Article
Cell Biology
Meike von Wulffen, Veronika Luehrmann, Stefanie Robeck, Antonella Russo, Lena Fischer-Riepe, Martijn van den Bosch, Peter van Lent, Karin Loser, Dmitry I. Gabrilovich, Sven Hermann, Johannes Roth, Thomas Vogl
Summary: This study demonstrates the crucial role of endogenous alarmin S100A8/A9 in autoimmune arthritis by reprogramming myeloid cells to a T cell suppressing phenotype. The reprogramming process is dependent on Toll-like receptor 4.
Article
Medicine, General & Internal
Wei Yan, Yingchun Shen, Jinny Huang, Ling Lu, Qian Zhang
Summary: MCC950 shows significant hepatoprotective effects in CCl4-induced ALI by enhancing M2 macrophage and MDSC function at different time points, suggesting a potential new therapeutic strategy.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Minjie Luo, Hao Wang, Ke Liu, Meidong Liu, Sipin Tan, Yaxi Zhu, Huali Zhang
Summary: This study demonstrates that blockade of IL-1R1 has a protective effect on liver injury in septic mice. Anakinra treatment and IL-1R1 deficiency inhibit the migration of MDSCs to the liver in sepsis, attenuating the immune suppression of MDSCs on effector T cells. Furthermore, IL-1R1 blockade promotes the switch from pro-inflammatory M1 macrophage to anti-inflammatory M2 phenotype and enhances bacterial clearance in the liver, contributing to the attenuation of liver injury.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Medicine, General & Internal
Suncica Kapor, Juan F. Santibanez
Summary: This review discusses the main features of MDSCs and MSCs in myeloid malignancies, revealing that MDSCs are elevated in numbers and exhibit strong immunosuppressive capabilities, while MSCs not only have immunosuppressive properties but also regulate the growth, apoptosis, and chemotherapy resistance of myeloid leukemia cells.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cell Biology
Vaishali Bhardwaj, Stephen M. M. Ansell
Summary: Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells composed of pathologically activated neutrophils and monocytes that negatively regulate the immune response to cancer and chronic infections. They exhibit distinct characteristics and exert strong immunosuppressive effects on T-cells and other immune cells, making them a major obstacle to cancer immunotherapies. However, the clinical outcomes of targeting MDSCs in hematological malignancies, particularly B-cell malignancies, still require further exploration. This review provides a comprehensive summary of the complex biology and immunosuppressive pathways of MDSCs, with a focus on their role in modulating T-cell function in hematological malignancies, and discusses the challenges, therapeutic strategies, and clinical relevance of targeting MDSCs in these diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Shweta Joshi, Andrew Sharabi
Summary: This review discusses the role of MDSCs in tumor growth, their interaction with NK cells, and the impact on NK cell-based immunotherapies, presenting strategies to enhance NK cell cytotoxicity.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biotechnology & Applied Microbiology
Richard Hopkins, Wenwei Xiang, Damien Marlier, Veonice Bijin Au, Qianting Ching, Lynn Xue Wu, Rujun Guan, Bernett Lee, Whay-Kuang Chia, Who-Whong Wang, Joseph Wee, Joanna Ng, Rachael Cheong, Shuting Han, Axel Chu, Chit Lai Chee, Timothy Shuen, Michael Podinger, Alexander Lezhava, Han Chong Toh, John E. Connolly
Summary: Late-stage EBV-positive NPC poses a challenge in treatment, but a combination of chemotherapy and EBVST immunotherapy has shown promising response rates. Analysis of EBV DNA plasma concentrations and peripheral monocyte levels can help predict overall survival in patients.
