Review
Microbiology
Beatrice Roche, Dirk Bumann
Summary: This review focuses on the role of single-cell reporters in elucidating host-pathogen interactions, including identifying different types of interactions and participating pathogen subsets, as well as determining individual outcomes and their impact on disease progression. It also highlights the gaps in available tools and exciting avenues to address these issues.
CURRENT OPINION IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Aswin Thacharodi, Iain L. Lamont
Summary: Bioinformatics analysis identified multiple aminoglycoside-modifying enzymes in P. aeruginosa, which significantly impact the antibiotic susceptibility of the bacteria and can even turn originally susceptible strains into resistant ones.
Article
Astronomy & Astrophysics
Stella Koch Ocker, James M. Cordes, Shami Chatterjee, Chen-Hui Niu, Di Li, James W. McKee, Casey J. Law, Chao-Wei Tsai, Reshma Anna-Thomas, Ju-Mei Yao, Marilyn Cruces
Summary: The repeating fast radio burst FRB 20190520B is localized to a nearby galaxy. The observed dispersion measure and scattering phenomena provide support for a novel technique for estimating FRB redshifts and are consistent with previous findings.
ASTROPHYSICAL JOURNAL
(2022)
Article
Agronomy
Tayebeh Saedi, Mohammad Reza Mosaddeghi, Mohammad Reza Sabzalian, Mohsen Zarebanadkouki
Summary: The presence of Epichloe endophyte improved the performance of tall fescue genotype 75B under anaerobic conditions, while it had an adverse effect on genotype 75C. The endophyte likely decreased flooding-induced oxidative stress and helped prevent the over-accumulation of reactive oxygen species in genotype 75B. Epichloe endophyte may have maintained oxidative conditions around the roots, reducing the need for flooding-tolerance mechanisms in E+ plants.
Article
Biochemistry & Molecular Biology
Anastasiya Merkushova, Anton Shikov, Anton Nizhnikov, Kirill Antonets
Summary: This study conducted a comprehensive pangenome analysis of Salmonella enterica and identified potential loci determining host specificity. The study revealed high genetic diversity in the pangenome and identified multiple genes potentially associated with host specificity. Additionally, antibiotic resistance loci were found in host-adapted strains.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Po-Hsun Fan, Yujie Geng, Anthony J. Romo, Aoshu Zhong, Jiawei Zhang, Yu-Cheng Yeh, Yu-Hsuan Lee, Hung-wen Liu
Summary: In this study, the biosynthetic gene cluster of albucidin was identified in Streptomyces, and it was confirmed that alsA and alsB genes are necessary and sufficient for the biosynthesis of albucidin. Moreover, the two-step construction of albucidin 4'-phosphate from 2'-dAMP was shown to be catalyzed by the enzymes AlsB and AlsA. Isotope labeling studies provided insights into the initial steps of the catalytic reaction.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Plant Sciences
Prathap Reddy Kallamadi, Praduman Yadav, Kamakshi Dandu, Prashant Kumar Soni, Chander Rao Sankaraneni, Kirti Pulugurtha Bharadwaja, Sujatha Mulpuri
Summary: Infection by a plant pathogen leads to the production of reactive oxygen intermediates (ROIs) in the plant, which play an important role in plant resistance. Susceptible genotypes exhibit higher levels of ROIs, resulting in cell damage, while resistant genotypes have lower levels of ROIs and higher antioxidant enzyme activities.
TROPICAL PLANT PATHOLOGY
(2022)
Review
Plant Sciences
Serena Schwenkert, Alisdair R. Fernie, Peter Geigenberger, Dario Leister, Torsten Moehlmann, Belen Naranjo, H. Ekkehard Neuhaus
Summary: Changes in chloroplast metabolism play a critical role in the comprehensive cellular response to challenging environments, starting with rapid modifications of processes in the thylakoid membrane, followed by changes in the stroma and transport activities across the chloroplast envelope. Understanding the characteristics of the 'modulators' involved is essential for enhancing plant stress tolerance and developing targeted breeding strategies.
