Article
Biotechnology & Applied Microbiology
Wenhao Wang, Jiansen Lu, Ying Song, Chun Zeng, Yongkui Wang, Cheng Yang, Bin Huang, Yifan Dai, Jian Yang, Liangxue Lai, Liping Wang, Daozhang Cai, Xiaochun Bai
Summary: In this study, GTKO pig cancellous bone showed advantages in repairing femoral condyle bone defects and inhibiting xenotransplant rejection. Compared with WT pig bone, GTKO pig bone had reduced heterologous immunogenicity, tightly integrated with the defect, and showed better osseointegration with an appropriate rate of resorption. Additionally, GTKO pig bone promoted new bone formation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Immunology
Hao Feng, Tao Li, Jiaxiang Du, Qiangbing Xia, Lu Wang, Song Chen, Lan Zhu, Dengke Pan, Yi Wang, Gang Chen
Summary: This study reveals the significance of Sda in pig-to-rhesus monkey xenotransplantation, highlighting the role of natural and induced anti-Sda antibodies in the immune response during transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medical Laboratory Technology
JinJu Kim, Woobin Yun, Yu Jin Park, Jieun Seo, Richard Dong Wook Lee, Saeam Shin, Hyun-Ji Lee, In Suk Kim, Jong Rak Choi, Seung-Tae Lee
Summary: CASAL is a simple, analytically sensitive and accurate assay that can be used in clinical samples after HSCT, with higher performance compared to traditional assays.
CLINICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Laura Breda, Tyler E. Papp, Michael P. Triebwasser, Amir Yadegari, Megan T. Fedorky, Naoto Tanaka, Osheiza Abdulmalik, Giulia Pavani, Yongping Wang, Stephan A. Grupp, Stella T. Chou, Houping Ni, Barbara L. Mui, Ying K. Tam, Drew Weissman, Stefano Rivella, Hamideh Parhiz
Summary: This study developed a nanoparticle system that can target hematopoietic stem cells in vivo and achieved correction of diseased cells through mRNA delivery. Furthermore, this system enables non-genotoxic conditioning for stem cells, providing a new approach for HSCT.
Article
Hematology
Rachael Hough, Andre Lopes, Pip Patrick, Nigel Russell, Kavita Raj, Eleni Tholouli, John A. Snowden, Matthew Collin, Nadjet El-Mehidi, Anthony Lawrie, Laura Clifton-Hadley, Paul Veys, Charles Craddock, Stephen Mackinnon, Gordon Cook, Bronwen Shaw, David Marks
Summary: Umbilical cord blood transplantation (UCBT) is a potentially curative therapy for patients with bone marrow and immune system disorders. Reduced intensity conditioning (RIC) regimens and double umbilical cord unit infusions (DUCBT) have expanded the applicability of UCBT to more frail or larger recipients. This study prospectively evaluated the role of lineage-specific chimerism after DUCBT in adult patients with hematologic malignancies in the United Kingdom, providing novel insights into the kinetics of donor and recipient chimerism after RIC DUCBT.
Article
Cell Biology
Hajime Sasaki, Takayuki Hirose, Tetsu Oura, Ryo Otsuka, Ivy Rosales, David Ma, Grace Lassiter, Ahmad Karadagi, Toshihide Tomosugi, Abbas Dehnadi, Masatoshi Matsunami, Susan Raju Paul, Patrick M. Reeves, Isabel Hanekamp, Samuel Schwartz, Robert B. Colvin, Hang Lee, Thomas R. Spitzer, A. Benedict Cosimi, Pietro E. Cippa, Thomas Fehr, Tatsuo Kawai
Summary: Hematopoietic stem cell transplantation (HSCT) has potential applications beyond current standard indications. Selective inhibition of B cell lymphoma 2 (Bcl-2) shows promise in promoting hematopoietic chimerism without myelosuppression and making HSCT more feasible for a variety of clinical indications.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Hematology
Allistair A. Abraham, John F. Tisdale
Summary: Gene therapy holds promise as a potential cure for sickle cell disease, with advancements in genome sequencing and molecular tools enabling gene modification of hematopoietic stem cells. Despite hurdles such as stem cell collection and gene expression levels, discovery of genome editors has enhanced the safety and efficacy of gene therapy. The progress to clinical trials has been supported by optimizing gene-addition strategies and addressing challenges such as patient conditioning and specialized facilities for gene modification.
