Article
Biochemistry & Molecular Biology
Eric Soupene, Frans A. Kuypers
Summary: The transfer of acyl chains to proteins and lipids is achieved by ACBD6 and NMT enzymes, which play an essential role in protecting acyl donor from competitive inhibition. The absence of ACBD6/NMT complex leads to increased sensitivity to inhibitors and reduced myristoylation. ACBD6 also interacts with LPLAT enzymes, contributing to lipid acylation processes.
Review
Cell Biology
Chee Wai Fhu, Azhar Ali
Summary: Protein lipidation, a posttranslational modification involving lipid moieties, plays a crucial role in modulating the properties and interactions of proteins, closely linked to cellular metabolism. The two most common protein lipid modifications, palmitoylation and myristoylation, have significant implications in regulating cancer metabolism and progression. Dysregulation of protein lipidation is strongly associated with various diseases, highlighting the importance of understanding its roles in health and disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Jiyeon Seo, Hongik Hwang, Yuri Choi, Sunmin Jung, Jung-Hwa Hong, Bong-June Yoon, Hyewhon Rhim, Mikyoung Park
Summary: Many psychiatric disorders are associated with deficits in cognitive functions and synaptic plasticity, which are linked to abnormal lipid modifications of neuronal proteins. Cyclin Y (CCNY), located in the postsynaptic compartment, plays an inhibitory role in synaptic plasticity and spatial learning through myristoylation and palmitoylation.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Krithika P. Karthigeyan, Lizhi Zhang, David R. Loiselle, Timothy A. J. Haystead, Menakshi Bhat, Jacob S. Yount, Jesse J. Kwiek
Summary: Mammalian cells obtain fatty acids from diet or by de novo synthesis through FASN. FASN is upregulated in cancers and essential for replication of various viruses. Alk-4 is a valuable tool for selectively probing FASN-mediated protein acylation in disease states.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Review
Cell Biology
Garrison Komaniecki, Hening Lin
Summary: Post-translational acylation of lysine side chains, particularly by long-chain fatty acyl groups, is an important mechanism of protein regulation that affects protein affinity for specific cellular membranes. The full biological function of lysine fatty acylation is still not completely understood despite advancements in research over the past 30 years.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Rushita A. Bagchi, Emma L. Robinson, Tianjing Hu, Ji Cao, Jun Young Hong, Charles A. Tharp, Hanan Qasim, Kathleen M. Gavin, Julie Pires da Silva, Jennifer L. Major, Bradley K. McConnell, Edward Seto, Hening Lin, Timothy A. McKinsey
Summary: This article highlights the importance of lysine myristoylation in regulating protein localization and function, as well as its role in controlling G protein-coupled receptor signaling. Inhibiting HDAC11 may have therapeutic potential for manipulating adipocyte phenotypes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Physiology
Fanny L. Lemarie, Shaun S. Sanders, Yen Nguyen, Dale D. O. Martin, Michael R. Hayden
Summary: Huntington's disease is a neurodegenerative disorder caused by CAG repeat expansion in the HTT gene. We found that huntingtin protein can be palmitoylated at cysteine 214, and proteolytic cleavage at aspartate 552 leads to myristoylation at glycine 553. Blocking caspase cleavage at aspartate 586 increases myristoylation of huntingtin and promotes the interaction between C-terminal and N-terminal fragments.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Immunology
Wan Du, Timothy L. Frankel, Michael Green, Weiping Zou
Summary: The majority of colorectal cancer patients do not respond to immune checkpoint blockade, with the IFN gamma signaling pathway playing a crucial role in antitumor immunity. Targeting IFN gamma signaling for novel clinical trials in treating patients with colorectal cancer is of significant importance.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mengyuan Qu, Xuan Zhou, Xiaotong Wang, Honggang Li
Summary: Lipid metabolites play a key role in regulating protein function and cell signaling, particularly through palmitoylation. Dysregulation of palmitoylation, the most-studied protein lipidation process, has been implicated in various diseases. Further research is ongoing to explore the impact of palmitate on different diseases and potential therapeutic opportunities.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Shayahati Bieerkehazhi, Ying Fan, Savannah J. West, Ritika Tewari, Junsuk Ko, Tingting Mills, Darren Boehning, Askar M. Akimzhanov
Summary: The study demonstrates the importance of the enzyme DHHC21 in T cell receptor signal transduction and protein acylation. DHHC21 is critical for the activation of CD4(+) T cells and plays a role in the differentiation of effector T helper lineages.