TRENDS IN PLANT SCIENCE
(2022)
Article
Medicine, Research & Experimental
Nirmal Kumar Mohakud, Rakesh Kumar Panda, Dibyangshee Singh, Saumya Darshana Patra, Faizan Zarreen Simnani, Adrija Sinha, Aditya Nandi, Ealisha Jha, Sarita Singh, Nagendra Kumar Kaushik, Pritam Kumar Panda, Deobrat Singh, Suresh K. Verma, Mrutyunjay Suar
Summary: This study evaluates the mechanistic antimicrobial effect of nitrofurantoin against a multidrug resistant strain of Salmonella. The results showed a potent dose-dependent antibacterial effect of nitrofurantoin through molecular interactions with membrane proteins and oxidative stress. This research highlights the potential use of nitrofurantoin as a treatment option against multidrug resistant Salmonella strains.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Engineering, Environmental
Congjun Li, Yu Fu, Yingxuan Tian, Zihan Zang, Eleni Gentekaki, Zhenyuan Wang, Alan Warren, Lifang Li
Summary: The development of industry has led to excessive zinc exposure in the environment, causing health problems in various organisms. This study investigates how aquatic microorganisms respond to zinc stress. The ciliated protozoan Paramecium was used as a cellular model to explore the toxicity and detoxification mechanisms during zinc stress response. The results show that long-term zinc exposure inhibits population growth in ciliates, and the response mechanism to zinc exposure is dose-dependent and time-dependent. The excessive zinc ions cause adverse effects on cellular structure and function, leading to damage to DNA and proteins, disturbance of mitochondrial function, and oxidative stress.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Plant Sciences
Nandni Sharma, Rajesh Kumari Manhas, Renu Bhardwaj, Puja Ohri
Summary: The study showed that the metabolites produced by Streptomyces sp. strain MR-14 have nematicidal potential against Meloidogyne incognita, reducing gall formation and enhancing photosynthetic activities and antioxidative defense mechanism in infected plants. Microscopic studies also confirmed the biocontrol potential of Streptomyces sp. strain MR-14 to not only promote plant growth but also improve biochemical responses in infected plants.
JOURNAL OF PLANT GROWTH REGULATION
(2022)
Article
Plant Sciences
Quan-Cheng Zhang, Xiao-Xia Deng, Jun-Gang Wang
Summary: The study found that DPC can enhance cotton resistance to cotton aphids by increasing soluble protein content and protective enzyme activity, while also exerting toxicity against cotton aphids. Under aphid stress, DPC can increase soluble protein content and protective enzyme activity in cotton, thereby enhancing tolerance to cotton aphids.
Article
Biotechnology & Applied Microbiology
Tatiana Botin, Luis Ramirez-Chamorro, Jasmina Vidic, Philippe Langella, Isabelle Martin-Verstraete, Jean-Marc Chatel, Sandrine Auger
Summary: This study investigated the impact of oxidative stress on various strains of faecalibacteria and found that they exhibited different sensitivities to oxidative stress. Through genomic analysis and experimental validation, it was discovered that the bacteria have protective mechanisms against oxidative stress, and a gene regulatory network model for F. longum L2-6 in response to oxidative stress was proposed.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Biology
Jack F. Cazet, Adrienne Cho, Celina E. Juliano
Summary: During whole-body regeneration in the cnidarian Hydra vulgaris, a bisection injury can trigger oral and aboral regeneration. The initial response to amputation at both wound sites is identical, but Wnt signaling becomes restricted to oral regeneration by 8 hr post amputation. Additionally, Wnt signaling is likely part of a conserved wound response predating the split of cnidarians and bilaterians.
Article
Multidisciplinary Sciences
Yang Hong, Han Dong, Jing Zhou, Ya Luo, Ming-Ming Yuan, Jia-Fei Zhan, Yang-Lu M. Liu, Jie-Ying M. Xia, Lei M. Zhang
Summary: Age-associated impairment in antioxidant defense is an important cause of oxidative stress, and elderly individuals are usually associated with gut microbiota (GM) changes. Studies have suggested a potential relationship between the GM and changes in antioxidant defense in aging animals. Direct evidence regarding the impact of aging-associated shifts in GM on the antioxidant defense is lacking.
Article
Dermatology
Helen Strandt, Odessa Voluzan, Tanja Niedermair, Uwe Ritter, Josef Thalhamer, Bernard Malissen, Angelika Stoecklinger, Sandrine Henri
Summary: The study shows that dermal macrophages and fibroblasts contribute differently to tattoo stability by carrying pigment particles in varying amounts. This research enhances our understanding of the persistence of tattoos.
