Article
Microbiology
Pradip R. Panta, William T. Doerrler
Summary: The DedA family is a crucial membrane protein for drug resistance in bacteria, and in B. thailandensis, the two arn operons responsible for lipid A modification play a key role in colistin resistance.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Ornella Morana, Jon Ander Nieto-Garai, Patrik Bjorkholm, Jorge Bernardino de la Serna, Oihana Terrones, Aroa Arboleya, Dalila Ciceri, Iratxe Rojo-Bartolome, Cedric M. Blouin, Christophe Lamaze, Maier Lorizate, Francesc-Xabier Contreras
Summary: This study identifies cholesterol as a molecular switch regulating the transmembrane signaling of the cytokine interferon-gamma receptor (IFN-gamma R). Cholesterol binds to a conserved motif in the IFN-gamma R, driving its partitioning into lipid nanodomains and facilitating oligomerization and transmembrane signaling. This discovery has significant implications for understanding lipid selectivity by membrane proteins and the role of lipids in modulating cell surface receptor function. In addition, inhibiting the cholesterol-IFN-gamma R2 interaction may be a potential therapeutic strategy for IFN-gamma-dependent diseases.
Article
Microbiology
Yalan Gao, Shengpei Zhang, He Li
Summary: The CfSET1 gene in Colletotrichum fructicola plays a crucial role in the development and pathogenicity of the anthracnose disease in tea-oil tree.
Article
Plant Sciences
Haruhiko Jimbo, Taichi Izuhara, Takashi Hirashima, Kaichiro Endo, Yuki Nakamura, Hajime Wada
Summary: Membrane lipid remodeling plays a crucial role in the survival of plants and microalgae under nutrient-deficient conditions. The study discovered a new system of membrane lipid remodeling in response to CO2 levels in Synechocystis sp. PCC 6803, with an increase in phosphatidylglycerol (PG) content benefiting the functioning of Photosystem II (PSII) under low CO2 conditions.
Article
Biology
Andrew Kuo, Antonio Checa, Colin Niaudet, Bongnam Jung, Zhongjie Fu, Craig E. Wheelock, Sasha A. Singh, Masanori Aikawa, Lois E. Smith, Richard L. Proia, Timothy Hla
Summary: This study reveals the crucial role of endothelial sphingolipid biosynthesis in regulating vascular development, maintaining circulatory and peripheral organ sphingolipid levels, and contributing to lipid raft formation and efficient signaling. The deletion of SPTLC1 in endothelial cells leads to impaired proliferation, differentiation, and delayed retinal vascular development. Furthermore, EC-derived sphingolipid metabolites are in constant flux between the vasculature, circulation, and non-CNS organs, and play a role in hepatocyte response to stress.
Article
Plant Sciences
Zongkuan Wang, Heng Zhang, Yingbo Li, Yiming Chen, Xiong Tang, Jia Zhao, Feifei Yu, Haiyan Wang, Jin Xiao, Jia Liu, Xu Zhang, Li Sun, Qi Xie, Xiue Wang
Summary: The heavy-metal-associated isoprenylated plant protein HIPP1-V plays an important role in regulating wheat resistance to powdery mildew, with its isoprenylation critical for plasma membrane localization and interaction with E3-ligase CMPG1-V. DGEs related to ROS and SA pathways were enriched in HIPP1-V, revealing their involvement in powdery mildew resistance.
PLANT CELL AND ENVIRONMENT
(2023)
Article
Immunology
Stuart Cantlay, Christian Kaftanic, Joseph Horzempa
Summary: This study found that PdpC plays a crucial role in the infection process of F. tularensis. It acts as an effector protein of the T6SS, involved in phagolysosomal escape and intracellular replication within host macrophages. Additionally, PdpC has been shown to participate in bacteria invasion of erythrocytes, and the reintroduction of PdpC can rescue the invasion ability.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jian Li, Chun Guo, Christopher Rood, Jinsong Zhang
Summary: This study demonstrates that the activation of histone deacetylase 3 (HDAC3) requires a priming step mediated by the C terminus to remodel HDAC3 conformation, and mutations in the C-terminal region prevent this activation process, indicating the crucial role of the C terminus in the proper complex formation of HDAC3 with DAD and IP4. The C terminus function is conformation dependent and necessary for HDAC3 activation prior to the conformational change, suggesting that it could be a potential new target for inhibiting HDAC3 in diseases such as cancer.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Virology
David Pasdeloup, Aurelien Chuard, Sylvie Remy, Katia Courvoisier-Guyader, Caroline Denesvre
Summary: Viruses spread through cell-released virus and/or cell-to-cell spread, but the molecular determinants and importance of cell-to-cell spread in viral infection are unclear. This study reveals that pUL51 is essential for the growth of Marek's disease virus, an oncogenic alphaherpesvirus of chickens that is strictly cell-associated. The study also shows the association of pUL51 with lipid droplets and the important role of its C-terminal half in viral replication and pathogenesis.
