Article
Multidisciplinary Sciences
Jakub Suchodolski, Daria Derkacz, Przemyslaw Bernat, Anna Krasowska
Summary: The study evaluated the effect of capric acid produced by probiotic yeast Saccharomyces boulardii on the activities of fluconazole and amphotericin B against pathogenic Candida albicans fungus. The results showed that capric acid may be a promising additive in combination with fluconazole, reducing efflux activity of multidrug resistance transporter Cdr1p. However, capric acid alone stimulated ergosterol production in C. albicans, leading to cross resistance towards amphotericin B. It is concluded that amphotericin B should not be administered with dietary supplements containing capric acid or S. boulardii cells.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Sabi Pokhrel, Nawarat Boonmee, Orawan Tulyaprawat, Sujiraphong Pharkjaksu, Iyarit Thaipisutikul, Phoom Chairatana, Popchai Ngamskulrungroj, Chalermchai Mitrpant
Summary: Biofilm formation is an important virulence factor for the pathogenesis of Candida albicans. This study used the zebrafish model to evaluate the in vivo virulence of strains with different biofilm formation strengths. The results showed that stronger biofilm formation was associated with shorter survival time in zebrafish and higher up-regulation of biofilm-associated genes.
Review
Immunology
Jose Pedro Lopes, Michail S. Lionakis
Summary: This review synthesizes our current knowledge of tissue-specific determinants of Candida albicans pathogenicity and host immune defense mechanisms.
Article
Infectious Diseases
Nashwa Mohamed Reda, Reem Mostafa Hassan, Sherifa Tarek Salem, Reham Hamed A. Yousef
Summary: Candidemia remains a significant problem in healthcare settings, with a changing distribution of Candida species. C. albicans is still the most prevalent species, but non-albicans species are increasing, particularly in pediatric patients. The emergence of uncommon Candida species is concerning and requires prompt management.
Article
Infectious Diseases
Jie Hou, Jin Deng, Ya Liu, Weili Zhang, Siying Wu, Quanfeng Liao, Ying Ma, Mei Kang
Summary: The aim of this study was to investigate the current status of candidemia and evaluate the clinical characteristics, risk factors, and outcomes among different species. The study found variations in the prevalence of Candida albicans and non-albicans Candida and differences in the susceptibility to antifungal agents among different species. Risk factors associated with Candida albicans and non-albicans Candida were identified, and no significant differences in mortality were observed between the two species.
Article
Multidisciplinary Sciences
Asal Safi-Samghabadi, Seyed-Mohammad Atyabi, Mehdi Razzaghi-Abyaneh
Summary: A study was conducted to investigate the effects of cold atmospheric plasma (CAP) irradiation on Trichophyton rubrum, the major human pathogenic dermatophyte. The results showed that CAP significantly inhibited fungal growth, reduced cell viability, disrupted cellular structures, and suppressed the expression of a specific gene. This suggests that CAP has potential as an effective and safe treatment for chronic dermatophytosis caused by T. rubrum.
SCIENTIFIC REPORTS
(2022)
Article
Dermatology
Gizem Guner Ozenen, Zumrut Sahbudak Bal, Gulhadiye Avcu, Pinar Ozkaya Yazici, Miray Karakoyun, Dilek Yesim Metin, Suleyha Hilmioglu Polat
Summary: This study evaluated the demographic and clinical characteristics of candidemia in hospitalized children and identified risk factors and outcomes for Candida albicans and non-albicans Candida spp. The prevalence of non-albicans Candida candidemia was higher than that of Candida albicans. Total parenteral nutrition, antifungal prophylaxis, and a history of coagulase-negative staphylococci culture positivity were identified as risk factors for non-albicans Candida candidemia. The rates of fluconazole and amphotericin B resistance in Candida species were also determined.
Article
Multidisciplinary Sciences
Robert Zarnowski, Andrea Noll, Marc G. Chevrette, Hiram Sanchez, Ryley Jones, Hanna Anhalt, Jen Fossen, Anna Jaromin, Cameron Currie, Jeniel E. Nett, Aaron Mitchell, David R. Andes
Summary: The fungal pathogen Candida albicans can form biofilms that protect it from drugs and the immune system by releasing extracellular vesicles (EVs) that promote extracellular matrix formation and resistance to antifungal drugs. The study identifies functions for numerous EV cargo proteins in biofilm matrix assembly, drug resistance, fungal cell adhesion, and dissemination. The findings suggest that EVs play a crucial role in coordinating biofilm development in C. albicans.
