Article
Pharmacology & Pharmacy
Xinhui Liu, Siqi Liu, Denggui Luo, Shiying Huang, Fochang Wang, Bing Zhang, Yulian Chen, Lin Zheng, Jiandong Lu, Shunmin Li
Summary: The Jian-Pi-Yi-Shen formula (JPYSF) has been used to treat chronic kidney disease (CKD) for decades, but its mechanisms are not fully understood. This study demonstrated that JPYSF has renoprotective effects in a CKD rat model and may act through modulation of exosomal miRNAs, particularly miR-192-5p.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jinzhou Zheng, Wenhao Xu, Wangrui Liu, Haijia Tang, Jingen Lu, Kui Yu, Xiaoyun Song, Feng Li, Yu Wang, Rui Wang, Lili Chen, Hailiang Zhang, Yunhua Qiu, Gaomeng Wei, Xiqiu Zhou, Jianfeng Yang
Summary: This study investigated the potential targets and mechanisms of traditional Chinese medicine Bu-Shen-Jian-Pi-Fang (BSJPF) in the treatment of clear cell renal cell carcinoma using network pharmacology. The results showed that BSJPF affects tumor proliferation and metabolism, providing novel strategies for the treatment of ccRCC patients.
BIOSCIENCE REPORTS
(2021)
Article
Pharmacology & Pharmacy
Xinhui Liu, Ruyu Deng, Yulian Chen, Shiying Huang, Jiandong Lu, Lin Zheng, Guoliang Xiong, Shunmin Li
Summary: This study investigated the renoprotective effect and potential mechanism of a traditional Chinese medicine formula, Jian-Pi-Yi-Shen formula (JPYSF), in treating chronic kidney disease (CKD). The results showed that JPYSF treatment improved renal function and pathology, down-regulated fibrotic markers expression, and modulated tryptophan metabolism and AHR activation to protect against CKD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Houpan Song, Jingyue Qiu, Chang Yu, Meng Xiong, Chen Ou, Baoping Ren, Meiqi Zhong, Meiyan Zeng, Qinghua Peng
Summary: This study investigated the protective effects of Huang-Qi-Jian-Zhong-Tang (HQJZT) against Indomethacin (IND)-induced duodenal ulceration in rats and the underlying mechanisms. The results showed that HQJZT effectively protected the duodenal mucosa by improving ulcer index, tissue architecture, and blood flow. Additionally, HQJZT regulated the expression of inflammation-related genes through NF-κB and STAT signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Plant Sciences
Weiwei Liu, Jingyu Shang, Yinxiang Deng, Xiuzhen Han, Yugen Chen, Shuangshuang Wang, Ruwen Yang, Fan Dong, Hongtao Shang
Summary: The study evaluated the effects and mechanisms of Jian Pi Qing Gan Yin (JPQGY) on hepatic steatosis in a high-fat diet-induced NAFLD mouse model, showing that JPQGY can alleviate fatty liver disease through targeting multiple pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Food Science & Technology
Qiuhui Ren, Wouter Bakker, Laura de Haan, Ivonne M. C. M. Rietjens, Hans Bouwmeester
Summary: This study investigated the effects of hydroxyanthraquinones found in traditional Chinese medicine (TCM) and herbal extracts on the activation of Nrf2-EpRE mediated gene expression. The results showed that certain hydroxyanthraquinones can induce Nrf2 mediated gene expressions, indicating their potential role in promoting intestinal health. This study contributes to our understanding of the mechanisms and applications of TCM and herbal medicine.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Plant Sciences
Xia Cao, Yi Wang, Ying Chen, Mantong Zhao, Lanyuan Liang, Mengru Yang, Jianhua Li, Mingming Peng, Wei Li, Yiming Yue, Han Zhang, Chuanqiu Li, Zunpeng Shu
Summary: This review summarizes the literature on traditional Chinese medicine (TCM) treatments for chronic obstructive pulmonary disease (COPD) from 2016 to 2021. It discusses the TCM theories, experimental methods, extracts, active ingredients, and formulas used in the treatment of COPD, as well as their effects and mechanisms. TCM can treat COPD by suppressing inflammation, reducing oxidative stress, inhibiting apoptosis, and improving airway remodeling.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jingyuan Liu, Yuyong Jiang, Yao Liu, Lin Pu, Chunjing Du, Yuxin Li, Xiaojing Wang, Jie Ren, Wei Liu, Zhiyun Yang, Zhihai Chen, Rui Song, Wen Xie, Xianbo Wang