Article
Nanoscience & Nanotechnology
Ravinder K. Singh, Camille Malosse, Joanne Davies, Bernard Malissen, Efrat Kochba, Yotam Levin, James C. Birchall, Sion A. Coulman, Jan Mous, Martina A. McAteer, Colin M. Dayan, Sandrine Henri, F. Susan Wong
Summary: The study showed that conjugating ultra-small gold nanoparticles with poorly soluble auto-antigenic peptides can increase the distribution of peptides in lymphoid organs, enhancing their potential as therapeutic agents.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Veronique Gasser, Laurianne Kuhn, Thibaut Hubert, Laurent Aussel, Philippe Hammann, Isabelle J. Schalk
Summary: Bacteria access iron through siderophores, but Pseudomonas aeruginosa can also pirate siderophores produced by other microorganisms. Deletion of the pfeE gene in P. aeruginosa prevents it from accessing iron through enterobactin. Under iron-restricted conditions, P. aeruginosa strongly represses E. coli growth as long as it can produce its own siderophores, but if it cannot, it relies on enterobactin produced by E. coli. If pfeE is deleted, E. coli gains the upper hand in the culture.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Thanida Laopanupong, Pinidphon Prombutara, Phongthon Kanjanasirirat, Salisa Benjaskulluecha, Atsadang Boonmee, Tanapat Palaga, Stephane Meresse, Jiraporn Paha, Tegar Adriansyah Putra Siregar, Tanawadee Khumpanied, Suparerk Borwornpinyo, Angkana Chaiprasert, Pongsak Utaisincharoen, Marisa Ponpuak
Summary: This study showed that specific genes such as Kxd1 and Plekhm2 are upregulated in macrophages infected with autophagy-resistant Beijing strain of Mycobacterium tuberculosis, compared to those infected with the reference strain H37Rv, leading to suppression of lysosome positioning and delivery during starvation-induced autophagy. These genes play a crucial role in allowing the BJN strain to evade autophagic restriction and survive within host cells.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Le He, Marie-Pierre Valignat, Lichen Zhang, Lena Gelard, Fanghui Zhang, Valentin Le Guen, Stephane Audebert, Luc Camoin, Even Fossum, Bjarne Bogen, Hui Wang, Sandrine Henri, Romain Roncagalli, Olivier Theodoly, Yinming Liang, Marie Malissen, Bernard Malissen
Summary: The study reveals that ARHGAP45 GAP plays a key role in the lifecycle of T and B cells, controlling cell deformability and motility which affect the entry of cells into lymph nodes and engraftment in the bone marrow.
Editorial Material
Medicine, Research & Experimental
Samuel Carien, Maverick Hannoun, Delphine Lefebvre, Audrey Tempier, Laurent Aussel
M S-MEDECINE SCIENCES
(2021)
Editorial Material
Medicine, Research & Experimental
Marie Corteggiani, Lucas Gombert, Callypso Pellegri, Laurent Aussel
M S-MEDECINE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Laurent Aussel, Benjamin Ezraty
Summary: Bacteria have evolved sophisticated systems, such as methionine sulfoxide reductases (Msr), to maintain protein structure and function during oxidative stress. Msr repair oxidatively protein-bound methionine residues (Met-O) and work in coordination with chaperone networks to rescue protein function. Integration of methionine redox homeostasis in protein quality control gives a complete picture of bacterial adaptive mechanism during oxidative stress.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Cell Biology
Ziyan Fang, Mathieu Fallet, Thomas Moest, Jean-Pierre Gorvel, Stephane Meresse
Summary: In this study, it was found that the microtubule molecular motor KIF1B beta plays a key role in the establishment of the Salmonella replication niche, and its absence affects the stability of bacterial vacuoles and the formation of associated tubules. Kinesin-3 interacts with the Salmonella effector SifA and the host protein complex SKIP. The presence of SifA establishes a recruitment pathway for kinesin-1 and kinesin-3 in infected cells.