JOURNAL OF VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mengyun Wang, Rui Cheng, Hongjuan He, Zhengbin Han, Yan Zhang, Qiong Wu
Summary: Defective ac(4)C modification of Nop2 mRNA mediated by NAT10 hinders the development of mouse embryos and influences the first cell fate decision.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Physiology
Ji H. Kang, Ji E. Park, Jason Dagoon, Stewart W. C. Masson, Troy L. Merry, Shannon N. Bremner, Jessica R. Dent, Simon Schenk
Summary: This study found that the loss of SIRT1 deacetylase function in muscle does not affect glucose uptake in response to ex vivo contractions, regardless of sex or muscle type. However, it was demonstrated that, similar to insulin-stimulated glucose uptake, contraction-stimulated glucose uptake is significantly higher in female compared to male skeletal muscle. This study is the first to show sex-based differences in contraction-stimulated glucose uptake in skeletal muscle.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Junjie Li, Qi Li, Wentao Wang, Xinran Zhang, Chen Chu, Xintian Tang, Bo Zhu, Lizhong Xiong, Yu Zhao, Dao-Xiu Zhou
Summary: DELLA proteins are important regulators of gibberellic acid signaling and have contributed to grain yield increases in rice and wheat varieties during the green revolution. This study identifies a complex involving the rice DELLA protein SLENDER RICE1 (SLR1), Polycomb-repressive complex 2 (PRC2), and histone deacetylase HDA702, which represses downstream genes through silent chromatin state formation. Disruption of this complex impairs SLR1-dependent histone modification and gene repression, highlighting the importance of chromatin regulators in DELLA-mediated gene regulation.
Review
Oncology
Ping Zhang, Mingzhi Zhang
Summary: CTCLs are a group of heterogeneous diseases involving malignant T cells, with unclear pathogenesis and etiology. Most CTCLs have an indolent course, but once large-cell transformation occurs, it progresses to more aggressive types. Epigenetic drugs have shown certain curative effects and have been selected as third-line drugs for patients with relapsing and refractory CTCL.
FRONTIERS IN ONCOLOGY
(2021)
Article
Hematology
Jeanne F. Rivera, April J. Baral, Fatima Nadat, Grace Boyd, Rachael Smyth, Hershna Patel, Emma L. Burman, Ghadah Alameer, Sally A. Boxall, Brian R. Jackson, E. Joanna Baxter, Peter Laslo, Anthony R. Green, David G. Kent, Ann Mullally, Edwin Chen
Summary: This study identified key motifs for the oncogenic activity of CALR(de)(l52), highlighting the essential role of the zinc-binding domain in multimerization of CALR(de)(l52) and interaction with MPL. Zinc chelators showed therapeutic potential in preferentially targeting CALR(de)(l52)-mutant cells, suggesting that modulation of intracellular zinc levels could be a novel approach to inhibit the oncogenic activity of CALR(de)(l52) in MPNs treatment.
Article
Plant Sciences
Yang Tao, Ting Zou, Xu Zhang, Rui Liu, Hao Chen, Guoqiang Yuan, Dan Zhou, Pingping Xiong, Zhiyuan He, Gongwen Li, Menglin Zhou, Sijing Liu, Qiming Deng, Shiquan Wang, Jun Zhu, Yueyang Liang, Xiumei Yu, Aiping Zheng, Aijun Wang, Huainian Liu, Lingxia Wang, Ping Li, Shuangcheng Li
Summary: This study identified a rice male-sterile mutant (l94) with defective pollen exine patterning and abnormal tapetal cell development, caused by a mutation in a gene encoding a type-G non-specific lipid transfer protein (OsLTPL94). Further investigations revealed that the transcription factor EAT1 activates OsLTPL94 expression, playing a key role in the coordinated development of tapetum and microspores.
