Article
Multidisciplinary Sciences
Robin A. Schoonderwoerd, Mischa de Rover, Jan A. M. Janse, Lydiane Hirschler, Channa R. Willemse, Leonie Scholten, Ilse Klop, Sander van Berloo, Matthias J. P. van Osch, Dick F. Swaab, Johanna H. Meijer
Summary: In modern society, the widespread use of artificial light at night disrupts our central circadian clock, the suprachiasmatic nucleus (SCN), by suppressing blood oxygen level-dependent (BOLD) functional MRI signals in the SCN. Contrary to expectations, not only blue light, but also green and orange light, can cause this suppression, while violet light does not. This suggests that strategies for light exposure need revision, with the possibility of using wavelengths other than blue to enhance light levels during the daytime and potential disruption from all colors during the nighttime.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Zhengfan Hu, Yima Mu, Lu Huang, Yuqing Hu, Zhiqing Chen, Yan Yang, Xiaodan Huang, Yunwei Fu, Yue Xi, Song Lin, Qian Tao, Fuqiang Xu, Kwok-Fai So, Chaoran Ren
Summary: Research has found that bright light treatment can suppress nocifensive behaviors in mice through a visual circuit related to the l/vlPAG. The mechanism involves a subset of retinal ganglion cells innervating GABAergic neurons in the vLGN/IGL, which in turn inhibit GABAergic neurons in the l/vlPAG. Activation of this inhibitory circuit can be achieved through bright light treatment.
Article
Ophthalmology
Mikayla D. Dilbeck, Zachary R. Spahr, Rakesh Nanjappa, John R. Economides, Jonathan C. Horton
Summary: This study demonstrates the segregation of direct retinal input into alternating columns and strata in the macaque superior colliculus. The projection from the peripheral retina is stronger than the projection from the macula.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Cell Biology
Fang Gao, Jun Ma, Yao-Qing Yu, Xiao-Fei Gao, Yang Bai, Yi Sun, Juan Liu, Xianyu Liu, Devin M. Barry, Steven Wilhelm, Tyler Piccinni-Ash, Na Wang, Dongyang Liu, Rachel A. Ross, Yan Hao, Xu Huang, Jin-Jing Jia, Qianyi Yang, Hao Zheng, Johan van Nispen, Jun Chen, Hui Li, Jiayi Zhang, Yun-Qing Li, Zhou-Feng Chen
Summary: This study reveals that visual itch information is transmitted from the retina to GRP neurons through ipRGCs and GRPR neurons in the SCN mediate contagious itch behavior. The PVT is involved in relaying itch information. These findings suggest the existence of a previously unknown visual pathway that encodes salient environmental cues and enables animals to imitate behaviors of conspecifics to cope with adverse conditions.
Article
Chemistry, Analytical
Sam B. Choi, Tarlan Vatan, Theresa A. Alexander, Chenghang Zhang, Shyrice M. Mitchell, Colenso M. Speer, Peter Nemes
Summary: During brain development, the formation of axonal projections in the mouse visual system is influenced by both spontaneous retinal activity and visual experience. However, the precise proteomic changes in the retinorecipient targets during this developmental transition are still unknown.
ANALYTICAL CHEMISTRY
(2023)
Review
Neurosciences
Nikolas Bergum, Casey-Tyler Berezin, Jozsef Vigh
Summary: Chronic opioid use is associated with sleep disturbances, but the mechanism is unclear. Animal studies suggest that opioids disrupt the circadian rhythms by affecting retinal cells responsible for light detection. Therefore, ipRGCs may be a potential therapeutic target for opioid-related sleep problems.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Josh W. Mouland, Franck P. Martial, Robert J. Lucas, Timothy M. Brown
Summary: This study found that changes in melanopsin irradiance largely account for the light-induced changes in SCN activity in naturalistic spatiotemporal variations, while cone signals only influenced SCN activity when spatiotemporal contrast was low. These results emphasize the importance of modulating effective irradiance for melanopsin in controlling the circadian impact of light.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Neurosciences
Hugo Calligaro, Azarin Shoghi, Xinyue Chen, Keun-Young Kim, Hsin Liu Yu, Brian Khov, Benjamin Finander, Hiep Le, Mark H. Ellisman, Satchidananda Panda
Summary: The hypothalamic suprachiasmatic nucleus (SCN) is the central circadian pacemaker in vertebrates that receives photic information to synchronize circadian rhythms. Two major types of peptidergic neurons in the core and shell regions of SCN and their interaction with melanopsin-expressing retinal ganglion cells (mRGCs) are essential to understanding light regulation of the circadian clock and local circuits within the SCN.
