Article
Food Science & Technology
Gang Du, Xingyu Zhang, Yuting Gao, Cunying Sun, Liwen Wang, Wei Zhao, Dan Meng, Wenqiang Guan, Hui Zhao
Summary: Ginger is commonly used in traditional Chinese medicine as a natural remedy for cold, and it has thermogenic effects when consumed. This study revealed that ginger oleoresin stress and heat stress had similar effects on yeast and shared genes. The transcription factor Hsf1 was found to be phosphorylated and activated in response to ginger oleoresin stress, leading to increased expression of heat shock proteins.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Attila Becskei, Sayanur Rahaman
Summary: Temperature has a significant impact on cells and RNA metabolism, and similar mechanisms of sensing and withstanding heat have been identified in different organisms. New questions have emerged regarding the temperature dependence of RNA metabolism, such as whether cells are exposed to greater temperature variations and gradients, and the contribution of enzymes to temperature compensation in mRNA turnover.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Fabio Hedayioglu, Emma J. Mead, Patrick B. F. O'Connor, Matas Skiotys, Owen J. Sansom, Giovanna R. Mallucci, Anne E. Willis, Pavel Baranov, C. Mark Smales, Tobias von der Haar
Summary: The study validates two experimental tools for assessing ribosome binding to mRNAs, highlighting the usefulness of polysome profile reconstructions in evaluating dataset quality.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Xiang Meng, Alan Reed, Sandie Lai, Juraj Szavits-Nossan, John E. G. McCarthy
Summary: Gene expression stochasticity is an inherent feature of biological systems, creating non-genetic cellular variation and influencing various processes. In this study, the researchers discovered a distinct form of non-transcriptional noise associated with the translation machinery and mRNA 5'UTR of the GCN4 gene in yeast. They characterized the heterogeneity of translation initiation mediated by GCN4-5'UTR using different techniques and found a subpopulation of cells that consistently exhibited enhanced GCN4 translation under non-starvation conditions.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
So-Young Yoon, Eunhong Jang, Naho Ko, Minseok Kim, Su Yoon Kim, Yeojin Moon, Jeong-Seok Nam, Sunjae Lee, Youngsoo Jun
Summary: The asymmetry in cytosolic pH between mother and daughter cells is believed to be responsible for cellular aging in budding yeast. Preferential accumulation of Pma1p in mother cells, which reduces the level of cytoplasmic protons, is thought to contribute to this pH increase. However, this study found that the accumulation of Pma1p in mother cells is not the key determinant of aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Grzegorz Klosowski, Beata Koim-Puchowska, Joanna Drozdz-Afelt, Dawid Mikulski
Summary: This study investigated the response mechanisms of yeast cells to mycotoxins and found that the growth of yeast biomass was inhibited at different concentrations of toxins. The level of malondialdehyde increased, and the expression of heat shock proteins varied depending on the mycotoxin used.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Agnes Baudin-Baillieu, Olivier Namy
Summary: Ribosomal RNA is a crucial component of ribosomes, playing a key role in peptide bond formation and accurate genetic code decoding. Recent research suggests that ribosomal RNA modifications are not 100% complete, leading to heterogeneous populations of ribosomes. Accumulated knowledge from yeast is valuable in understanding the role of ribosomal RNA modifications in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Dewei Du, Wenbo Jiang, Lei Feng, Yu Zhang, Peng Chen, Chengqiang Wang, Zhiyong Hu
Summary: The study investigated the effect of adding Saccharomyces cerevisiae culture on heat-stressed cows. It was found that the addition of S. cerevisiae culture can improve rumen microbial composition, function, and metabolites in heat-stressed cows, thereby enhancing rumen cellulolytic capacity.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chen Liu, Andriani Mentzelopoulou, Ioannis H. Hatzianestis, Epameinondas Tzagkarakis, Vasileios Skaltsogiannis, Xuemin Ma, Vassiliki A. Michalopoulou, Francisco J. Romero-Campero, Ana B. Romero-Losada, Panagiotis F. Sarris, Peter Marhavy, Bettina Boelter, Alexandros Kanterakis, Emilio Gutierrez-Beltran, Panagiotis N. Moschou
Summary: This study presents a proximity-biotinylation approach for capturing the RNAs in cellular condensates known as processing bodies (PBs). The researchers found that the RNA composition in PBs is more dynamic compared to the total transcriptome. They identified enriched RNAs involved in cell wall development, plant hormonal signaling, and RNA metabolism within PBs. The study also revealed that RNA-binding proteins and the liquidity of PBs modulate RNA recruitment, and RNAs in PBs can have different fates depending on the size and type of the PB.