Article
Ophthalmology
Imani M. Williams, Roberto Pineda, Vamsee K. Neerukonda, Anna M. Stagner
Summary: This study investigates the anterior segment clinical features, histopathologic, and histochemical characteristics of corneas from patients with MPS I spectrum disease undergoing corneal transplantation. The results show significant corneal clouding in MPS I patients, which can be successfully treated with deep anterior lamellar keratoplasty. The excised corneas exhibit characteristic changes and deposits, providing important clues for the possibility of an underlying lysosomal storage disorder.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Immunology
Daniel L. Eisenson, Yu Hisadome, Kazuhiko Yamada
Summary: Organ transplantation is the most effective treatment for end stage organ failure, but there is a shortage of organs. Xenotransplantation using pig tissues is a potential solution to this issue. While gene editing has made significant progress, recent data suggests that it alone cannot overcome all immune barriers in xenotransplantation, necessitating active and innovative immunologic strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Kai Dai, Qinghao Zhang, Shunshu Deng, Yuanman Yu, Fuwei Zhu, Shuang Zhang, YuanZhong Pan, Dandan Long, Jing Wang, Changsheng Liu
Summary: Constructing in vivo osteo-organoids by implanting bone morphogenetic protein-2-loaded scaffolds into the internal muscle pocket near the femur of mice supports the growth and subsequent harvest of therapeutically useful cells, and these cells demonstrate therapeutic potentials in cell therapies such as mitigating chronic liver fibrosis and reconstituting impaired immune organs.
Article
Hematology
Hannah Kinoshita, Mamatha Mandava, Mariah Jensen-Wachspress, Haili Lang, Elisabeth Joy, Jay Tanna, Chase D. McCann, Samuel O'Brien, Sianna Burnett, Abeer Shibli, Fahmida Hoq, Monica Bhatia, Patrick J. Hanley, Blachy Davila Saldana, Kris M. Mahadeo, Catherine M. Bollard, Michael D. Keller, Allistair Abraham
Summary: Hematopoietic stem cell transplantation (HSCT) is increasingly used to treat sickle cell disease (SCD). However, this treatment increases the risk of viral infection. This study explores the use of virus-specific T-cell (VST) therapies after HSCT to prevent or treat viral infections in SCD patients.
Article
Immunology
Jae Won Oh, Chang Ho Yoon, Jin Suk Ryu, Kwang Pyo Kim, Mee Kum Kim
Summary: This study aimed to investigate the major rejection pathways in corneal xenotransplantation and to find biomarkers in aqueous humor for predicting rejection. The results showed that complement proteins and cholesterol metabolic proteins were related to xenogeneic rejection, and alternative pathways of the complement system played an important role in rejection. Additionally, NF-kappa B1 and proteosomes seemed to be associated with xenogeneic graft rejection, and oxidative phosphorylation and leukocyte activation-related pathways were involved in rejection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Michael H. Albert, Mary A. Slatter, Andrew R. Gennery, Tayfun Gungor, Katerina Bakunina, Benyamin Markovitch, Sheree Hazelaar, Tiarlan Sirait, Virginie Courteille, Alessandro Aiuti, Olga Aleinikova, Dmitry Balashov, Maria Ester Bernardo, Ivana Bodova, Benedicte Bruno, Marina Cavazzana, Robert Chiesa, Alain Fischer, Fabian Hauck, Marianne Ifversen, Krzysztof Kalwak, Christoph Klein, Alexander Kulagin, Alphan Kupesiz, Baris Kuskonmaz, Caroline A. Lindemans, Franco Locatelli, Su Han Lum, Alexey Maschan, Roland Meisel, Despina Moshous, Fulvio Porta, Martin G. Sauer, Petr Sedlacek, Ansgar Schulz, Felipe Suarez, Tanja C. Vallee, Jacek H. Winiarski, Marco Zecca, Benedicte Neven, Paul Veys, Arjan C. Lankester
Summary: This study analyzed the data of 197 patients with Wiskott-Aldrich syndrome (WAS) who underwent HSCT treatment at European Society for Blood and Marrow Transplantation centers between 2006 and 2017. The study found that there was no significant impact on overall survival and chronic GVHD-free survival based on conditioning regimen, donor type, or period of HSCT. Patients aged under 5 years had a significantly better overall survival.
Article
Neurosciences
Zhong-Yuan Yu, Man-Yu Xu, Zhi-Hao Liu, Gui-Hua Zeng, Huan Fan, Cheng-Rong Tan, Yun-Feng Tu, Xian-Le Bu, Yan-Jiang Wang
Summary: This study investigated the effects of chemotherapy dosage on brain damage in bone marrow transplantation. Higher dosage was found to cause brain injury and neuroinflammation, while lower dosage showed no such adverse effects.
NEUROTOXICITY RESEARCH
(2022)
Article
Medicine, Research & Experimental
Hidetaka Hara, Jeremy B. Foote, Christophe Hansen-Estruch, Mohamed H. Bikhet, Huy Q. Nguyen, Mariyam Javed, Max Oscherwitz, Dalis E. Collins, David Ayares, Takayuki Yamamoto, Timothy W. King, David K. C. Cooper
Summary: Genetically modified pig skin xenografts can survive as long as monkey skin allografts, making them a realistic clinical option for temporary treatment of burns. The presence of anti-pig antibodies in monkeys with pig skin grafts does not have detrimental effects on subsequent monkey skin allografts.
XENOTRANSPLANTATION
(2023)