Summary: The study found that YDJDG can shorten the recovery time of COVID-19 patients, especially for those with mild/moderate cases or CD4 <660 cells/mu L, and performed better in terms of fever and pulmonary exudative lesions.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Plant Sciences
Yingying Li, Xinyu Ji, Haonan Wu, Xiang Li, Huamin Zhang, Danli Tang
Summary: This study reviewed the regulation of lipid metabolism by microbial metabolites in Traditional Chinese Medicine (TCM). It was found that TCM can effectively improve lipid metabolism through various mechanisms such as increasing SCFA levels, regulating BA metabolism, and reducing TMAO production. The findings suggest a potential new approach for better management of dyslipidemia in future clinical treatments.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Safaet Alam, Md. Moklesur Rahman Sarker, Sadia Afrin, Fahmida Tasnim Richi, Chao Zhao, Jin-Rong Zhou, Isa Naina Mohamed
Summary: The COVID-19 pandemic has greatly affected global public health and posed serious threats to human life. Researchers and pharmaceutical companies are actively seeking plant-based drug treatments for this virus and conducting multiple clinical trials to find effective solutions.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Musun Park, Min Hee Kim, So-Young Park, Inhwa Choi, Chang-Eop Kim
Summary: This study proposes a machine learning-based analysis tool to evaluate the clinical decision-making process of pattern identification in traditional medicine. The tool successfully identifies explicit and implicit knowledge in the process, and the analysis shows differences in the importance of explicit and implicit knowledge. This is the first study to evaluate the impact of explicit and implicit knowledge on the choice of traditional medicine doctors.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Chemistry, Medicinal
Yuan Sun, Xuan Chen, Lei Zhang, Wei-an Yuan, Qi Chen, Yi-bao Zhang, Lu-jiong Liu, Wei Zhang, Meng Sun
Summary: This article describes a clinical trial aimed at evaluating the efficacy and safety of Baofei Granules for COPD patients with lung and spleen qi deficiency syndrome. The trial will provide valuable clinical evidence for the integrated management of COPD with traditional Chinese medicine and Western medicine.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Respiratory System
Xue-Qing Yu, Jia-Qi Di, Wei Zhang, Geng-Shu Wei, Zhan-Ping Ma, Lei Wu, Xue-Feng Yu, Hui-Zhi Zhu, Miao Zhou, Cui-Ling Feng, Ji-Hong Feng, Ping Fan, Jian-Sheng Li, Jian-Ya Yang
Summary: The efficacy and safety of Bu-fei Yi-shen granules (BYGs) for chronic obstructive pulmonary disease (COPD) were evaluated. The results showed that BYG significantly reduced the frequencies of acute exacerbations (AEs) and AE-related hospitalizations in COPD patients, while improving clinical symptoms, quality of life, and exercise capacity.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Stephen T. Deyrup, Natalie C. Stagnitti, Mackenzie J. Perpetua, Siu Wah Wong-Deyrup
Summary: Traditional Chinese medicine (TCM) has been a primary source of medical treatment in East Asia for thousands of years, incorporating a wide variety of materia medica including insects like beetles. Research found that 48 species of beetles from 34 genera in TCM contain 129 chemical constituents with documented uses in Traditional Korean Medicine (TKM).
BIOMOLECULES & THERAPEUTICS
(2021)
Review
Clinical Neurology
Renjun Lv, Yan Zhao, Zhou Wang, Xueying Liu, Zhe Wang, Shangbin Li, Qin Yu, Hongmei Yue, Qingqing Yin
Summary: Western medicine and traditional Chinese medicine have different theoretical perspectives on OSAHS. However, ancient Chinese medicine has a long history of recognizing and treating this disease, and some of the traditional treatments are still used in clinical practice today.