Article
Immunology
Bo Li, Min Lian, Yikang Li, Qiwei Qian, Jun Zhang, Qiaoyan Liu, Ruqi Tang, Xiong Ma
Summary: The study found that upregulation of LXR alpha in patients with autoimmune hepatitis can promote the expansion of MDSCs and alleviate hepatic injury. By downregulating IRF-8, LXR alpha plays an important role in MDSCs, providing a new approach to treating AIH.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Andrea Gaissler, Jonas Bochem, Janine Spreuer, Shannon Ottmann, Alexander Martens, Teresa Amaral, Nikolaus Benjamin Wagner, Manfred Claassen, Friedegund Meier, Patrick Terheyden, Claus Garbe, Thomas Eigentler, Benjamin Weide, Graham Pawelec, Kilian Wistuba-Hamprecht
Summary: This study investigated potential cellular biomarkers in patients with stage IV M1c melanoma undergoing immune checkpoint blockade (ICB). It was found that elevated baseline monocytic MDSC frequencies were associated with poorer outcomes, but a subgroup of patients with rapidly decreasing MDSC frequencies during therapy showed better prognosis, suggesting an imperfect correlation between high baseline MDSCs and patient outcomes.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Dentistry, Oral Surgery & Medicine
Kyu Hwan Kwack, Victoria Maglaras, Ramkumar Thiyagarajan, Lixia Zhang, Keith L. Kirkwood
Summary: Periodontitis is a common chronic inflammatory disease characterized by destruction of the supporting structures of the teeth. Severe periodontitis affects 10%-15% of adults and is associated with negative comorbidities. There is a clear relationship between obesity and incidence of periodontal disease, but the biological mechanisms are not fully understood. A new two-hit model is proposed to explain obesity-exacerbated periodontal bone loss, emphasizing the role of myeloid-derived suppressor cells.
PERIODONTOLOGY 2000
(2021)
Article
Immunology
Xueping Yu, Jian Sun, Feifei Yang, Richeng Mao, Zhiqing Shen, Lan Ren, Songhua Yuan, Qian He, Linxia Zhang, Yu Yang, Xiangqing Ding, Yongquan He, Haoxiang Zhu, Zhongliang Shen, Mengqi Zhu, Chao Qiu, Zhijun Su, Jiming Zhang
Summary: This study found that the proportion of granulocytic myeloid-derived suppressor cells (gMDSC) increased significantly in patients with Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF), and this increase was associated with disease severity, prognosis, and infection. Further experiments revealed that TNF-alpha induced gMDSC expansion and inhibited T cell proliferation and interferon-gamma production through the IDO signaling pathway. These findings have important implications for understanding the pathogenesis of HBV-ACLF and developing potential therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Houhui Shi, Kai Li, Yanghong Ni, Xiao Liang, Xia Zhao
Summary: T cell-based immunotherapy plays a crucial role in cancer treatment, but many patients still do not benefit from it. Researchers have identified myeloid-derived suppressor cells (MDSCs) as a key factor in immunotherapy resistance and are exploring combination therapies to improve efficacy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Samantha L. Tucker, Demba Sarr, Balazs Rada
Summary: Cystic Fibrosis is a genetic disease that causes chronic lung inflammation and infections, leading to high mortality rates. Immune system disruption in CF results in impaired immune responses, chronic infections with pathogens, and alterations in T cell and neutrophil functions. The role of P. aeruginosa and gMDSCs in T cell suppression and immune evasion in CF remains a subject of ongoing research.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Mengyi Shen, Xiaoli Fan, Yi Shen, Xiaoze Wang, Ruiqi Wu, Yi Wang, Chen Huang, Shenglan Zhao, Yanyi Zheng, Ruoting Men, Xuefeng Luo, Li Yang
Summary: The study investigated the efficacy and safety of myeloid-derived suppressor cells (MDSCs) in protecting against autoimmune hepatitis (AIH) and found that MDSCs ameliorate liver mitochondrial damage by releasing small extracellular vesicles, thus protecting the body from AIH.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Oncology
Zhaonian Hao, Ruyuan Li, Yuanyuan Wang, Shuangying Li, Zhenya Hong, Zhiqiang Han
Summary: MDSC play vital roles in cancer microenvironment, influencing the responses to immunotherapies and prognosis of cancer patients. Therefore, proposing MDSC-inhibiting strategies becomes crucial in the field of cancer immunotherapies.
BIOMARKER RESEARCH
(2021)