Article
Geriatrics & Gerontology
Felipe P. Fiuza, Jose Pablo G. Queiroz, Antonio Carlos Q. Aquino, Diego A. Camara, Luiz Eduardo M. Brandao, Ramon H. Lima, Jose Rodolfo L. P. Cavalcanti, Rovena Clara G. J. Engelberth, Jeferson S. Cavalcante
Summary: This study found that aging affects the daily changes in the number of calretinin (CR) neurons in the inter-geniculate leaflet (IGL) and ventral lateral geniculate nucleus (vLGN) in rats. CR cells decreased with age in the IGL and retinorecipient part of vLGN, and age-related CR loss was observed in all nuclei during the light to dark transition. CR expression showed daily rhythms in these regions, with no specific spatial restrictions for age-related changes.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Xiaodan Huang, Pengcheng Huang, Lu Huang, Zhengfang Hu, Xianwei Liu, Jiawei Shen, Yue Xi, Yan Yang, Yunwei Fu, Qian Tao, Song Lin, Anding Xu, Fuqiang Xu, Tian Xue, Kwok-Fai So, Haohong Li, Chaoran Ren
Summary: Exposure to bright-light treatment promotes spatial memory through a di-synaptic visual circuit involving specific retinal ganglion cells and thalamic neurons, with the effects dependent on the activation of these pathways.
Article
Neurosciences
Rachana D. Somaiya, Natalie A. Huebschman, Lata Chaunsali, Ubadah Sabbagh, Gabriela L. Carrillo, Bhanu P. Tewari, Michael A. Fox
Summary: The study investigated the transcriptional identity and development of astrocytes in the mouse visual thalamus, revealing that these cells have acquired adult-like morphology and functional characteristics before eye-opening. The results also showed that thalamic astrocytes ensheathe retinogeniculate synapses and are capable of efficient uptake of glutamate by eye-opening.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Neurosciences
Anna Magdalena Sanetra, Katarzyna Palus-Chramiec, Marian Henryk Lewandowski
Summary: Circadian rhythms are regulated by a set of brain structures, one of which is the IGL that integrates various stimuli influencing rhythmicity through the norepinephrinergic system. Norepinephrine affects different types of IGL neurons, exerting multiple effects on them. This is the first study to confirm the effects of norepinephrine on the activity of the IGL network.
Article
Neurosciences
Lukasz Chrobok, Anna Alwani, Kamil Pradel, Jasmin Daniela Klich, Marian Henryk Lewandowski
Summary: This study investigates the role of the olivary pretectal nucleus (OPN) in regulating circadian rhythms, showing that its neurons increase firing rate during the behaviorally quiescent light phase, and exhibit different responses to orexin A and PAC1 receptor activation. These findings suggest a daily modulation of OPN activity via intrinsic and extrinsic mechanisms, providing insights into the temporal physiology of this brain structure.
Article
Multidisciplinary Sciences
R. C. Feord, A. Gomoliszewska, A. Pienaar, J. W. Mouland, T. M. Brown
Summary: This study establishes a new method for studying cone function in mice and reveals the widespread presence of cone-opponent processing in the mouse visual system. This research provides new insights into the functional characteristics of color processing pathways in mice.
SCIENTIFIC REPORTS
(2023)
Article
Genetics & Heredity
Peter A. Perrino, Dianne F. Newbury, R. Holly Fitch
Summary: The study highlights that mutations in the USH2A gene causing cochlear developmental abnormalities results in an impact on the higher-level processing abilities characteristic of CAPD after peripheral sensory loss.
