Article
Biochemistry & Molecular Biology
Aurora Eliana Merulla, Michele Stella, Cristina Barbagallo, Rosalia Battaglia, Angela Caponnetto, Giuseppe Broggi, Roberto Altieri, Francesco Certo, Rosario Caltabiano, Marco Ragusa, Giuseppe Maria Vincenzo Barbagallo, Cinzia Di Pietro, Michele Purrello, Davide Barbagallo
Summary: This study investigates the role of circSMARCA5 in controlling miRNAs 126-3p and 515-5p in GBM cells, revealing a new subnetwork regulated by circSMARCA5 which affects downstream mRNA targets IGFBP2 and NRAS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Gordana Supic, Debora Stefik, Nemanja Ivkovic, Ahmad Sami, Katarina Zeljic, Sasa Jovic, Ruzica Kozomara, Danilo Vojvodic, Srboljub Stosic
Summary: miR-34b/c hypermethylation and low miR-34b expression may promote the progression of HPV-negative OSCC and predict a poor prognosis, providing evidence for miR-34b/c as a promising biomarker and therapeutic target for OSCC in the future.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Steven He, Rajdeep Chakraborty, Shoba Ranganathan
Summary: Oral cancer is a common type of head and neck squamous cell carcinoma, with a high mortality rate. International research on the molecular pathways of oral cancer has implications for early diagnosis, prognosis, and the development of new drugs. This review focuses on the pathways of proliferation and apoptosis in OSCC progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chikashi Minemura, Shunichi Asai, Ayaka Koma, Ikuko Kase-Kato, Nozomi Tanaka, Naoko Kikkawa, Atsushi Kasamatsu, Hidetaka Yokoe, Toyoyuki Hanazawa, Katsuhiro Uzawa, Naohiko Seki
Summary: Our recent study focused on the passenger strand of pre-miR-30e, miR-30e-3p, which was found to be downregulated in cancer tissues. We identified 11 target genes of miR-30e-3p that were highly expressed in head and neck squamous cell carcinoma (HNSCC) patients, and these genes were associated with poor survival rates. Silencing the expression of one of the target genes, SERPINE1, suppressed the malignant phenotypes of HNSCC cells. This study contributes to our understanding of the molecular pathogenesis of HNSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Chikashi Minemura, Shunichi Asai, Ayaka Koma, Naoko Kikkawa, Mayuko Kato, Atsushi Kasamatsu, Katsuhiro Uzawa, Toyoyuki Hanazawa, Naohiko Seki
Summary: Analysis of miRNA expression in head and neck squamous cell carcinoma (HNSCC) revealed downregulation of the miR-30 family, especially miR-30e-5p and miR-30c-1-3p, which are associated with shorter patient survival. Further investigation showed that miR-30e-5p suppresses HNSCC cell migration and controls multiple oncogenic genes, including FOXD1. Knockdown of FOXD1 inhibited malignant phenotypes of HNSCC cells. These findings provide potential prognostic markers and therapeutic targets for HNSCC.
Review
Biochemistry & Molecular Biology
Shang-Hung Chen, Sheng-Yen Hsiao, Kwang-Yu Chang, Jang-Yang Chang
Summary: Oral squamous cell carcinoma is a prevalent malignant disease worldwide, with Taiwan being particularly affected. Early detection is crucial, while understanding invasive features and the tumor microenvironment is essential for effective treatment strategies, especially for advanced cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Kodai Nakamura, Naomi Hiyake, Tomofumi Hamada, Seiya Yokoyama, Kazuki Mori, Kouta Yamashiro, Mahiro Beppu, Yasuaki Sagara, Yoshiaki Sagara, Tsuyoshi Sugiura
Summary: The study identified a combination of six microRNAs that could accurately distinguish oral squamous cell carcinoma (OSCC) from the control group with a higher degree of accuracy compared to traditional serum tumor markers like SCC-Ag. This specific microRNA panel may serve as a novel candidate biomarker for oral cancer diagnosis.
Article
Biochemistry & Molecular Biology
Sachi Oshima, Shunichi Asai, Naohiko Seki, Chikashi Minemura, Takashi Kinoshita, Yusuke Goto, Naoko Kikkawa, Shogo Moriya, Atsushi Kasamatsu, Toyoyuki Hanazawa, Katsuhiro Uzawa
Summary: The miRNAs miR-31-5p and miR-31-3p play important roles in regulating the oncogenic properties of HNSCC cells, affecting patient prognosis by controlling a series of genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Jingpeng Liu, Xiao Jiang, Ailing Zou, Zhaoyi Mai, Zhijie Huang, Liying Sun, Jianjiang Zhao
Summary: The study identified a unique circRNA, circIGHG, which is significantly upregulated in oral squamous cell carcinoma (OSCC) and associated with poor prognosis. It promotes OSCC invasion and metastasis by interacting with miR-142-5p and IGF2BP3, with epithelial-mesenchymal transition being the main mechanism. These findings suggest that circIGHG could serve as a biomarker and therapeutic target for early diagnosis and treatment of OSCC.
Article
Cell Biology
Kailing Zhou, Yu Sun, Dan Dong, Chenghai Zhao, Wei Wang
Summary: EMP3 acts as a potential tumor suppressor in breast cancer by inhibiting cell cycle progression, DNA repair, and stem-like properties, leading to enhanced sensitivity of breast cancer cells to DNA-damaging agents.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Shahin Alizadeh-Fanalou, Mohsen Khosravi, Fatemeh Alian, Shirin Rokhsartalb-Azar, Ali Nazarizadeh, Maryam Karimi-Dehkordi, Forogh Mohammadi
Summary: miR-1297, a microRNA with dual functions, exhibits abnormal expression in various human cancers, acting as both a tumor suppressor and an oncogene.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Jie Liu, Wen-Ping Lin, Yao Xiao, Nyimi Bushabu Fidele, Hai-Jun Yu, Zhi-Jun Sun
Summary: VISTA is highly and stably expressed in oral squamous cell carcinoma (OSCC), primarily in myeloid-derived immunosuppressive cells (MDSCs). VISTA blockade reduces the immunosuppressive microenvironment and delays tumor growth, potentially by suppressing the quantity and function of MDSCs while boosting the function of tumor-infiltrating T cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Retraction
Biotechnology & Applied Microbiology
W. Ruoming, Y. Zhen, Z. Tengteng, H. Jisheng
Summary: The article has been retracted. More details can be found in the Retraction Notice at https://doi.org/10.1038/s41417-021-00325-5.
CANCER GENE THERAPY
(2021)
Article
Nanoscience & Nanotechnology
Yuan Tao, Yingke Liu, Ziyan Dong, Xiaoxiao Chen, Yashi Wang, Ting Li, Jiaxin Li, Shuya Zang, Xuan He, Dong Chen, Zhihe Zhao, Man Li
Summary: This study developed dandelion-like size-shrinkable nanoparticles for tumor-targeted delivery of hypoxia regulator resveratrol and photodynamic agent chlorine e6, which enhanced the therapeutic effects of photodynamic therapy in oral squamous cell carcinoma by elevating oxygen content in tumor cells and inducing autophagic cell death and apoptosis.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Medicine, Research & Experimental
Qian Yi, Hanwei Cui, Yi Liao, Jianyi Xiong, Xiufeng Ye, Weichao Sun
Summary: MicroRNAs play critical roles in various biological processes; miRNA-338 is identified to participate in the progression of several cancers; the functions and underlying mechanisms of miRNA-338 in tumor progression remain unclear.
BIOMEDICINE & PHARMACOTHERAPY
(2021)