NATURE COMMUNICATIONS
(2021)
Article
Public, Environmental & Occupational Health
S. Umamaheshwari, M. N. Sumana
Summary: This study retrospectively analyzed the distribution of Candida in various clinical samples in a tertiary care hospital in India. It found that urine samples were the major source of Candida infection, and non-albicans Candida (NAC) was the predominant species. The susceptibility test revealed that about 75.44% of isolates were susceptible to the tested drugs, while about 24.56% were resistant to one or more drugs.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Sivaraman Dhanasekaran, Pradeep Pushparaj Selvadoss, Solomon Sundar Manoharan, Srikanth Jeyabalan, Vijayarangan Devi Rajeswari
Summary: This study aimed to explore the inhibitory role of selected bioactive molecules against Candida albicans SAP5 enzyme using in silico approach. The results showed significant interactions between these molecules and the core catalytic residues of the target protein, and the stability of the ligand-protein complexes was confirmed in molecular dynamics simulation. The study highlights the remarkable potential of bioactive therapeutics found in medicinal herbs in managing Candida infection.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Oncology
Angeliki-Ioanna Giannopoulou, Charalampos Xanthopoulos, Christina Piperi, Efterpi Kostareli
Summary: TRIM proteins play a crucial role in glioma progression and may become potential targets for future treatment. Gliomas are highly heterogeneous and invasive tumors, requiring a better understanding of their molecular mechanisms. TRIM proteins may serve as prognostic biomarkers and therapeutic targets, providing more promising tools for the diagnosis and treatment of gliomas.
Article
Cell Biology
Mao Zhang, Cheng Zhu, Yuanyuan Duan, Tongbao Liu, Haoping Liu, Chang Su, Yang Lu
Summary: A unique group of PP2C phosphatases from fungi and plants have been found to sense CO2, but not HCO3-, to control diverse cellular programmes. They have intrinsically disordered regions (IDR) that form reversible liquid-like droplets through phase separation and are activated in response to elevated environmental CO2 in an IDR-dependent manner.
NATURE CELL BIOLOGY
(2022)
Article
Medicine, General & Internal
Huifang Lian, XiaoLong Fang, Qingyu Li, Shuang Liu, Qiuhong Wei, Xia Hua, Wenguang Li, Chunyang Liao, Xiaoyong Yuan
Summary: This study revealed the involvement of NLRP3 inflammasome activation and pyroptosis in C. albicans-infected mouse corneas and HCECs. The NLRP3 inflammasome-mediated pyroptosis signaling contributes to the severity of C. albicans keratitis. Targeting this NLRP3 inflammasome-dependent pathway may provide a potential treatment strategy for fungal keratitis.
FRONTIERS IN MEDICINE
(2022)
Article
Microbiology
J. D. Sobel
Summary: A review of vaginal isolates of Candida albicans obtained from a university vaginitis referral clinic over a 10-year period revealed an increase in fluconazole resistance, which has been associated with treatment choice. Factors contributing to azole resistance in Candida albicans vaginal infection are discussed.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Microbiology
Glaucia S. Arita, Daniella R. Faria, Isis R. G. Capoci, Erika S. Kioshima, Patricia S. Bonfim-Mendonca, Terezinha I. E. Svidzinski
Summary: This review focuses on the studies of C. albicans mutants for genes that encode cell wall-associated proteins, highlighting the importance of these proteins in virulence and hyphal morphogenesis. Some proteins with mutations are associated with attenuated virulence and defective filamentation, while others are still important for C. albicans virulence despite their inactivation not impairing filamentation.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Immunology
