Article
Biotechnology & Applied Microbiology
Yuxiao Zheng, Feng Qi, Lu Li, Bin Yu, Yifei Cheng, Minghui Ge, Chao Qin, Xiao Li
Summary: This study identified lncNAP1L6 as an oncogene in prostate cancer (PCa) and suggested it as a potential therapeutic target. Functional assays revealed that lncNAP1L6 promotes cell migration, invasion, and epithelial-mesenchymal transition (EMT) in PCa. Mechanism assays showed that lncNAP1L6 regulates NAP1L2 mRNA stability through METTL14/METTL3 complex-mediated m6A methylation and interacts with YY1 to activate MMP signaling pathway.
CANCER GENE THERAPY
(2023)
Article
Oncology
Yara Rodriguez, Kenji Unno, Mihai I. Truica, Zachary R. Chalmers, Young A. Yoo, Rajita Vatapalli, Vinay Sagar, Jindan Yu, Barbara Lysy, Maha Hussain, Huiying Han, Sarki A. Abdulkadir
Summary: This study identifies PRRX2 as a driver of enzalutamide resistance in prostate cancer. PRRX2 expression is highest in double-negative prostate cancer cases and its associated gene signature can serve as a biomarker for enzalutamide resistance, which can be reversed with CDK4/6 and BCL2 inhibitors.
Article
Medicine, Research & Experimental
Xia Gan, Hailing Huang, Jing Wen, Kai Liu, Yuting Yang, Xiaoning Li, Gang Fang, Yonghong Liu, Xueni Wang
Summary: The natural compound alpha-terthienyl was found to inhibit the growth of prostate cancer cells by targeting the androgen receptor and its signaling pathway. It also showed anti-prostate cancer effects in a mouse xenograft model. This study highlights the potential of alpha-terthienyl as a promising small molecule for prostate cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Fei Peng, Haohuan Li, Jianping Li, Zhe Wang
Summary: The study on TMEM206 gene silencing revealed that it can attenuate tumorigenic behavior of osteosarcoma cells by inhibiting the Wnt/beta-catenin signaling pathway, particularly showing promising results in suppressing pulmonary metastasis.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Oncology
Zhigang Zhao, Shankun Zhao, Lianmin Luo, Qian Xiang, Zhiguo Zhu, Jiamin Wang, Yangzhou Liu, Jintai Luo
Summary: The study demonstrates a tumor-suppressive role of miR-199b-5p in invasion and metastasis of PCa by inhibiting DDR1 expression and EMT, leading to poor prognosis in patients. Additionally, the miR-199b-5p-DDR1-ERK signaling axis represents a novel mechanism for regulating EMT in PCa metastases.
BRITISH JOURNAL OF CANCER
(2021)
Article
Biology
Nil Vanli, Jinghao Sheng, Shuping Li, Zhengping Xu, Guo-Fu Hu
Summary: RNASE4 serves as a biomarker for prostate cancer and can predict aggressiveness of the disease and enhance diagnosis accuracy. It also promotes tumor cell proliferation and angiogenesis.
COMMUNICATIONS BIOLOGY
(2022)
Article
Oncology
Dong Han, Jude N. Owiredu, Bridget M. Healy, Muqing Li, Maryam Labaf, Jocelyn S. Steinfeld, Susan Patalano, Shuai Gao, Mingyu Liu, Jill A. Macoska, Kourosh Zarringhalam, Kellee R. Siegfried, Xin Yuan, Timothy R. Rebbeck, Changmeng Cai
Summary: Prostate cancer affects men of African ancestry disproportionately with higher prevalence and worse outcomes compared to American men of European ancestry. Genetic variations such as SNP, particularly in the NEDD9 gene, may play a crucial role in driving racial disparities in prostate cancer aggressiveness and treatment outcomes. The identified prostate cancer susceptibility SNP in NEDD9 increases NEDD9 expression and promotes tumor growth and metastasis, providing new insights into the genetic mechanisms of prostate cancer disparities.