Article
Multidisciplinary Sciences
Anna C. Llewellyn, Claressa E. Lucas, Sarah E. Roberts, Ellen W. Brown, Bina S. Nayak, Brian H. Raphael, Jonas M. Winchell
Article
Public, Environmental & Occupational Health
Don Weiss, Christopher Boyd, Jennifer L. Rakeman, Sharon K. Greene, Robert Fitzhenry, Trevor McProud, Kimberlee Musser, Li Huang, John Kornblum, Elizabeth J. Nazarian, Annie D. Fine, Sarah L. Braunstein, Daniel Kass, Keren Landman, Pascal Lapierre, Scott Hughes, Anthony Tran, Jill Taylor, Deborah Baker, Lucretia Jones, Laura Kornstein, Boning Liu, Rodolfo Perez, David E. Lucero, Eric Peterson, Isaac Benowitz, Kristen F. Lee, Stephanie Ngai, Mitch Stripling, Jay K. Varma
PUBLIC HEALTH REPORTS
(2017)
Review
Microbiology
Crystal L. Jones, Brooke A. Napier, Timothy R. Sampson, Anna C. Llewellyn, Max R. Schroeder, David S. Weiss
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
(2012)
Article
Multidisciplinary Sciences
Timothy R. Sampson, Sunil D. Saroj, Anna C. Llewellyn, Yih-Ling Tzeng, David S. Weiss
Article
Multidisciplinary Sciences
Anna C. Llewellyn, Crystal L. Jones, Brooke A. Napier, James E. Bina, David S. Weiss
Article
Multidisciplinary Sciences
Timothy R. Sampson, Brooke A. Napier, Max R. Schroeder, Rogier Louwen, Jinshi Zhao, Chui-Yoke Chin, Hannah K. Ratner, Anna C. Liewellyn, Crystal L. Jones, Hamed Laroui, Didier Merlin, Pei Zhou, Hubert P. Endtz, David S. Weiss
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Editorial Material
Public, Environmental & Occupational Health
Jacqueline Fournier-Caruana, Nicoletta Previsani, Harpal Singh, Liliane Boualam, Joseph Swan, Anna Llewellyn, Roland W. Sutter, Michel Zaffran
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2018)
Article
Multidisciplinary Sciences
Margaret C. Hardy, Rita C. Stinnett, Kristine J. Kines, Danisha M. Rivera-Nazario, David E. Lowe, Alexandra M. Mercante, Nathalie Gonzalez Jimenez, Rosa I. Cuevas Ruiz, Hector I. Rivera Arbolay, Rafael L. Gonzalez Pena, Mayra Toro, Alma A. Trujillo, Claudia L. Pappas, Anna C. Llewellyn, Francisco Candal, Maria Burgos Garay, Gerardo A. Gomez, Jeniffer Concepcion Acevedo, Marisela Ansbro, Hercules Moura, Michael W. Shaw, Atis Muehlenbachs, Lovisa C. Romanoff, Brittany J. Sunshine, Dale A. Rose, Anita Patel, Craig N. Shapiro, S. Carolina Luna-Pinto, Satish K. Pillai, Eduardo O'Neill
NATURE COMMUNICATIONS
(2019)
Article
Public, Environmental & Occupational Health
Daphne B. Moffett, Anna Llewellyn, Harpal Singh, Eugene Saxentoff, Jeffrey Partridge, Maria Iakovenko, Sigrun Roesel, Humayun Asghar, Najam Baig, Varja Grabovac, Santosh Gurung, Nicksy Gumede-Moeletsi, Jacob Barnor, Andros Theo, Gloria Rey-Benito, Andrea Villalobos, Liliane Boualam, Joseph Swan, Roland W. Sutter, Ekkehart Pandel, Steven Wassilak, M. Steven Oberste, Ian Lewis, Michel Zaffran
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2019)
Article
Cell Biology
Chui-Yoke Chin, Jinshi Zhao, Anna C. Llewellyn, Igor Golovliov, Anders Sjostedt, Pei Zhou, David S. Weiss
Summary: The study reveals the important role of an uncharacterized protein FlmX in the intracellular pathogen Francisella, affecting bacterial virulence and resistance to antibiotics by regulating LPS modification process. FlmX may represent a potential novel drug target for reducing bacterial virulence and increasing sensitivity to innate antimicrobials and antibiotics, with its conservation in other intracellular pathogens also noted.
Article
Public, Environmental & Occupational Health
Daphne B. Moffett, Anna Llewellyn, Harpal Singh, Eugene Saxentoff, Jeffrey Partridge, Liliane Boualam, Mark Pallansch, Steven Wassilak, Humayun Asghar, Signin Roesel, Varja Grabovac, Gloria Rey-Benito, Jacob Barnor, Andros Theo, Joseph Swan, Maria Lakovenko, Najam Baig, Santosh Gurung, Ekkehart Pandel, Michel Zaffran
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2020)