JOURNAL OF CELL SCIENCE
(2022)
Article
Oncology
Austin Shipley, Gabriel Frampton, Bryan W. Davies, Benjamin J. Umlauf
Summary: In this study, we present a novel bacterial platform that selectively internalizes into brain tumor cells. This system has numerous potential benefits over current interventions and other microbial strategies for treating brain tumors.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Guangrong Zhu, Xiangyang Zheng, Zhifeng Wang, Xingzhi Xu
Summary: This review summarizes the role of lipid metabolite-associated post-translational modifications in regulating the DNA damage response and tumorigenesis, and discusses potential novel targets for anti-cancer drug development.
Article
Biology
Mengyang Fan, Wenchao Lu, Jianwei Che, Nicholas P. Kwiatkowski, Yang Gao, Hyuk-Soo Seo, Scott B. Ficarro, Prafulla C. Gokhale, Yao Liu, Ezekiel A. Geffken, Jimit Lakhani, Kijun Song, Miljan Kuljanin, Wenzhi Ji, Jie Jiang, Zhixiang He, Jason Tse, Andrew S. Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Joseph D. Mancias, Jarrod A. Marto, Sirano Dhe-Paganon, Tinghu Zhang, Nathanael S. Gray
Summary: This study reveals the development of covalent TEAD inhibitors and demonstrates their high therapeutic potential for treating cancers driven by TEAD-YAP alteration.
Article
Biochemistry & Molecular Biology
Man-Man Zhang, Min-Xia Guo, Qiu-Ping Zhang, Xue-Qin Chen, Na-Zhi Li, Qing Liu, Jie Cheng, Shi-Le Wang, Guang-Hui Xu, Cheng-Fu Li, Ji-Xiao Zhu, Li-Tao Yi
Summary: This study investigates the dynamic alteration of complement C3 and its receptor C3aR during depression and the mechanism of astrocyte-microglia IL-1R/C3/C3aR on synaptic pruning. The activation of complement C3/C3aR may be helpful in predicting the onset stage of depression.
CELL AND BIOSCIENCE
(2022)
Article
Oncology
Mahinbanu Mammadli, Rebecca Harris, Liye Suo, Adriana May, Teresa Gentile, Adam T. Waickman, Alaji Bah, Avery August, Elmar Nurmemmedov, Mobin Karimi
Summary: Regulatory T cells play a crucial role in controlling autoimmunity and inflammation. Inhibiting the Itk signaling pathway can increase the frequency of noncanonical Tregs and reduce the incidence of acute graft-versus-host disease without affecting graft-versus-leukemia effects. Targeting Itk signaling could be a potential therapeutic strategy for autoimmune disorders.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ana Lucia Giannini, Yifang Gao, Marie-Jose Bijlmakers
BIOCHEMICAL JOURNAL
(2008)
Article
Biochemistry & Molecular Biology
Francesca Capon, Marie-Jose Bijlmakers, Natalie Wolf, Maria Quaranta, Ulrike Huffmeier, Michael Allen, Kirsten Timms, Victor Abkevich, Alexander Gutin, Rhodri Smith, Richard B. Warren, Helen S. Young, Jane Worthington, A. David Burden, Christopher E. M. Griffiths, Adrian Hayday, Frank O. Nestle, Andre Reis, Jerry Lanchbury, Jonathan N. Barker, Richard C. Trembath
HUMAN MOLECULAR GENETICS
(2008)
Article
Biochemistry & Molecular Biology
Marie-Jose Bijlmakers, Seshu K. Kanneganti, Jonathan N. Barker, Richard C. Trembath, Francesca Capon
HUMAN MOLECULAR GENETICS
(2011)
Letter
Oncology
K. C. Lee, I. Ouwehand, A. L. Giannini, N. S. Thomas, N. J. Dibb, M. J. Bijlmakers
Article
Multidisciplinary Sciences
Matthew Lovatt, Marie-Jose Bijlmakers
Article
Multidisciplinary Sciences
Asghar Nasir, John D. Norton, Maria Baou, Anna Zekavati, Marie-Jose Bijlmakers, Steve Thompson, John J. Murphy
Article
Biochemistry & Molecular Biology
Dick John Pang, Adrian C. Hayday, Marie-Jose Bijlmakers
JOURNAL OF BIOLOGICAL CHEMISTRY
(2007)
Article
Chemistry, Multidisciplinary
Howard C. Hang, Ernst-Jan Geutjes, Gijsbert Grotenbreg, Annette M. Pollington, Marie Jose Bijlmakers, Hidde L. Ploegh
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2007)
Article
Biochemistry & Molecular Biology
A Giannini, MJ Bijlmakers
MOLECULAR AND CELLULAR BIOLOGY
(2004)
Article
Cell Biology
MJJE Bijlmakers, M Marsh
MOLECULAR BIOLOGY OF THE CELL
(2000)
Review
Cell Biology
MJ Bijlmakers, M Marsh
TRENDS IN CELL BIOLOGY
(2003)