David Ermert, Antonin Weckel, Michal Magda, Matthias Morgelin, Jutamas Shaughnessy, Peter A. Rice, Lars Bjorck, Sanjay Ram, Anna M. Blom
JOURNAL OF IMMUNOLOGY
(2018)
Review
Cell Biology
Constantin F. Urban, Jeniel E. Nett
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2019)
Article
Microbiology
Aaron C. Crawford, Laura E. Lehtovirta-Morley, Omran Alamir, Maria J. Niemiec, Bader Alawfi, Mohammad Alsarraf, Volha Skrahina, Anna C. B. P. Costa, Andrew Anderson, Sujan Yellagunda, Elizabeth R. Ballou, Bernhard Hube, Constantin F. Urban, Duncan Wilson
Article
Immunology
Maisem Laabei, Guanghui Liu, David Ermert, John D. Lambris, Kristian Riesbeck, Anna M. Blom
JOURNAL OF IMMUNOLOGY
(2018)
Review
Immunology
Maisem Laabei, David Ermert
JOURNAL OF INNATE IMMUNITY
(2019)
Article
Immunology
Anna Thunstrom Salzer, Maria J. Niemiec, Ave Hosseinzadeh, Marios Stylianou, Fredrik Astrom, Marc Rohm, Clas Ahlm, Anders Wahlin, David Ermert, Constantin F. Urban
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Oncology
Kelly L. Singel, Kassondra S. Grzankowski, A. N. M. Nazmul H. Khan, Melissa J. Grimm, Anthony C. D'Auria, Kayla Morrell, Kevin H. Eng, Bonnie Hylander, Paul C. Mayor, Tiffany R. Emmons, Nikolett Lenart, Rebeka Fekete, Zsuzsanna Kornyei, Uma Muthukrishnan, Jonathan D. Gilthorpe, Constantin F. Urban, Kiyoshi Itagaki, Carl J. Hauser, Cynthia Leifer, Kirsten B. Moysich, Kunle Odunsi, Adam Denes, Brahm H. Segal
BRITISH JOURNAL OF CANCER
(2019)
Article
Immunology
Jose Pedro Lopes, Marios Stylianou, Emelie Backman, Sandra Holmberg, Maria Ekoff, Gunnar Nilsson, Constantin F. Urban
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2019)
Article
Microbiology
Ava Hosseinzadeh, Marios Stylianou, Jose Pedro Lopes, Daniel C. Muller, Andre Haggman, Sandra Holmberg, Christian Grumaz, Anders Johansson, Kai Sohn, Christoph Dieterich, Constantin F. Urban
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Chemistry, Analytical
Bjorn De Samber, Riet De Rycke, Michiel De Bruyne, Michiel Kienhuis, Linda Sandblad, Sylvain Bohic, Peter Cloetens, Constantin Urban, Lubos Polerecky, Laszlo Vincze
ANALYTICA CHIMICA ACTA
(2020)
Review
Microbiology
Constantin F. Urban, Emelie Backman
CURRENT OPINION IN MICROBIOLOGY
(2020)
Article
Immunology
Madhu Shankar, Nathalie Uwamahoro, Emelie Backman, Sandra Holmberg, Maria Joanna Niemiec, Johannes Roth, Thomas Vogl, Constantin F. Urban
Summary: S100A8/A9 protein complex plays a critical role in inflammatory collateral tissue damage, with its deficiency reducing tissue injury and increasing fungal clearance. Restoring S100A8/A9 levels can increase tissue damage and fungal clearance, indicating that targeting S100A8/A9 could serve as a promising adjunct therapy against challenging intra-abdominal infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Urology & Nephrology
Jose Antonio Tesser Poloni, Clotilde Druck Garcia, Liane Nanci Rotta, Constantin F. Urban
Summary: Neutrophils are known to phagocytize fungal structures, but this case study demonstrates a rare observation of neutrophil phagocytosis of hyphal structures in the urine of a kidney allograft recipient. It highlights the importance of considering unusual immune responses in clinical sample evaluation.
JORNAL BRASILEIRO DE NEFROLOGIA
(2021)
Article
Biochemistry & Molecular Biology
Lucas Unger, Samuel Skoluda, Emelie Backman, Borko Amulic, Fernando M. Ponce-Garcia, Chinelo N. C. Etiaba, Sujan Yellagunda, Renate Krueger, Horst von Bernuth, Johan Bylund, Bernhard Hube, Julian R. Naglik, Constantin F. Urban
Summary: Candidalysin triggers both canonical NETs and NLS, forming a fibrous sticky network that inhibits the growth of Candida albicans hyphae effectively.
Article
Biology
Jose Pedro Lopes, Constantin F. Urban