SLEEP AND BREATHING
(2023)
Article
Integrative & Complementary Medicine
Liping Yang, Jiansheng Li, Ya Li, Yange Tian, Suyun Li, Suli Jiang, Ying Wang, Xuekun Song
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2015)
Article
Biochemical Research Methods
Xin-Cheng Sun, YunLong Wang, Liping Yang, HuiRu Zhang
JOURNAL OF VIROLOGICAL METHODS
(2015)
Article
Multidisciplinary Sciences
Jiansheng Li, Peng Zhao, Liping Yang, Ya Li, Yange Tian, Suyun Li
SCIENTIFIC REPORTS
(2016)
Article
Oncology
Peng Zhao, Jiansheng Li, Liping Yang, Ya Li, Yange Tian, Suyun Li
MOLECULAR MEDICINE REPORTS
(2018)
Article
Microbiology
Shaohui Geng, Liping Yang, Feng Cheng, Zhumou Zhang, Jiangbo Li, Wenbo Liu, Yujie Li, Yukun Chen, Yu Bao, Lin Chen, Zihao Fei, Xinmin Li, Junlin Hou, Yuan Lin, Zhilin Liu, Shuai Zhang, Hengtao Wang, Qing Zhang, Honggang Wang, Xiaodan Wang, Jingtao Zhang
FRONTIERS IN MICROBIOLOGY
(2020)
Letter
Public, Environmental & Occupational Health
Zhao-Yao Qi, Pci-Yuan Zhao, Shao-Hui Geng, Huai-Min Yi, Li-Ping Yang
JOURNAL OF EPIDEMIOLOGY
(2020)
Article
Neurosciences
Yu-jie Li, Li-ping Yang, Jun-lin Hou, Xin-min Li, Lei Chen, Jiang-hui Zhu, Qi-yang Wang, Gai Li, Pei-yuan Zhao, Xi-hong Liu, Zhan-jiang Shi
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2020)
Article
Psychiatry
Zhaoyao Qi, Mengke Lyu, Liping Yang, Haiyan Yuan, Yun Cao, Linlin Zhai, Weili Dang, Juan Liu, Fan Yang, Ying Li
Summary: This study established an autism rat model by transplanting fecal sample extract of ASD children into pregnant rats, showing typical behavioral characteristics of ASD. The gut microbiota of the model mainly consisted of Firmicutes and Bacteroidetes, reflecting the abnormal gut microbiota of ASD patients. The model displayed high structural validity and potential as a new and reliable animal model for studying ASD.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Yujie Li, Dandan Wei, Minghao Zhang, Tiantian Yue, Huimin Du, Qi Liu, Shihu Gan, Hanbin Liu, Yijie Dong, Xinyue Qiao, Yichi Zhang, Liping Yang
Summary: This study demonstrates that Xiaoyao Pill treatment can prevent behavioral deficits induced by sleep deprivation in mice by promoting the recovery of brain tissue injury and up-regulating the levels of NE, 5-HT, and DA in the brain tissue.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2022)
Article
Genetics & Heredity
Qiyang Wang, Mingmin Pan, Tong Zhang, Yu Jiang, Peiyuan Zhao, Xihong Liu, Anqi Gao, Liping Yang, Junlin Hou
Summary: Fear stress during pregnancy can lead to structural alterations in the placenta and affect placental development, and m6A modifications may play an important role in this process.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, General & Internal
Qingzhou Guan, Peng Zhao, Yange Tian, Liping Yang, Zhenzhen Zhang, Jiansheng Li
Summary: A cancer risk assessment signature was identified for patients with chronic obstructive pulmonary disease (COPD). The signature is insensitive to batch effects and has been well validated. The COPD key genes identified in this study may play a crucial role in traditional Chinese medicine treatment and cancer prevention.
ANNALS OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Peiyuan Zhao, Xihong Liu, Yunqian Wang, Xinyan Zhang, Han Wang, Xiaodan Du, Zhixin Du, Liping Yang, Junlin Hou
Summary: This study investigated the gray matter lesion-related genes in multiple sclerosis (MS) and identified TLR9, CCL5, CXCL8, and PDGFRB as potential biomarkers for gray matter injuries in MS. A reliable prediction model was established, and gene enrichment analysis revealed their association with cell adhesion molecules, cytokine-cytokine receptor interaction, and the JAK-STAT signaling pathway. These findings provide guidance for therapeutic intervention in MS.
Article
Behavioral Sciences
Yu Jiang, Tong Zhang, Liping Yang, Zhixin Du, Qiyang Wang, Junlin Hou, Yuexuan Liu, Qi Song, Jiajia Zhao, Yongye Wu
Summary: Mental disorders during pregnancy, such as anxiety and depression, can lead to adverse outcomes, but the underlying mechanisms are still being investigated. This study found that the FTO protein, which is involved in RNA modification, plays a role in and regulates mental disorders induced by fear stress in pregnant rats. The study also identified specific genes that are directly regulated by FTO and may be involved in the development of mental disorders.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Immunology
Zhixin Du, Yaohui Wang, Liping Yang, Tong Zhang, Yu Jiang, Zhenqiang Zhang
Summary: This study integrated bioinformatics and experimental validation to explore the mechanisms of inflammaging in the brain. The research found that inflammatory-related genes were closely associated with brain aging, and animal studies were conducted to validate the selected biomarkers. The study also discovered that CX3CL1 may play a role in the development of inflammaging by regulating macrophages, which suggests that targeting CX3CL1 can potentially delay inflammaging and immunosenescence in the brain.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jiansheng Li, Peng Zhao, Liping Yang, Ya Li, Yange Tian, Suyun Li, Yunping Bai
BIOSCIENCE REPORTS
(2017)