Article
Developmental Biology
Rana N. El-Danaf, Thomas E. Krahe, Emily K. Dilger, Martha E. Bickford, Michael A. Fox, William Guido
NEURAL DEVELOPMENT
(2015)
Article
Multidisciplinary Sciences
Vrushali Chavan, Jeffery Willis, Sidney K. Walker, Helen R. Clark, Xinran Liu, Michael A. Fox, Sarika Srivastava, Konark Mukherjee
Article
Microbiology
Justin M. Brooks, Gabriela L. Carrillo, Jianmin Su, David S. Lindsay, Michael A. Fox, Ira J. Blader
Article
Cell Biology
Sarah Hammer, Aboozar Monavarfeshani, Tyler Lemon, Jianmin Su, Michael Andrew Fox
Article
Cell Biology
Jianmin Su, Jiang Chen, Kumiko Lippold, Aboozar Monavarfeshani, Gabriela Lizana Carrillo, Rachel Jenkins, Michael A. Fox
JOURNAL OF CELL BIOLOGY
(2016)
Article
Biology
Aboozar Monavarfeshani, Gail Stanton, Jonathan Van Name, Kaiwen Su, William A. Mills, Kenya Swilling, Alicia Kerr, Natalie A. Huebschman, Jianmin Su, Michael A. Fox
Article
Neurosciences
C. Levy, J. M. Brooks, J. Chen, J. Su, M. A. Fox
JOURNAL OF COMPARATIVE NEUROLOGY
(2015)
Article
Developmental Biology
Sarah Hammer, Gabriela L. Carrillo, Gubbi Govindaiah, Aboozar Monavarfeshani, Joseph S. Bircher, Jianmin Su, William Guido, Michael A. Fox
NEURAL DEVELOPMENT
(2014)
Article
Neurosciences
Gabriela L. Carrillo, Valerie A. Ballard, Taylor Glausen, Zack Boone, Joseph Teamer, Cyrus L. Hinkson, Elizabeth A. Wohlfert, Ira J. Blader, Michael A. Fox
Article
Biochemistry & Molecular Biology
Ubadah Sabbagh, Gubbi Govindaiah, Rachana D. Somaiya, Ryan Ha, Jessica C. Wei, William Guido, Michael A. Fox
Summary: This study identified novel neuronal cell types in mouse vLGN using various techniques, revealing distinct GABAergic cell types in different laminae of vLGN. The results suggest that the subtype-specific laminar distribution of retinorecipient cells in vLGNe may play a crucial role in receiving, processing, and transmitting light-derived signals in parallel channels of the subcortical visual system.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Neurosciences
Rachana D. Somaiya, Natalie A. Huebschman, Lata Chaunsali, Ubadah Sabbagh, Gabriela L. Carrillo, Bhanu P. Tewari, Michael A. Fox
Summary: The study investigated the transcriptional identity and development of astrocytes in the mouse visual thalamus, revealing that these cells have acquired adult-like morphology and functional characteristics before eye-opening. The results also showed that thalamic astrocytes ensheathe retinogeniculate synapses and are capable of efficient uptake of glutamate by eye-opening.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gabriela L. Carrillo, Jianmin Su, Mikel L. Cawley, Derek Wei, Simran K. Gill, Ira J. Blader, Michael A. Fox
Summary: The parasitic infection of Toxoplasma gondii can alter neural circuits by selectively removing inhibitory synapses on excitatory pyramidal neurons, leading to central nervous system infection and increased risk for neurological and neuropsychiatric disorders.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Biology
Rachana Deven Somaiya, Katelyn Stebbins, Ellen C. Gingrich, Hehuang Xie, John N. Campbell, A. Denise R. Garcia, Michael A. Fox
Summary: Axons of retinal ganglion cells induce astrocytes in the visual thalamus to generate Fgf15, which influences the migration of interneurons. The release of SHH from retinal axons is crucial for the recruitment of interneurons.
Article
Multidisciplinary Sciences
Jianmin Su, Ubadah Sabbagh, Yanping Liang, Lucie Olejnikova, Karen G. Dixon, Ashley L. Russell, Jiang Chen, Yuchin Albert Pan, Jason W. Triplett, Michael A. Fox
Summary: The molecular mechanisms directing the precise laminar targeting of ipsilateral-projecting RGC axons to the deep sublamina of SC have been identified to involve the extracellular glycoprotein NPNT and integrin receptors, providing the assembly of eye-specific parallel visual pathways.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Jianmin Su, James Cole, Michael A. Fox