JOURNAL OF CELL SCIENCE
(2022)
Correction
Biochemistry & Molecular Biology
Aleksandra Deczkowska, Eyal David, Pierluigi Ramadori, Dominik Pfister, Michal Safran, Baoguo Li, Amir Giladi, Diego Adhemar Jaitin, Oren Barboy, Merav Cohen, Ido Yofe, Chamutal Gur, Shir Shlomi-Loubaton, Sandrine Henri, Yousuf Suhail, Mengjie Qiu, Shing Kam, Hila Hermon, Eylon Lahat, Gil Ben Yakov, Oranit Cohen-Ezra, Yana Davidov, Mariya Likhter, David Goitein, Susanne Roth, Achim Weber, Bernard Malissen, Assaf Weiner, Ziv Ben-Ari, Mathias Heikenwalder, Eran Elinav, Ido Amit
Article
Multidisciplinary Sciences
S. Holbert, E. Barilleau, S. M. Roche, J. Trotereau, S. Georgeault, J. Burlaud-Gaillard, A. Wiedemann, S. Meresse, I Virlogeux-Payant, P. Velge
Summary: Numerous studies have shown that the Salmonella Pathogenicity Island 1-encoded type III secretion system (T3SS1) apparatus and its associated effectors play a key role in the invasion and intracellular fate of Salmonella in host cells. Some cell lines have been identified where Salmonella Typhimurium can enter without using its three known invasion factors. In the murine AML12 hepatocyte cell line, the T3SS1 mutant induced an intracellular fate similar to the wild-type strain, indicating that invasion and survival of Salmonella Typhimurium can be independent of T3SS1.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Theresa Rohm, Lena Keller, Angela J. T. Bosch, Shefaa AlAsfoor, Zora Baumann, Amandine Thomas, Sophia J. Wiedemann, Laura Steiger, Elise Dalmas, Josua Wehner, Leila Rachid, Catherine Mooser, Bahtiyar Yilmaz, Nerea Fernandez Trigo, Annaise J. Jauch, Stephan Wueest, Daniel Konrad, Sandrine Henri, Jan H. Niess, Petr Hruz, Stephanie C. Ganal-Vonarburg, Julien Roux, Daniel T. Meier, Claudia Cavelti-Weder
Summary: Expansion of pro-inflammatory macrophages in the colon occurs early after high-fat diet initiation, prior to macrophage accumulation in the adipose tissue, in a microbiome-dependent fashion. Macrophage depletion systemically and/or exclusively in the colon improves glucose metabolism. This study highlights the importance of colonic macrophage subpopulations in regulating glucose homeostasis and suggests that pharmacological targeting of these macrophages may be a potential therapy for obesity-related glycemic control.
COMMUNICATIONS BIOLOGY
(2022)
Article
Genetics & Heredity
Alexandra Vergnes, Camille Henry, Gaia Grassini, Laurent Loiseau, Sara El Hajj, Yann Denis, Anne Galinier, Didier Vertommen, Laurent Aussel, Benjamin Ezraty
Summary: Methionine residues are sensitive to oxidation by ROS/RCS, which can be reversed by Msr proteins. In E. coli, the MsrPQ system is induced by both reactive oxygen species and copper stress, playing a role in maintaining copper homeostasis.
Article
Biology
Richard Miallot, Virginie Millet, Yann Groult, Angelika Modelska, Lydie Crescence, Sandrine Roulland, Sandrine Henri, Bernard Malissen, Nicolas Brouilly, Laurence Panicot-Dubois, Renaud Vincentelli, Gerlind Sulzenbacher, Pascal Finetti, Aurelie Dutour, Jean-Yves Blay, Francois Bertucci, Franck Galland, Philippe Naquet
Summary: Aggressive tumors often have dysfunctional mitochondria. OMA1 mediates fission of mitochondria in response to oxidative stress through cleavage of the fusion effector OPA1. In this study, mutation of cysteine 403 in OMA1 impaired mitochondrial responses to stress, resulting in reduced ATP production, resistance to apoptosis, and enhanced mitochondrial DNA release. Inactivation of OMA1 increased anti-tumor immunity and may enhance sarcoma immunogenicity.
LIFE SCIENCE ALLIANCE
(2023)
Meeting Abstract
Immunology
R. Miallot, V. Millet, A. Roger, R. Fenouil, G. Charbonnier, T. Vannier, C. Tardivel, M. Grange, H. Luche, J. C. Martin, L. Shintu, P. Berchard, N. Brouilly, F. Richard, Lanza J. Souza, T. T. Nguyen, F. Galland, A. Dutour, S. Henri, S. Ugolini, F. Bertucci, J. Y. Blay, P. Naquet
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)