADHERENCE
(2023)
Article
Medicine, General & Internal
Anan S. Jarab, Walid Al-Qerem, Salam Alqudah, Shrouq R. Abu Heshmeh, Tareq L. Mukattash, Karem H. Alzoubi
Summary: This retrospective study examined the medical records of hypertensive patients with type 2 diabetes to identify factors associated with poor blood pressure control. Binary regression analysis revealed that retinopathy and not receiving DPP4 inhibitors were independently associated with uncontrolled blood pressure. The findings suggest a need for greater efforts to improve blood pressure control, particularly in hypertensive patients with retinopathy.
ELECTRONIC JOURNAL OF GENERAL MEDICINE
(2023)
Article
Medicine, General & Internal
Sawsan Abuhammad, Omar F. Khabour, Karem H. Alzoubi, Shaher Hamaideh, Basheer Y. Khassawneh, Baha F. Alsmadi, Abdelrahman M. Ababneh, Safa Alqudah
Summary: This study investigated the relationship between COVID-19 infection and long-term mental consequences among recovering patients. The findings show that individuals who have recovered from COVID-19 are susceptible to mental illnesses such as anxiety and depression. Factors such as employment status, tobacco use, and severity of infection are associated with this susceptibility.
ELECTRONIC JOURNAL OF GENERAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Rawan H. Alsharedeh, Nid'a H. Alshraiedeh, Majed M. Masadeh, Karem H. Alzoubi, Mohamed G. Al-Fandi, Rawan H. Hayajneh, Farah H. Atawneh, Zaina A. Shubair
Summary: Presence of pathogens on cellphones and accessories is a significant public health risk. This study investigated the biofilm-forming capability of S. aureus and E. coli on different cell phone pieces and tested the effectiveness of common sanitizers. Results showed that S. aureus and E. coli can form biofilms on all cellphone covers. Sanitizers containing sodium hypochlorite 5.25% and ethanol/dodecyl dimethyl ammonium chloride 38.9% were most effective in reducing viable cells in biofilms compared to other sanitizers. In conclusion, cellphone covers are suitable surfaces for biofilm formation, and certain sanitizers show higher efficacy against these biofilms.
Article
Multidisciplinary Sciences
Anan S. Jarab, Walid Al-Qerem, Karem H. Alzoubi, Shrouq Abu Heshmeh, Tareq L. Mukattash, Abdallah Y. Naser, Yazid N. Al Hamarneh
Summary: This study evaluated the health-related quality of life (HRQOL) among COPD patients and explored the factors associated with poor HRQOL. The study found that an increased number of prescribed medications, older age, male gender, low education level, and low average income were associated with poorer HRQOL. On the other hand, being married, living in a rural area, non-use of steroids inhalers, not receiving long acting muscarinic antagonists (LAMA) and LABA, and medication adherence were associated with improved HRQOL. Furthermore, lower disease severity and absence of comorbidities were associated with better HRQOL.
Article
Pharmacology & Pharmacy
Anan S. Jarab, Walid Al-Qerem, Karem H. Alzoubi, Haneen Obeidat, Shrouq Abu Heshmeh, Tareq L. Mukattash, Yara A. Naser, Ahmad Al-Azayzih
Summary: This study assessed the willingness and attitudes of community pharmacists in Jordan towards the adoption of AI technology in pharmacy settings, as well as the barriers to AI implementation. The results showed that despite positive attitudes and willingness towards AI, there were several barriers, including lack of AI-related software and hardware, the need for human supervision, and high operating costs. Therefore, providing education and training programs to improve pharmacists' knowledge of AI, as well as ensuring adequate funding support, are important.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Multidisciplinary Sciences
Nour A. Elsahoryi, Mohanad M. Odeh, Seham Abu Jadayil, Andrea M. McGrattan, Fwziah J. Hammad, Ola D. Al-Maseimi, Karem H. Alzoubi
Summary: This study investigated the prevalence, knowledge, attitude, and practice of dietary supplements (DSs) use among university students in Jordan. The results showed that more than half of the students used DSs, with single-nutrient ingredient supplements being the most commonly used type. The study also revealed poor knowledge and a negative attitude towards DSs usage, as well as high-risk practices among DSs users.