Article
Microbiology
Ligang Xue, Shuyi Zhou, Dan Wang, Fangyu Zhang, Junfeng Li, Liyuan Cai
Summary: This study investigated the effects of Saccharomyces cerevisiae on rumen fermentation and the growth performance of heat-stressed goats. The results showed that supplementing with a low dose of Saccharomyces cerevisiae could improve rumen fermentation and growth performance in heat-stressed goats. The study suggests that Saccharomyces cerevisiae has the potential to be used as a supplement for heat-stressed goats.
Article
Biochemistry & Molecular Biology
Saadat Hussain, Nori Sadouni, Dominic van Essen, Lan T. M. Dao, Quentin Ferre, Guillaume Charbonnier, Magali Torres, Frederic Gallardo, Charles-Henri Lecellier, Tom Sexton, Simona Saccani, Salvatore Spicuglia
Summary: This study uses the STARR-seq method to identify and characterize silencer elements in mammals. The identified silencers are associated with chromatin marks and known transcriptional repressors, and are involved in the repression of non-T cell genes and genes regulated during T cell differentiation. Additionally, the study reveals the role of short tandem repeats in silencer activity.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Computer Science, Artificial Intelligence
Payal Khullar
Summary: This article presents an experiment evaluating the impact of different types of ellipsis on Neural Machine Translation, showing that reconstructing ellipses with their antecedents can improve translation adequacy. It suggests a possible correlation between morphological incongruity of source and target languages and the translation of discourse devices like ellipses, advocating for varied treatment of different types of ellipses in research.
COMPUTATIONAL LINGUISTICS
(2021)
Article
Microbiology
Tianyu Zhao, Asaka Chida, Yuichi Shichino, Dongwoo Choi, Masaki Mizunuma, Shintaro Iwasaki, Yoshikazu Ohya
Summary: This study reveals the global translational regulation during replicative aging in yeast using ribosome profiling technique. The research found that the translational efficiency of genes involved in DNA repair and chromosome organization increased, while the translational efficiency of genes encoding ribosome components, transposons and cell wall assembly decreased during replicative aging.
Article
Biochemistry & Molecular Biology
Tehseen Rubbab, Cassandra L. Pegg, Toan K. Phung, Amanda S. Nouwens, K. Y. Benjamin Yeo, Lucia F. Zacchi, Amna Muhammad, S. M. Saqlan Naqvi, Benjamin L. Schulz
Summary: The University of Queensland, School of Chemistry and Molecular Biosciences Mass Spectrometry Facility provided assistance and expertise. This work was supported by a grant from the HEC Pakistan to Tehseen Rubbab under the International Research Support Initiative Program.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Hong Zhang, Parker Murphy, Jason Yu, Sukyeong Lee, Francis T. F. Tsai, Ambro van Hoof, Jiqiang Ling
Summary: Aminoacyl-tRNA synthetases (aaRSs), essential enzymes for protein synthesis, can cause neurological disorders when mutated. This study investigates the mechanism behind these mutations and found that combined defects in aminoacylation and editing result in severe proteotoxicity. The results show that aminoacylation deficiency predisposes cells to proteotoxic stress and impairs ribosome-associated quality control.
NUCLEIC ACIDS RESEARCH
(2023)