Article
Cell Biology
Yi-Fan Tan, Yang Zhang, Sheng-Yang Ge, Fan Zhong, Chuan-Yu Sun, Guo-Wei Xia
Summary: ZIC5, a transcription factor, plays a potential role in the progression of prostate cancer (PCa). It is upregulated in PCa, especially in metastatic lesions, and is associated with poor prognosis. Inhibition of ZIC5 can attenuate invasion, metastasis, and oncogenic properties of PCa cells. ZIC5 functions as a transcription factor to promote TWIST1-mediated EMT progression and strengthens beta-catenin-TCF4 association, stimulating Wnt/beta-catenin signaling. ZIC5 and androgen receptor (AR) form a positive feed-forward loop to mutually stimulate their expression and promote metastasis and resistance to enzalutamide treatment in PCa.
CELL DEATH DISCOVERY
(2022)
Article
Cell Biology
Junhui Yu, Zhengshui Xu, Jing Guo, Kui Yang, Jianbao Zheng, Xuejun Sun
Summary: The study demonstrated that MMP1 derived from TAMs accelerates colon cancer cell proliferation by facilitating cell cycle transition. Inhibition of PAR1 or blocking MAPK/Erk signal pathway can eliminate the proliferation induced by exogenous MMP1. ETV4 may activate MMP1 transcription, establishing a positive feedback loop in CRC.
CELL DEATH DISCOVERY
(2021)
Review
Cell Biology
Fan Chao, Shiyu Wang, Cong Zhang, Dunsheng Han, Guoxiong Xu, Gang Chen
Summary: circRNAs play a crucial role in prostate cancer, being involved in processes such as the growth, migration, and drug resistance of cancer cells, as well as serving as prognostic and diagnostic biomarkers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Zhiguang Xiao, Stephen R. Hammes
Summary: Neutrophil elastase (NE) plays a role in promoting tumorigenesis by triggering ERK signaling and cell migration in prostate cells. NE stimulates the release of amphiregulin to initiate EGFR-dependent signaling. In prostate cancer cells, NE-mediated migration shifts from EGFR dependence to AXL dependence, suggesting the potential use of combined EGFR and AXL targeted therapy in prostate cancer treatment.
Article
Cell Biology
Attila Varga, Minh Tu Nguyen, Kinga Penzes, Bence Batai, Pal Gyulavari, Bianka Gurbi, Jozsef Muranyi, Peter Csermely, Miklos Csala, Tibor Vantus, Csaba Soti
Summary: Prostate cancer metastasis is a major cause of male mortality. Hsp90 promotes cancer cell migration by ensuring the conformational stability and function of PKD3, revealing a potential mechanism of Hsp90 in prostate cancer metastasis.
Review
Biochemistry & Molecular Biology
You-Take Oh, Shi-Yong Sun
Summary: The involvement of the TRAIL/death receptor signaling pathway in the regulation of cancer invasion and metastasis is complex, with both positive and negative roles reported. The underlying molecular mechanisms are even more complicated. This review focuses on discussing the current understanding of how TRAIL/death receptor-mediated signaling regulates cancer cell invasion and metastasis.
Article
Cell Biology
Jing Shen, Guiling Liu, Hongyan Qi, Xueping Xiang, Jimin Shao
Summary: The study found that JMJD5 can cooperate with HUWE1 to degrade EGFR, thereby inhibiting the growth of NSCLC and enhancing the sensitivity of TKI. Additionally, JMJD5 can be transported into recipient cells via extracellular vesicles, thus inhibiting NSCLC growth.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Sara Garcia-Garcia, Maria Rodrigo-Faus, Noelia Fonseca, Sara Manzano, Balazs Gyorffy, Alberto Ocana, Paloma Bragado, Almudena Porras, Alvaro Gutierrez-Uzquiza
Summary: The study identifies MAP4K4 as a key gene in prostate cancer metastasis, with its deletion or inhibition blocking cell migration and clonogenic properties, suggesting a potential role of MAP4K4 in promoting tumor dissemination and growth. Moreover, the upregulation of HGK correlates with poor prognosis in prostate cancer, indicating its potential use as a prognostic biomarker for predicting aggressive phenotype and metastasis appearance.
SCIENTIFIC REPORTS
(2021)
