Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1

Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density

(2016) Yong Pan et al.   Aging-US

Reducing sphingolipid synthesis orchestrates global changes to extend yeast lifespan

(2013) Jun Liu et al.   AGING CELL

TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis

(2013) Mitsugu Shimobayashi et al.   MOLECULAR BIOLOGY OF THE CELL

Dietary Restriction Depends on Nutrient Composition to Extend Chronological Lifespan in Budding Yeast Saccharomyces cerevisiae

(2013) Ziyun Wu et al.   PLoS One

Replicative and Chronological Aging in Saccharomyces cerevisiae

(2012) Valter D. Longo et al.   Cell Metabolism

Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1

(2012) M. Paulina Ordonez et al.   HUMAN MOLECULAR GENETICS

Impaired proteolysis underlies autophagic dysfunction in Niemann–Pick type C disease

(2012) Matthew J. Elrick et al.   HUMAN MOLECULAR GENETICS

δ-Tocopherol Reduces Lipid Accumulation in Niemann-Pick Type C1 and Wolman Cholesterol Storage Disorders

(2012) Miao Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of sphingolipid synthesis through Orm1 and Orm2 in yeast

(2012) M. Liu et al.   JOURNAL OF CELL SCIENCE

Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways

(2012) Yidi Sun et al.   MOLECULAR BIOLOGY OF THE CELL

Oxidative Stress: A Pathogenic Mechanism for Niemann-Pick Type C Disease

(2012) Mary Carmen Vázquez et al.   Oxidative Medicine and Cellular Longevity

Quantitative Proteomic Analysis of Niemann-Pick Disease, Type C1 Cerebellum Identifies Protein Biomarkers and Provides Pathological Insight

(2012) Stephanie M. Cologna et al.   PLoS One

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release

(2012) Dongbiao Shen et al.   Nature Communications

Down-Regulating Sphingolipid Synthesis Increases Yeast Lifespan

(2012) Xinhe Huang et al.   PLoS Genetics

Oxidative Stress and Programmed Cell Death in Yeast

(2012) Gianluca Farrugia et al.   Frontiers in Oncology

Lysosomal Ca2+ homeostasis: Role in pathogenesis of lysosomal storage diseases

(2011) Emyr Lloyd-Evans et al.   CELL CALCIUM

How Budding Yeast Sense and Transduce the Oxidative Stress Signal and the Impact in Cell Growth and Morphogenesis

(2011) Maria Angeles de la Torre-Ruiz et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Mitochondria, reactive oxygen species, and chronological aging: A message from yeast

(2011) Yong Pan   EXPERIMENTAL GERONTOLOGY

An “Exacerbate-reverse” Strategy in Yeast Identifies Histone Deacetylase Inhibition as a Correction for Cholesterol and Sphingolipid Transport Defects in Human Niemann-Pick Type C Disease

(2011) Andrew B. Munkacsi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Yeast 3-Phosphoinositide-dependent Protein Kinase-1 (PDK1) Orthologs Pkh1–3 Differentially Regulate Phosphorylation of Protein Kinase A (PKA) and the Protein Kinase B (PKB)/S6K Ortholog Sch9

(2011) Karin Voordeckers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Unusual Presentation of Copper Metabolism Disorder and a Possible Connection With Niemann-Pick Type C

(2011) Helly R. Goez et al.   JOURNAL OF CHILD NEUROLOGY

Genome-Wide Analysis Reveals the Vacuolar pH-Stat of Saccharomyces cerevisiae

(2011) Christopher L. Brett et al.   PLoS One

Alteration of Gene Expression Profile in Niemann-Pick Type C Mice Correlates with Tissue Damage and Oxidative Stress

(2011) Mary C. Vázquez et al.   PLoS One

Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae

(2011) F. M. Roelants et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of evolutionarily conserved genetic regulators of cellular aging

(2010) Gerhard T. Laschober et al.   AGING CELL

Niemann-Pick disease type C

(2010) Marie T Vanier   Orphanet Journal of Rare Diseases

Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity

(2010) A. Mesquita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New therapies in the management of Niemann-Pick type C disease: clinical utility of miglustat

(2010) Ed Wraith   Therapeutics and Clinical Risk Management

Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

(2009) Hyock Joo Kwon et al.   CELL

Association of autophagy with cholesterol-accumulated compartments in Niemann-Pick disease type C cells

(2009) Seiya Ishibashi et al.   JOURNAL OF CLINICAL NEUROSCIENCE

MLN64 mediates egress of cholesterol from endosomes to mitochondria in the absence of functional Niemann-Pick Type C1 protein

(2009) Mark Charman et al.   JOURNAL OF LIPID RESEARCH

Cholesterol involvement in the pathogenesis of neurodegenerative diseases

(2009) Jun-Ping Liu et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Clinical experience with miglustat therapy in pediatric patients with Niemann–Pick disease type C: A case series

(2009) M. Pineda et al.   MOLECULAR GENETICS AND METABOLISM

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Increased Respiration in thesch9ΔMutant Is Required for Increasing Chronological Life Span but Not Replicative Life Span

(2008) Hugo Lavoie et al.   EUKARYOTIC CELL

Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone

(2008) Stefania Zampieri et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

(2008) Emyr Lloyd-Evans et al.   NATURE MEDICINE

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Isc1p Plays a Key Role in Hydrogen Peroxide Resistance and Chronological Lifespan through Modulation of Iron Levels and Apoptosis

(2007) Teresa Almeida et al.   MOLECULAR BIOLOGY OF THE CELL